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Aliases for TEDC1 Gene

Aliases for TEDC1 Gene

  • Tubulin Epsilon And Delta Complex 1 2 3
  • C14orf80 3 4 5
  • Chromosome 14 Open Reading Frame 80 2 5
  • Uncharacterized Protein C14orf80 3

External Ids for TEDC1 Gene

Previous HGNC Symbols for TEDC1 Gene

  • C14orf80

Summaries for TEDC1 Gene

GeneCards Summary for TEDC1 Gene

TEDC1 (Tubulin Epsilon And Delta Complex 1) is a Protein Coding gene.

Additional gene information for TEDC1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEDC1 Gene

Genomics for TEDC1 Gene

Regulatory Elements for TEDC1 Gene

Enhancers for TEDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H105292 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 -196.0 -196048 2.9 HDGF RFX1 SIN3A MAX BMI1 EBF1 ZIC2 POLR2A EED IKZF1 BRF1 BTBD6 TEDC1 GPR132 PACS2 GC14P105252
GH14H105058 1.5 FANTOM5 ENCODE dbSUPER 1.8 -426.7 -426670 10 HDGF PKNOX1 ATF1 TBL1XR1 SIN3A BATF ZNF143 ZNF207 ATF7 ETV6 GPR132 AHNAK2 CDCA4 JAG2 NUDT14 CLBA1 TEDC1 PLD4 BRF1 GC14P105040
GH14H105497 1.1 ENCODE dbSUPER 0.4 +9.0 8970 2.7 ELF3 MLX ZFP64 ARID4B RARA GLIS2 CREM MIXL1 EGR2 HMG20B TMEM121 IGHV3-15 TEDC1
GH14H105511 0.9 ENCODE 0.3 +21.9 21894 0.2 PKNOX1 ZSCAN4 SIN3A ZNF76 KLF17 KLF7 RCOR1 EGR2 YY2 TSHZ1 MTA1 ENSG00000257270 ENSG00000258811 LINC02298 TMEM121 TEDC1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TEDC1 on UCSC Golden Path with GeneCards custom track

Promoters for TEDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000276320 1045 2201 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Locations for TEDC1 Gene

Genomic Locations for TEDC1 Gene
chr14:105,489,855-105,499,575
(GRCh38/hg38)
Size:
9,721 bases
Orientation:
Plus strand
chr14:105,956,192-105,965,912
(GRCh37/hg19)

Genomic View for TEDC1 Gene

Genes around TEDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TEDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TEDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEDC1 Gene

Proteins for TEDC1 Gene

  • Protein details for TEDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SX3-CN080_HUMAN
    Recommended name:
    Uncharacterized protein C14orf80
    Protein Accession:
    Q86SX3
    Secondary Accessions:
    • B5MDG3
    • E9PAQ4
    • Q86TT3
    • Q86TT4
    • Q86TT5
    • Q96B41
    • Q9H7H4

    Protein attributes for TEDC1 Gene

    Size:
    495 amino acids
    Molecular mass:
    54231 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62363.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TEDC1 Gene

neXtProt entry for TEDC1 Gene

Post-translational modifications for TEDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TEDC1 Gene

Domains & Families for TEDC1 Gene

Gene Families for TEDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TEDC1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TEDC1: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TEDC1 Gene

Function for TEDC1 Gene

Phenotypes From GWAS Catalog for TEDC1 Gene

Phenotypes for TEDC1 Gene

GenomeRNAi human phenotypes for TEDC1:
genes like me logo Genes that share phenotypes with TEDC1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TEDC1 Gene

Localization for TEDC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TEDC1 gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TEDC1 Gene

Pathways & Interactions for TEDC1 Gene

SuperPathways for TEDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TEDC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TEDC1 Gene

Drugs & Compounds for TEDC1 Gene

No Compound Related Data Available

Transcripts for TEDC1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEDC1 Gene

No ASD Table

Relevant External Links for TEDC1 Gene

GeneLoc Exon Structure for
TEDC1
ECgene alternative splicing isoforms for
TEDC1

Expression for TEDC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TEDC1 Gene:

TEDC1
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TEDC1 Gene

Orthologs for TEDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TEDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf80 34
  • 100 (a)
OneToOne
LOC453219 33
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia C8H14orf80 33
  • 77.89 (n)
C14orf80 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930427A07Rik 34 33
  • 74.32 (n)
OneToOne
Tedc1 16
rat
(Rattus norvegicus)
Mammalia LOC690422 33
  • 73.35 (n)
cow
(Bos Taurus)
Mammalia C14orf80 34
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf80 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves C14ORF80 33
  • 55.61 (n)
C14orf80 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf80 34
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485326 33
  • 46.23 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570574 33
  • 46.93 (n)
C17H14orf80 34
  • 25 (a)
OneToOne
Species where no ortholog for TEDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TEDC1 Gene

ENSEMBL:
Gene Tree for TEDC1 (if available)
TreeFam:
Gene Tree for TEDC1 (if available)

Paralogs for TEDC1 Gene

No data available for Paralogs for TEDC1 Gene

Variants for TEDC1 Gene

Sequence variations from dbSNP and Humsavar for TEDC1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000295542 -- 105,488,052(+) GGATG(C/T)GGGCT intron-variant, upstream-variant-2KB
rs1000385504 -- 105,496,941(+) CCTGC(A/G)GTCCC intron-variant
rs1000667177 -- 105,487,883(+) CTCGC(C/T)CTCTA intron-variant, upstream-variant-2KB
rs1000698837 -- 105,495,770(+) GGGAC(C/T)ACCCT intron-variant
rs1000740184 -- 105,491,550(+) GCGGG(C/T)CGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEDC1 Gene

Variant ID Type Subtype PubMed ID
nsv952282 CNV deletion 24416366
nsv827088 CNV gain 20364138
nsv566206 CNV loss 21841781
nsv517055 CNV gain+loss 19592680
nsv470679 CNV loss 18288195
nsv1054190 CNV gain 25217958
dgv3998n54 CNV loss 21841781
dgv3987n54 CNV loss 21841781

Variation tolerance for TEDC1 Gene

Gene Damage Index Score: 5.46; 71.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TEDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TEDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEDC1 Gene

Disorders for TEDC1 Gene

Relevant External Links for TEDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TEDC1

No disorders were found for TEDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TEDC1 Gene

Publications for TEDC1 Gene

  1. Direct interaction of Chivosazole F with actin elicits cell responses similar to Latrunculin A but distinct from Chondramide. (PMID: 28796488) Filipuzzi I … Hoepfner D (ACS chemical biology 2017) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for TEDC1 Gene

Sources for TEDC1 Gene

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