TECTB Gene
protein-coding GIFtS: 43
GCID: GC10P114033
|
|
tectorin beta
| |
Aliases
for TECTB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tectorin Beta1 2 | | Beta-Tectorin1 |
Export aliases for TECTB gene to outside databasesPrevious GC identifers: GC10P112936 GC10P113277 GC10P114174 GC10P113708 GC10P107671 |
Summaries
for TECTB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TECTB:
The genes for alpha-tectorin (MIM 602574) and beta-tectorin encode the major noncollagenous proteins of the tectorialmembrane of the cochlea.(supplied by OMIM, Jul 2002)
UniProtKB/Swiss-Prot: TECTB_HUMAN, Q96PL2Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membraneis an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts thestereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to thetectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducingsound into electrical signals
Gene Wiki entry for TECTB
|
Genomic Views
for TECTB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TECTB gene promoter:
ER-alpha TBP HSF1 (long) LCR-F1 Tal-1beta RORalpha2 Egr-4 TFIID HSF1short ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TECTB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TECTB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q25-q26 Ensembl cytogenetic band: 10q25.2 HGNC cytogenetic band: 10q25-q26TECTB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P114033: view genomic region
(about GC identifiers)
Start:
|
114,043,493 bp from pter |
End:
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114,064,793 bp from pter |
Size:
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21,301 bases |
Orientation:
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plus strand |
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Proteins
for TECTB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TECTB_HUMAN, Q96PL2 (See
protein sequence)Recommended Name: Beta-tectorin precursor Size: 329 amino acids; 36956 Da
Subunit: May form homomeric filament after self-association or heteromeric filament after association withalpha-tectorin
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (Probable). Secreted, extracellularspace, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane (By similarity)
Secondary accessions: Q5VW53Explore the universe of human proteins at neXtProt for TECTB: NX_Q96PL2
Post-translational modifications:
The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins aresynthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apicalsurface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment1
View neXtProt modification sites for NX_Q96PL2
TECTB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_478129.1
ENSEMBL proteins: ENSP00000358430
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005578 | proteinaceous extracellular matrix |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- | | GO:0031225 | anchored to membrane |
IEA | -- |
TECTB for ontologies About GeneDecksing
TECTB Antibody Products:
Assay Products for TECTB: |
Protein
Domains /
Families
for TECTB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TECTB for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PL2ProtoNet protein and cluster: Q96PL2 UniProtKB/Swiss-Prot: TECTB_HUMAN, Q96PL2Domain: Zona pellucida domain may enable to form filamentsSimilarity: Contains 1 ZP domain |
Function
for TECTB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TECTB_HUMAN, Q96PL2Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membraneis an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts thestereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to thetectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducingsound into electrical signals
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TECTB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for TECTB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TECTB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TECTB |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005201 | extracellular matrix structural constituent |
-- | -- |
TECTB for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tectbtm1Gpr for TECTB
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tectb):
TECTB for phenotypes About GeneDecksing
|
Pathways & Interactions
for TECTB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TECTB
|
Drugs & Compounds
for TECTB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TECTB
Search CenterWatch for drugs/clinical trials and news about TECTB
|
Transcripts
for TECTB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TECTB gene: NM_058222.1 Unigene Cluster for TECTB: Tectorin beta Hs.348615 [show with all ESTs]Unigene Representative Sequence: BC1134972 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369422(uc001kzr.1) ENST00000494328
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TECTB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TECTB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TECTB (NM_058222) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TECTB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TECTB |
Additional cDNA sequence: AF312827.1 BC113497.1 BC113499.1 2 DOTS entries: DT.97788079 DT.97814614 4 AceView cDNA sequences: AF312827 NM_058222 BQ185496 BQ187858
GeneLoc Exon Structure
|
Expression
for TECTB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TECTB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAATGGGAG
About this image
See TECTB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TECTB
SOURCE GeneReport for Unigene cluster: Hs.348615
SABiosciences Custom PCR Arrays for TECTB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TECTB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TECTB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TECTB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TECTB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TECTB |
Orthologs
for TECTB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TECTB gene from 5/10 species (see all 10) About this table
ENSEMBL Gene Tree for TECTB (if available)
TreeFam Gene Tree for TECTB (if available) |
Paralogs
for TECTB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TECTB gene
- ZPLD12
TECTB for paralogs About GeneDecksing
|
Genomic Variants
for TECTB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TECTB (114043493 - 114064793 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TECTB
1 CNV: 0766 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TECTB |
|
Disorders
/ Diseases
for TECTB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TECTB for disorders About GeneDecksing
OMIM gene information: 602653
OMIM disorders: --
4  diseases for TECTB: About MalaCardsenlarged vestibular aqueduct sensorineural hearing loss hearing loss alzheimer's disease
3 diseases from the University of Copenhagen DISEASES database for TECTB:Enlarged vestibular aqueduct Sensorineural hearing loss Nonsyndromic deafness Human Genome Epidemiology (HuGE) Navigator: TECTB (2 documents)
Export disorders for TECTB gene to outside databases
|
Publications
for TECTB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TECTB gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with TECTB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system. (PubMed id 9079715)1, 3 Legan P.K....Richardson G.P. (1997)
- Loss of mammal-specific tectorial membrane component c arcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing im pairment at low and high frequencies. (PubMed id 22544735)1 Kammerer R....Zimmermann W. (2012)
- Identification of polymorphisms in ultraconserved elem ents associated with clinical outcomes in locally advanced colorectal adenocarci noma. (PubMed id 22673945)1 Lin M....Wu X. (2012)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Molecular cloning of chick beta-tectorin, an extracel lular matrix molecule of the inner ear. (PubMed id 7721949)9 Killick R....Richardson G.P. (1995)
|
External Searches for TECTB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TECTB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TECTB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TECTB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TECTB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TECTB gene:
Search GeneIP for patents involving TECTB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TECTB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TECTB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TECTB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TECTB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TECTB | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TECTB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TECTB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TECTB |
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