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Aliases for TECTB Gene

Aliases for TECTB Gene

  • Tectorin Beta 2 3 5
  • Beta-Tectorin 3

External Ids for TECTB Gene

Previous GeneCards Identifiers for TECTB Gene

  • GC10P112936
  • GC10P113277
  • GC10P114174
  • GC10P113708
  • GC10P114033
  • GC10P107671

Summaries for TECTB Gene

Entrez Gene Summary for TECTB Gene

  • This gene encodes a non-collagenous glycoprotein component of the tectorial membrane, which covers the auditory hair cells in the cochlea of the inner ear. A similar protein in mouse functions in low-frequency hearing. [provided by RefSeq, Jul 2013]

GeneCards Summary for TECTB Gene

TECTB (Tectorin Beta) is a Protein Coding gene. Diseases associated with TECTB include Deafness, Autosomal Recessive 21 and Usher Syndrome, Type 1B. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins. An important paralog of this gene is ZPLD1.

UniProtKB/Swiss-Prot for TECTB Gene

  • One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

Gene Wiki entry for TECTB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECTB Gene

Genomics for TECTB Gene

Regulatory Elements for TECTB Gene

Enhancers for TECTB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G112259 1.3 ENCODE dbSUPER 24.8 -22.1 -22095 2.6 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 TCF12 SLC30A9 TECTB GPAM LOC101927600
GH10G112242 0.7 dbSUPER 24 -39.5 -39469 3.2 CTCF HLF MAX CEBPG RAD21 YY1 SREBF1 JUND ATF3 CEBPA TECTB GPAM LOC101927600
GH10G112330 1.5 FANTOM5 ENCODE dbSUPER 10.8 +50.5 50470 7.1 ELF3 THRB RAD21 EGR1 ZSCAN5C ETV6 FOS IKZF2 CREM CBFB ACSL5 TECTB ZDHHC6 PIR60176 MIR6715B
GH10G112279 1.1 ENCODE dbSUPER 13.6 -2.9 -2889 2.3 FOXA2 RAD21 RARA CREM THAP11 CEBPB PPARG CEBPA RCOR2 ZBTB33 TECTB LOC101927600
GH10G112303 1.2 ENCODE dbSUPER 11.6 +21.1 21058 1.6 FOXA2 ATF1 MLX THRB ZSCAN9 RAD21 RARA YY1 GATA4 CREM TECTB MIR6715B PIR60176
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TECTB on UCSC Golden Path with GeneCards custom track

Genomic Location for TECTB Gene

Chromosome:
10
Start:
112,283,345 bp from pter
End:
112,305,035 bp from pter
Size:
21,691 bases
Orientation:
Plus strand

Genomic View for TECTB Gene

Genes around TECTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TECTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TECTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECTB Gene

Proteins for TECTB Gene

  • Protein details for TECTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PL2-TECTB_HUMAN
    Recommended name:
    Beta-tectorin
    Protein Accession:
    Q96PL2
    Secondary Accessions:
    • Q5VW53

    Protein attributes for TECTB Gene

    Size:
    329 amino acids
    Molecular mass:
    36956 Da
    Quaternary structure:
    • May form homomeric filament after self-association or heteromeric filament after association with alpha-tectorin.

neXtProt entry for TECTB Gene

Post-translational modifications for TECTB Gene

  • The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.
  • Glycosylation at Asn80, posLast=104104, posLast=116116, and Asn145

Other Protein References for TECTB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TECTB Gene

Domains & Families for TECTB Gene

Protein Domains for TECTB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TECTB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PL2

UniProtKB/Swiss-Prot:

TECTB_HUMAN :
  • Zona pellucida domain may enable to form filaments.
Domain:
  • Zona pellucida domain may enable to form filaments.
genes like me logo Genes that share domains with TECTB: view

No data available for Gene Families for TECTB Gene

Function for TECTB Gene

Molecular function for TECTB Gene

UniProtKB/Swiss-Prot Function:
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

Gene Ontology (GO) - Molecular Function for TECTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IEA --
genes like me logo Genes that share ontologies with TECTB: view
genes like me logo Genes that share phenotypes with TECTB: view

Animal Models for TECTB Gene

MGI Knock Outs for TECTB:

Animal Model Products

miRNA for TECTB Gene

miRTarBase miRNAs that target TECTB

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TECTB Gene

Localization for TECTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECTB Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TECTB gene
Compartment Confidence
extracellular 5
plasma membrane 4
mitochondrion 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TECTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with TECTB: view

Pathways & Interactions for TECTB Gene

genes like me logo Genes that share pathways with TECTB: view

Interacting Proteins for TECTB Gene

Selected Interacting proteins: Q96PL2-TECTB_HUMAN for TECTB Gene via IID

Gene Ontology (GO) - Biological Process for TECTB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
genes like me logo Genes that share ontologies with TECTB: view

No data available for SIGNOR curated interactions for TECTB Gene

Drugs & Compounds for TECTB Gene

No Compound Related Data Available

Transcripts for TECTB Gene

mRNA/cDNA for TECTB Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TECTB Gene

Tectorin beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TECTB Gene

No ASD Table

Relevant External Links for TECTB Gene

GeneLoc Exon Structure for
TECTB
ECgene alternative splicing isoforms for
TECTB

Expression for TECTB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TECTB Gene

mRNA differential expression in normal tissues according to GTEx for TECTB Gene

This gene is overexpressed in Liver (x10.2), Brain - Putamen (basal ganglia) (x6.4), Thyroid (x5.9), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TECTB Gene:

TECTB

SOURCE GeneReport for Unigene cluster for TECTB Gene:

Hs.348615

Evidence on tissue expression from TISSUES for TECTB Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with TECTB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TECTB Gene

Orthologs for TECTB Gene

This gene was present in the common ancestor of chordates.

Orthologs for TECTB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TECTB 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia TECTB 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TECTB 34 35
  • 92 (n)
rat
(Rattus norvegicus)
Mammalia Tectb 34
  • 88.45 (n)
mouse
(Mus musculus)
Mammalia Tectb 34 16 35
  • 88.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TECTB 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TECTB 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TECTB 34 35
  • 74.19 (n)
lizard
(Anolis carolinensis)
Reptilia TECTB 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tectb 34
  • 72.02 (n)
Str.5707 34
zebrafish
(Danio rerio)
Actinopterygii tectb 34 35
  • 57.38 (n)
Species where no ortholog for TECTB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TECTB Gene

ENSEMBL:
Gene Tree for TECTB (if available)
TreeFam:
Gene Tree for TECTB (if available)

Paralogs for TECTB Gene

Paralogs for TECTB Gene

genes like me logo Genes that share paralogs with TECTB: view

Variants for TECTB Gene

Sequence variations from dbSNP and Humsavar for TECTB Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000106690 -- 112,286,368(+) AGAGC(C/T)AACTG reference, stop-gained
rs1000319892 -- 112,291,685(+) TTATT(A/C)TCCTA intron-variant
rs1000357040 -- 112,282,755(+) CAGTG(A/G)GATCT upstream-variant-2KB
rs1000381436 -- 112,297,088(+) GTCTT(C/T)GTTAA intron-variant
rs1000411626 -- 112,283,055(+) AAAAA(A/T)AAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TECTB Gene

Variant ID Type Subtype PubMed ID
nsv471669 CNV gain 15918152
nsv510233 OTHER sequence alteration 20534489
nsv526495 CNV loss 19592680
nsv7211 OTHER inversion 18451855
nsv831989 CNV gain 17160897

Variation tolerance for TECTB Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TECTB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TECTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECTB Gene

Disorders for TECTB Gene

MalaCards: The human disease database

(2) MalaCards diseases for TECTB Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 21
  • autosomal recessive nonsyndromic deafness 21
usher syndrome, type 1b
  • usher syndrome type 1
- elite association - COSMIC cancer census association via MalaCards
Search TECTB in MalaCards View complete list of genes associated with diseases

Relevant External Links for TECTB

Genetic Association Database (GAD)
TECTB
Human Genome Epidemiology (HuGE) Navigator
TECTB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TECTB
genes like me logo Genes that share disorders with TECTB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TECTB Gene

Publications for TECTB Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The mouse tectorins. Modular matrix proteins of the inner ear homologous to components of the sperm-egg adhesion system. (PMID: 9079715) Legan P.K. … Richardson G.P. (J. Biol. Chem. 1997) 2 3 64

Products for TECTB Gene

Sources for TECTB Gene

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