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TECTA Gene

protein-coding   GIFtS: 50
GCID: GC11P121007

Tectorin Alpha


(Previous symbols: DFNA12, DFNA8, DFNB21)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tectorin Alpha1 2
DFNA121 2 5
DFNA81 2 5
DFNB211 2 5
alpha-tectorin2

External Ids:    HGNC: 117201   Entrez Gene: 70072   Ensembl: ENSG000001099277   OMIM: 6025745   UniProtKB: O754433   

Export aliases for TECTA gene to outside databases

Previous GC identifers: GC11P122972 GC11P122485 GC11P120511 GC11P120478 GC11P116913


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TECTA Gene:
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of
specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane,
deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into
electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane.
Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing
impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. (provided by RefSeq, Jul
2008)

GeneCards Summary for TECTA Gene:
TECTA (tectorin alpha) is a protein-coding gene. Diseases associated with TECTA include deafness, autosomal recessive 21, and dfna 8/12 nonsyndromic hearing loss and deafness. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is MUC5AC.

UniProtKB/Swiss-Prot: TECTA_HUMAN, O75443
Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial
membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts
the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to
the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential,
transducing sound into electrical signals

Gene Wiki entry for TECTA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TECTA gene promoter:
         E2F-4   E2F-3a   E2F-5   MEF-2   E2F-2   GATA-2   MEF-2A   E2F   E2F-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTECTA promoter sequence
   Search Chromatin IP Primers for TECTA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TECTA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q24   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q22-q24

TECTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TECTA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P121007:  view genomic region     (about GC identifiers)

Start:
120,971,882 bp from pter      End:
121,062,202 bp from pter
Size:
90,321 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TECTA_HUMAN, O75443 (See protein sequence)
Recommended Name: Alpha-tectorin precursor  
Size: 2155 amino acids; 239527 Da
Subunit: May form homomeric filament after self-association or heteromeric filament after association with
beta-tectorin. Interacts with CEACAM16

Explore the universe of human proteins at neXtProt for TECTA: NX_O75443

Explore proteomics data for TECTA at MOPED

Post-translational modifications: 

  • The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins
    are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the
    apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular
    compartment1
  • Glycosylation2 at Asn34, Asn187, Asn215, Asn278, Asn455, Asn506, Asn528, Asn560, Asn670, Asn687,
                                 Asn813, Asn843, Asn855, Asn898, Asn920, Asn931, Asn949, Asn1048, Asn1235, Asn1364 (see all 30)
  • Modification sites at PhosphoSitePlus

  • See TECTA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005413.2  
    ENSEMBL proteins: 
     ENSP00000376543   ENSP00000264037  

    TECTA Human Recombinant Protein Products:

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    Novus Biologicals TECTA Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    LSBio Antibodies in human, mouse, rat for TECTA

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR014853 Unchr_dom_Cys-rich
     IPR006552 VWC_out
     IPR017977 ZP_dom_CS
     IPR003886 Nidogen_extracell_dom
     IPR002919 TIL_dom

    Graphical View of Domain Structure for InterPro Entry O75443

    ProtoNet protein and cluster: O75443

    Selected Blocks protein domains (see all 7):
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB001007 von Willebrand factor
    IPB001507 Endoglin/CD105 antigen
    IPB001846 Von Willebrand factor
    IPB002919 Trypsin inhibitor-like


    UniProtKB/Swiss-Prot: TECTA_HUMAN, O75443
    Domain: Zona pellucida domain may enable to form filaments
    Similarity: Contains 1 NIDO domain
    Similarity: Contains 3 TIL (trypsin inhibitory-like) domains
    Similarity: Contains 1 VWFC domain
    Similarity: Contains 4 VWFD domains
    Similarity: Contains 1 ZP domain


    TECTA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TECTA_HUMAN, O75443
    Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial
    membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts
    the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to
    the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential,
    transducing sound into electrical signals

         Genatlas biochemistry entry for TECTA:
    alpha tectorin,239kDa,non collagenous component of tectorial extracellular matrix membrane of the inner ear

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005201extracellular matrix structural constituent ----
    GO:0005515protein binding ----
         
    TECTA for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Tecta):
     behavior/neurological  hearing/vestibular/ear  nervous system 

    TECTA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tectatm1Gpr for TECTA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TECTA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TECTA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TECTA

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    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TECTA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TECTA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TECTA_HUMAN, O75443: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side (Probable). Secreted,
    extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    nucleus2
    cytoskeleton1
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005886plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    TECTA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TECTA
    Interactions:

        Search GeneGlobe Interaction Network for TECTA

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007160cell-matrix adhesion IEA--
    GO:0007605sensory perception of sound IEA--

    TECTA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TECTA

    1 Novoseek inferred chemical compound relationship for TECTA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 9.06 2 15319541 (1), 10987647 (1)



    TECTA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TECTA gene: 
    NM_005422.2  

    Unigene Cluster for TECTA:

    Tectorin alpha
    Hs.248162  [show with all ESTs]
    Unigene Representative Sequence: NM_005422
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392793 ENST00000478058 ENST00000264037(uc010rzo.2)
    miRNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TECTA (NM_005422)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TECTA
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TECTA
      QuantiFast Probe-based Assays in human, mouse, rat TECTA

    Additional mRNA sequence: AF143331.1 

    3 DOTS entries:

    DT.40217927  DT.307552  DT.40221143 

    15 AceView cDNA sequences:

    AA782076 AA889017 NM_005422 T86051 AW001605 BX110584 AA400801 AF143331 
    BM994412 BI828832 BG944068 R84585 AA393625 T86996 AW129644 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TECTA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCTTTGG
    TECTA Expression
    About this image


    TECTA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    TECTA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TECTA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248162
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TECTA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TECTA gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tecta1 , 5 tectorin alpha1, 5 88.75(n)1
    95.87(a)1
      9 (23.63 cM)5
    216831  NM_009347.21  NP_033373.21 
     423296195 
    chicken
    (Gallus gallus)
    Aves TECTA1 tectorin alpha 77.07(n)
    78.32(a)
      395686  XM_004948018.1  XP_004948075.1 
    lizard
    (Anolis carolinensis)
    Reptilia TECTA6
    tectorin alpha
    81(a)
    1 ↔ 1
    LGa(2148059-2209040)
    African clawed frog
    (Xenopus laevis)
    Amphibia ID142 ID14 protein 69.86(n)    AY363162.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.184082 Transcribed sequence with moderate similarity to protein refNP_005413.1 (H.sapiens) tectorin alpha precursor; Tectorin, alpha [Homo sapiens] less 74.89(n)    BQ284238.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cv-26
    crossveinless 2
    18(a)
    1 → many
    2R(17242520-17266967)


    ENSEMBL Gene Tree for TECTA (if available)
    TreeFam Gene Tree for TECTA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TECTA gene
    MUC5AC2  ZAN2  MUC22  OTOG2  OTOGL2  MUC62  MUC192  FCGBP2  
    VWF2  BMPER2  
    1 SIMAP similar gene for TECTA using alignment to 2 protein entries:     TECTA_HUMAN (see all proteins):
    GP2

    TECTA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TECTA
    PGOHUM00000234670


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TECTA (see all 2215)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1478906161,2,,4
    CDeafness, autosomal dominant, 12 (DFNA12)4 --120875162(+) GCTCAG/CACTCT 2 /H /D mis11Minor allele frequency- C:0.00NA 4550
    rs1387689181,2,,4
    C,FDeafness, autosomal dominant, 12 (DFNA12)4 --120883033(+) CAACCC/TTGATG 2 P L mis11Minor allele frequency- T:0.00NA 4552
    VAR_0660884
    Deafness, autosomal dominant, 12 (DFNA12)4--see VAR_0660882 C G mis40--------
    VAR_0660954
    Deafness, autosomal dominant, 12 (DFNA12)4--see VAR_0660952 C R mis40--------
    VAR_0660774
    Deafness, autosomal dominant, 12 (DFNA12)4--see VAR_0660772 F S mis40--------
    VAR_0660944
    Deafness, autosomal dominant, 12 (DFNA12)4--see VAR_0660942 R C mis40--------
    VAR_0660784
    Deafness, autosomal dominant, 12 (DFNA12)4--see VAR_0660782 V E mis40--------
    VAR_0364244
    A breast cancer sample4--see VAR_0364242 I N mis40--------
    rs289396901,2,4
    Deafness, autosomal dominant, 12 (DFNA12)4--see VAR_0189762 mis40--------
    VAR_0660814
    Deafness, autosomal dominant, 12 (DFNA12)4--see VAR_0660812 T M mis40--------

    HapMap Linkage Disequilibrium report for TECTA (120971882 - 121062202 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TECTA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745149CNV Deletion23290073
    esv2745148CNV Deletion23290073
    esv2745150CNV Deletion23290073
    nsv525CNV Insertion18451855
    nsv524CNV Loss18451855
    esv25267CNV Loss19812545

    Human Gene Mutation Database (HGMD): TECTA
    Locus Specific Mutation Databases (LSDB): TECTA

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TECTA
    DNA2.0 Custom Variant and Variant Library Synthesis for TECTA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602574   
    OMIM disorders: 601543  603629  
    UniProtKB/Swiss-Prot: TECTA_HUMAN, O75443
  • Deafness, autosomal dominant, 12 (DFNA12) [MIM:601543]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Deafness, autosomal recessive, 21 (DFNB21) [MIM:603629]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 19 diseases for TECTA:    
    About MalaCards
    deafness, autosomal recessive 21    dfna 8/12 nonsyndromic hearing loss and deafness    dfnb21 nonsyndromic hearing loss and deafness    deafness, autosomal dominant 8/12
    autosomal dominant nonsyndromic deafness    deafness, autosomal dominant 4b    nonsyndromic hearing loss and deafness    scotoma
    deafness, autosomal recessive 76    nonsyndromic hearing loss and deafness, autosomal dominant    nonsyndromic hearing loss and deafness, autosomal recessive    nonsyndromic deafness
    deafness and hereditary hearing loss    sensorineural hearing loss    breast and colorectal cancer    hodgkin's lymphoma
    colorectal cancer    multiple myeloma    myeloma

    3 diseases from the University of Copenhagen DISEASES database for TECTA:
    Nonsyndromic deafness     Hodgkin's lymphoma, nodular sclerosis     Sensorineural hearing loss

    TECTA for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TECTA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dfna8 99.2 16 17136632 (3), 18575463 (2), 9763681 (2), 16718611 (2) (see all 9)
    dfna12 98.4 10 9503015 (2), 15319541 (1), 9590290 (1), 10196713 (1) (see all 5)
    dfnb2 90.3 1 11101839 (1)

    Genetic Association Database (GAD): TECTA
    Human Genome Epidemiology (HuGE) Navigator: TECTA (2 documents)

    Export disorders for TECTA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TECTA gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with TECTA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss. (PubMed id 12162770)1, 2, 4, 9 Iwasaki S.... Hoshino T. (Arch. Otolaryngol. Head Neck Surg. 2002)
    2. Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment. (PubMed id 9590290)1, 2, 3, 9 Verhoeven K.... Van Camp G. (Nat. Genet. 1998)
    3. Two novel missense mutations in the TECTA gene in Korean families with autosomal dominant nonsyndromic hearing loss. (PubMed id 20947814)1, 2, 4 Sagong B.... Lee S.H. (Ann. Clin. Lab. Sci. 2010)
    4. A genotype-phenotype correlation with gender-effect for hearing impairment caused by TECTA mutations. (PubMed id 15319541)1, 2, 9 Pfister M.... Kupka S. (Cell. Physiol. Biochem. 2004)
    5. Alpha-tectorin involvement in hearing disabilities: one gene -- two phenotypes. (PubMed id 10987647)1, 2, 9 Balciuniene J.... Jazin E.E. (Hum. Genet. 1999)
    6. Mutation in the zonadhesin-like domain of alpha-tectorin associated with autosomal dominant non-syndromic hearing loss. (PubMed id 10196713)1, 2, 9 Alloisio N.... Lina-Granade G. (Eur. J. Hum. Genet. 1999)
    7. Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness. (PubMed id 9503015)1, 3, 9 Hughes D.C....Richardson G.P. (Genomics 1998)
    8. A novel TECTA mutation in a Dutch DFNA8/12 family confirms genotype- phenotype correlation. (PubMed id 16718611)1, 2, 9 Plantinga R.F....Cremers C.W. (J. Assoc. Res. Otolaryngol. 2006)
    9. An alpha-tectorin gene defect causes a newly identified autosomal recessive form of sensorineural pre-lingual non-syndromic deafness, DFNB21. (PubMed id 9949200)1, 2, 9 Mustapha M.... Petit C. (Hum. Mol. Genet. 1999)
    10. A cysteine substitution in the zona pellucida domain of alpha- tectorin results in autosomal dominant, postlingual, progressive, mid frequency hearing loss in a Spanish family. (PubMed id 11333869)1, 2, 9 Moreno-Pelayo M.A.... Moreno F. (J. Med. Genet. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7007 HGNC: 11720 AceView: TECTA Ensembl:ENSG00000109927 euGenes: HUgn7007
    ECgene: TECTA H-InvDB: TECTA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TECTA Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TECTA[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TECTA gene:
    Search GeneIP for patents involving TECTA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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