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Aliases for TECTA Gene

Aliases for TECTA Gene

  • Tectorin Alpha 2 3
  • DFNA12 3 6
  • DFNB21 3 6
  • DFNA8 3 6
  • Alpha-Tectorin 3

External Ids for TECTA Gene

Previous HGNC Symbols for TECTA Gene

  • DFNA12
  • DFNA8
  • DFNB21

Previous GeneCards Identifiers for TECTA Gene

  • GC11P122972
  • GC11P122485
  • GC11P121007
  • GC11P120511
  • GC11P120478
  • GC11P116913

Summaries for TECTA Gene

Entrez Gene Summary for TECTA Gene

  • The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]

GeneCards Summary for TECTA Gene

TECTA (Tectorin Alpha) is a Protein Coding gene. Diseases associated with TECTA include deafness, autosomal recessive 21 and deafness, autosomal dominant 8/12. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is OTOGL.

UniProtKB/Swiss-Prot for TECTA Gene

  • One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

Gene Wiki entry for TECTA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECTA Gene

Genomics for TECTA Gene

Regulatory Elements for TECTA Gene

Genomic Location for TECTA Gene

Start:
121,101,173 bp from pter
End:
121,191,493 bp from pter
Size:
90,321 bases
Orientation:
Plus strand

Genomic View for TECTA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TECTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECTA Gene

Proteins for TECTA Gene

  • Protein details for TECTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75443-TECTA_HUMAN
    Recommended name:
    Alpha-tectorin
    Protein Accession:
    O75443
    Secondary Accessions:

    Protein attributes for TECTA Gene

    Size:
    2155 amino acids
    Molecular mass:
    239527 Da
    Quaternary structure:
    • May form homomeric filament after self-association or heteromeric filament after association with beta-tectorin. Interacts with CEACAM16.

neXtProt entry for TECTA Gene

Proteomics data for TECTA Gene at MOPED

Post-translational modifications for TECTA Gene

  • The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment
  • Glycosylation at Asn34, Asn187, Asn215, Asn278, Asn455, Asn506, Asn528, Asn560, Asn670, Asn687, Asn813, Asn843, Asn855, Asn898, Asn920, Asn931, Asn949, Asn1048, Asn1235, Asn1364, Asn1538, Asn1565, Asn1756, Asn1772, Asn1794, Asn1851, Asn1864, Asn1880, Asn1920, and Asn1939
  • Modification sites at PhosphoSitePlus

Other Protein References for TECTA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TECTA Gene

Domains for TECTA Gene

Suggested Antigen Peptide Sequences for TECTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75443

UniProtKB/Swiss-Prot:

TECTA_HUMAN :
  • O75443
Domain:
  • Zona pellucida domain may enable to form filaments
  • Contains 1 NIDO domain.
  • Contains 3 TIL (trypsin inhibitory-like) domains.
  • Contains 1 VWFC domain.
  • Contains 4 VWFD domains.
  • Contains 1 ZP domain.
genes like me logo Genes that share domains with TECTA: view

No data available for Gene Families for TECTA Gene

Function for TECTA Gene

Molecular function for TECTA Gene

GENATLAS Biochemistry: alpha tectorin,239kDa,non collagenous component of tectorial extracellular matrix membrane of the inner ear
UniProtKB/Swiss-Prot Function: One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

Gene Ontology (GO) - Molecular Function for TECTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TECTA: view
genes like me logo Genes that share phenotypes with TECTA: view

Animal Models for TECTA Gene

MGI Knock Outs for TECTA:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TECTA Gene

Localization for TECTA Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECTA Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix. Note=Found in the non-collagenous matrix of the tectorial membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TECTA Gene COMPARTMENTS Subcellular localization image for TECTA gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TECTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TECTA: view

Pathways for TECTA Gene

SuperPathways for TECTA Gene

No Data Available

Interacting Proteins for TECTA Gene

Gene Ontology (GO) - Biological Process for TECTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IEA --
GO:0007605 sensory perception of sound IEA --
genes like me logo Genes that share ontologies with TECTA: view

No data available for Pathways by source for TECTA Gene

Compounds for TECTA Gene

(1) Novoseek inferred chemical compound relationships for TECTA Gene

Compound -log(P) Hits PubMed IDs
cysteine 9.06 2
genes like me logo Genes that share compounds with TECTA: view

Transcripts for TECTA Gene

mRNA/cDNA for TECTA Gene

(15) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TECTA Gene

Tectorin alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TECTA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TECTA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TECTA Gene

No ASD Table

Relevant External Links for TECTA Gene

GeneLoc Exon Structure for
TECTA
ECgene alternative splicing isoforms for
TECTA

Expression for TECTA Gene

mRNA expression in normal human tissues for TECTA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TECTA Gene

SOURCE GeneReport for Unigene cluster for TECTA Gene Hs.248162

genes like me logo Genes that share expressions with TECTA: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TECTA Gene

Orthologs for TECTA Gene

This gene was present in the common ancestor of animals.

Orthologs for TECTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TECTA 35
  • 99.4 (n)
  • 99.21 (a)
TECTA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TECTA 35
  • 90.66 (n)
  • 95.31 (a)
TECTA 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TECTA 35
  • 91.09 (n)
  • 95.73 (a)
TECTA 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tecta 35
  • 88.75 (n)
  • 95.87 (a)
Tecta 16
Tecta 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TECTA 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TECTA 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tecta 35
  • 89.06 (n)
  • 95.45 (a)
chicken
(Gallus gallus)
Aves TECTA 35
  • 77.07 (n)
  • 78.32 (a)
TECTA 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TECTA 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ID14 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490936 35
  • 72.3 (n)
  • 79.76 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18408 35
LOC561355 35
  • 63.29 (n)
  • 61.85 (a)
tecta 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cv-2 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for TECTA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TECTA Gene

ENSEMBL:
Gene Tree for TECTA (if available)
TreeFam:
Gene Tree for TECTA (if available)

Paralogs for TECTA Gene

Paralogs for TECTA Gene

Selected SIMAP similar genes for TECTA Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TECTA Gene

genes like me logo Genes that share paralogs with TECTA: view

Variants for TECTA Gene

Sequence variations from dbSNP and Humsavar for TECTA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1829 -- 121,110,699(+) GCAAT(C/T)GATAA intron-variant
rs22298 -- 121,148,245(+) AGGCC(A/G)ATACG intron-variant
rs87466 -- 121,111,154(+) TACTG(A/G)GGGTT intron-variant
rs470134 -- 121,185,488(+) ATGTT(C/G)AATGC intron-variant
rs475731 -- 121,133,515(+) attgt(C/T)gtgtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TECTA Gene

Variant ID Type Subtype PubMed ID
nsv524 CNV Loss 18451855
esv2745148 CNV Deletion 23290073
esv2745149 CNV Deletion 23290073
nsv525 CNV Insertion 18451855
esv25267 CNV Loss 19812545
esv2745150 CNV Deletion 23290073

Relevant External Links for TECTA Gene

HapMap Linkage Disequilibrium report
TECTA
Human Gene Mutation Database (HGMD)
TECTA
Locus Specific Mutation Databases (LSDB)
TECTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECTA Gene

Disorders for TECTA Gene

(2) OMIM Diseases for TECTA Gene (602574)

UniProtKB/Swiss-Prot

TECTA_HUMAN
  • Deafness, autosomal dominant, 12 (DFNA12) [MIM:601543]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:10196713, ECO:0000269 PubMed:10987647, ECO:0000269 PubMed:12162770, ECO:0000269 PubMed:15319541, ECO:0000269 PubMed:16718611, ECO:0000269 PubMed:17661817, ECO:0000269 PubMed:20947814, ECO:0000269 PubMed:21520338, ECO:0000269 PubMed:9590290}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Deafness, autosomal recessive, 21 (DFNB21) [MIM:603629]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:12746400, ECO:0000269 PubMed:9949200}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) Novoseek inferred disease relationships for TECTA Gene

Disease -log(P) Hits PubMed IDs
dfna8 99.2 14
dfna12 98.4 6
dfnb2 90.3 1

Relevant External Links for TECTA

Genetic Association Database (GAD)
TECTA
Human Genome Epidemiology (HuGE) Navigator
TECTA
genes like me logo Genes that share disorders with TECTA: view

Publications for TECTA Gene

  1. Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment. (PMID: 9590290) Verhoeven K. … Van Camp G. (Nat. Genet. 1998) 2 3 4 23
  2. Association of clinical features with mutation of TECTA in a family with autosomal dominant hearing loss. (PMID: 12162770) Iwasaki S. … Hoshino T. (Arch. Otolaryngol. Head Neck Surg. 2002) 3 4 23 48
  3. A genotype-phenotype correlation with gender-effect for hearing impairment caused by TECTA mutations. (PMID: 15319541) Pfister M. … Kupka S. (Cell. Physiol. Biochem. 2004) 3 4 23
  4. A novel TECTA mutation in a Dutch DFNA8/12 family confirms genotype- phenotype correlation. (PMID: 16718611) Plantinga R.F. … Cremers C.W. (J. Assoc. Res. Otolaryngol. 2006) 3 4 23
  5. Audioprofiling identifies TECTA and GJB2-related deafness segregating in a single extended pedigree. (PMID: 17661817) Meyer N.C. … Smith R.J. (Clin. Genet. 2007) 3 4 23

Products for TECTA Gene

Sources for TECTA Gene

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