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Aliases for TECRL Gene

Aliases for TECRL Gene

  • Trans-2,3-Enoyl-CoA Reductase-Like 2 3
  • Steroid 5-Alpha-Reductase 2-Like 2 Protein 3 4
  • SRD5A2L2 3 4
  • Steroid 5 Alpha-Reductase 2-Like 2 3
  • Glycoprotein, Synaptic 2-Like 3
  • Synaptic 2-Like 2
  • Glycoprotein 2
  • EC 1.3.1.- 4
  • GPSN2L 3
  • TERL 3

External Ids for TECRL Gene

Previous GeneCards Identifiers for TECRL Gene

  • GC04M064827
  • GC04M065143
  • GC04M061053

Summaries for TECRL Gene

GeneCards Summary for TECRL Gene

TECRL (Trans-2,3-Enoyl-CoA Reductase-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is TECR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECRL Gene

Genomics for TECRL Gene

Genomic Location for TECRL Gene

64,275,257 bp from pter
64,409,471 bp from pter
134,215 bases
Minus strand

Genomic View for TECRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TECRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECRL Gene

No data available for Regulatory Elements for TECRL Gene

Proteins for TECRL Gene

  • Protein details for TECRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trans-2,3-enoyl-CoA reductase-like
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TECRL Gene

    363 amino acids
    Molecular mass:
    42009 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TECRL Gene

Proteomics data for TECRL Gene at MOPED

Post-translational modifications for TECRL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TECRL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TECRL Gene

Domains for TECRL Gene

Protein Domains for TECRL Gene

Suggested Antigen Peptide Sequences for TECRL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5HYJ1
  • Belongs to the steroid 5-alpha reductase family.
genes like me logo Genes that share domains with TECRL: view

No data available for Gene Families for TECRL Gene

Function for TECRL Gene

Enzyme Numbers (IUBMB) for TECRL Gene

Gene Ontology (GO) - Molecular Function for TECRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
genes like me logo Genes that share ontologies with TECRL: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TECRL Gene

Localization for TECRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECRL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TECRL Gene COMPARTMENTS Subcellular localization image for TECRL gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TECRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TECRL: view

Pathways for TECRL Gene

genes like me logo Genes that share pathways with TECRL: view

Interacting Proteins for TECRL Gene

Gene Ontology (GO) - Biological Process for TECRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with TECRL: view

Transcripts for TECRL Gene

Unigene Clusters for TECRL Gene

Trans-2,3-enoyl-CoA reductase-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TECRL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TECRL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TECRL Gene

No ASD Table

Relevant External Links for TECRL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TECRL Gene

mRNA expression in normal human tissues for TECRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TECRL Gene

This gene is overexpressed in Heart - Left Ventricle (32.1) and Heart - Atrial Appendage (17.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TECRL Gene

SOURCE GeneReport for Unigene cluster for TECRL Gene Hs.227752

genes like me logo Genes that share expressions with TECRL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TECRL Gene

Orthologs for TECRL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TECRL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TECRL 35
  • 99.63 (n)
  • 99.45 (a)
  • 99 (a)
(Bos Taurus)
Mammalia TECRL 35
  • 90.27 (n)
  • 87.6 (a)
  • 87 (a)
(Canis familiaris)
Mammalia TECRL 35
  • 88.71 (n)
  • 86.23 (a)
  • 86 (a)
(Mus musculus)
Mammalia Tecrl 35
  • 84.49 (n)
  • 82.55 (a)
Tecrl 16
Tecrl 36
  • 83 (a)
(Monodelphis domestica)
Mammalia TECRL 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TECRL 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Tecrl 35
  • 85.04 (n)
  • 82.83 (a)
(Gallus gallus)
Aves TECRL 35
  • 73.66 (n)
  • 70.72 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia TECRL 36
  • 63 (a)
(Danio rerio)
Actinopterygii tecrl2 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Sc2 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea art-1 36
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSC13 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7956 36
  • 46 (a)
Species with no ortholog for TECRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TECRL Gene

Gene Tree for TECRL (if available)
Gene Tree for TECRL (if available)

Paralogs for TECRL Gene

Paralogs for TECRL Gene

Selected SIMAP similar genes for TECRL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TECRL: view

Variants for TECRL Gene

Sequence variations from dbSNP and Humsavar for TECRL Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs282238 -- 64,344,805(-) CAAAC(A/G)AAAAA intron-variant
rs282239 -- 64,342,128(-) TTTTa(C/T)gagat intron-variant
rs282240 -- 64,341,200(-) gaaga(A/G)gagct intron-variant
rs282241 -- 64,340,871(-) atggg(C/T)ttcag intron-variant
rs282242 -- 64,330,076(-) ATAGA(C/T)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TECRL Gene

Variant ID Type Subtype PubMed ID
nsv461389 CNV Gain 19166990
nsv879107 CNV Loss 21882294
dgv5560n71 CNV Loss 21882294
nsv879126 CNV Loss 21882294
dgv5562n71 CNV Loss 21882294
dgv5563n71 CNV Loss 21882294
nsv879132 CNV Loss 21882294
nsv879133 CNV Loss 21882294
nsv879134 CNV Loss 21882294
esv2727728 CNV Deletion 23290073
nsv291771 CNV Loss 16902084
dgv5564n71 CNV Loss 21882294
nsv509904 CNV Loss 20534489
esv269517 CNV Insertion 20981092
esv274442 CNV Insertion 20981092
esv1348338 CNV Insertion 17803354
nsv879137 CNV Loss 21882294
nsv292154 CNV Loss 16902084
nsv879138 CNV Loss 21882294
nsv507171 CNV Insertion 20534489

Relevant External Links for TECRL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECRL Gene

Disorders for TECRL Gene

Relevant External Links for TECRL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TECRL: view

No data available for UniProtKB/Swiss-Prot for TECRL Gene

Publications for TECRL Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. (PMID: 22446961) Lee Y.C. … Wu J.Y. (Nat. Genet. 2012) 3 48
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for TECRL Gene

Sources for TECRL Gene

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