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Aliases for TECRL Gene

Aliases for TECRL Gene

  • Trans-2,3-Enoyl-CoA Reductase-Like 2 3 5
  • Steroid 5-Alpha-Reductase 2-Like 2 Protein 3 4
  • SRD5A2L2 3 4
  • Steroid 5 Alpha-Reductase 2-Like 2 3
  • Glycoprotein, Synaptic 2-Like 3
  • Synaptic 2-Like 2
  • Glycoprotein 2
  • EC 1.3.1.- 4
  • GPSN2L 3
  • TERL 3

External Ids for TECRL Gene

Previous GeneCards Identifiers for TECRL Gene

  • GC04M064827
  • GC04M065143
  • GC04M061053

Summaries for TECRL Gene

GeneCards Summary for TECRL Gene

TECRL (Trans-2,3-Enoyl-CoA Reductase-Like) is a Protein Coding gene. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is TECR.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECRL Gene

Genomics for TECRL Gene

Genomic Location for TECRL Gene

Chromosome:
4
Start:
64,275,257 bp from pter
End:
64,409,494 bp from pter
Size:
134,238 bases
Orientation:
Minus strand

Genomic View for TECRL Gene

Genes around TECRL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TECRL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TECRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECRL Gene

No data available for Regulatory Elements for TECRL Gene

Proteins for TECRL Gene

  • Protein details for TECRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYJ1-TECRL_HUMAN
    Recommended name:
    Trans-2,3-enoyl-CoA reductase-like
    Protein Accession:
    Q5HYJ1

    Protein attributes for TECRL Gene

    Size:
    363 amino acids
    Molecular mass:
    42009 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TECRL Gene

Proteomics data for TECRL Gene at MOPED

Post-translational modifications for TECRL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TECRL Gene

No data available for DME Specific Peptides for TECRL Gene

Domains & Families for TECRL Gene

Protein Domains for TECRL Gene

Suggested Antigen Peptide Sequences for TECRL Gene

Graphical View of Domain Structure for InterPro Entry

Q5HYJ1

UniProtKB/Swiss-Prot:

TECRL_HUMAN :
  • Belongs to the steroid 5-alpha reductase family.
Family:
  • Belongs to the steroid 5-alpha reductase family.
genes like me logo Genes that share domains with TECRL: view

No data available for Gene Families for TECRL Gene

Function for TECRL Gene

Enzyme Numbers (IUBMB) for TECRL Gene

Phenotypes for TECRL Gene

GenomeRNAi human phenotypes for TECRL:
genes like me logo Genes that share phenotypes with TECRL: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TECRL Gene

Localization for TECRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECRL Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TECRL Gene COMPARTMENTS Subcellular localization image for TECRL gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TECRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TECRL: view

Pathways & Interactions for TECRL Gene

genes like me logo Genes that share pathways with TECRL: view

Interacting Proteins for TECRL Gene

Gene Ontology (GO) - Biological Process for TECRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
genes like me logo Genes that share ontologies with TECRL: view

No data available for SIGNOR curated interactions for TECRL Gene

Drugs & Compounds for TECRL Gene

No Compound Related Data Available

Transcripts for TECRL Gene

Unigene Clusters for TECRL Gene

Trans-2,3-enoyl-CoA reductase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TECRL Gene

No ASD Table

Relevant External Links for TECRL Gene

GeneLoc Exon Structure for
TECRL
ECgene alternative splicing isoforms for
TECRL

Expression for TECRL Gene

mRNA expression in normal human tissues for TECRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TECRL Gene

This gene is overexpressed in Heart - Left Ventricle (x32.1) and Heart - Atrial Appendage (x17.9).

Protein differential expression in normal tissues from HIPED for TECRL Gene

This gene is overexpressed in Heart (63.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TECRL Gene



SOURCE GeneReport for Unigene cluster for TECRL Gene Hs.227752

genes like me logo Genes that share expression patterns with TECRL: view

Protein tissue co-expression partners for TECRL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TECRL Gene

Orthologs for TECRL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TECRL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TECRL 35
  • 90.27 (n)
  • 87.6 (a)
TECRL 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TECRL 35
  • 88.71 (n)
  • 86.23 (a)
TECRL 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tecrl 35
  • 84.49 (n)
  • 82.55 (a)
Tecrl 16
Tecrl 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TECRL 35
  • 99.63 (n)
  • 99.45 (a)
TECRL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tecrl 35
  • 85.04 (n)
  • 82.83 (a)
oppossum
(Monodelphis domestica)
Mammalia TECRL 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TECRL 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TECRL 35
  • 73.66 (n)
  • 70.72 (a)
TECRL 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TECRL 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tecrl2 36
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Sc2 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea art-1 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSC13 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7956 36
  • 46 (a)
OneToMany
Species with no ortholog for TECRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TECRL Gene

ENSEMBL:
Gene Tree for TECRL (if available)
TreeFam:
Gene Tree for TECRL (if available)

Paralogs for TECRL Gene

Paralogs for TECRL Gene

(2) SIMAP similar genes for TECRL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TECRL: view

Variants for TECRL Gene

Sequence variations from dbSNP and Humsavar for TECRL Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_074183 -
rs406687 -- 64,333,071(-) TCATA(C/T)GTCTT intron-variant
rs282238 -- 64,344,805(-) CAAAC(A/G)AAAAA intron-variant
rs282239 -- 64,342,128(-) TTTTa(C/T)gagat intron-variant
rs282240 -- 64,341,200(-) gaaga(A/G)gagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TECRL Gene

Variant ID Type Subtype PubMed ID
nsv461389 CNV Gain 19166990
nsv879107 CNV Loss 21882294
dgv5560n71 CNV Loss 21882294
nsv879126 CNV Loss 21882294
dgv5562n71 CNV Loss 21882294
dgv5563n71 CNV Loss 21882294
nsv879132 CNV Loss 21882294
nsv879133 CNV Loss 21882294
nsv879134 CNV Loss 21882294
esv2727728 CNV Deletion 23290073
nsv291771 CNV Loss 16902084
dgv5564n71 CNV Loss 21882294
nsv509904 CNV Loss 20534489
esv269517 CNV Insertion 20981092
esv274442 CNV Insertion 20981092
esv1348338 CNV Insertion 17803354
nsv879137 CNV Loss 21882294
nsv292154 CNV Loss 16902084
nsv879138 CNV Loss 21882294
nsv507171 CNV Insertion 20534489

Variation tolerance for TECRL Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TECRL Gene

HapMap Linkage Disequilibrium report
TECRL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECRL Gene

Disorders for TECRL Gene

Relevant External Links for TECRL

Genetic Association Database (GAD)
TECRL
Human Genome Epidemiology (HuGE) Navigator
TECRL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TECRL

No disorders were found for TECRL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TECRL Gene

Publications for TECRL Gene

  1. Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. (PMID: 22446961) Lee Y.C. … Wu J.Y. (Nat. Genet. 2012) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. (PMID: 23726511) Xie P. … Gelernter J. (Biol. Psychiatry 2013) 3
  4. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TECRL Gene

Sources for TECRL Gene

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