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Aliases for TECR Gene

Aliases for TECR Gene

  • Trans-2,3-Enoyl-CoA Reductase 2 3 4 5
  • Synaptic Glycoprotein SC2 3 4
  • Glycoprotein, Synaptic 2 2 3
  • GPSN2 3 4
  • SC2 3 4
  • TER 3 4
  • Very-Long-Chain Enoyl-CoA Reductase 3
  • EC 1.3.1.38 61
  • EC 1.3.1.93 4
  • EC 1.3.1 61
  • MRT14 3

External Ids for TECR Gene

Previous HGNC Symbols for TECR Gene

  • SC2
  • GPSN2

Previous GeneCards Identifiers for TECR Gene

  • GC19P014641
  • GC19P014210
  • GC19P014642
  • GC19P014629

Summaries for TECR Gene

Entrez Gene Summary for TECR Gene

  • This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

GeneCards Summary for TECR Gene

TECR (Trans-2,3-Enoyl-CoA Reductase) is a Protein Coding gene. Diseases associated with TECR include Mental Retardation, Autosomal Recessive 14 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Metabolism and Fatty acid metabolism. GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is TECRL.

UniProtKB/Swiss-Prot for TECR Gene

  • Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Gene Wiki entry for TECR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECR Gene

Genomics for TECR Gene

Regulatory Elements for TECR Gene

Enhancers for TECR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F014512 1.5 FANTOM5 ENCODE 7.7 +1.4 1445 12.0 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 AKAP8 SYDE1 DNAJB1 ITGB1P1 MIR639 TECR GIPC1 IL27RA ADGRE5 PKN1
GH19F014525 1.3 FANTOM5 ENCODE 6.7 +11.1 11107 5.9 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 DNAJB1 TECR GIPC1 OR7C2 PIR54842 GC19P014532 GC19P014530
GH19F014362 0.8 FANTOM5 ENCODE 6.2 -153.5 -153532 1.9 YBX1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF263 SP3 NCOA1 REST MBD2 ADGRE5 CCDC130 TECR ZNF333 PKN1 RFX1 DCAF15 ADGRE2 LINC01841 LINC01842
GH19F014542 0.5 Ensembl ENCODE 6.1 +25.8 25783 1.1 ZNF121 KLF1 HLF ZMYM3 FOXP2 KDM1A NDUFB7 GIPC1 TECR LOC100507373 DNAJB1
GH19F014365 1.3 FANTOM5 ENCODE 5.8 -146.0 -145973 11.4 HDGF PKNOX1 CREB3L1 ZNF2 CBX5 ZNF143 ZNF207 FOS SP3 NFYC ADGRE5 MRI1 ZNF333 CCDC130 NANOS3 PKN1 TECR DDX39A DCAF15 IL27RA
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TECR on UCSC Golden Path with GeneCards custom track

Promoters for TECR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215294 715 2401 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for TECR Gene

Chromosome:
19
Start:
14,517,085 bp from pter
End:
14,565,980 bp from pter
Size:
48,896 bases
Orientation:
Plus strand

Genomic View for TECR Gene

Genes around TECR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TECR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TECR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECR Gene

Proteins for TECR Gene

  • Protein details for TECR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ01-TECR_HUMAN
    Recommended name:
    Very-long-chain enoyl-CoA reductase
    Protein Accession:
    Q9NZ01
    Secondary Accessions:
    • B2RD55
    • O75350
    • Q6IBB2
    • Q9BWK3
    • Q9Y6P0

    Protein attributes for TECR Gene

    Size:
    308 amino acids
    Molecular mass:
    36034 Da
    Quaternary structure:
    • Interacts with ELOVL1 and LASS2.
    • Interacts with ELOVL1 and LASS2.

    Three dimensional structures from OCA and Proteopedia for TECR Gene

    Alternative splice isoforms for TECR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TECR Gene

Selected DME Specific Peptides for TECR Gene

Post-translational modifications for TECR Gene

  • Glycosylated.
  • Ubiquitination at Lys 2, Lys 12, Lys 16, Lys 22, Lys 33, Lys 38, Lys 67, and Lys 291
  • Glycosylation at Asn 164 and Asn 247
  • Modification sites at PhosphoSitePlus

Domains & Families for TECR Gene

Suggested Antigen Peptide Sequences for TECR Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZ01

UniProtKB/Swiss-Prot:

TECR_HUMAN :
  • Belongs to the steroid 5-alpha reductase family.
Family:
  • Belongs to the steroid 5-alpha reductase family.
genes like me logo Genes that share domains with TECR: view

No data available for Gene Families for TECR Gene

Function for TECR Gene

Molecular function for TECR Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A very-long-chain acyl-CoA + NADP(+) = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Enzyme Numbers (IUBMB) for TECR Gene

Gene Ontology (GO) - Molecular Function for TECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA,IBA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity TAS --
genes like me logo Genes that share ontologies with TECR: view
genes like me logo Genes that share phenotypes with TECR: view

Human Phenotype Ontology for TECR Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TECR

miRNA for TECR Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TECR Gene

Localization for TECR Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECR Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TECR Gene COMPARTMENTS Subcellular localization image for TECR gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1
extracellular 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TECR: view

Pathways & Interactions for TECR Gene

genes like me logo Genes that share pathways with TECR: view

UniProtKB/Swiss-Prot Q9NZ01-TECR_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for TECR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0030497 fatty acid elongation IDA 12482854
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with TECR: view

No data available for SIGNOR curated interactions for TECR Gene

Drugs & Compounds for TECR Gene

(3) Additional Compounds for TECR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
stearoyl-coa
  • Octadecanoyl-CoA
  • Octadecanoyl-coenzyme A
  • S-Octadecanoate
  • S-Octadecanoate CoA
  • S-Octadecanoate Coenzyme A
362-66-3
genes like me logo Genes that share compounds with TECR: view

Transcripts for TECR Gene

Unigene Clusters for TECR Gene

Trans-2,3-enoyl-CoA reductase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TECR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for TECR Gene

GeneLoc Exon Structure for
TECR
ECgene alternative splicing isoforms for
TECR

Expression for TECR Gene

mRNA expression in normal human tissues for TECR Gene

Protein differential expression in normal tissues from HIPED for TECR Gene

This gene is overexpressed in Nasal epithelium (18.2), Placenta (6.8), and Fetal testis (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TECR Gene



Protein tissue co-expression partners for TECR Gene

NURSA nuclear receptor signaling pathways regulating expression of TECR Gene:

TECR

SOURCE GeneReport for Unigene cluster for TECR Gene:

Hs.515642

mRNA Expression by UniProt/SwissProt for TECR Gene:

Q9NZ01-TECR_HUMAN
Tissue specificity: Expressed in most tissues tested. Highly expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with TECR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TECR Gene

Orthologs for TECR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TECR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TECR 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia TECR 34 35
  • 93.83 (n)
dog
(Canis familiaris)
Mammalia TECR 34 35
  • 93.72 (n)
oppossum
(Monodelphis domestica)
Mammalia TECR 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tecr 34 16 35
  • 89.72 (n)
rat
(Rattus norvegicus)
Mammalia Tecr 34
  • 89.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TECR 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TECR 34 35
  • 68.53 (n)
lizard
(Anolis carolinensis)
Reptilia TECR 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tecr 34
  • 78.25 (n)
Str.9089 34
African clawed frog
(Xenopus laevis)
Amphibia gpsn2-prov 34
zebrafish
(Danio rerio)
Actinopterygii tecrb 34 35
  • 78.35 (n)
tecra 35
  • 67 (a)
OneToMany
gpsn2 34
fruit fly
(Drosophila melanogaster)
Insecta Sc2 34 35
  • 61.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010714 34
  • 59.48 (n)
worm
(Caenorhabditis elegans)
Secernentea art-1 34 35
  • 58.39 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER215W 34
  • 51.54 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C04367g 34
  • 46.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSC13 34 35 37
  • 43.53 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons CER10 34
  • 49.52 (n)
rice
(Oryza sativa)
Liliopsida Os01g0150000 34
  • 51.48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7956 35
  • 62 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03362 34
  • 52.98 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC646.07c 34
  • 50.07 (n)
Species where no ortholog for TECR was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TECR Gene

ENSEMBL:
Gene Tree for TECR (if available)
TreeFam:
Gene Tree for TECR (if available)

Paralogs for TECR Gene

Paralogs for TECR Gene

Pseudogenes.org Pseudogenes for TECR Gene

genes like me logo Genes that share paralogs with TECR: view

Variants for TECR Gene

Sequence variations from dbSNP and Humsavar for TECR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs199469705 Mental retardation, autosomal recessive 14 (MRT14) [MIM:614020], Pathogenic 14,564,841(+) TCACC(C/T)TCTCT nc-transcript-variant, reference, missense
rs10405483 Likely benign 14,565,669(+) GTGAG(C/T)CTGCC intron-variant, downstream-variant-500B
rs113855270 Likely benign 14,562,510(+) AGGCT(A/G)TTCTC intron-variant
rs59273619 Likely benign 14,565,077(+) CAGCT(C/T)GGCAA nc-transcript-variant, reference, synonymous-codon
rs61732092 Likely benign 14,565,766(+) GTGGG(C/T)TTCAC nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TECR Gene

Variant ID Type Subtype PubMed ID
dgv625e199 CNV deletion 23128226
esv3643743 CNV loss 21293372
esv3643744 CNV loss 21293372
esv3643745 CNV loss 21293372
esv3643746 CNV loss 21293372

Variation tolerance for TECR Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TECR Gene

Human Gene Mutation Database (HGMD)
TECR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TECR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECR Gene

Disorders for TECR Gene

MalaCards: The human disease database

(4) MalaCards diseases for TECR Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 14
  • mental retardation non-syndromic autosomal recessive 14
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
tinea pedis
  • athlete's foot
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
- elite association - COSMIC cancer census association via MalaCards
Search TECR in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TECR_HUMAN
  • Mental retardation, autosomal recessive 14 (MRT14) [MIM:614020]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:21212097}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TECR

Human Genome Epidemiology (HuGE) Navigator
TECR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TECR
genes like me logo Genes that share disorders with TECR: view

No data available for Genatlas for TECR Gene

Publications for TECR Gene

  1. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. (PMID: 12482854) Moon Y.-A. … Horton J.D. (J. Biol. Chem. 2003) 2 3 4 64
  2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
  3. Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13. (PMID: 21212097) Caliskan M. … Ober C. (Hum. Mol. Genet. 2011) 3 4 64
  4. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y. … Kihara A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TECR Gene

Sources for TECR Gene

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