Aliases for TECR Gene
External Ids for TECR Gene
Previous HGNC Symbols for TECR Gene
Previous GeneCards Identifiers for TECR Gene
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
GeneCards Summary for TECR Gene
TECR (Trans-2,3-Enoyl-CoA Reductase) is a Protein Coding gene. Diseases associated with TECR include mental retardation, autosomal recessive 14 and tinea pedis. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is TECRL.
UniProtKB/Swiss-Prot for TECR Gene
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.