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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TECR Gene

protein-coding   GIFtS: 61
GCID: GC19P014642

trans-2,3-enoyl-CoA reductase

(Previous names: glycoprotein, synaptic 2 )
(Previous symbols: SC2, GPSN2)
 Explore 4 diseases affiliated with
TECR via
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Biological research products
for TECR    

Aliases
for TECR gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Trans-2,3-Enoyl-CoA Reductase1 2 3     MRT142
GPSN21 2 3     Very-Long-Chain Enoyl-CoA Reductase2
SC21 2 3     EC 1.3.1.933
TER1 2 3     EC 1.3.18
Glycoprotein, Synaptic 21 2     EC 1.3.1.388
Synaptic Glycoprotein SC22 3     

External Ids:    HGNC: 45511   Entrez Gene: 95242   Ensembl: ENSG000000997977   OMIM: 6100575   UniProtKB: Q9NZ013   
ORGUL members:         
NONCODE:n410711    

Export aliases for TECR gene to outside databases

Previous GC identifers: GC19P014504 GC19P014641 GC19P014210


Summaries
for TECR gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TECR:
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid
5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential
reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively
spliced transcript variants have been found for this gene.(provided by RefSeq, Apr 2011)

UniProtKB/Swiss-Prot: TECR_HUMAN, Q9NZ01
Function: Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids

Gene Wiki entry for TECR


Genomic Views
for TECR gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TECR
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TECR promoter sequence
   Search SABiosciences Chromatin IP Primers for TECR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TECR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

TECR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TECR gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014642:  view genomic region     (about GC identifiers)

Start:
 14,640,382 bp from pter      End:
 14,676,792 bp from pter
Size:
 36,411 bases      Orientation:
 plus strand

Proteins
for TECR gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TECR_HUMAN, Q9NZ01 (See protein sequence)
Recommended Name: Very-long-chain enoyl-CoA reductase  
Size: 308 amino acids; 36034 Da
Subunit: Interacts with ELOVL1 and LASS2
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for TECR:
2DZJ (3D)    
Secondary accessions: B2RD55 O75350 Q6IBB2 Q9BWK3 Q9Y6P0
Alternative splicing: 2 isoforms:  Q9NZ01-1   Q9NZ01-2   

Explore the universe of human proteins at neXtProt for TECR: NX_Q9NZ01

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NZ01

    • 3 DME Specific Peptides for TECR (Q9NZ01)
     LRDLRPAGSK  TMPLRNIFKNC  FVHRFSHGTMP 

    TECR Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_612510.1  
    ENSEMBL proteins: 
     ENSP00000215567   ENSP00000397206  
    Reactome Protein details: Q9NZ01
    Human Recombinant Protein Products: 
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    Novus Biologicals TECR Protein
    Novus Biologicals TECR Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TECR

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane ----
    GO:0030176integral to endoplasmic reticulum membrane IDA12482854


    TECR for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TECR gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TECR for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001104 3-oxo-5_a-steroid_4-DH_C

    Graphical View of Domain Structure for InterPro Entry Q9NZ01

    ProtoNet protein and cluster: Q9NZ01

    1 Blocks protein family: IPB001104 3-oxo-5-alpha-steroid 4-dehydrogenase

    UniProtKB/Swiss-Prot: TECR_HUMAN, Q9NZ01
    Similarity: Belongs to the steroid 5-alpha reductase family


    Function
    for TECR gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TECR_HUMAN, Q9NZ01
    Function: Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids
    Catalytic activity: A very-long-chain acyl-CoA + NADP(+) = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH

    Enzyme Numbers (IUBMB): EC 1.3.12 EC 1.3.1.931 EC 1.3.1.382

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TECR (see all 4)
    OriGene shRNA RFP: TECR
    OriGene siRNA: TECR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TECR

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for TECR

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016627oxidoreductase activity, acting on the CH-CH group of donors IEA--
    GO:0019166trans-2-enoyl-CoA reductase (NADPH) activity ----


    TECR for ontologies           About GeneDecksing



    Pathways & Interactions
    for TECR gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Fatty Acyl-CoA Biosynthesis
    		Fatty Acyl-CoA Biosynthesis1.00
    		Triglyceride Biosynthesis0.47
    		Synthesis of very long-chain fatty acyl-CoAs0.78
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3Biosynthesis of unsaturated fatty acids
    		Biosynthesis of unsaturated fatty acids1.00
    4Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    		Fatty acid, triacylglycerol, and ketone body metabolism0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for TECR (see all 6)
        Metabolism
    Synthesis of very long-chain fatty acyl-CoAs
    Triglyceride Biosynthesis
    Fatty Acyl-CoA Biosynthesis
    Fatty acid, triacylglycerol, and ketone body metabolism


    1         Kegg Pathway  (Kegg details for TECR):
        Biosynthesis of unsaturated fatty acids


    TECR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TECR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/97 Interacting proteins for TECR (Q9NZ013 ENSP000002155674) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0019432triglyceride biosynthetic process TAS--
    GO:0030497fatty acid elongation IDA12482854
    GO:0035338long-chain fatty-acyl-CoA biosynthetic process TAS--
    GO:0042761very long-chain fatty acid biosynthetic process IDA12482854


    TECR for ontologies           About GeneDecksing



    Drugs & Compounds
    for TECR gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TECR

    1 HMDB Compound for TECR    About this table
    CompoundSynonyms CAS #PubMed Ids
    Stearoyl-CoAOctadecanoyl-CoA (see all 16)362-66-3--
    Search CenterWatch for drugs/clinical trials and news about TECR 

    Transcripts
    for TECR gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TECR gene (2 alternative transcripts): 
    NM_138501.5  NM_004868.1  

    Unigene Cluster for TECR:

    Trans-2,3-enoyl-CoA reductase
    Hs.515642  [show with all ESTs]
    Unigene Representative Sequence: BC034484
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000215567(uc010xns.2 uc002mza.3 uc002mzc.3 uc002mze.3)
    ENST00000436007(uc002mzb.3)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TECR (see all 4)
    OriGene shRNA RFP: TECR
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TECR
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF038958.1 AF038959.1 AF222742.1 AK001416.1 AK094087.1 AK299134.1 AK315412.1 BC000174.2 
    BC002425.1 BC005384.1 BC005952.1 BC007801.2 BC013881.2 BC034484.1 BT007179.1 CR456892.1 
    NR_038103.1 NR_038104.1 

    24/33 DOTS entries (see all 33):

    DT.448643  DT.92454672  DT.100892565  DT.100769750  DT.92454664  DT.100892521  DT.75178763  DT.100892549 
    DT.100892541  DT.95251676  DT.40290333  DT.92454666  DT.92454699  DT.121494484  DT.100892596  DT.86835741 
    DT.95229193  DT.95266194  DT.100892653  DT.100892659  DT.102843564  DT.121271723  DT.121494576  DT.97842103 

    24/554 AceView cDNA sequences (see all 554):

    BG832281 CD674004 AL712862 R73522 CR615202 BU932123 BE741455 BC005384 
    BU684261 BM049748 AW340499 CR600147 BM553206 CF126112 BM925111 BF968614 
    BE876454 BM694397 BX354718 BU179634 BM917022 BI828399 CB218184 BF969532 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TECR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                          -           -           -                                 
    SP2:                          -           -                                             
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for TECR

    Expression
    for TECR gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TECR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCATCATCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TECR expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    BoneMandibular CondyleBone
    EyeRetinaEye
    Primitive StreakNotochordPrimitive Streak
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TECR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TECR

    SOURCE GeneReport for Unigene cluster: Hs.515642

    UniProtKB/Swiss-Prot: TECR_HUMAN, Q9NZ01
    Tissue specificity: Expressed in most tissues tested. Highly expressed in skeletal muscle

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    In Situ
    Assay Products:     
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    Orthologs
    for TECR gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TECR gene from 10/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tecr1 , 5 trans-2,3-enoyl-CoA reductase1, 5 89.72(n)1
    96.75(a)1    		   8 (40.22 cM)5
    1065291  NM_134118.51  NP_598879.11 
     835717005 
    chicken
    (Gallus gallus)    		 Aves TECR1 trans-2,3-enoyl-CoA reductase 68.31(n)
    75.33(a)    		   424491  XM_422331.3  XP_422331.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TECR6
    		 --
    		 85(a)
    		 1 ↔ 1
    		 2(102729445-102752278)
    African clawed frog
    (Xenopus laevis)    		 Amphibia gpsn2-prov2 glycoprotein, synaptic 2 79.2(n)    BC056018.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii gpsn22 glycoprotein, synaptic 2 79.13(n)   326954  BC053209.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Sc21 CG10849-PA 61.44(n)
    54.67(a)    		   38457  NM_139579.2  NP_647836.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea art-11 Protein ART-1 58.39(n)
    53.64(a)    		   174140  NM_063029.4  NP_495430.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TSC13(YDL015C)4
    TSC131    		 Enoyl reductase that catalyzes the last step in each more4
    Tsc13p1    		 45.4(n)1
    38.1(a)1    		   4(426934-426002)4
    8515471, 4  NP_010269.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CER101 enoyl reductase 49.66(n)
    42.81(a)    		   824702  NM_115394.3  NP_191096.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g01500001 hypothetical protein 51.6(n)
    41.1(a)    		   4324516  NM_001048565.1  NP_001042030.1 


    ENSEMBL Gene Tree for TECR (if available)
    TreeFam Gene Tree for TECR (if available) 

    Paralogs
    for TECR gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TECR gene
    TECRL2  
    2 SIMAP similar genes for TECR using alignment to 10 protein entries:     TECR_HUMAN (see all proteins):
    SRD5A2L2    TECRL

    TECR for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TECR
    PGOHUM00000245619 PGOHUM00000245691


    Genomic Variants
    for TECR gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/723 NCBI SNPs in TECR are shown (see all 723)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116731261,2
    		H--14638449(+) CTTCAA/GAAGTT 4 -- us2k10--------
    rs1503166591,2
    		--14638456(+) AGTTTC/GCAGAG 4 -- us2k10--------
    rs1378968971,2
    		--14638558(+) ATCGTA/GTCTCT 4 -- us2k10--------
    rs1130831151,2
    		C--14638626(+) ATCTGA/C/GAAACA 4 -- us2k11CSA 1
    rs1423335361,2
    		--14638668(+) AGGTAC/TTGCCT 4 -- us2k10--------
    rs104063461,2
    		C,--14638944(+) gcctgC/Tcttgg 4 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1824271831,2
    		--14638985(+) GCCACC/TGTGCC 4 -- us2k10--------
    rs711667521,2
    		C--14639065(-) GTCTCA/-AAAAA 4 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1864281051,2
    		--14639444(+) TGTCCA/CTAGGG 4 -- us2k10--------
    rs72494581,2
    		C,F,A,H,--14639947(+) CGCCAA/TCCAGA 4 -- us2k118Minor allele frequency- T:0.46NS EA NA WA CSA 790

    HapMap Linkage Disequilibrium report for TECR (14640382 - 14676792 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TECR: --
    Human Gene Mutation Database (HGMD): TECR

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TECR gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TECR for disorders           About GeneDecksing

    OMIM gene information: 610057    OMIM disorders: --

    UniProtKB/Swiss-Prot: TECR_HUMAN, Q9NZ01
  • Defects in TECR are the cause of mental retardation autosomal recessive type 14 (MRT14) [MIM:614020]. Mental
    • retardation is characterized by significantly below average general intellectual functioning associated with
    impairments in adaptative behavior and manifested during the developmental period

    4 diseases for TECR:    About MalaCards
    tinea pedis    oral cancer    malaria    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for TECR:
    Squamous cell carcinoma     Tinea pedis
    Human Genome Epidemiology (HuGE) Navigator: TECR (0 documents)

    Export disorders for TECR gene to outside databases

    Publications
    for TECR gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TECR gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with TECR)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade. (PubMed id 12482854)1, 2, 3 Moon Y.-A. and Horton J.D. (2003)
    2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (1998)
    3. Exome sequencing reveals a novel mutation for autosom al recessive non-syndromic mental retardation in the TECR gene on chromosome 19 p13. (PubMed id 21212097)1, 2 A8alA+A9kan M....Ober C. (2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    10. Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)

    External Searches for TECR gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TECR gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9524 HGNC: 4551 AceView: GPSN2 Ensembl:ENSG00000099797 euGenes: HUgn9524
    ECgene: TECR Kegg: 9524 H-InvDB: TECR

    Other Databases showing TECR gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TECR gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TECR Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TECR gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TECR gene:
    Search GeneIP for patents involving TECR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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