TECPR2 Gene
protein-coding GIFtS: 41
GCID: GC14P102829
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tectonin beta-propeller repeat containing 2(Previous name: KIAA0329 )
(Previous symbol: KIAA0329)
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Aliases
for TECPR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tectonin Beta-Propeller Repeat Containing 21 2 | | KIAA03291 2 3 | | SPG492 | | Tectonin Beta-Propeller Repeat-Containing Protein 22 | | KIAA02973 | | WD Repeat-Containing Protein KIAA0329/KIAA02973 |
Export aliases for TECPR2 gene to outside databasesPrevious GC identifers: GC14P101901 GC14P083006 |
Summaries
for TECPR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TECPR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TECPR2 gene promoter:
SRF USF1 SRF (504 AA) USF2 Olf-1 USF-1:USF-2 HEN1 PPAR-gamma1 USF-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TECPR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TECPR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.31 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.33TECPR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P102829: view genomic region
(about GC identifiers)
Start:
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102,829,300 bp from pter |
End:
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102,968,818 bp from pter |
Size:
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139,519 bases |
Orientation:
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plus strand |
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Proteins
for TECPR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCPR2_HUMAN, O15040 (See
protein sequence)Recommended Name: Tectonin beta-propeller repeat-containing protein 2 Size: 1411 amino acids; 153848 Da
Sequence caution: Sequence=BAA20787.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A5PKY3 A6NFY9 A7E2X3 H0YMM9 Q9UEG6Alternative splicing: 2 isoforms: O15040-1 O15040-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TECPR2: NX_O15040
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15040
TECPR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001166102.1 NP_055659.2
ENSEMBL proteins: ENSP00000352510 ENSP00000453671
Human Recombinant Protein Products:
TECPR2 Antibody Products:
Assay Products for TECPR2: |
Protein
Domains /
Families
for TECPR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TECPR2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15040ProtoNet protein and cluster: O15040 2 Blocks protein families: IPB001680 G-protein beta WD-40 repeat signature IPB006624 Beta-propeller repeat TECPR
UniProtKB/Swiss-Prot: TCPR2_HUMAN, O15040Similarity: Belongs to the WD repeat KIAA0329 familySimilarity: Contains 6 TECPR repeatsSimilarity: Contains 3 WD repeats |
Function
for TECPR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TECPR2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TECPR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TECPR2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TECPR2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TECPR2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
TECPR2 for ontologies About GeneDecksing
|
Pathways & Interactions
for TECPR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TECPR2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5 Interacting proteins for TECPR2 (O150401, 3 ENSP000003525104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for TECPR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TECPR2
Search CenterWatch for drugs/clinical trials and news about TECPR2 / TCPR2
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Transcripts
for TECPR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TECPR2 gene (2 alternative transcripts): NM_001172631.1 NM_014844.3 Unigene Cluster for TECPR2: Tectonin beta-propeller repeat containing 2 Hs.195667 [show with all ESTs]Unigene Representative Sequence: NM_0148447 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359520(uc010txw.2 uc001ylw.2 uc010txx.2) ENST00000561228
ENST00000558678(uc010awl.3) ENST00000560060 ENST00000557786 ENST00000561099
ENST00000559124
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TECPR2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TECPR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TECPR2 (NM_014844) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TECPR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TECPR2 |
Additional cDNA sequence: AB002295.1 AB002327.1 AK127721.1 AK296395.1 AK299690.1 BC030791.1 BC136647.1 BC142667.1 BC142715.1 BC151230.1 7 DOTS entries: DT.315306 DT.101982198 DT.108044 DT.97826685 DT.120750215 DT.120750253 DT.91707976 24/129 AceView cDNA sequences (see all 129): AW054894 AI026790 AW271524 BU632244 CF553053 AI244826 AI753137 AW168152 AI870614 AB002295 AI697725 BQ025571 BE905063 AA468525 AI753372 AI914649 AW954427 C01547 BQ023338 CF130082 BQ773045 BM709324 AA972038 AW006393
GeneLoc Exon Structure
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Expression
for TECPR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TECPR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TECPR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TECPR2
SOURCE GeneReport for Unigene cluster: Hs.195667
SABiosciences Custom PCR Arrays for TECPR2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TECPR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TECPR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TECPR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TECPR2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TECPR2 |
Orthologs
for TECPR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TECPR2 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for TECPR2 (if available)
TreeFam Gene Tree for TECPR2 (if available) |
Paralogs
for TECPR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TECPR2 gene
- HPS52
TECPR2 for paralogs About GeneDecksing
|
Genomic Variants
for TECPR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TECPR2 (102829300 - 102968818 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TECPR2
3 CNVs: 29634 53624 4847
2 Indels: 60163 66712 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TECPR2 |
|
Disorders
/ Diseases
for TECPR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TECPR2 for disorders About MalaCards
TECPR2 for disorders About GeneDecksing
OMIM gene information: 615000
OMIM disorders: --
Export disorders for TECPR2 gene to outside databases
|
Publications
for TECPR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TECPR2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TECPR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Mutation in TECPR2 reveals a role for autophagy in her editary spastic paraparesis. (PubMed id 23176824)1 Oz-Levi D....Lancet D. (2012)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TECPR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TECPR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TECPR2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TECPR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TECPR2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TECPR2 gene:
Search GeneIP for patents involving TECPR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TECPR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TECPR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TECPR2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TECPR2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TECPR2 |
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