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Aliases for TECPR1 Gene

Aliases for TECPR1 Gene

  • Tectonin Beta-Propeller Repeat Containing 1 2 3
  • KIAA1358 4 6

External Ids for TECPR1 Gene

Previous GeneCards Identifiers for TECPR1 Gene

  • GC07M097684
  • GC07M097843
  • GC07M092446

Summaries for TECPR1 Gene

Entrez Gene Summary for TECPR1 Gene

  • This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]

GeneCards Summary for TECPR1 Gene

TECPR1 (Tectonin Beta-Propeller Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for TECPR1 Gene

  • Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECPR1 Gene

Genomics for TECPR1 Gene

Regulatory Elements for TECPR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TECPR1 Gene

Start:
98,214,624 bp from pter
End:
98,252,251 bp from pter
Size:
37,628 bases
Orientation:
Minus strand

Genomic View for TECPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TECPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECPR1 Gene

Proteins for TECPR1 Gene

  • Protein details for TECPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6L1-TCPR1_HUMAN
    Recommended name:
    Tectonin beta-propeller repeat-containing protein 1
    Protein Accession:
    Q7Z6L1
    Secondary Accessions:
    • A8KAD1
    • B3KPZ1
    • C9J024
    • F5GX57
    • Q96EB0
    • Q9P2I9
    • Q9UFR6

    Protein attributes for TECPR1 Gene

    Size:
    1165 amino acids
    Molecular mass:
    129696 Da
    Quaternary structure:
    • Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

    Three dimensional structures from OCA and Proteopedia for TECPR1 Gene

    Alternative splice isoforms for TECPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TECPR1 Gene

Proteomics data for TECPR1 Gene at MOPED

Post-translational modifications for TECPR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TECPR1 Gene

No data available for DME Specific Peptides for TECPR1 Gene

Domains for TECPR1 Gene

Suggested Antigen Peptide Sequences for TECPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6L1

UniProtKB/Swiss-Prot:

TCPR1_HUMAN :
  • Q7Z6L1
Domain:
  • The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P (PubMed:22342342).
  • Contains 1 PH domain.
Family:
  • Belongs to the TECPR1 family.
Similarity:
  • Contains 9 TECPR repeats.
genes like me logo Genes that share domains with TECPR1: view

No data available for Gene Families for TECPR1 Gene

Function for TECPR1 Gene

Molecular function for TECPR1 Gene

UniProtKB/Swiss-Prot Function: Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Gene Ontology (GO) - Molecular Function for TECPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20562859
GO:0032266 phosphatidylinositol-3-phosphate binding IDA 22342342
genes like me logo Genes that share ontologies with TECPR1: view

Phenotypes for TECPR1 Gene

genes like me logo Genes that share phenotypes with TECPR1: view

Animal Models for TECPR1 Gene

MGI Knock Outs for TECPR1:

Animal Model Products

CRISPR Products

miRNA for TECPR1 Gene

miRTarBase miRNAs that target TECPR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TECPR1 Gene

Localization for TECPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECPR1 Gene

Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TECPR1 Gene COMPARTMENTS Subcellular localization image for TECPR1 gene
Compartment Confidence
lysosome 5
vacuole 5
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TECPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagic vacuole membrane IDA 21575909
GO:0005765 lysosomal membrane IDA 22342342
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with TECPR1: view

Pathways for TECPR1 Gene

SuperPathways for TECPR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TECPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000046 autophagic vacuole fusion IMP 22342342
GO:0006914 autophagy IDA 21575909
genes like me logo Genes that share ontologies with TECPR1: view

No data available for Pathways by source for TECPR1 Gene

Transcripts for TECPR1 Gene

Unigene Clusters for TECPR1 Gene

Tectonin beta-propeller repeat containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TECPR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TECPR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TECPR1 Gene

No ASD Table

Relevant External Links for TECPR1 Gene

GeneLoc Exon Structure for
TECPR1
ECgene alternative splicing isoforms for
TECPR1

Expression for TECPR1 Gene

mRNA expression in normal human tissues for TECPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TECPR1 Gene

This gene is overexpressed in Pancreas (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TECPR1 Gene

SOURCE GeneReport for Unigene cluster for TECPR1 Gene Hs.592281

genes like me logo Genes that share expressions with TECPR1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TECPR1 Gene

Orthologs for TECPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TECPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TECPR1 35
  • 99.23 (n)
  • 99.06 (a)
TECPR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TECPR1 35
  • 86.61 (n)
  • 85.63 (a)
dog
(Canis familiaris)
Mammalia TECPR1 35
  • 87.43 (n)
  • 88.61 (a)
TECPR1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tecpr1 35
  • 84.7 (n)
  • 87.17 (a)
Tecpr1 16
Tecpr1 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TECPR1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TECPR1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tecpr1 35
  • 84.41 (n)
  • 88.03 (a)
chicken
(Gallus gallus)
Aves TECPR1 35
  • 71.08 (n)
  • 74.57 (a)
TECPR1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TECPR1 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9912 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tecpr1 35
  • 67.6 (n)
  • 71.1 (a)
zebrafish
(Danio rerio)
Actinopterygii tecpr1a 35
  • 66.18 (n)
  • 68.64 (a)
tecpr1a 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GALE3 35
  • 51.15 (n)
  • 40.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pex23 35
  • 52.43 (n)
  • 42.08 (a)
Pex23 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T01H3.2 36
  • 23 (a)
OneToOne
Species with no ortholog for TECPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TECPR1 Gene

ENSEMBL:
Gene Tree for TECPR1 (if available)
TreeFam:
Gene Tree for TECPR1 (if available)

Paralogs for TECPR1 Gene

No data available for Paralogs for TECPR1 Gene

Variants for TECPR1 Gene

Sequence variations from dbSNP and Humsavar for TECPR1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3148 -- 98,215,266(-) ACAAT(C/T)GCGGT downstream-variant-500B
rs747630 -- 98,229,975(-) GAATG(A/C)GGTTC intron-variant
rs747631 -- 98,229,870(-) TGGGG(G/T)TGTTC intron-variant
rs747632 -- 98,229,748(-) AGACC(A/G)CCTCT intron-variant
rs747633 -- 98,230,075(-) AGGCT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TECPR1 Gene

Variant ID Type Subtype PubMed ID
nsv831066 CNV Loss 17160897
nsv888760 CNV Loss 21882294
nsv888762 CNV Loss 21882294
nsv888763 CNV Loss 21882294
nsv888765 CNV Gain 21882294
nsv525934 CNV Loss 19592680
nsv831067 CNV Loss 17160897
nsv512916 CNV Insertion 21212237

Relevant External Links for TECPR1 Gene

HapMap Linkage Disequilibrium report
TECPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECPR1 Gene

Disorders for TECPR1 Gene

No disorders were found for TECPR1 Gene.

No data available for UniProtKB/Swiss-Prot for TECPR1 Gene

Publications for TECPR1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. (PMID: 22342342) Chen D. … Zhong Q. (Mol. Cell 2012) 3 4
  5. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. (PMID: 21575909) Ogawa M. … Sasakawa C. (Cell Host Microbe 2011) 3 4

Products for TECPR1 Gene

  • antibodies-online peptides for TECPR1
  • antibodies-online antibodies for TECPR1
  • antibodies-online kits for TECPR1

Sources for TECPR1 Gene

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