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Aliases for TECPR1 Gene

Aliases for TECPR1 Gene

  • Tectonin Beta-Propeller Repeat Containing 1 2 3 5
  • KIAA1358 4

External Ids for TECPR1 Gene

Previous GeneCards Identifiers for TECPR1 Gene

  • GC07M097684
  • GC07M097843
  • GC07M092446

Summaries for TECPR1 Gene

Entrez Gene Summary for TECPR1 Gene

  • This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]

GeneCards Summary for TECPR1 Gene

TECPR1 (Tectonin Beta-Propeller Repeat Containing 1) is a Protein Coding gene. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding.

UniProtKB/Swiss-Prot for TECPR1 Gene

  • Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TECPR1 Gene

Genomics for TECPR1 Gene

Regulatory Elements for TECPR1 Gene

Enhancers for TECPR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TECPR1 on UCSC Golden Path with GeneCards custom track

Promoters for TECPR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TECPR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TECPR1 Gene

Chromosome:
7
Start:
98,214,624 bp from pter
End:
98,252,251 bp from pter
Size:
37,628 bases
Orientation:
Minus strand

Genomic View for TECPR1 Gene

Genes around TECPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TECPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TECPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TECPR1 Gene

Proteins for TECPR1 Gene

  • Protein details for TECPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6L1-TCPR1_HUMAN
    Recommended name:
    Tectonin beta-propeller repeat-containing protein 1
    Protein Accession:
    Q7Z6L1
    Secondary Accessions:
    • A8KAD1
    • B3KPZ1
    • C9J024
    • F5GX57
    • Q96EB0
    • Q9P2I9
    • Q9UFR6

    Protein attributes for TECPR1 Gene

    Size:
    1165 amino acids
    Molecular mass:
    129696 Da
    Quaternary structure:
    • Interacts with ATG5; the interaction is direct. Interacts with WIPI2. Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

    Three dimensional structures from OCA and Proteopedia for TECPR1 Gene

    Alternative splice isoforms for TECPR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TECPR1 Gene

Proteomics data for TECPR1 Gene at MOPED

Post-translational modifications for TECPR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TECPR1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TECPR1 (TECPR1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for TECPR1

No data available for DME Specific Peptides for TECPR1 Gene

Domains & Families for TECPR1 Gene

Suggested Antigen Peptide Sequences for TECPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6L1

UniProtKB/Swiss-Prot:

TCPR1_HUMAN :
  • The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P (PubMed:22342342).
  • Belongs to the TECPR1 family.
  • Contains 9 TECPR repeats.
Domain:
  • The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns(3)P). While full-length protein is unable to bind PtdIns(3)P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns(3)P (PubMed:22342342).
  • Contains 1 PH domain.
Family:
  • Belongs to the TECPR1 family.
Similarity:
  • Contains 9 TECPR repeats.
genes like me logo Genes that share domains with TECPR1: view

No data available for Gene Families for TECPR1 Gene

Function for TECPR1 Gene

Molecular function for TECPR1 Gene

UniProtKB/Swiss-Prot Function:
Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.

Phenotypes for TECPR1 Gene

MGI mutant phenotypes for TECPR1:
inferred from 1 alleles
GenomeRNAi human phenotypes for TECPR1:
genes like me logo Genes that share phenotypes with TECPR1: view

Animal Models for TECPR1 Gene

MGI Knock Outs for TECPR1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TECPR1 Gene

Localization for TECPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TECPR1 Gene

Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TECPR1 Gene COMPARTMENTS Subcellular localization image for TECPR1 gene
Compartment Confidence
lysosome 5
vacuole 5
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TECPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 22342342
genes like me logo Genes that share ontologies with TECPR1: view

Pathways & Interactions for TECPR1 Gene

SuperPathways for TECPR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TECPR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TECPR1 Gene

Drugs & Compounds for TECPR1 Gene

No Compound Related Data Available

Transcripts for TECPR1 Gene

Unigene Clusters for TECPR1 Gene

Tectonin beta-propeller repeat containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TECPR1 Gene

No ASD Table

Relevant External Links for TECPR1 Gene

GeneLoc Exon Structure for
TECPR1
ECgene alternative splicing isoforms for
TECPR1

Expression for TECPR1 Gene

mRNA expression in normal human tissues for TECPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TECPR1 Gene

This gene is overexpressed in Pancreas (x8.3).

Protein differential expression in normal tissues from HIPED for TECPR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.2), Frontal cortex (9.4), Liver, secretome (9.3), and Lymph node (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TECPR1 Gene



SOURCE GeneReport for Unigene cluster for TECPR1 Gene Hs.592281

genes like me logo Genes that share expression patterns with TECPR1: view

Protein tissue co-expression partners for TECPR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TECPR1 Gene

Orthologs for TECPR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TECPR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TECPR1 35
  • 86.61 (n)
  • 85.63 (a)
dog
(Canis familiaris)
Mammalia TECPR1 35
  • 87.43 (n)
  • 88.61 (a)
TECPR1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tecpr1 35
  • 84.7 (n)
  • 87.17 (a)
Tecpr1 16
Tecpr1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TECPR1 35
  • 99.23 (n)
  • 99.06 (a)
TECPR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tecpr1 35
  • 84.41 (n)
  • 88.03 (a)
oppossum
(Monodelphis domestica)
Mammalia TECPR1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TECPR1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TECPR1 35
  • 71.08 (n)
  • 74.57 (a)
TECPR1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TECPR1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tecpr1 35
  • 67.6 (n)
  • 71.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9912 35
zebrafish
(Danio rerio)
Actinopterygii tecpr1a 35
  • 66.18 (n)
  • 68.64 (a)
tecpr1a 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GALE3 35
  • 51.15 (n)
  • 40.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pex23 35
  • 52.43 (n)
  • 42.08 (a)
Pex23 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T01H3.2 36
  • 23 (a)
OneToOne
Species with no ortholog for TECPR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TECPR1 Gene

ENSEMBL:
Gene Tree for TECPR1 (if available)
TreeFam:
Gene Tree for TECPR1 (if available)

Paralogs for TECPR1 Gene

No data available for Paralogs for TECPR1 Gene

Variants for TECPR1 Gene

Sequence variations from dbSNP and Humsavar for TECPR1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35623371 - 98,231,045(-) CTGGT(A/C)CATCA nc-transcript-variant, reference, missense
rs11762014 - 98,223,087(+) CACCC(A/G)GGCTC reference, missense
rs903592 -- 98,244,782(+) TGAAA(C/T)ACCCG intron-variant
rs954050 -- 98,250,914(-) ACGAC(A/G)GGTGC intron-variant
rs1045850 -- 98,215,221(+) AGCTC(A/C)GAAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TECPR1 Gene

Variant ID Type Subtype PubMed ID
nsv831066 CNV Loss 17160897
nsv888760 CNV Loss 21882294
nsv888762 CNV Loss 21882294
nsv888763 CNV Loss 21882294
nsv888765 CNV Gain 21882294
nsv525934 CNV Loss 19592680
nsv831067 CNV Loss 17160897
nsv512916 CNV Insertion 21212237

Variation tolerance for TECPR1 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TECPR1 Gene

HapMap Linkage Disequilibrium report
TECPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TECPR1 Gene

Disorders for TECPR1 Gene

Relevant External Links for TECPR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TECPR1

No disorders were found for TECPR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TECPR1 Gene

Publications for TECPR1 Gene

  1. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. (PMID: 22342342) Chen D. … Zhong Q. (Mol. Cell 2012) 3 4 67
  2. Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners. (PMID: 25484072) Kim J.H. … Song H.K. (Autophagy 2015) 3
  3. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. (PMID: 21575909) Ogawa M. … Sasakawa C. (Cell Host Microbe 2011) 3
  4. The role of Tecpr1 in selective autophagy as a cargo receptor. (PMID: 21795850) Ogawa M. … Sasakawa C. (Autophagy 2011) 3
  5. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3

Products for TECPR1 Gene

Sources for TECPR1 Gene

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