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Aliases for TEC Gene

Aliases for TEC Gene

  • Tec Protein Tyrosine Kinase 2 3
  • EC 2.7.10.2 4 63
  • PSCTK4 3 4
  • Tyrosine-Protein Kinase Tec 3
  • EC 2.7.10 63

External Ids for TEC Gene

Summaries for TEC Gene

Entrez Gene Summary for TEC Gene

  • The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEC Gene

TEC (Tec Protein Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TEC include transient erythroblastopenia of childhood and b cell deficiency. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include phospholipid binding and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for TEC Gene

  • Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 Tyr-215. May also be involved in the regulation of osteoclast differentiation.

Gene Wiki entry for TEC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEC Gene

Genomics for TEC Gene

Genomic Location for TEC Gene

Start:
48,135,783 bp from pter
End:
48,269,864 bp from pter
Size:
134,082 bases
Orientation:
Minus strand

Genomic View for TEC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEC Gene

Regulatory Elements for TEC Gene

Proteins for TEC Gene

  • Protein details for TEC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42680-TEC_HUMAN
    Recommended name:
    Tyrosine-protein kinase Tec
    Protein Accession:
    P42680
    Secondary Accessions:
    • B7ZKZ6
    • Q3MIS5

    Protein attributes for TEC Gene

    Size:
    631 amino acids
    Molecular mass:
    73581 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with CD28, FASLG, FGF2, GRB10, LYN and KIT. Interacts with VAV1 and JAK2 (By similarity).

    Three dimensional structures from OCA and Proteopedia for TEC Gene

neXtProt entry for TEC Gene

Proteomics data for TEC Gene at MOPED

Selected DME Specific Peptides for TEC Gene

Post-translational modifications for TEC Gene

  • Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TEC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for TEC Gene

Gene Families for TEC Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for TEC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P42680

UniProtKB/Swiss-Prot:

TEC_HUMAN
Domain:
  • The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain:
    • P42680
  • The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule.:
    • P42680
  • Contains 1 PH domain.:
    • P42680
  • Contains 1 protein kinase domain.:
    • P42680
  • Contains 1 SH2 domain.:
    • P42680
  • Contains 1 SH3 domain.:
    • P42680
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.:
    • P42680
Similarity:
  • Contains 1 Btk-type zinc finger.:
    • P42680
genes like me logo Genes that share domains with TEC: view

Function for TEC Gene

Molecular function for TEC Gene

GENATLAS Biochemistry: Tec non receptor protein tyrosine kinase,73.6kDa
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Tyr-519. Also activated in response to SCF. Integrin engagement induces tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the activity of TEC. SOCS1 is an inhibitor of TEC kinase activity.
UniProtKB/Swiss-Prot Function: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 Tyr-215. May also be involved in the regulation of osteoclast differentiation.

Enzyme Numbers (IUBMB) for TEC Gene

Gene Ontology (GO) - Molecular Function for TEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004715 non-membrane spanning protein tyrosine kinase activity IDA 10518561
GO:0005102 NOT receptor binding IBA --
GO:0005515 protein binding IPI 10518561
genes like me logo Genes that share ontologies with TEC: view
genes like me logo Genes that share phenotypes with TEC: view

Animal Models for TEC Gene

MGI Knock Outs for TEC:

miRNA for TEC Gene

miRTarBase miRNAs that target TEC

No data available for Transcription Factor Targeting and HOMER Transcription for TEC Gene

Localization for TEC Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEC Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEC Gene COMPARTMENTS Subcellular localization image for TEC gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
extracellular 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IDA 9299487
GO:0005886 plasma membrane --
GO:0005911 cell-cell junction IEA --
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with TEC: view

Pathways for TEC Gene

genes like me logo Genes that share pathways with TEC: view

Gene Ontology (GO) - Biological Process for TEC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IBA --
GO:0006468 protein phosphorylation TAS 7934162
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007229 integrin-mediated signaling pathway IDA 9652744
GO:0010543 regulation of platelet activation IDA 9299487
genes like me logo Genes that share ontologies with TEC: view

Compounds for TEC Gene

(2) HMDB Compounds for TEC Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(11) Novoseek inferred chemical compound relationships for TEC Gene

Compound -log(P) Hits PubMed IDs
tyrosine 81.7 140
phosphatidylinositol-3,4,5-trisphosphate 64.8 1
phosphatidylinositol 50.3 7
phosphoinositide 37 3
inositol 35.1 1
genes like me logo Genes that share compounds with TEC: view

Transcripts for TEC Gene

Unigene Clusters for TEC Gene

Tec protein tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TEC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - -
SP2:
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for TEC Gene

GeneLoc Exon Structure for
TEC
ECgene alternative splicing isoforms for
TEC

Expression for TEC Gene

mRNA expression in normal human tissues for TEC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TEC Gene

SOURCE GeneReport for Unigene cluster for TEC Gene Hs.479670

mRNA Expression by UniProt/SwissProt for TEC Gene

P42680-TEC_HUMAN
Tissue specificity: Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages
genes like me logo Genes that share expressions with TEC: view

No data available for mRNA differential expression in normal tissues for TEC Gene

Orthologs for TEC Gene

This gene was present in the common ancestor of animals.

Orthologs for TEC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEC 35
  • 99.74 (n)
  • 99.84 (a)
TEC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEC 35
  • 91.9 (n)
  • 96.03 (a)
TEC 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEC 35
  • 92.02 (n)
  • 96.2 (a)
TEC 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tec 35
  • 88.99 (n)
  • 95.08 (a)
Tec 16
Tec 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEC 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEC 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tec 35
  • 87.76 (n)
  • 94.75 (a)
chicken
(Gallus gallus)
Aves TEC 35
  • 78.72 (n)
  • 83.44 (a)
TEC 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEC 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tec 35
  • 73.6 (n)
  • 76.64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13650 35
zebrafish
(Danio rerio)
Actinopterygii tec 35
  • 65.99 (n)
  • 68.92 (a)
tec 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008317 35
  • 55.74 (n)
  • 56.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Btk29A 35
  • 52.72 (n)
  • 50.6 (a)
Btk29A 36
  • 38 (a)
OneToMany
Btk29A 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea kin-24 37
  • 25 (a)
spe-8 37
  • 32 (a)
F22B3.8 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
CSA.1818 36
  • 43 (a)
ManyToMany
Species with no ortholog for TEC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TEC Gene

ENSEMBL:
Gene Tree for TEC (if available)
TreeFam:
Gene Tree for TEC (if available)

Paralogs for TEC Gene

Paralogs for TEC Gene

Pseudogenes.org Pseudogenes for TEC Gene

genes like me logo Genes that share paralogs with TEC: view

Variants for TEC Gene

Sequence variations from dbSNP and Humsavar for TEC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs882715 -- 48,156,507(+) AACTG(A/G)ATTTG intron-variant
rs906901 -- 48,233,392(+) AGGCC(G/T)GACTC intron-variant
rs925288 -- 48,271,190(+) ATGCT(A/G)ACAAG upstream-variant-2KB
rs937952 -- 48,271,729(+) cctcg(A/C)atgca upstream-variant-2KB
rs961153 -- 48,158,295(+) CCAAG(A/C)TAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TEC Gene

Variant ID Type Subtype PubMed ID
nsv820308 CNV Loss 19587683
nsv819666 CNV Loss 19587683
nsv819982 CNV Loss 19587683
esv275189 CNV Loss 21479260
nsv461357 CNV Gain 19166990
nsv470032 CNV Gain 18288195
nsv461358 CNV Loss 19166990
nsv509003 CNV Insertion 20534489
nsv4329 CNV Loss 18451855

Relevant External Links for TEC Gene

HapMap Linkage Disequilibrium report
TEC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEC Gene

Disorders for TEC Gene

(1) University of Copenhagen DISEASES for TEC Gene

(8) Novoseek inferred disease relationships for TEC Gene

Disease -log(P) Hits PubMed IDs
x-linked agammaglobulinemia 91.4 5
agammaglobulinemia 75.7 1
wiskott-aldrich syndrome 45.3 1
immunodeficiency 39 1
behcet disease 16.7 2

Relevant External Links for TEC

Genetic Association Database (GAD)
TEC
Human Genome Epidemiology (HuGE) Navigator
TEC
genes like me logo Genes that share disorders with TEC: view

No data available for UniProtKB/Swiss-Prot for TEC Gene

Publications for TEC Gene

  1. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. (PMID: 7934162) Sato K. … Hirai H. (Leukemia 1994) 2 3 4 23
  2. Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. (PMID: 7526158) Tang B. … Ihle J.N. (Mol. Cell. Biol. 1994) 3 4 23
  3. Integrin-dependent tyrosine phosphorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. (PMID: 9299487) Laffargue M. … Chap H. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  4. Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. (PMID: 9652744) Hamazaki Y. … Nagasawa T. (Oncogene 1998) 3 4 23
  5. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. (PMID: 10518561) Ohya K. … Mano H. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23

Products for TEC Gene

  • Addgene plasmids for TEC

Sources for TEC Gene

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