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TEC Gene

protein-coding   GIFtS: 70
GCID: GC04M048137

Tec Protein Tyrosine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tec Protein Tyrosine Kinase1 2
PSCTK42 3
EC 2.7.10.23 8
Tyrosine-Protein Kinase Tec2
EC 2.7.108

External Ids:    HGNC: 117191   Entrez Gene: 70062   Ensembl: ENSG000001356057   OMIM: 6005835   UniProtKB: P426803   

Export aliases for TEC gene to outside databases

Previous GC identifers: GC04M048214 GC04M048447 GC04M047987 GC04M048053 GC04M047978 GC04M047832 GC04M047457


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEC Gene:
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a
pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine
receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They
are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell
signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic
syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for TEC Gene:
TEC (tec protein tyrosine kinase) is a protein-coding gene. Diseases associated with TEC include transient erythroblastopenia of childhood, and congenital fibrosarcoma. GO annotations related to this gene include phospholipid binding and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is CSK.

UniProtKB/Swiss-Prot: TEC_HUMAN, P42680
Function: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a
signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a
redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and
differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene
induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals
that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in
BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling
protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation
mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical
cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in
platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to
mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation
pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated
signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in
HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum
(ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2
'Tyr-215'. May also be involved in the regulation of osteoclast differentiation

Gene Wiki entry for TEC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_006238.12  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEC gene promoter:
         FOXD3   HNF-3beta   Arnt   E47   PPAR-alpha   SRY   POU2F1   POU2F1a   SEF-1 (1)   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEC promoter sequence
   Search Chromatin IP Primers for TEC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p11   HGNC cytogenetic band: 4p12

TEC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M048137:  view genomic region     (about GC identifiers)

Start:
48,137,800 bp from pter      End:
48,271,881 bp from pter
Size:
134,082 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TEC_HUMAN, P42680 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Tec  
Size: 631 amino acids; 73581 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with CD28, FASLG, FGF2, GRB10, LYN and KIT.
Interacts with VAV1 and JAK2 (By similarity)
Caution: It is uncertain whether Met-1 is the initiator
1 PDB 3D structure from and Proteopedia for TEC:
2LUL (3D)    
Secondary accessions: B7ZKZ6 Q3MIS5

Explore the universe of human proteins at neXtProt for TEC: NX_P42680

Explore proteomics data for TEC at MOPED

Post-translational modifications: 

  • Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated
    at Tyr-519. Undergoes also tyrosine phosphorylation during platelet activation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TEC (P42680) (see all 7)
     PIYIVTE  RDLAARN  YYLAEKH  KSDVWSFG 


    See TEC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003206.2  
    ENSEMBL proteins: 
     ENSP00000370912   ENSP00000424567   ENSP00000424365  
    Reactome Protein details: P42680

    TEC Human Recombinant Protein Products:

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    Novus Biologicals TEC Protein
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    Cloud-Clone Corp. Antibodies for TEC
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    LSBio Antibodies in human, mouse, rat for TEC

    TEC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TEC
    Cloud-Clone Corp. CLIAs for TEC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: tec protein tyrosine kinase
    Tec family

    Selected InterPro protein domains (see all 11):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR001849 Pleckstrin_homology
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry P42680

    ProtoNet protein and cluster: P42680

    5 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001562 Tec/Btk domain signature
    IPB001849 Pleckstrin-like
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: TEC_HUMAN, P42680
    Domain: The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its
    targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec
    homology) domain, which consists of about 80 residues preceding the SH3 domain
    Domain: The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule (By similarity)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
    Similarity: Contains 1 Btk-type zinc finger
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    TEC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEC_HUMAN, P42680
    Function: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a
    signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a
    redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and
    differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene
    induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals
    that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in
    BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling
    protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation
    mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical
    cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in
    platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to
    mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation
    pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated
    signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in
    HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum
    (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2
    'Tyr-215'. May also be involved in the regulation of osteoclast differentiation
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by tyrosine phosphorylation by a wide range of cytokine stimulations. When T-cells or
    B-cells receptors are activated, a series of phosphorylation leads to the recruitment of TEC to the cell
    membrane, where it is phosphorylated at Tyr-519. Also activated in response to SCF. Integrin engagement induces
    tyrosine phosphorylation of TEC in platelets. STAP1 participates in a positive feedback loop by increasing the
    activity of TEC. SOCS1 is an inhibitor of TEC kinase activity

         Genatlas biochemistry entry for TEC:
    Tec non receptor protein tyrosine kinase,73.6kDa

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IDA10518561
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
         
    TEC for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tec):
     hematopoietic system  homeostasis/metabolism  immune system 

    TEC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tectm1Welm for TEC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TEC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEC

    miRNA
    Products:
        
    miRTarBase miRNAs that target TEC:
    hsa-mir-204-5p (MIRT047018)

    Block miRNA regulation of human, mouse, rat TEC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEC (see all 16):
    hsa-miR-607 hsa-miR-601 hsa-miR-429 hsa-miR-3120-3p hsa-miR-410 hsa-miR-570 hsa-miR-1305 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidTEC 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TEC

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for TEC
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    GenScript: all cDNA clones in your preferred vector: TEC (NM_058222)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEC_HUMAN, P42680: Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
    Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its
    PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet
    activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is
    recruited to striated structures upon various stimuli, including ATP (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    extracellular2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IDA9299487
    GO:0005886plasma membrane IEA--

    TEC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TEC About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Prolactin Signaling Pathway0.39
    2Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    Kit Receptor Signaling Pathway0.37
    3PI-3K cascade
    Signaling by SCF-KIT0.72
    Fc epsilon receptor (FCERI) signaling0.64
    4ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    CD28 Signaling in T-Helper Cell0.66
    5Signaling by Interleukins
    Interleukin-3, 5 and GM-CSF signaling0.59
    Signaling by Interleukins0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TEC (see all 6)
        G12-G13 in Cellular Signaling
    ICos-ICosL Pathway in T-Helper Cell
    PI3K Signaling in B-Lymphocyte
    CD28 Signaling in T-Helper Cell
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for TEC
        Lymphocyte Signaling
    Tyrosine Kinases / Adaptors

    1 GeneGo (Thomson Reuters) Pathway for TEC
        Development Prolactin receptor signaling

    Selected BioSystems Pathways for TEC (see all 7)
        Kit Receptor Signaling Pathway
    IL-6 Signaling Pathway
    B Cell Receptor Signaling Pathway
    IL-3 Signaling Pathway
    Prolactin Signaling Pathway

    3 Reactome Pathways for TEC
        Interleukin-3, 5 and GM-CSF signaling
    Signaling by SCF-KIT
    FCERI mediated Ca+2 mobilization


    2 Kegg Pathways  (Kegg details for TEC):
        Osteoclast differentiation
    T cell receptor signaling pathway


    TEC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TEC: 
              Notch Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TEC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TEC (P426802, 3 ENSP000003709124) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74777 I2D: score=2 STRING: ENSP00000269571
    ASAP1Q9ULH12, 3, ENSP000003502974MINT-7145675 I2D: score=1 STRING: ENSP00000350297
    MED28Q9H2042, 3, ENSP000002373804MINT-7041716 I2D: score=1 STRING: ENSP00000237380
    DOK1Q997043, ENSP000002336684I2D: score=4 STRING: ENSP00000233668
    VAV1P154983, ENSP000003022694I2D: score=3 STRING: ENSP00000302269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS7934162
    GO:0007229integrin-mediated signaling pathway IDA9652744
    GO:0010543regulation of platelet activation IDA9299487
    GO:0018108peptidyl-tyrosine phosphorylation TAS7934162
    GO:0035556intracellular signal transduction IEA--

    TEC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEC

    2 HMDB Compounds for TEC    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for TEC gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 81.7 212 15899983 (4), 9446655 (4), 14647425 (3), 11123316 (3) (see all 99)
    phosphatidylinositol-3,4,5-trisphosphate 64.8 1 15492005 (1)
    phosphatidylinositol 50.3 8 11123316 (3), 10688822 (1), 11382770 (1), 15492005 (1) (see all 5)
    phosphoinositide 37 3 15240663 (2), 11994416 (1)
    inositol 35.1 1 9240435 (1)
    wortmannin 22.3 4 15899983 (1), 11123316 (1)
    proline 18.5 5 12163161 (3), 15214045 (2)
    calcium 4.8 5 15899983 (2), 15184383 (1), 10224128 (1), 11058574 (1)
    adp 2.23 1 12734372 (1)
    fibrinogen 0 1 9652744 (1)



    TEC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TEC gene: 
    NM_003215.2  

    Unigene Cluster for TEC:

    Tec protein tyrosine kinase
    Hs.479670  [show with all ESTs]
    Unigene Representative Sequence: D29767
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381501(uc003gxz.3) ENST00000505452 ENST00000515146 ENST00000511150
    ENST00000511471
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TEC (see all 16):
    hsa-miR-607 hsa-miR-601 hsa-miR-429 hsa-miR-3120-3p hsa-miR-410 hsa-miR-570 hsa-miR-1305 hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidTEC 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TEC (NM_058222)
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      QuantiTect SYBR Green Assays in human, mouse, rat TEC
      QuantiFast Probe-based Assays in human, mouse, rat TEC

    Additional mRNA sequence: 

    BC101711.1 BC101713.1 BC143487.1 D29767.1 

    6 DOTS entries:

    DT.309718  DT.91969344  DT.91716446  DT.95152949  DT.95342354  DT.86857648 

    Selected AceView cDNA sequences (see all 27):

    AI652941 AI640432 AV714704 AW451753 AA779321 AL602776 BF791619 CD369126 
    BX092226 CB046252 D29767 AA262400 BE378187 AW292943 CB985022 NM_003215 
    AW268498 CB046251 AA934653 AA243613 AV711220 AA534336 BQ353545 BM148012 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TEC (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                    -                                                           -                                                                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                          -                                 
    SP4:                                                                                                                                                            
    SP5:                                            -                                                                                                               


    ECgene alternative splicing isoforms for TEC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEC expression in normal human tissues (normalized intensities)      TEC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTTCCGTG
    TEC Expression
    About this image


    TEC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
    TEC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479670

    UniProtKB/Swiss-Prot: TEC_HUMAN, P42680
    Tissue specificity: Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and
    T-cell lineages

        Pathway & Disease-focused RT2 Profiler PCR Array including TEC: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEC gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tec1 , 5 tec protein tyrosine kinase1, 5 88.99(n)1
    95.08(a)1
      5 (38.44 cM)5
    216821  NM_001113460.21  NP_001106931.11 
     727557185 
    chicken
    (Gallus gallus)
    Aves TEC1 tec protein tyrosine kinase 78.72(n)
    83.44(a)
      396407  NM_001030372.1  NP_001025543.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEC6
    tec protein tyrosine kinase
    83(a)
    1 ↔ 1
    GL343293.1(653842-733346)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tec1 tec protein tyrosine kinase 73.6(n)
    76.64(a)
      100491653  XM_002933459.2  XP_002933505.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tec1 tec protein tyrosine kinase 65.99(n)
    68.92(a)
      571588  NM_001114743.1  NP_001108215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Btk29A1 , 3 male genital morphogenesis (sensu
    Holometabola) more3
    Btk family kinase at 29A1
    54(a)3
    52.72(n)1
    50.6(a)1
      29A13
    341321  NM_001103651.21  NP_001097121.11 


    ENSEMBL Gene Tree for TEC (if available)
    TreeFam Gene Tree for TEC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEC gene
    CSK2  FER2  ITK2  TXK2  FES2  DSTYK2  MATK2  BMX2  
    BTK2  
    Selected SIMAP similar genes for TEC using alignment to 3 protein entries:     TEC_HUMAN (see all proteins) (see all similar genes):
    BTK kinase deficient isoform 4    TXK    BTK kinase deficient isoform 2    DKFZp686M05208    ITK    BMX
    BTK    EPHA2    BLK    FGR    FYN    ABL1
    ABL2    BCR/ABL fusion    FRK    SRC    YES1    LYN

    TEC for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TEC
    PGOHUM00000243697


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEC (see all 2640)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0418514
    A lung adenocarcinoma sample4--see VAR_0418512 R K mis40--------
    rs587478791,2
    C--47571606(+) AAACT-/GTAGTTT 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs750423341,2
    C,F--48138333(+) GAAAAA/CCGTCC 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs168610291,2
    C,F,H--48138374(+) CTCTCC/TGTAGC 1 -- ut31 ese319Minor allele frequency- T:0.05NA NS EA WA 1780
    rs38051831,2
    C,F,H--48138511(-) ATTCCC/TTGGGA 1 -- ut31 ese35Minor allele frequency- T:0.02NS EA 540
    rs1433789511,2
    --48138515(+) AGGGAA/GTATTC 1 -- ut310--------
    rs10082771,2
    C,F,O,A,H--48138535(-) AATCTG/ACTTCT 1 -- ut31 ese3106Minor allele frequency- A:0.43NS MN EA PA EU CA WA NA CSA 6630
    rs19799721,2
    C,F,O,H--48138613(-) ACCACG/ATGCAT 1 -- ut31 ese39Minor allele frequency- A:0.02MN NS EA NA WA 842
    rs793034661,2
    C,F--48138668(+) GGGGCG/ATTACT 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1895428001,2
    --48138670(+) GGCGTC/TACTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TEC (48137800 - 48271881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TEC:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509003CNV Insertion20534489
    nsv819666CNV Loss19587683
    nsv819982CNV Loss19587683
    nsv820308CNV Loss19587683
    esv275189CNV Loss21479260
    nsv4329CNV Loss18451855
    nsv461358CNV Loss19166990
    nsv461357CNV Gain19166990
    nsv470032CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600583    OMIM disorders: --

    Selected diseases for TEC (see all 24):    About MalaCards
    transient erythroblastopenia of childhood    congenital fibrosarcoma    b cell deficiency    agammaglobulinemia
    myelodysplastic syndromes    myxoid chondrosarcoma    t cell deficiency    extraskeletal myxoid chondrosarcoma
    behcet's disease    chondrosarcoma    wiskott-aldrich syndrome    lymphedema
    cervical squamous cell carcinoma    fibrosarcoma    candidiasis    gout
    narcolepsy    cervicitis    inflammatory bowel disease    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for TEC:
    Leukemia

    TEC for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for TEC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    x-linked agammaglobulinemia 91.4 6 9280283 (1), 9446655 (1), 11104803 (1), 8892607 (1) (see all 5)
    agammaglobulinemia 75.7 2 8090769 (1)
    wiskott-aldrich syndrome 45.3 1 10688822 (1)
    immunodeficiency 39 1 11104803 (1)
    behcet disease 16.7 2 16809408 (1), 15654836 (1)
    tumors 5.46 2 15251464 (1), 18171525 (1)
    necrosis 0 1 15251464 (1)
    cancer 0 2 18171525 (1)

    Genetic Association Database (GAD): TEC
    Human Genome Epidemiology (HuGE) Navigator: TEC (13 documents)

    Export disorders for TEC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEC gene, integrated from 10 sources (see all 192):
    (articles sorted by number of sources associating them with TEC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. (PubMed id 7934162)1, 2, 3, 9 Sato K.... Hirai H. (Leukemia 1994)
    2. SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. (PubMed id 15492005)1, 2, 9 Tomlinson M.G.... Weiss A. (J. Biol. Chem. 2004)
    3. Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets. (PubMed id 9652744)1, 2, 9 Hamazaki Y....Nagasawa T. (Oncogene 1998)
    4. Tec protein tyrosine kinase inhibits CD25 expression in human T- lymphocyte. (PubMed id 19883687)1, 2, 9 Susaki K.... Ishida T. (Immunol. Lett. 2010)
    5. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. (PubMed id 10518561)1, 2, 9 Ohya K.... Mano H. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. Integrin-dependent tyrosine phosphorylation and cytoskeletal translocation of Tec in thrombin-activated platelets. (PubMed id 9299487)1, 2, 9 Laffargue M.... Chap H. (Biochem. Biophys. Res. Commun. 1997)
    7. Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. (PubMed id 7526158)1, 2, 9 Tang B.... Ihle J.N. (Mol. Cell. Biol. 1994)
    8. Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. (PubMed id 12573241)1, 2, 9 Nore B.F.... Smith C.I.E. (Biochim. Biophys. Acta 2003)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7006 HGNC: 11719 AceView: TEC Ensembl:ENSG00000135605 euGenes: HUgn7006
    ECgene: TEC Kegg: 7006 H-InvDB: TEC

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TEC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TEC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEC gene:
    Search GeneIP for patents involving TEC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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