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TEAD4 Gene

protein-coding   GIFtS: 63
GCID: GC12P003068

TEA Domain Family Member 4


(Previous symbol: TCF13L1)
  See TEAD4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TEA Domain Family Member 41 2 3     TEFR-12
TCF13L11 2 3 5     hRTEF-1B2
RTEF12 3 5     Related Transcription Enhancer Factor 1B2
Transcription Factor 13-Like 12 3     Transcriptional Enhancer Factor 1-Related2
Transcription Factor RTEF-12 3     Transcriptional Enhancer Factor 32
TEF32 3     Transcriptional Enhancer Factor TEF-32
EFTR-22     TEAD-43
TEF-32     

External Ids:    HGNC: 117171   Entrez Gene: 70042   Ensembl: ENSG000001979057   OMIM: 6017145   UniProtKB: Q155613   

Export aliases for TEAD4 gene to outside databases

Previous GC identifers: GC12U990098 GC12M123588 GC12P002947 GC12P002938


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEAD4 Gene:
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which
contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the
M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression.
Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a
non-AUG (UUG) initiation codon, have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TEAD4 Gene:
TEAD4 (TEA domain family member 4) is a protein-coding gene. Diseases associated with TEAD4 include cardiac conduction defect. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot: TEAD4_HUMAN, Q15561
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and
non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the
M-CAT motif

Gene Wiki entry for TEAD4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEAD4 gene promoter:
         NRSF form 1   Pax-2   IRF-7A   Pax-2a   HNF-4alpha1   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEAD4 promoter sequence
   Search Chromatin IP Primers for TEAD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEAD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3-p13.2   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.3-p13.2

TEAD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEAD4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P003068:  view genomic region     (about GC identifiers)

Start:
3,068,478 bp from pter      End:
3,149,842 bp from pter
Size:
81,365 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEAD4_HUMAN, Q15561 (See protein sequence)
Recommended Name: Transcriptional enhancer factor TEF-3  
Size: 434 amino acids; 48329 Da
Subunit: Interacts with YAP1 and WWTR1/TAZ
Sequence caution: Sequence=CAA64212.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator
methionine is coded by a non-canonical ATA isoleucine codon;
Secondary accessions: H0Y308 Q6MZR9 Q8NEV5 Q92883 Q96BK2
Alternative splicing: 3 isoforms:  Q15561-1   Q15561-2   Q15561-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TEAD4: NX_Q15561

Explore proteomics data for TEAD4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys73
  • Modification sites at PhosphoSitePlus

  • See TEAD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_003204.2  NP_958849.1  NP_958851.1  

    ENSEMBL proteins: 
     ENSP00000351184   ENSP00000438960   ENSP00000438453   ENSP00000352926   ENSP00000444528  
     ENSP00000380311   ENSP00000411475   ENSP00000441959  
    Reactome Protein details: Q15561

    TEAD4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TEAD4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000818 TEA/ATTS
     IPR016361 TEF
     IPR027255 TEF-3

    Graphical View of Domain Structure for InterPro Entry Q15561

    ProtoNet protein and cluster: Q15561

    1 Blocks protein domain: IPB000818 TEA/ATTS family

    UniProtKB/Swiss-Prot: TEAD4_HUMAN, Q15561
    Similarity: Contains 1 TEA DNA-binding domain


    Find genes that share domains with TEAD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEAD4_HUMAN, Q15561
    Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
    size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
    is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
    and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
    YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
    proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and
    non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the
    M-CAT motif

         Genatlas biochemistry entry for TEAD4:
    SV40-transcriptional enhancer factor 4 (TEF4)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA18579750
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with TEAD4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TEAD4:
     Decreased TP53 protein express 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tead4):
     embryogenesis  mortality/aging  normal 

    Find genes that share phenotypes with TEAD4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TEAD4: Tead4tm1Hssk Tead4tm1.1Bnno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEAD4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TEAD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEAD4

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CCWGGAATGY 

    miRNA
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    miRTarBase miRNAs that target TEAD4:
    hsa-mir-98-5p (MIRT027435), hsa-mir-181a-5p (MIRT047332)

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    4 qRT-PCR Assays for microRNAs that regulate TEAD4:
    hsa-miR-146a* hsa-miR-185* hsa-miR-629 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidTEAD4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TEAD4

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    Addgene plasmids for TEAD4 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEAD4_HUMAN, Q15561: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----

    Find genes that share ontologies with TEAD4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TEAD4 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    Human Embryonic Stem Cell Pluripotency0.50
    3ERK Signaling
    MAPK Signaling0.58
    ILK Signaling0.49
    4Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with TEAD4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TEAD4 (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway

    2 Reactome Pathways for TEAD4
        PPARA activates gene expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression


    1 Kegg Pathway  (Kegg details for TEAD4):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEAD4
    Interactions:

        Search GeneGlobe Interaction Network for TEAD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TEAD4 (Q155611, 3 ENSP000003529264) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWTR1Q9GZV51, 3, ENSP000003538474EBI-747736,EBI-747743 I2D: score=5 STRING: ENSP00000353847
    CCDC85BQ158343, ENSP000003116954I2D: score=4 STRING: ENSP00000311695
    MYH7P128833, ENSP000003475074I2D: score=1 STRING: ENSP00000347507
    VGLL1Q999903, ENSP000003596684I2D: score=2 STRING: ENSP00000359668
    YAP1P469373, ENSP000002824414I2D: score=2 STRING: ENSP00000282441
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS8662936
    GO:0001701in utero embryonic development ----
    GO:0001708cell fate specification ----
    GO:0001825blastocyst formation ----
    GO:0001830trophectodermal cell fate commitment ----

    Find genes that share ontologies with TEAD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEAD4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEAD4 gene (3 alternative transcripts): 
    NM_003213.3  NM_201441.2  NM_201443.2  

    Unigene Cluster for TEAD4:

    TEA domain family member 4
    Hs.94865  [show with all ESTs]
    Unigene Representative Sequence: NM_003213
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358409(uc010sek.2) ENST00000540314 ENST00000536826 ENST00000359864(uc010sej.2)
    ENST00000543035 ENST00000397122(uc001qln.3) ENST00000443986 ENST00000544666

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    hsa-miR-146a* hsa-miR-185* hsa-miR-629 hsa-miR-3647-3p
    SwitchGear 3'UTR luciferase reporter plasmidTEAD4 3' UTR sequence
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    Additional mRNA sequence: 

    AK222947.1 AY101179.1 BC015497.1 BX640921.1 X94438.1 

    10 DOTS entries:

    DT.312979  DT.100783590  DT.100783583  DT.121175705  DT.92438814  DT.95374930  DT.121175699  DT.100783584 
    DT.121175694  DT.97822605 

    Selected AceView cDNA sequences (see all 144):

    CA424554 BU168255 BM927076 BG679445 BM762890 BQ954533 BQ674956 BM694256 
    BM559556 W72159 BM555991 BU733128 BU930868 CB160781 BU856599 W74602 
    BM784252 AL558808 BX369603 BG332245 W77941 BM552678 AI688400 BM784326 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TEAD4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                    -           -     -     -                                                                                       
    SP2:                    -           -     -     -                                         -                                             
    SP3:                    -     -     -     -     -                                                                                       
    SP4:                                            -                                                                                       
    SP5:                                -     -     -                                         -                                             


    ECgene alternative splicing isoforms for TEAD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEAD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAACAGCG
    TEAD4 Expression
    About this image


    TEAD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 8 entries
             Trophoblast Cells Trophoblast
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 6 entries
             Zygote Zygote
     
     Inner Cell Mass (Early Embryo)    fully expand to see all 6 entries
             Zygote Zygote
     
     Placenta (Extraembryonic Tissues)
    TEAD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEAD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.94865

    UniProtKB/Swiss-Prot: TEAD4_HUMAN, Q15561
    Tissue specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEAD4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tead41 , 5 TEA domain family member 41, 5 88.84(n)1
    93.91(a)1
      6 (62.92 cM)5
    216791  NM_011567.21  NP_035697.31 
     1282242885 
    chicken
    (Gallus gallus)
    Aves TEAD41 TEA domain family member 4 78.6(n)
    88.45(a)
      395542  NM_001001339.1  NP_001001339.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tead41 TEA domain family member 4 70.25(n)
    75.66(a)
      100144667  XM_002938514.2  XP_002938560.2 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01090021.16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    25(2423570-2439037) ENSDARG00000075274
    fruit fly
    (Drosophila melanogaster)
    Insecta sd3 neurogenesis transcription factor 57(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea egl-443 Expression: hyp3, hyp4, hyp6, hyp7,
    intestine, more
    40(a)   II(5933501-5940191)   --


    ENSEMBL Gene Tree for TEAD4 (if available)
    TreeFam Gene Tree for TEAD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEAD4 gene
    TEAD12  TEAD22  TEAD32  
    3 SIMAP similar genes for TEAD4 using alignment to 8 protein entries:     TEAD4_HUMAN (see all proteins):
    TEAD3    TEAD1    TEAD2

    Find genes that share paralogs with TEAD4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TEAD4 (see all 2107)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732469311,2
    C,F--2997696(+) GCTTCG/ACTAAA 2 -- us2k14Minor allele frequency- A:0.15WA CSA 124
    rs1867715861,2
    C--2997941(+) GGTGTA/CAAAGT 2 -- us2k10--------
    rs1916107551,2
    C--2998007(+) ACAGGA/GTTTCG 3 -- us2k10--------
    rs1822428641,2
    --2998012(+) GTTTCA/GCTCTG 3 -- us2k10--------
    rs118312611,2
    C,F,H--2998031(+) GCTGGT/CGTGTA 3 -- us2k19Minor allele frequency- C:0.14NA CSA WA EA 371
    rs619163871,2
    C--2998049(+) ATTCAC/TGGCTC 3 -- us2k15Minor allele frequency- T:0.12NA EA 246
    rs1155981411,2
    F--2998059(+) CACTGC/TAGCCT 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1865029191,2
    --2998124(+) TACAGA/GTGCAG 3 -- us2k10--------
    rs740577211,2
    C,F--2998216(+) CAGGCG/ATGAGC 3 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1458690571,2
    --2998269(+) AGTGTA/GTACTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEAD4 (3068478 - 3149842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TEAD4 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673655CNV Deletion23128226
    esv2662595CNV Deletion23128226
    nsv832311CNV Loss17160897
    nsv468974CNV Loss19166990
    nsv528500CNV Loss19592680
    dgv1345n71CNV Loss21882294
    nsv898613CNV Loss21882294
    nsv468975CNV Loss19166990
    nsv898610CNV Loss21882294
    nsv470261CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEAD4
    DNA2.0 Custom Variant and Variant Library Synthesis for TEAD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601714    OMIM disorders: --

    1 disease for TEAD4:    
    About MalaCards
    cardiac conduction defect

    1 disease from the University of Copenhagen DISEASES database for TEAD4:
    Fallopian tube carcinoma

    Find genes that share disorders with TEAD4           About GenesLikeMe


    Export disorders for TEAD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TEAD4 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with TEAD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. (PubMed id 8921372)1, 2, 3 Stewart A.F.R.... Adra C.N. (Genomics 1996)
    2. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PubMed id 19324877)1, 2 Zhang H.... Guan K.L. (J. Biol. Chem. 2009)
    3. TEAD mediates YAP-dependent gene induction and growth control. (PubMed id 18579750)1, 2 Zhao B.... Guan K.L. (Genes Dev. 2008)
    4. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PubMed id 9889009)1, 3 Jacquemin P....Davidson I. (Genomics 1999)
    5. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. (PubMed id 8702974)1, 2 Jacquemin P.... Davidson I. (J. Biol. Chem. 1996)
    6. Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. (PubMed id 18840614)1, 9 Liu X....Zeng H. (J. Biol. Chem. 2008)
    7. Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. (PubMed id 15520314)1, 9 Chen H.H....Stewart A.F. (Circulation 2004)
    8. YAP/TEAD-mediated transcription controls cellular senescence. (PubMed id 23576552)1 Xie Q....Yuan Z. (Cancer Res. 2013)
    9. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. (PubMed id 23496005)1 Luca G....Tafti M. (J Sleep Res 2013)
    10. RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium. (PubMed id 22843786)1 Messmer-Blust A.F....Li J. (Circ. Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7004 HGNC: 11717 AceView: TEAD4 Ensembl:ENSG00000197905 euGenes: HUgn7004
    ECgene: TEAD4 Kegg: 7004 H-InvDB: TEAD4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TEAD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TEAD4 gene:
    Search GeneIP for patents involving TEAD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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