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Aliases for TEAD3 Gene

Aliases for TEAD3 Gene

  • TEA Domain Family Member 3 2 3 4
  • TEAD5 3 4 6
  • TEF5 3 4 6
  • DTEF-1 3 4
  • TEAD-3 3 4
  • Transcriptional Enhancer Factor TEF-5 (DTEF-1) 3
  • Transcriptional Enhancer Factor TEF-5 3
  • Transcriptional Enhancer Factor 5 3
  • TEA Domain Family Member 5 3
  • ETFR-1 3
  • TEF-5 3

External Ids for TEAD3 Gene

Previous HGNC Symbols for TEAD3 Gene

  • TEAD5

Previous GeneCards Identifiers for TEAD3 Gene

  • GC06M035443
  • GC06M035488
  • GC06M035549
  • GC06M035162
  • GC06M035441

Summaries for TEAD3 Gene

Entrez Gene Summary for TEAD3 Gene

  • This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

GeneCards Summary for TEAD3 Gene

TEAD3 (TEA Domain Family Member 3) is a Protein Coding gene. Among its related pathways are Hippo signaling pathway and Metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot for TEAD3 Gene

  • Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Gene Wiki entry for TEAD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TEAD3 Gene

Genomics for TEAD3 Gene

Regulatory Elements for TEAD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TEAD3 Gene

Start:
35,473,597 bp from pter
End:
35,497,084 bp from pter
Size:
23,488 bases
Orientation:
Minus strand

Genomic View for TEAD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TEAD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TEAD3 Gene

Proteins for TEAD3 Gene

  • Protein details for TEAD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99594-TEAD3_HUMAN
    Recommended name:
    Transcriptional enhancer factor TEF-5
    Protein Accession:
    Q99594
    Secondary Accessions:
    • O95910
    • Q5BJG7
    • Q8N6Y4

    Protein attributes for TEAD3 Gene

    Size:
    435 amino acids
    Molecular mass:
    48676 Da
    Quaternary structure:
    • Interacts with YAP1 and WWTR1/TAZ.
    SequenceCaution:
    • Sequence=AAH27877.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305}; Sequence=AAH91488.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305}; Sequence=CAA64213.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.; Evidence={ECO:0000305};

neXtProt entry for TEAD3 Gene

Proteomics data for TEAD3 Gene at MOPED

Post-translational modifications for TEAD3 Gene

  • Ubiquitination at Lys65
  • Modification sites at PhosphoSitePlus

Other Protein References for TEAD3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TEAD3 (TEAD3)

No data available for DME Specific Peptides for TEAD3 Gene

Domains for TEAD3 Gene

Protein Domains for TEAD3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99594

UniProtKB/Swiss-Prot:

TEAD3_HUMAN :
  • Q99594
Domain:
  • Contains 1 TEA DNA-binding domain.
genes like me logo Genes that share domains with TEAD3: view

No data available for Gene Families for TEAD3 Gene

Function for TEAD3 Gene

Molecular function for TEAD3 Gene

GENATLAS Biochemistry: SV40-transcriptional enhancer factor 3 (TEF5),expressed in syncytiotrophoblast,where it binds to CSH2 enhancer
UniProtKB/Swiss-Prot Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Gene Ontology (GO) - Molecular Function for TEAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 23946438
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 18579750
GO:0005515 protein binding IPI 18579750
genes like me logo Genes that share ontologies with TEAD3: view

Animal Model Products

CRISPR Products

miRNA for TEAD3 Gene

miRTarBase miRNAs that target TEAD3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEAD3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TEAD3 Gene

Localization for TEAD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TEAD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TEAD3 Gene COMPARTMENTS Subcellular localization image for TEAD3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TEAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with TEAD3: view

Pathways for TEAD3 Gene

genes like me logo Genes that share pathways with TEAD3: view

Gene Ontology (GO) - Biological Process for TEAD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9148898
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007565 female pregnancy TAS 9148898
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TEAD3: view

Transcripts for TEAD3 Gene

mRNA/cDNA for TEAD3 Gene

Unigene Clusters for TEAD3 Gene

TEA domain family member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TEAD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TEAD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TEAD3 Gene

No ASD Table

Relevant External Links for TEAD3 Gene

GeneLoc Exon Structure for
TEAD3
ECgene alternative splicing isoforms for
TEAD3

Expression for TEAD3 Gene

mRNA expression in normal human tissues for TEAD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TEAD3 Gene

SOURCE GeneReport for Unigene cluster for TEAD3 Gene Hs.485205

mRNA Expression by UniProt/SwissProt for TEAD3 Gene

Q99594-TEAD3_HUMAN
Tissue specificity: Preferentially expressed in the placenta
genes like me logo Genes that share expressions with TEAD3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TEAD3 Gene

Orthologs for TEAD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TEAD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TEAD3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TEAD3 35
  • 92.07 (n)
  • 96.76 (a)
TEAD3 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TEAD3 35
  • 92.43 (n)
  • 97.58 (a)
TEAD3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tead3 35
  • 90.33 (n)
  • 98.11 (a)
Tead3 16
Tead3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TEAD3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TEAD3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tead3 35
  • 90.94 (n)
  • 98.82 (a)
chicken
(Gallus gallus)
Aves TEAD3 35
  • 80.86 (n)
  • 89.29 (a)
TEAD3 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TEAD3 36
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tead3a 36
  • 76 (a)
OneToMany
tead3b 35
  • 74.58 (n)
  • 78.25 (a)
tead3b 36
  • 77 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sd 36
  • 41 (a)
OneToMany
sd 37
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea egl-44 36
  • 36 (a)
OneToMany
egl-44 37
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for TEAD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TEAD3 Gene

ENSEMBL:
Gene Tree for TEAD3 (if available)
TreeFam:
Gene Tree for TEAD3 (if available)

Paralogs for TEAD3 Gene

Paralogs for TEAD3 Gene

Selected SIMAP similar genes for TEAD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TEAD3: view

Variants for TEAD3 Gene

Sequence variations from dbSNP and Humsavar for TEAD3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs760782 -- 35,480,412(-) TGTCT(A/G)TGTTT intron-variant
rs1016146 -- 35,477,739(+) TGAGC(A/G)GAAAG intron-variant
rs1040434 -- 35,476,574(-) acact(A/G)tacaa intron-variant
rs1040435 -- 35,476,573(-) cactg(C/T)acaag intron-variant
rs1061645 -- 35,473,979(-) CAGTT(C/T)TGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TEAD3 Gene

Variant ID Type Subtype PubMed ID
nsv528351 CNV Loss 19592680
nsv885799 CNV Loss 21882294
nsv519370 CNV Loss 19592680
nsv462909 CNV Loss 19166990
dgv1940e1 CNV Complex 17122850
esv23268 CNV Loss 19812545

Relevant External Links for TEAD3 Gene

HapMap Linkage Disequilibrium report
TEAD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TEAD3 Gene

Disorders for TEAD3 Gene

Relevant External Links for TEAD3

Genetic Association Database (GAD)
TEAD3
genes like me logo Genes that share disorders with TEAD3: view

No data available for UniProtKB/Swiss-Prot for TEAD3 Gene

Publications for TEAD3 Gene

  1. Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin- B gene enhancer. (PMID: 9148898) Jacquemin P. … Davidson I. (J. Biol. Chem. 1997) 2 3 4 23
  2. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PMID: 9889009) Jacquemin P. … Davidson I. (Genomics 1999) 2 3 23
  3. Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer. (PMID: 10379887) Jiang S.W. … Eberhardt N.L. (Mol. Endocrinol. 1999) 3 23
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TEAD3 Gene

Sources for TEAD3 Gene

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