Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TEAD3 Gene

protein-coding   GIFtS: 57
GCID: GC06M035441

TEA Domain Family Member 3


(Previous symbol: TEAD5)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TEA Domain Family Member 31 2 3     TEF-52
TEAD51 2 3 5     TEA Domain Family Member 52
TEF52 3 5     Transcriptional Enhancer Factor 52
DTEF-12 3     Transcriptional Enhancer Factor TEF-52
TEAD-32 3     Transcriptional Enhancer Factor TEF-5 (DTEF-1)2
ETFR-12     

External Ids:    HGNC: 117161   Entrez Gene: 70052   Ensembl: ENSG000000078667   OMIM: 6031705   UniProtKB: Q995943   

Export aliases for TEAD3 gene to outside databases

Previous GC identifers: GC06M035443 GC06M035488 GC06M035549 GC06M035162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TEAD3 Gene:
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which
contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the
transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a
non-AUG (AUA) start codon. (provided by RefSeq, Jul 2008)

GeneCards Summary for TEAD3 Gene:
TEAD3 (TEA domain family member 3) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot: TEAD3_HUMAN, Q99594
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional
elements of the human chorionic somatomammotropin-B gene enhancer

Gene Wiki entry for TEAD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEAD3 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEAD3 promoter sequence
   Search Chromatin IP Primers for TEAD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEAD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.2

TEAD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEAD3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035441:  view genomic region     (about GC identifiers)

Start:
35,441,374 bp from pter      End:
35,464,861 bp from pter
Size:
23,488 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TEAD3_HUMAN, Q99594 (See protein sequence)
Recommended Name: Transcriptional enhancer factor TEF-5  
Size: 435 amino acids; 48676 Da
Subunit: Interacts with YAP1 and WWTR1/TAZ
Sequence caution: Sequence=AAH27877.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator
methionine is coded by a non-canonical ATA isoleucine codon; Sequence=AAH91488.2; Type=Miscellaneous discrepancy;
Note=Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon;
Sequence=CAA64213.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by
a non-canonical ATA isoleucine codon;
Secondary accessions: O95910 Q5BJG7 Q8N6Y4

Explore the universe of human proteins at neXtProt for TEAD3: NX_Q99594

Explore proteomics data for TEAD3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys65
  • Modification sites at PhosphoSitePlus

  • See TEAD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003205.2  
    ENSEMBL proteins: 
     ENSP00000384577   ENSP00000345772   ENSP00000416400  
    Reactome Protein details: Q99594

    TEAD3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TEAD3
    GenScript Custom Purified and Recombinant Proteins Services for TEAD3
    Novus Biologicals TEAD3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TEAD3

     
    Search eBioscience for Proteins for TEAD3 

    TEAD3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TEAD3
    OriGene Custom Antibody Services for TEAD3
    Novus Biologicals TEAD3 Antibodies
    Abcam antibodies for TEAD3
    Cloud-Clone Corp. Antibodies for TEAD3
    Search ThermoFisher Antibodies for TEAD3
    LSBio Antibodies in human, mouse, rat for TEAD3

    TEAD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TEAD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TEAD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TEAD3
    Cloud-Clone Corp. CLIAs for TEAD3
    Search eBioscience for ELISAs for TEAD3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR027253 TEF-5
     IPR000818 TEA/ATTS
     IPR016361 TEF

    Graphical View of Domain Structure for InterPro Entry Q99594

    ProtoNet protein and cluster: Q99594

    1 Blocks protein domain: IPB000818 TEA/ATTS family

    UniProtKB/Swiss-Prot: TEAD3_HUMAN, Q99594
    Similarity: Contains 1 TEA DNA-binding domain


    Find genes that share domains with TEAD3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEAD3_HUMAN, Q99594
    Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
    size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
    is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
    and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
    YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
    proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional
    elements of the human chorionic somatomammotropin-B gene enhancer

         Genatlas biochemistry entry for TEAD3:
    SV40-transcriptional enhancer factor 3 (TEF5),expressed in syncytiotrophoblast,where it binds to CSH2 enhancer

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001085RNA polymerase II transcription factor binding IPI--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA18579750
    GO:0005515protein binding IPI18579750
         
    Find genes that share ontologies with TEAD3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEAD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEAD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TEAD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TEAD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TEAD3:
    hsa-mir-26b-5p (MIRT029870)

    Block miRNA regulation of human, mouse, rat TEAD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEAD3 (see all 46):
    hsa-miR-323-3p hsa-miR-1321 hsa-let-7d hsa-miR-374a hsa-miR-3167 hsa-let-7g hsa-let-7a hsa-miR-518c
    SwitchGear 3'UTR luciferase reporter plasmidTEAD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TEAD3
    Predesigned siRNA for gene silencing in human, mouse, rat TEAD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TEAD3

    Clone
    Products:
         
    OriGene clones in human, mouse for TEAD3 (see all 7)
    OriGene ORF clones in mouse, rat for TEAD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TEAD3 (NM_003214)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEAD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEAD3
    Addgene plasmids for TEAD3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TEAD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TEAD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TEAD3_HUMAN, Q99594: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--

    Find genes that share ontologies with TEAD3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TEAD3 About    
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4Circadian Repression of Expression by REV-ERBA
    YAP1- and WWTR1 (TAZ)-stimulated gene expression0.40
    5Hippo signaling pathway
    Hippo signaling pathway


    Find genes that share SuperPaths with TEAD3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for TEAD3
        PPARA activates gene expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression


    1 Kegg Pathway  (Kegg details for TEAD3):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEAD3
    Interactions:

        Search GeneGlobe Interaction Network for TEAD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TEAD3 (Q995943 ENSP000003457724) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWTR1Q9GZV53, ENSP000003538474I2D: score=5 STRING: ENSP00000353847
    CTBP2P565453, ENSP000003118254I2D: score=4 STRING: ENSP00000311825
    E2F1Q010943, ENSP000003455714I2D: score=1 STRING: ENSP00000345571
    MYH7P128833, ENSP000003475074I2D: score=1 STRING: ENSP00000347507
    TNIKQ9UKE53, ENSP000003995114I2D: score=1 STRING: ENSP00000399511
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9148898
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007565female pregnancy TAS9148898
    GO:0010467gene expression TAS--

    Find genes that share ontologies with TEAD3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEAD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TEAD3 gene: 
    NM_003214.3  

    Unigene Cluster for TEAD3:

    TEA domain family member 3
    Hs.485205  [show with all ESTs]
    Unigene Representative Sequence: AK226144
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402886 ENST00000338863(uc003okt.3 uc003oku.4 uc010jvx.3)
    ENST00000433586
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TEAD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEAD3 (see all 46):
    hsa-miR-323-3p hsa-miR-1321 hsa-let-7d hsa-miR-374a hsa-miR-3167 hsa-let-7g hsa-let-7a hsa-miR-518c
    SwitchGear 3'UTR luciferase reporter plasmidTEAD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TEAD3
    Predesigned siRNA for gene silencing in human, mouse, rat TEAD3
    Clone
    Products:
         
    OriGene clones in human, mouse for TEAD3 (see all 7)
    OriGene ORF clones in mouse, rat for TEAD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TEAD3 (NM_003214)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEAD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEAD3
    Addgene plasmids for TEAD3 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TEAD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEAD3
      QuantiTect SYBR Green Assays in human, mouse, rat TEAD3
      QuantiFast Probe-based Assays in human, mouse, rat TEAD3

    Additional mRNA sequence: 

    AK226144.1 BC010053.2 BC027877.1 BC091488.1 X94439.1 

    14 DOTS entries:

    DT.91725897  DT.445213  DT.100785354  DT.92007915  DT.100736862  DT.100785346  DT.121360533  DT.40234273 
    DT.75104023  DT.91728703  DT.91979498  DT.99947586  DT.100785348  DT.435102 

    Selected AceView cDNA sequences (see all 186):

    BM792363 NM_003214 BC027877 AU131365 AI571142 AI219719 AA852463 BF083147 
    BU944693 BX355885 BQ687363 BE732045 BE731877 BF435305 CA429546 AL047433 
    BC010053 BQ719548 AI803742 BU162821 X94439 CD516212 BM560903 BM910398 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TEAD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGGGAG
    TEAD3 Expression
    About this image

    TEAD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEAD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485205

    UniProtKB/Swiss-Prot: TEAD3_HUMAN, Q99594
    Tissue specificity: Preferentially expressed in the placenta

        Custom PCR Arrays for TEAD3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TEAD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEAD3
    QuantiTect SYBR Green Assays in human, mouse, rat TEAD3
    QuantiFast Probe-based Assays in human, mouse, rat TEAD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TEAD3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tead31 , 5 TEA domain family member 31, 5 90.33(n)1
    98.11(a)1
      17 (14.66 cM)5
    216781  NM_001098226.31  NP_001091696.21 
     283316715 
    chicken
    (Gallus gallus)
    Aves TEAD31 TEA domain family member 3 80.86(n)
    89.29(a)
      395810  XM_004934793.1  XP_004934850.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEAD36
    TEA domain family member 3
    84(a)
    1 ↔ 1
    4(124217125-124255451)
    zebrafish
    (Danio rerio)
    Actinopterygii tead3b1 TEA domain family member 3 b 74.58(n)
    78.25(a)
      794293  NM_001109724.1  NP_001103194.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sd3 neurogenesis transcription factor 58(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea egl-443 Expression: hyp3, hyp4, hyp6, hyp7,
    intestine, pharyngeal muscle, head,
    ventral ganglia, retrovesicular
    ganglion, preanal ganglion, lumbar
    neurons, hypodermal, tail, tail
    neurons, intestinal, all stages less
    40(a)   II(5933501-5940191)   --


    ENSEMBL Gene Tree for TEAD3 (if available)
    TreeFam Gene Tree for TEAD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TEAD3 gene
    TEAD12  TEAD42  TEAD22  
    3 SIMAP similar genes for TEAD3 using alignment to 4 protein entries:     TEAD3_HUMAN (see all proteins):
    TEAD4    TEAD1    TEAD2

    Find genes that share paralogs with TEAD3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TEAD3 (see all 538)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1841052931,2
    --35440910(+) GTGCCC/TGGCCG 1 -- ds50010--------
    rs569418391,2
    C,F--35440923(+) GAAAGT/GCTTGA 1 -- ds50012Minor allele frequency- G:0.17CSA WA 119
    rs1171551941,2
    C,F--35440929(+) CTTGAA/GCTATC 1 -- ds50011Minor allele frequency- G:0.05EA 120
    rs1168373581,2
    C,F--35441156(+) TGTGCG/AACCTT 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs119623351,2
    C,F,A,H--35441167(+) GAGCAA/CATCAC 1 -- ds500121Minor allele frequency- N:0.00EA NA NS WA CSA 1598
    rs1869652061,2
    --35441304(+) GGTGAC/TGACAC 1 -- ds50010--------
    rs2002765101,2
    C--35441405(+) ACTTTA/TATTTT 1 -- ut310--------
    rs1997823661,2
    C--35441428(-) CTGCTA/CAAAAA 1 -- ut310--------
    rs1931990441,2
    --35441607(+) AGCTCA/GGGCAG 1 -- ut310--------
    rs1849809921,2
    --35441636(+) AAGGGA/GCACAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TEAD3 (35441374 - 35464861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TEAD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528351CNV Loss19592680
    esv23268CNV Loss19812545
    nsv462909CNV Loss19166990
    nsv885799CNV Loss21882294
    nsv519370CNV Loss19592680
    dgv1940e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEAD3
    DNA2.0 Custom Variant and Variant Library Synthesis for TEAD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603170    OMIM disorders: --


    Find genes that share disorders with TEAD3           About GenesLikeMe

    Genetic Association Database (GAD): TEAD3

    Export disorders for TEAD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TEAD3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with TEAD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin- B gene enhancer. (PubMed id 9148898)1, 2, 3, 9 Jacquemin P.... Davidson I. (J. Biol. Chem. 1997)
    2. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PubMed id 9889009)1, 3, 9 Jacquemin P....Davidson I. (Genomics 1999)
    3. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PubMed id 19324877)1, 2 Zhang H.... Guan K.L. (J. Biol. Chem. 2009)
    4. TEAD mediates YAP-dependent gene induction and growth control. (PubMed id 18579750)1, 2 Zhao B.... Guan K.L. (Genes Dev. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer. (PubMed id 10379887)1, 9 Jiang S.W.... Eberhardt N.L. (Mol. Endocrinol. 1999)
    8. Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1. (PubMed id 15131259)1, 9 Peng L....Payne A.H. (Mol. Endocrinol. 2004)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. YAP/TEAD-mediated transcription controls cellular senescence. (PubMed id 23576552)1 Xie Q....Yuan Z. (Cancer Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7005 HGNC: 11716 AceView: TEAD3 Ensembl:ENSG00000007866 euGenes: HUgn7005
    ECgene: TEAD3 Kegg: 7005 H-InvDB: TEAD3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TEAD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TEAD3 gene:
    Search GeneIP for patents involving TEAD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TEAD3   OriGene RNAi products in human, mouse, rat for TEAD3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TEAD3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TEAD3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TEAD3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TEAD3   OriGene Custom Protein Services for TEAD3  

     
     
     Block miRNA regulation of human, mouse, rat TEAD3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TEAD3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEAD3 Predesigned siRNA for gene silencing in human, mouse, rat TEAD3
     QuantiFast Probe-based Assays in human, mouse, rat TEAD3 QuantiTect SYBR Green Assays in human, mouse, rat TEAD3
     Custom PCR Arrays for TEAD3 Search Chromatin IP Primers for TEAD3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEAD3  Search GeneGlobe Interaction Network for TEAD3
     Regulatory tfbs in TEAD3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TEAD3 GenScript cDNA clones with any tag delivered in your preferred vector for TEAD3
     GenScript Custom Assay Services for TEAD3 GenScript Custom overexpressing Cell Line Services for TEAD3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TEAD3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TEAD3 antibodies
     TEAD3 proteins
     Antibodies for TEAD3
     See all of Abcam's Antibodies, Kits and Proteins for TEAD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TEAD3
     Antibodies for TEAD3
     ELISAs for TEAD3
     CLIAs for TEAD3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TEAD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD3
     SwitchGear 3'UTR luciferase reporter plasmids for TEAD3
     SwitchGear Promoter luciferase reporter plasmids for TEAD3
     Search ThermoFisher Antibodies for TEAD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEAD3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEAD3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TEAD3
     LSBio Antibodies in human, mouse, rat for TEAD3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for TEAD3
      Search eBioscience for proteins for TEAD3
      Search eBioscience for elisas for TEAD3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TEAD3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4