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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TEAD2 Gene

protein-coding   GIFtS: 57
GCID: GC19M049843

TEA domain family member 2
 Explore 7 diseases affiliated with
TEAD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TEAD2    

Aliases
for TEAD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TEA Domain Family Member 21 2 3
TEF41 2 3 5
ETF1 2
TEF-41 2
TEAD-22 3
Transcriptional Enhancer Factor TEF-42

External Ids:    HGNC: 117151   Entrez Gene: 84632   Ensembl: ENSG000000742197   OMIM: 6017295   UniProtKB: Q155623   

Export aliases for TEAD2 gene to outside databases

Previous GC identifers: GC19M050502 GC19M050211 GC19M054519 GC19M054535 GC19M046220


Summaries
for TEAD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TEAD2_HUMAN, Q15562
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size
control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and
activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC
'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif

Gene Wiki entry for TEAD2


Genomic Views
for TEAD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TEAD2 gene promoter:
         MZF-1   TBP   FAC1   RREB-1   HSF1 (long)   HSF1short   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TEAD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TEAD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TEAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

TEAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEAD2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049843:  view genomic region     (about GC identifiers)

Start:
 49,843,852 bp from pter      End:
 49,865,714 bp from pter
Size:
 21,863 bases      Orientation:
 minus strand

Proteins
for TEAD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TEAD2_HUMAN, Q15562 (See protein sequence)
Recommended Name: Transcriptional enhancer factor TEF-4  
Size: 447 amino acids; 49243 Da
Subunit: Interacts with YAP1 and WWTR1/TAZ
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for TEAD2:
3L15 (3D)    
Secondary accessions: B4DTJ6 Q8NA25 Q96IG3
Alternative splicing: 3 isoforms:  Q15562-1   Q15562-2   Q15562-3   

Explore the universe of human proteins at neXtProt for TEAD2: NX_Q15562

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15562

    • TEAD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001243587.1  NP_001243588.1  NP_001243589.1  NP_001243590.1  NP_001243591.1  NP_003589.1  

    ENSEMBL proteins: 
     ENSP00000310701   ENSP00000366419   ENSP00000437928  
    Reactome Protein details: Q15562
    Human Recombinant Protein Products: 
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    Novus Biologicals TEAD2 Proteins
    Novus Biologicals TEAD2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TEAD2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8702974
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--


    TEAD2 for ontologies           About GeneDecksing



    TEAD2 Antibody Products: 
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    Uscn ELISAs and CLIAs for TEAD2

    Protein Domains /
    Families
    for TEAD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TEAD2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000818 TEA/ATTS
     IPR016361 TEF

    Graphical View of Domain Structure for InterPro Entry Q15562

    ProtoNet protein and cluster: Q15562

    1 Blocks protein family: IPB000818 TEA/ATTS family

    UniProtKB/Swiss-Prot: TEAD2_HUMAN, Q15562
    Similarity: Contains 1 TEA DNA-binding domain


    Function
    for TEAD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TEAD2_HUMAN, Q15562
    Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size
    control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is
    composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and
    activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1
    oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
    proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC
    'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif

         Genatlas biochemistry entry for TEAD2:
    SV40-transcriptional enhancer factor 4 (TEF4),expressed throughout the embryo from the onset of gene
    expression,required for cardiac muscle and skeletal muscle specific genes

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEAD2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TEAD2 (see all 9):
    hsa-miR-1294 hsa-miR-615-5p hsa-miR-1224-3p hsa-miR-340 hsa-miR-3918 hsa-miR-323b-5p hsa-miR-483-3p hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: TEAD2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEAD2 (see all 7)
    OriGene shRNA RFP: TEAD2
    OriGene siRNA: TEAD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEAD2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TEAD2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TEAD2 (see all 4)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8702974
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI19324877


    TEAD2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TEAD2:
     Increased cell number in G2M,   Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for TEAD2: Tead2tm1Hssk Tead2tm1.1Mldp
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tead2):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 
     nervous system  no phenotypic analysis  normal  reproductive system  skeleton 

    TEAD2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TEAD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Generic Transcription Pathway
    		Generic Transcription Pathway1.00
    		Gene Expression0.46
    2Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    3YAP1- and WWTR1 (TAZ)-stimulated gene expression
    		YAP1- and WWTR1 (TAZ)-stimulated gene expression1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TEAD2
        Wnt / Hedgehog / Notch

    3        Reactome Pathways for TEAD2
        Generic Transcription Pathway
    Gene Expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression



    TEAD2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/21 Interacting proteins for TEAD2 (Q155623 ENSP000003107014) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWTR1Q9GZV53, ENSP000003538474I2D: score=1 STRING: ENSP00000353847
    YAP1P469373, ENSP000002824414I2D: score=1 STRING: ENSP00000282441
    NCOA1Q157883, ENSP000003209404I2D: score=1 STRING: ENSP00000320940
    VGLL1Q999903, ENSP000003596684I2D: score=1 STRING: ENSP00000359668
    MPDZO759703I2D: score=1 
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001843neural tube closure IEA--
    GO:0003143embryonic heart tube morphogenesis IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS8702974
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--


    TEAD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TEAD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEAD2
    Search CenterWatch for drugs/clinical trials and news about TEAD2 

    Transcripts
    for TEAD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TEAD2 gene (6 alternative transcripts): 
    NM_001256658.1  NM_001256659.1  NM_001256660.1  NM_001256661.1  NM_001256662.1  NM_003598.1  

    Unigene Cluster for TEAD2:

    TEA domain family member 2
    Hs.515534  [show with all ESTs]
    Unigene Representative Sequence: AK093236
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311227(uc002pnh.3 uc002pni.3 uc002pnj.3 uc010yao.2 uc010emw.3)
    ENST00000377214(uc002png.3) ENST00000539846

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TEAD2
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TEAD2
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate TEAD2 (see all 9):
    hsa-miR-1294 hsa-miR-615-5p hsa-miR-1224-3p hsa-miR-340 hsa-miR-3918 hsa-miR-323b-5p hsa-miR-483-3p hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmid: TEAD2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TEAD2 (see all 7)
    OriGene shRNA RFP: TEAD2
    OriGene siRNA: TEAD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TEAD2
    Clone
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    GenScript: all cDNA clones in your preferred vector: TEAD2 (NM_003598)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEAD2 
    Primer
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    Additional cDNA sequence: 

    AK093236.1 AK290736.1 AK300241.1 AL832240.1 BC007556.1 BC018803.1 BC051301.1 X94440.1 

    11 DOTS entries:

    DT.75103124  DT.100027135  DT.100740583  DT.428159  DT.121427251  DT.121643586  DT.95265805  DT.100027134 
    DT.121427305  DT.91912575  DT.92426081 

    24/122 AceView cDNA sequences (see all 122):

    AA669124 CB996375 AI765127 BM893998 AA293420 BE870313 CR603452 BQ669117 
    AA358269 AI887219 CB157938 NM_003598 BQ674040 X94440 BQ673907 BU191622 
    AW590336 AW025675 BC051301 CK823544 AX748004 CA407025 BM893833 CF264949 

    GeneLoc Exon Structure


    Expression
    for TEAD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TEAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTGTGAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TEAD2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Midbrain dopaminergic-like neurons (Generation of midbra...)

    See TEAD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TEAD2

    SOURCE GeneReport for Unigene cluster: Hs.515534
        SABiosciences Custom PCR Arrays for TEAD2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TEAD2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD2

    Orthologs
    for TEAD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TEAD2 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tead21 , 5 TEA domain family member 21, 5 86.22(n)1
    93.71(a)1    		   7 (29.19 cM)5
    216771  NM_011565.21  NP_035695.11 
     452157535 
    lizard
    (Anolis carolinensis)    		 Reptilia TEAD26
    		 --
    		 59(a)
    		 1 ↔ 1
    		 GL343355.1(98607-112238)
    fruit fly
    (Drosophila melanogaster)    		 Insecta sd3 neurogenesis transcription factor 56(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea egl-443 Expression: hyp3, hyp4, hyp6, hyp7,
    intestine, more    		 39(a)   II(5933501-5940191)   --


    ENSEMBL Gene Tree for TEAD2 (if available)
    TreeFam Gene Tree for TEAD2 (if available) 

    Paralogs
    for TEAD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TEAD2 gene
    TEAD12  TEAD42  TEAD32  
    3 SIMAP similar genes for TEAD2 using alignment to 4 protein entries:     TEAD2_HUMAN (see all proteins):
    TEAD4    TEAD3    TEAD1

    TEAD2 for paralogs           About GeneDecksing



    Genomic Variants
    for TEAD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/465 NCBI SNPs in TEAD2 are shown (see all 465)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1113438161,2
    		--46241803(+) GGACAC/GAGACT 2 -- us2k12Minor allele frequency- G:0.12CSA WA 120
    rs72573231,2
    		C,F,H,--46241876(+) GACCTA/CGAAAG 2 -- us2k17Minor allele frequency- C:0.06NS EA NA WA 542
    rs735901511,2
    		C,--46243642(+) TTGGAG/ACGTGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1131257291,2
    		C--46243835(+) GAAGGA/C/TGAGGA 1 -- int11CSA 1
    rs1132889951,2
    		F--46243850(+) GATCTG/AGTGGT 1 -- int12Minor allele frequency- A:0.50CSA 4
    rs1429818641,2
    		C,--49844503(+) CAAAT-/AAGAAGCA 6 -- ut310--------
    rs1466808891,2
    		C,F--49844633(+) TGGTGG/CAGACC 12 /S /C mis11Minor allele frequency- C:0.00NA 4550
    rs1141299331,2
    		C,F,--49844721(+) GGGACT/GTATGC 6 -- int11Minor allele frequency- G:0.05WA 118
    rs1152937741,2
    		F,--49844770(+) AGCTAT/GCATGG 6 -- int11Minor allele frequency- G:0.09WA 118
    rs1167299191,2
    		C,F,--49844943(+) TCCCAT/GCACAT 6 -- int11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for TEAD2 (49843852 - 49865714 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TEAD2
         2 CNVs: 5110 32261

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    Disorders / Diseases
    for TEAD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TEAD2 for disorders           About GeneDecksing

    OMIM gene information: 601729    OMIM disorders: --

    7 diseases for TEAD2:    About MalaCards
    patulous eustachian tube    alpha-mannosidosis    plasmodium falciparum malaria    mannosidosis
    pharyngitis    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: TEAD2 (3 documents)

    Export disorders for TEAD2 gene to outside databases

    Publications
    for TEAD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TEAD2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with TEAD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. (PubMed id 8702974)1, 2, 3 Jacquemin P.... Davidson I. (1996)
    2. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PubMed id 9889009)1, 3, 9 Jacquemin P....Davidson I. (1999)
    3. TEAD transcription factors mediate the function of TA Z in cell growth and epithelial-mesenchymal transition. (PubMed id 19324877)1, 2 Zhang H....Guan K.L. (2009)
    4. TEAD mediates YAP-dependent gene induction and growth control. (PubMed id 18579750)1, 2 Zhao B.... Guan K.L. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Structural and functional analysis of the YAP-binding domain of human TEAD2. (PubMed id 20368466)1 Tian W....Luo X. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)

    External Searches for TEAD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    		PubMed
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    Genome Databases showing TEAD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8463 HGNC: 11715 AceView: TEAD2 Ensembl:ENSG00000074219 euGenes: HUgn8463
    ECgene: TEAD2 H-InvDB: TEAD2

    Other Databases showing TEAD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TEAD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TEAD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TEAD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TEAD2 gene:
    Search GeneIP for patents involving TEAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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