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TEAD2 Gene

protein-coding   GIFtS: 61
GCID: GC19M049843

TEA Domain Family Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TEA Domain Family Member 21 2 3
TEF42 3 5
TEAD-22 3
ETF2
TEF-42
Transcriptional Enhancer Factor TEF-42

External Ids:    HGNC: 117151   Entrez Gene: 84632   Ensembl: ENSG000000742197   OMIM: 6017295   UniProtKB: Q155623   

Export aliases for TEAD2 gene to outside databases

Previous GC identifers: GC19M050502 GC19M050211 GC19M054519 GC19M054535 GC19M046220


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TEAD2 Gene:
TEAD2 (TEA domain family member 2) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TEAD1.

UniProtKB/Swiss-Prot: TEAD2_HUMAN, Q15562
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC
'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT
motif

Gene Wiki entry for TEAD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEAD2 gene promoter:
         MZF-1   TBP   FAC1   RREB-1   HSF1 (long)   HSF1short   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEAD2 promoter sequence
   Search Chromatin IP Primers for TEAD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEAD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

TEAD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEAD2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049843:  view genomic region     (about GC identifiers)

Start:
49,843,852 bp from pter      End:
49,865,714 bp from pter
Size:
21,863 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TEAD2_HUMAN, Q15562 (See protein sequence)
Recommended Name: Transcriptional enhancer factor TEF-4  
Size: 447 amino acids; 49243 Da
Subunit: Interacts with YAP1 and WWTR1/TAZ
1 PDB 3D structure from and Proteopedia for TEAD2:
3L15 (3D)    
Secondary accessions: B4DTJ6 Q8NA25 Q96IG3
Alternative splicing: 3 isoforms:  Q15562-1   Q15562-2   Q15562-3   

Explore the universe of human proteins at neXtProt for TEAD2: NX_Q15562

Explore proteomics data for TEAD2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys75
  • Modification sites at PhosphoSitePlus

  • See TEAD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001243587.1  NP_001243588.1  NP_001243589.1  NP_001243590.1  NP_001243591.1  NP_003589.1  

    ENSEMBL proteins: 
     ENSP00000472109   ENSP00000469640   ENSP00000469672   ENSP00000310701   ENSP00000366419  
     ENSP00000437928   ENSP00000471743   ENSP00000472397  
    Reactome Protein details: Q15562

    TEAD2 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    OriGene Custom Protein Services for TEAD2
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    Novus Biologicals TEAD2 Proteins
    Novus Biologicals TEAD2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TEAD2

     
    Search eBioscience for Proteins for TEAD2 

     
    antibodies-online proteins for TEAD2 (3 products) 

     
    antibodies-online peptides for TEAD2

    TEAD2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for TEAD2 (37 products) 

    TEAD2 Assay Products:

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    antibodies-online kits for TEAD2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000818 TEA/ATTS
     IPR016361 TEF

    Graphical View of Domain Structure for InterPro Entry Q15562

    ProtoNet protein and cluster: Q15562

    1 Blocks protein domain: IPB000818 TEA/ATTS family

    UniProtKB/Swiss-Prot: TEAD2_HUMAN, Q15562
    Similarity: Contains 1 TEA DNA-binding domain


    Find genes that share domains with TEAD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEAD2_HUMAN, Q15562
    Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
    size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
    is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
    and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
    YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
    proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC
    'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT
    motif

         Genatlas biochemistry entry for TEAD2:
    SV40-transcriptional enhancer factor 4 (TEF4),expressed throughout the embryo from the onset of gene
    expression,required for cardiac muscle and skeletal muscle specific genes

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8702974
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI18579750
         
    Find genes that share ontologies with TEAD2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TEAD2:
     Increased cell number in G2M,   Synthetic lethal with Ras 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tead2):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     nervous system  no phenotypic analysis  normal  reproductive system  skeleton 

    Find genes that share phenotypes with TEAD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TEAD2: Tead2tm1Hssk Tead2tm1.1Mldp

       genOway: Develop your customized and physiologically relevant rodent model for TEAD2

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  CCWGGAATGY 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TEAD2:
    hsa-mir-346 (MIRT042715), hsa-mir-335-5p (MIRT017098), hsa-mir-193b-3p (MIRT041334)

    Block miRNA regulation of human, mouse, rat TEAD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEAD2 (see all 9):
    hsa-miR-1294 hsa-miR-615-5p hsa-miR-1224-3p hsa-miR-340 hsa-miR-3918 hsa-miR-323b-5p hsa-miR-483-3p hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTEAD2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TEAD2
    Predesigned siRNA for gene silencing in human, mouse, rat TEAD2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TEAD2 (see all 7)
    OriGene ORF clones in mouse, rat for TEAD2
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    GenScript: all cDNA clones in your preferred vector: TEAD2 (NM_003598)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEAD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEAD2
    Addgene plasmids for TEAD2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TEAD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for TEAD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEAD2_HUMAN, Q15562: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8702974
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex ----

    Find genes that share ontologies with TEAD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TEAD2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    4Circadian Repression of Expression by REV-ERBA
    YAP1- and WWTR1 (TAZ)-stimulated gene expression0.40
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch


    Find genes that share SuperPaths with TEAD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TEAD2
        Wnt / Hedgehog / Notch

    2 Reactome Pathways for TEAD2
        PPARA activates gene expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression


    1 Kegg Pathway  (Kegg details for TEAD2):
        Hippo signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEAD2
    Interactions:

        Search GeneGlobe Interaction Network for TEAD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TEAD2 (Q155623 ENSP000003107014) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WWTR1Q9GZV53, ENSP000003538474I2D: score=1 STRING: ENSP00000353847
    YAP1P469373, ENSP000002824414I2D: score=1 STRING: ENSP00000282441
    NCOA1Q157883, ENSP000003209404I2D: score=1 STRING: ENSP00000320940
    VGLL1Q999903, ENSP000003596684I2D: score=1 STRING: ENSP00000359668
    MPDZO759703, ENSP000003704104I2D: score=1 STRING: ENSP00000370410
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis ----
    GO:0001843neural tube closure ----
    GO:0003143embryonic heart tube morphogenesis ----
    GO:0006355regulation of transcription, DNA-templated NAS8702974
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with TEAD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEAD2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TEAD2 gene (6 alternative transcripts): 
    NM_001256658.1  NM_001256659.1  NM_001256660.1  NM_001256661.1  NM_001256662.1  NM_003598.1  

    Unigene Cluster for TEAD2:

    TEA domain family member 2
    Hs.515534  [show with all ESTs]
    Unigene Representative Sequence: AK093236
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000598810 ENST00000593945 ENST00000601519 ENST00000311227(uc002pnh.3 uc002pni.3 uc002pnj.3 uc010yao.2 uc010emw.3)
    ENST00000377214(uc002png.3) ENST00000539846 ENST00000598823 ENST00000598397
    ENST00000596757 ENST00000595233
    miRNA
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    Block miRNA regulation of human, mouse, rat TEAD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEAD2 (see all 9):
    hsa-miR-1294 hsa-miR-615-5p hsa-miR-1224-3p hsa-miR-340 hsa-miR-3918 hsa-miR-323b-5p hsa-miR-483-3p hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTEAD2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TEAD2 (NM_003598)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TEAD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TEAD2
    Addgene plasmids for TEAD2 
    Primer
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    OriGene qPCR primer pairs and template standards for TEAD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TEAD2
      QuantiTect SYBR Green Assays in human, mouse, rat TEAD2
      QuantiFast Probe-based Assays in human, mouse, rat TEAD2

    Additional mRNA sequence: 

    AK093236.1 AK290736.1 AK300241.1 AL832240.1 BC007556.1 BC018803.1 BC051301.1 X94440.1 

    12 DOTS entries:

    DT.75103124  DT.100027135  DT.100740583  DT.428159  DT.121427251  DT.121643586  DT.95265805  DT.100027134 
    DT.121427305  DT.91912575  DT.92426081  DT.86835852 

    Selected AceView cDNA sequences (see all 122):

    BC018803 AK093236 BE870313 BM893998 CR603452 AA293420 AI765127 CB996375 
    BQ673907 AW025675 CA407025 BQ675125 BM893833 AI887219 AL832240 NM_003598 
    CK823544 AI798093 BU191622 BQ675786 BQ674040 AW590336 X94440 AX748004 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEAD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTGAGA
    TEAD2 Expression
    About this image


    TEAD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             Midbrain dopaminergic-like neurons
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    TEAD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEAD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515534
        Custom PCR Arrays for TEAD2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TEAD2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEAD2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tead21 , 5 TEA domain family member 21, 5 86.14(n)1
    93.71(a)1
      7 (29.19 cM)5
    216771  NM_001285498.11  NP_001272427.11 
     452157535 
    lizard
    (Anolis carolinensis)
    Reptilia TEAD26
    TEA domain family member 2
    63(a)
    1 ↔ 1
    GL343355.1(98225-113689)
    fruit fly
    (Drosophila melanogaster)
    Insecta sd3 neurogenesis transcription factor 56(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea egl-443 Expression: hyp3, hyp4, hyp6, hyp7,
    intestine, more
    39(a)   II(5933501-5940191)   --


    ENSEMBL Gene Tree for TEAD2 (if available)
    TreeFam Gene Tree for TEAD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEAD2 gene
    TEAD12  TEAD42  TEAD32  
    3 SIMAP similar genes for TEAD2 using alignment to 4 protein entries:     TEAD2_HUMAN (see all proteins):
    TEAD4    TEAD3    TEAD1

    Find genes that share paralogs with TEAD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEAD2 (see all 529)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1435751191,2
    --46243343(+) GTGCAC/GGGGCG 1 -- int10--------
    rs1865812761,2
    --46243359(+) CAGTGC/TAGGGG 1 -- int10--------
    rs1481074621,2
    --46243387(+) GGGCGA/TGGCCA 1 -- int10--------
    rs1383931641,2
    C--46243450(+) GGACT-/TCCAGG
    ACTTGGTC
    TCCAG
    1 -- int10--------
    rs22884781,2
    C,F,A,H--46243487(+) TGACGG/TGGGCG 1 -- int1 tfbs323Minor allele frequency- T:0.40EA NS NA WA CSA 3832
    rs22884791,2
    C,F,A--46243577(+) TGGCTC/GTGTCA 1 -- int111Minor allele frequency- G:0.38NA WA CSA EA 373
    rs22884801,2
    C,F,A--46243584(+) GTCACC/GAAGGG 1 -- int18Minor allele frequency- G:0.31NA WA EA 368
    rs735901511,2
    C--46243642(+) TTGGAG/ACGTGG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1927855061,2
    --46243690(+) AACCAA/GCGCTC 1 -- int10--------
    rs2017773581,2
    C--46243799(+) AAAGGA/CGGAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TEAD2 (49843852 - 49865714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TEAD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv52n68CNV Loss17160897
    nsv912261CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601729    OMIM disorders: --


    Find genes that share disorders with TEAD2           About GenesLikeMe

    Genetic Association Database (GAD): TEAD2
    Human Genome Epidemiology (HuGE) Navigator: TEAD2 (3 documents)

    Export disorders for TEAD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEAD2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TEAD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. (PubMed id 8702974)1, 2, 3 Jacquemin P.... Davidson I. (J. Biol. Chem. 1996)
    2. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PubMed id 9889009)1, 3, 9 Jacquemin P....Davidson I. (Genomics 1999)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PubMed id 19324877)1, 2 Zhang H.... Guan K.L. (J. Biol. Chem. 2009)
    5. TEAD mediates YAP-dependent gene induction and growth control. (PubMed id 18579750)1, 2 Zhao B.... Guan K.L. (Genes Dev. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8463 HGNC: 11715 AceView: TEAD2 Ensembl:ENSG00000074219 euGenes: HUgn8463
    ECgene: TEAD2 Kegg: 8463 H-InvDB: TEAD2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TEAD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TEAD2 gene:
    Search GeneIP for patents involving TEAD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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