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TEAD1 Gene

protein-coding   GIFtS: 64
GCID: GC11P012652

TEA Domain Family Member 1 (SV40 Transcriptional Enhancer...

(Previous names: atrophia areata, peripapillary chorioretinal degeneration)
(Previous symbols: TCF13, AA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor)1 2     REF12 5
TCF131 2 3 5     Atrophia Areata, Peripapillary Chorioretinal Degeneration1
AA1 2     TEF-12
Protein GT-IIC2 3     Transcriptional Enhancer Factor 12
Transcription Factor 132 3     Transcriptional Enhancer Factor TEF-12
NTEF-12 3     TEF13
TCF-132 3     TEA Domain Family Member 13
TEAD-12 3     

External Ids:    HGNC: 117141   Entrez Gene: 70032   Ensembl: ENSG000001870797   OMIM: 1899675   UniProtKB: P283473   

Export aliases for TEAD1 gene to outside databases

Previous GC identifers: GC11P014056 GC11P013515 GC11P012737 GC11P012730 GC11P012660 GC11P012376


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TEAD1 Gene:
This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family.
This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a
transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript
variants have been described but their full-length natures have not been experimentally verified. (provided by
RefSeq, May 2010)

GeneCards Summary for TEAD1 Gene:
TEAD1 (TEA domain family member 1 (SV40 transcriptional enhancer factor)) is a protein-coding gene. Diseases associated with TEAD1 include chorioretinitis, and sveinsson choreoretinal atrophy. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TEAD4.

UniProtKB/Swiss-Prot: TEAD1_HUMAN, P28347
Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and
cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a
cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional
intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif

Gene Wiki entry for TEAD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TEAD1 gene promoter:
         Sp1   CUTL1   AP-2gamma   SREBP-1a   GATA-6   FOXO4   AP-2beta   AP-2alpha   AP-2alphaA   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTEAD1 promoter sequence
   Search Chromatin IP Primers for TEAD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TEAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15.4

TEAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEAD1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P012652:  view genomic region     (about GC identifiers)

Start:
12,695,969 bp from pter      End:
12,966,298 bp from pter
Size:
270,330 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TEAD1_HUMAN, P28347 (See protein sequence)
Recommended Name: Transcriptional enhancer factor TEF-1  
Size: 426 amino acids; 47946 Da
Subunit: Interacts with YAP1 and WWTR1/TAZ
Caution: It is uncertain whether Met-1 or Met-16 is the initiator
Sequence caution: Sequence=AAB00791.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator
methionine is coded by a non-canonical ATT isoleucine codon;
2 PDB 3D structures from and Proteopedia for TEAD1:
2HZD (3D)        3KYS (3D)    

Explore the universe of human proteins at neXtProt for TEAD1: NX_P28347

Explore proteomics data for TEAD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys65
  • Modification sites at PhosphoSitePlus

  • See TEAD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068780.2  
    ENSEMBL proteins: 
     ENSP00000435233   ENSP00000432587   ENSP00000435977   ENSP00000435393   ENSP00000354588  
     ENSP00000355332   ENSP00000334754  
    Reactome Protein details: P28347

    TEAD1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000818 TEA/ATTS
     IPR016361 TEF

    Graphical View of Domain Structure for InterPro Entry P28347

    ProtoNet protein and cluster: P28347

    1 Blocks protein domain: IPB000818 TEA/ATTS family

    UniProtKB/Swiss-Prot: TEAD1_HUMAN, P28347
    Similarity: Contains 1 TEA DNA-binding domain


    TEAD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TEAD1_HUMAN, P28347
    Function: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ
    size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway
    is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates
    and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates
    YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell
    proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and
    cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a
    cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional
    intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif

         Genatlas biochemistry entry for TEAD1:
    SV40-transcriptional enhancer factor 1,required for cardiac muscle specific genes expression

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA18579750
    GO:0005515protein binding IPI18579750
         
    TEAD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TEAD1:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tead1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     muscle  nervous system 

    TEAD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tead1tm1Hssk for TEAD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TEAD1
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    miRNA
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    miRTarBase miRNAs that target TEAD1:
    hsa-mir-124-3p (MIRT002701), hsa-mir-320a (MIRT044437), hsa-mir-98-5p (MIRT027571)

    Block miRNA regulation of human, mouse, rat TEAD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TEAD1 (see all 239):
    hsa-miR-140-5p hsa-miR-579 hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-519a hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TEAD1_HUMAN, P28347: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    TEAD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TEAD1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Fatty acid, triacylglycerol, and ketone body metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism0.65
    PPARA Activates Gene Expression0.63
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.65
    2Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    Human Embryonic Stem Cell Pluripotency0.50
    3ERK Signaling
    MAPK Signaling0.58
    ILK Signaling0.49
    4Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    5Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TEAD1 (see all 7)
        MAPK Signaling
    ILK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Human Embryonic Stem Cell Pluripotency
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for TEAD1
        Wnt / Hedgehog / Notch

    2 Reactome Pathways for TEAD1
        PPARA activates gene expression
    YAP1- and WWTR1 (TAZ)-stimulated gene expression


    1 Kegg Pathway  (Kegg details for TEAD1):
        Hippo signaling pathway


    TEAD1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TEAD1
    Interactions:

        GeneGlobe Interaction Network for TEAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TEAD1 (P283471, 2, 3 ENSP000003545884) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POU2F1P148592, 3, ENSP000002714114MINT-73316 I2D: score=1 STRING: ENSP00000271411
    TBPP202262, 3, ENSP000002303544MINT-73315 I2D: score=1 STRING: ENSP00000230354
    YAP1P469371, 3, ENSP000002824414EBI-529156,EBI-1044059 I2D: score=1 STRING: ENSP00000282441
    WWTR1Q9GZV53, ENSP000003538474I2D: score=1 STRING: ENSP00000353847
    SRFP118313, ENSP000002653544I2D: score=1 STRING: ENSP00000265354
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003143embryonic heart tube morphogenesis ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007507heart development ----
    GO:0010467gene expression TAS--

    TEAD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TEAD1

    4 Novoseek inferred chemical compound relationships for TEAD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mcat 88.4 36 17962623 (4), 15628970 (3), 11306707 (2), 12388056 (2) (see all 10)
    zinc 0 1 8621623 (1)
    serine 0 2 11313339 (1), 10764782 (1)
    vegf 0 1 17652751 (1)



    TEAD1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TEAD1 gene: 
    NM_021961.5  

    Unigene Cluster for TEAD1:

    TEA domain family member 1 (SV40 transcriptional enhancer factor)
    Hs.655331  [show with all ESTs]
    Unigene Representative Sequence: NM_021961
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527636 ENST00000527376 ENST00000527575 ENST00000525312(uc009ygk.3)
    ENST00000526600(uc001mkk.4) ENST00000361985 ENST00000361905(uc021qdx.1 uc009ygl.3)
    ENST00000334310
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    hsa-miR-140-5p hsa-miR-579 hsa-miR-376b hsa-miR-199a-3p hsa-miR-128 hsa-miR-3653 hsa-miR-519a hsa-miR-298
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    Additional mRNA sequence: 

    AB209858.1 AK027342.1 AK075070.1 AK075176.1 AK075236.1 AK310928.1 AL117450.1 AL133574.1 
    AL833289.1 BC026959.1 BC115398.1 

    8 DOTS entries:

    DT.95165276  DT.211047  DT.91754982  DT.95149550  DT.95094369  DT.120680290  DT.40131519  DT.95210648 

    Selected AceView cDNA sequences (see all 279):

    N43958 AI073784 BQ440786 BF431762 CB150165 AA479329 BM728947 BQ227989 
    AW023183 BM905186 BE867642 AW663523 BE858775 BG251078 AK075070 BM669802 
    AW473730 BF108371 AA040787 AA311260 BM314618 CR617889 AA767678 BM314308 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TEAD1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                                                  
    SP4:              -                                                   


    ECgene alternative splicing isoforms for TEAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TEAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTGCAAA
    TEAD1 Expression
    About this image

    TEAD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TEAD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655331

    UniProtKB/Swiss-Prot: TEAD1_HUMAN, P28347
    Tissue specificity: Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TEAD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TEAD1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tead11 , 5 TEA domain family member 11, 5 91.81(n)1
    99.27(a)1
      7 (58.80 cM)5
    216761  NM_001166584.11  NP_001160056.11 
     1126793185 
    chicken
    (Gallus gallus)
    Aves TEAD11 TEA domain family member 1 (SV40 transcriptional enhancer more 87.66(n)
    98.53(a)
      403089  NM_001199405.1  NP_001186334.1 
    lizard
    (Anolis carolinensis)
    Reptilia TEAD16
    TEA domain family member 1 (SV40 transcriptional e...
    92(a)
    1 ↔ 1
    GL343237.1(973065-1199621)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.290882 Xenopus laevis transcribed sequence with moderate similarity more 75.66(n)    BQ728229.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005374671 transcriptional enhancer factor TEF-1-like 80.23(n)
    91.67(a)
      100537467  XM_005172364.1  XP_005172421.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sd1 , 3 neurogenesis transcription factor3
    scalloped1
    60(a)3
    63.18(n)1
    69.63(a)1
      325361  NM_001272652.11  NP_001259581.11 
    worm
    (Caenorhabditis elegans)
    Secernentea egl-441 egl-44 51.04(n)
    45.83(a)
      174005  NM_062785.3  NP_495186.3 


    ENSEMBL Gene Tree for TEAD1 (if available)
    TreeFam Gene Tree for TEAD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TEAD1 gene
    TEAD42  TEAD22  TEAD32  
    3 SIMAP similar genes for TEAD1 using alignment to 6 protein entries:     TEAD1_HUMAN (see all proteins):
    TEAD4    TEAD3    TEAD2

    TEAD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TEAD1
    PGOHUM00000242532


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TEAD1 (see all 5488)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115678471,2,,4
    C,HSveinsson chorioretinal atrophy (SCRA)4 pathogenic188593226(+) ATATTT/CACAGG 2 /H /Y mis1 ese38Minor allele frequency- C:0.00EU NA NS EA 914
    rs592440991,2
    C,F--12374364(+) CACTGC/TCATCG 1 -- us2k13Minor allele frequency- T:0.22WA 122
    rs1927408131,2
    --12374404(+) ATTTGG/TAGAGA 1 -- us2k10--------
    rs1841958881,2
    --12374455(+) TTTTCC/TAACAC 1 -- us2k10--------
    rs1898535511,2
    --12374560(+) TTGTAC/GTTGAC 1 -- us2k10--------
    rs1114816891,2
    C,F--12374581(+) CCTACA/GCAAGT 1 -- us2k12Minor allele frequency- G:0.08CSA WA 120
    rs734219241,2
    C,F--12374625(+) ACGAAC/TACGTA 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1495831711,2
    C--12374632(+) CGTACA/GAGTAA 1 -- us2k10--------
    rs785874051,2
    C--12374848(+) TGGCTC/GACTTT 1 -- us2k10--------
    rs1862477471,2
    --12374956(+) AAAAAA/GTTTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TEAD1 (12695969 - 12945969 bp, first 250kb of TEAD1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TEAD1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422965CNV Deletion19546169
    esv2744121CNV Deletion23290073
    esv2744120CNV Deletion23290073
    esv2671303CNV Deletion23128226
    esv2139118CNV Deletion18987734
    esv2744122CNV Deletion23290073
    esv2744118CNV Deletion23290073
    dgv193e199CNV Deletion23128226
    esv2483449CNV Deletion19546169
    esv9239CNV Loss19470904

    Human Gene Mutation Database (HGMD): TEAD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TEAD1
    DNA2.0 Custom Variant and Variant Library Synthesis for TEAD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 189967   
    OMIM disorders: 108985  
    UniProtKB/Swiss-Prot: TEAD1_HUMAN, P28347
  • Sveinsson chorioretinal atrophy (SCRA) [MIM:108985]: Characterized by symmetrical lesions radiating from
    the optic disk involving the retina and the choroid. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 13 diseases for TEAD1:    
    About MalaCards
    chorioretinitis    sveinsson choreoretinal atrophy    choriocarcinoma    choroiditis
    cervical cancer    cervicitis    prostate cancer    prostatitis
    endotheliitis    hiv-1    multiple myeloma    myeloma
    malaria


    TEAD1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TEAD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 59 4 7775450 (1), 8621623 (1), 9259314 (1)

    Genetic Association Database (GAD): TEAD1
    Human Genome Epidemiology (HuGE) Navigator: TEAD1 (1 document)

    Export disorders for TEAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TEAD1 gene, integrated from 10 sources (see all 123):
    (articles sorted by number of sources associating them with TEAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1. (PubMed id 1851669)1, 2, 3, 9 Xiao J.H.... Chambon P. (Cell 1991)
    2. A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration). (PubMed id 15016762)1, 2, 3, 9 Fossdal R.... Stefansson K. (Hum. Mol. Genet. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    5. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. (PubMed id 19324877)1, 2 Zhang H.... Guan K.L. (J. Biol. Chem. 2009)
    6. TEAD mediates YAP-dependent gene induction and growth control. (PubMed id 18579750)1, 2 Zhao B.... Guan K.L. (Genes Dev. 2008)
    7. Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis. (PubMed id 9889009)1, 3 Jacquemin P....Davidson I. (Genomics 1999)
    8. Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1. (PubMed id 11136726)1, 9 Gupta M....Gupta M.P. (J. Biol. Chem. 2001)
    9. Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter. (PubMed id 8253797)1, 9 Kariya K....Simpson P.C. (J. Biol. Chem. 1993)
    10. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. (PubMed id 8921372)1, 9 Stewart A.F.R.... Adra C.N. (Genomics 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7003 HGNC: 11714 AceView: TEAD1 Ensembl:ENSG00000187079 euGenes: HUgn7003
    ECgene: TEAD1 Kegg: 7003 H-InvDB: TEAD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TEAD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TEAD1 gene:
    Search GeneIP for patents involving TEAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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