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Aliases for TDRP Gene

Aliases for TDRP Gene

  • Testis Development Related Protein 2 3 5
  • C8orf42 3 4
  • Chromosome 8 Open Reading Frame 42 2
  • Protein INM01 4
  • Inm01 3
  • TDRP1 3
  • TDRP2 3

External Ids for TDRP Gene

Previous HGNC Symbols for TDRP Gene

  • C8orf42

Previous GeneCards Identifiers for TDRP Gene

  • GC08M000440
  • GC08M000443

Summaries for TDRP Gene

GeneCards Summary for TDRP Gene

TDRP (Testis Development Related Protein) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRP Gene

Genomics for TDRP Gene

Regulatory Elements for TDRP Gene

Enhancers for TDRP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TDRP on UCSC Golden Path with GeneCards custom track

Promoters for TDRP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TDRP on UCSC Golden Path with GeneCards custom track

Genomic Location for TDRP Gene

Chromosome:
8
Start:
457,018 bp from pter
End:
545,781 bp from pter
Size:
88,764 bases
Orientation:
Minus strand

Genomic View for TDRP Gene

Genes around TDRP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRP Gene

Proteins for TDRP Gene

  • Protein details for TDRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YL5-TDRP_HUMAN
    Recommended name:
    Testis development-related protein
    Protein Accession:
    Q86YL5
    Secondary Accessions:
    • B6VF03
    • B9EG53

    Protein attributes for TDRP Gene

    Size:
    185 amino acids
    Molecular mass:
    20403 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TDRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRP Gene

Proteomics data for TDRP Gene at MOPED

Post-translational modifications for TDRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRP Gene

No data available for DME Specific Peptides for TDRP Gene

Domains & Families for TDRP Gene

Protein Domains for TDRP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TDRP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TDRP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TDRP Gene

Function for TDRP Gene

genes like me logo Genes that share phenotypes with TDRP: view

Animal Models for TDRP Gene

MGI Knock Outs for TDRP:
  • Tdrp tm1.1(KOMP)Vlcg

Animal Model Products

miRNA for TDRP Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TDRP Gene

Localization for TDRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRP Gene

Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for TDRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TDRP: view

No data available for Subcellular locations from COMPARTMENTS for TDRP Gene

Pathways & Interactions for TDRP Gene

SuperPathways for TDRP Gene

No Data Available

Interacting Proteins for TDRP Gene

Gene Ontology (GO) - Biological Process for TDRP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TDRP Gene

Drugs & Compounds for TDRP Gene

No Compound Related Data Available

Transcripts for TDRP Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TDRP Gene

No ASD Table

Relevant External Links for TDRP Gene

GeneLoc Exon Structure for
TDRP
ECgene alternative splicing isoforms for
TDRP

Expression for TDRP Gene

mRNA expression in normal human tissues for TDRP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TDRP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.7), Platelet (21.4), and Placenta (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDRP Gene



mRNA Expression by UniProt/SwissProt for TDRP Gene

Q86YL5-TDRP_HUMAN
Tissue specificity: Expressed in spermatogenic cells, especially in spermatocytes (at protein level).
genes like me logo Genes that share expression patterns with TDRP: view

Protein tissue co-expression partners for TDRP Gene

Primer Products

No data available for mRNA differential expression in normal tissues for TDRP Gene

Orthologs for TDRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDRP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1H8orf42 35
  • 82.43 (n)
  • 78.26 (a)
TDRP 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C25H8orf42 35
  • 84.68 (n)
  • 82.16 (a)
TDRP 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tdrp 35
  • 78.45 (n)
  • 76.8 (a)
Tdrp 16
Tdrp 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf42 35
  • 99.46 (n)
  • 99.46 (a)
TDRP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tdrp 35
  • 77.9 (n)
  • 74.59 (a)
oppossum
(Monodelphis domestica)
Mammalia TDRP 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRP 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves C8ORF42 35
  • 72.41 (n)
  • 71.03 (a)
TDRP 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRP 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15789 35
tdrp 35
  • 64.68 (n)
  • 57.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2936 35
Species with no ortholog for TDRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TDRP Gene

ENSEMBL:
Gene Tree for TDRP (if available)
TreeFam:
Gene Tree for TDRP (if available)

Paralogs for TDRP Gene

No data available for Paralogs for TDRP Gene

Variants for TDRP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TDRP Gene

TDRP_HUMAN-Q86YL5
The poly-Ala region seems to be polymorphic and the number of Ala varies between 4 and 6.

Sequence variations from dbSNP and Humsavar for TDRP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2034351 -- 491,856(-) CAAAG(C/G)TTATA intron-variant, utr-variant-3-prime
rs2034352 -- 490,921(-) AGTCT(A/G)CATCC intron-variant, utr-variant-3-prime
rs2034354 -- 543,262(-) AATCT(C/T)GGCTC intron-variant, upstream-variant-2KB
rs2034355 -- 542,899(-) TTTTC(C/T)CTTTA intron-variant, upstream-variant-2KB
rs2053787 -- 537,815(-) tttat(C/G)ctatc intron-variant, nc-transcript-variant, reference, missense

Variation tolerance for TDRP Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TDRP Gene

Disorders for TDRP Gene

Relevant External Links for TDRP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TDRP

No disorders were found for TDRP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRP Gene

Publications for TDRP Gene

  1. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis. (PMID: 20170638) Wang X. … Hu R. (Biochem. Biophys. Res. Commun. 2010) 2 3 4 67
  2. Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population. (PMID: 24667176) Kan M. … Liu Y. (Diagn Pathol 2014) 3
  3. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PMID: 21646302) Bielinski S.J. … Chute C.G. (Mayo Clin. Proc. 2011) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TDRP Gene

Sources for TDRP Gene

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