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Aliases for TDRP Gene

Aliases for TDRP Gene

  • Testis Development Related Protein 2 3
  • C8orf42 3 4
  • Chromosome 8 Open Reading Frame 42 2
  • Testis Development-Related Protein 3
  • Protein INM01 4
  • Inm01 3
  • TDRP1 3
  • TDRP2 3

External Ids for TDRP Gene

Previous Symbols for TDRP Gene

  • C8orf42

Summaries for TDRP Gene

GeneCards Summary for TDRP Gene

TDRP (Testis Development Related Protein) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRP Gene

Genomics for TDRP Gene

Genomic Location for TDRP Gene

Start:
456,462 bp from pter
End:
545,781 bp from pter
Size:
89,320 bases
Orientation:
Minus strand

Genomic View for TDRP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDRP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRP Gene

No data available for Regulatory Elements for TDRP Gene

Proteins for TDRP Gene

  • Protein details for TDRP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YL5-TDRP_HUMAN
    Recommended name:
    Testis development-related protein
    Protein Accession:
    Q86YL5
    Secondary Accessions:
    • B6VF03
    • B9EG53

    Protein attributes for TDRP Gene

    Size:
    185 amino acids
    Molecular mass:
    20403 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TDRP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRP Gene

Proteomics data for TDRP Gene at MOPED

Post-translational modifications for TDRP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRP Gene

No data available for DME Specific Peptides for TDRP Gene

Domains for TDRP Gene

Protein Domains for TDRP Gene

ProtoNet:
genes like me logo Genes that share domains with TDRP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TDRP Gene

Function for TDRP Gene

Gene Ontology (GO) - Molecular Function for TDRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TDRP: view

miRNA for TDRP Gene

miRTarBase miRNAs that target TDRP

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TDRP Gene

Localization for TDRP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRP Gene

Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for TDRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20170638
GO:0005737 cytoplasm IDA 20170638
genes like me logo Genes that share ontologies with TDRP: view

Pathways for TDRP Gene

SuperPathways for TDRP Gene

No Data Available

Interacting Proteins for TDRP Gene

Gene Ontology (GO) - Biological Process for TDRP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IDA 20170638
genes like me logo Genes that share ontologies with TDRP: view

No data available for Pathways by source for TDRP Gene

Transcripts for TDRP Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TDRP Gene

No ASD Table

Relevant External Links for TDRP Gene

GeneLoc Exon Structure for
TDRP
ECgene alternative splicing isoforms for
TDRP

Expression for TDRP Gene

mRNA expression in normal human tissues for TDRP Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TDRP Gene

mRNA Expression by UniProt/SwissProt for TDRP Gene

Q86YL5-TDRP_HUMAN
Tissue specificity: Expressed in spermatogenic cells, especially in spermatocytes (at protein level).
genes like me logo Genes that share expressions with TDRP: view

Orthologs for TDRP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDRP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C8H8orf42 36
  • 99.46 (n)
  • 99.46 (a)
TDRP 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1H8orf42 36
  • 82.43 (n)
  • 78.26 (a)
TDRP 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C25H8orf42 36
  • 84.68 (n)
  • 82.16 (a)
TDRP 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2610019F03Rik 16
Tdrp 36
  • 78.45 (n)
  • 76.8 (a)
Tdrp 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRP 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRP 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tdrp 36
  • 77.9 (n)
  • 74.59 (a)
chicken
(Gallus gallus)
Aves C8ORF42 36
  • 72.41 (n)
  • 71.03 (a)
TDRP 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRP 37
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2936 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15789 36
tdrp 36
  • 64.68 (n)
  • 57.84 (a)
Species with no ortholog for TDRP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TDRP Gene

ENSEMBL:
Gene Tree for TDRP (if available)
TreeFam:
Gene Tree for TDRP (if available)

Paralogs for TDRP Gene

No data available for Paralogs for TDRP Gene

Variants for TDRP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TDRP Gene

Q86YL5-TDRP_HUMAN
The poly-Ala region seems to be polymorphic and the number of Ala varies between 4 and 6

Sequence variations from dbSNP and Humsavar for TDRP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1760 -- 492,079(+) TGAAA(A/G)TCATT intron-variant, utr-variant-3-prime
rs2241 -- 505,383(+) AAAGG(A/G)TAAAT intron-variant
rs2242 -- 505,360(+) ACAGG(G/T)GTGGG intron-variant
rs7864 -- 477,913(+) CAACC(C/T)GATTT intron-variant
rs12209 -- 491,041(-) TTATG(C/G)AAAAA utr-variant-3-prime, intron-variant

Relevant External Links for TDRP Gene

HapMap Linkage Disequilibrium report
TDRP

No data available for Structural Variations from Database of Genomic Variants (DGV) for TDRP Gene

Disorders for TDRP Gene

No disorders were found for TDRP Gene.

No data available for UniProtKB/Swiss-Prot for TDRP Gene

Publications for TDRP Gene

  1. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis. (PMID: 20170638) Wang X. … Hu R. (Biochem. Biophys. Res. Commun. 2010) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PMID: 21646302) Bielinski S.J. … Chute C.G. (Mayo Clin. Proc. 2011) 3
  4. Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population. (PMID: 24667176) Kan M. … Liu Y. (Diagn Pathol 2014) 3
  5. Gene expression profiling in human insulinoma tissue: genes involved in the insulin secretion pathway and cloning of novel full-length cDNAs. (PMID: 15163304) Wang X.-C. … Hu R.-M. (Endocr. Relat. Cancer 2004) 4

Products for TDRP Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TDRP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TDRP
    • Block miRNA regulation of TDRP using miScript Target Protectors

    Sources for TDRP Gene

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