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TDRKH Gene

protein-coding   GIFtS: 55
GCID: GC01M151745

Tudor And KH Domain Containing

(Previous name: tudor and KH domain containing)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tudor And KH Domain Containing1 2     Tudor And KH Domain Containing Protein2
Tudor Domain-Containing Protein 22 3     Tudor And KH Domain-Containing Protein2
TDRD22 3     Tudor Domain Containing 22
Putative RNA Binding Protein2     

External Ids:    HGNC: 117131   Entrez Gene: 110222   Ensembl: ENSG000001821347   OMIM: 6095015   UniProtKB: Q9Y2W63   

Export aliases for TDRKH gene to outside databases

Previous GC identifers: GC01M149584 GC01M147526 GC01M148517 GC01M148960 GC01M148557 GC01M150010 GC01M123120


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TDRKH Gene:
TDRKH (tudor and KH domain containing) is a protein-coding gene. Diseases associated with TDRKH include myxoid chondrosarcoma, and extraskeletal myxoid chondrosarcoma. GO annotations related to this gene include RNA binding. An important paralog of this gene is TDRD7.

UniProtKB/Swiss-Prot: TDRKH_HUMAN, Q9Y2W6
Function: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress
transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA
metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed
of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the
final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature
piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these
granules (By similarity)

Gene Wiki entry for TDRKH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDRKH gene promoter:
         Elk-1   AP-1   p53   AP-4   AREB6   c-Rel   HOXA5   Pax-4a   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDRKH promoter sequence
   Search Chromatin IP Primers for TDRKH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDRKH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

TDRKH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDRKH gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151745:  view genomic region     (about GC identifiers)

Start:
151,742,583 bp from pter      End:
151,763,892 bp from pter
Size:
21,310 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TDRKH_HUMAN, Q9Y2W6 (See protein sequence)
Recommended Name: Tudor and KH domain-containing protein  
Size: 561 amino acids; 62046 Da
Subunit: Interacts with (symmetrically methylated) PIWIL1, PIWIL2 and PIWIL4 (By similarity)
Sequence caution: Sequence=AAD30971.1; Type=Erroneous termination; Positions=562; Note=Translated as stop;
Sequence=BC022467; Type=Erroneous termination; Positions=175; Note=Translated as Lys;
2 PDB 3D structures from and Proteopedia for TDRKH:
2DIQ (3D)        3FDR (3D)    
Secondary accessions: D3DV24 Q5SZR3 Q5SZR5 Q8N582 Q9NYV5
Alternative splicing: 2 isoforms:  Q9Y2W6-2   Q9Y2W6-3   

Explore the universe of human proteins at neXtProt for TDRKH: NX_Q9Y2W6

Explore proteomics data for TDRKH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TDRKH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001077432.1  NP_001077433.1  NP_001077434.1  NP_006853.2  

    ENSEMBL proteins: 
     ENSP00000437147   ENSP00000357819   ENSP00000357817   ENSP00000357815   ENSP00000357813  
     ENSP00000357812   ENSP00000395718   ENSP00000433678   ENSP00000431557   ENSP00000432452  
     ENSP00000416645  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    3 InterPro protein domains:
     IPR004087 KH_dom
     IPR004088 KH_dom_type_1
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry Q9Y2W6

    ProtoNet protein and cluster: Q9Y2W6

    4 Blocks protein domains:
    IPB002999 Tudor domain
    IPB004087 KH domain
    IPB004088 KH
    IPB008191 Maternal tudor protein


    UniProtKB/Swiss-Prot: TDRKH_HUMAN, Q9Y2W6
    Similarity: Contains 2 KH domains
    Similarity: Contains 1 Tudor domain


    TDRKH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDRKH_HUMAN, Q9Y2W6
    Function: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress
    transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA
    metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed
    of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the
    final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature
    piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these
    granules (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding ----
         
    TDRKH for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tdrkh):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  no phenotypic analysis  reproductive system 

    TDRKH for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tdrkhtm1.2Hfl for TDRKH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDRKH
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    Selected qRT-PCR Assays for microRNAs that regulate TDRKH (see all 21):
    hsa-miR-485-5p hsa-miR-146a hsa-miR-548v hsa-miR-1205 hsa-miR-1184 hsa-miR-3622b-3p hsa-miR-205* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidTDRKH 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDRKH_HUMAN, Q9Y2W6: Cytoplasm (By similarity). Mitochondrion (By similarity). Note=Probable component of the
    meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity
    during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs.
    Associated with mitochondria in the germline (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    mitochondrion2
    nucleus2
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ISS--
    GO:0071546pi-body ISS--
    GO:0071547piP-body ISS--

    TDRKH for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TDRKH
    Interactions:

        Search GeneGlobe Interaction Network for TDRKH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TDRKH (Q9Y2W63 ENSP000003578124) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIWIL1Q96J943, ENSP000002452554I2D: score=1 STRING: ENSP00000245255
    ENSG00000236063ENSP000004069654STRING: ENSP00000406965
    TDRD1ENSP000002518644STRING: ENSP00000251864
    EIF2AENSP000004172294STRING: ENSP00000417229
    TDRD6ENSP000003460654STRING: ENSP00000346065
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007140male meiosis ISS--
    GO:0007283spermatogenesis ISS--
    GO:0009566fertilization ISS--
    GO:0030154cell differentiation IEA--
    GO:0031047gene silencing by RNA IEA--

    TDRKH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TDRKH



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TDRKH gene (4 alternative transcripts): 
    NM_001083963.1  NM_001083964.1  NM_001083965.1  NM_006862.3  

    Unigene Cluster for TDRKH:

    Tudor and KH domain containing
    Hs.144439  [show with all ESTs]
    Unigene Representative Sequence: AK225160
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525790(uc001eyy.2) ENST00000368827(uc009wnb.1) ENST00000368825
    ENST00000368824(uc001ezb.4 uc001ezc.4 uc001eza.4 uc001ezd.4 uc010pdn.1)
    ENST00000368823 ENST00000368822 ENST00000458431 ENST00000526413 ENST00000484421
    ENST00000486986 ENST00000526378 ENST00000494725 ENST00000530202 ENST00000463553
    ENST00000440583
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TDRKH (see all 21):
    hsa-miR-485-5p hsa-miR-146a hsa-miR-548v hsa-miR-1205 hsa-miR-1184 hsa-miR-3622b-3p hsa-miR-205* hsa-miR-330-3p
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      QuantiFast Probe-based Assays in human, mouse, rat TDRKH

    Additional mRNA sequence: 

    AF119121.2 AF227192.1 AK056402.1 AK225160.1 AK226092.1 AK295948.1 AK303063.1 AK316279.1 
    BC022467.1 BC032690.1 

    11 DOTS entries:

    DT.309114  DT.100780973  DT.40129661  DT.102842755  DT.95167247  DT.452303  DT.121399300  DT.121399340 
    DT.422794  DT.91704117  DT.95237379 

    Selected AceView cDNA sequences (see all 97):

    BQ185258 AI381919 BQ024437 AL598977 BQ613819 AA883334 NM_006862 AI632917 
    BE890740 CB122701 BU542162 BI914192 AI561125 AF119121 CA416063 AA360929 
    AI621078 AI923858 BQ434621 BI554111 AW296176 CF141109 CR601319 CB164159 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TDRKH (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^
    SP1:                                      -     -                                         -                                                                     
    SP2:                                      -     -                                         -                                                                     
    SP3:                                -     -     -                 -                       -                                                                     
    SP4:                                -     -     -                                         -                                                                     
    SP5:                                      -     -                             -     -     -                                                                     

    ExUns: 13 ^ 14 ^ 15a · 15b · 15c ^ 16
    SP1:              -     -     -         
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for TDRKH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDRKH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCGTTAAGA
    TDRKH Expression
    About this image


    TDRKH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
             Primordial germ cell-like cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
    TDRKH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDRKH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.144439
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRKH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TDRKH gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdrkh1 , 5 tudor and KH domain containing protein1, 5 89.82(n)1
    91.43(a)1
      3 (40.62 cM)5
    726341  NM_028307.11  NP_082583.11 
     944133185 
    chicken
    (Gallus gallus)
    Aves TDRKH1 tudor and KH domain containing 62.09(n)
    62.59(a)
      425667  XM_423400.4  XP_423400.4 
    lizard
    (Anolis carolinensis)
    Reptilia TDRKH6
    tudor and KH domain containing
    53(a)
    1 ↔ 1
    AAWZ02036993(2734-19631)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480488922   -- 74.26(n)    48048892 
    zebrafish
    (Danio rerio)
    Actinopterygii tdrkh1 tudor and KH domain containing 52.87(n)
    45.84(a)
      541541  NM_001014355.1  NP_001014377.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta papi6
    papi
    23(a)
    1 → many
    2L(2220750-2225544)


    ENSEMBL Gene Tree for TDRKH (if available)
    TreeFam Gene Tree for TDRKH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TDRKH gene
    TDRD72  
    1 SIMAP similar gene for TDRKH using alignment to 6 protein entries:     TDRKH_HUMAN (see all proteins):
    NOVA1

    TDRKH for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDRKH (see all 442)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2015132141,2
    --151744353(+) GTCTT-/ATGA  
            
    ATGAT
    1 -- ut310--------
    rs37905131,2
    C,F,H--151744434(-) GAAGCA/GTGCTC 1 -- ut318Minor allele frequency- G:0.16NS EA NA WA 648
    rs48455561,2
    C,F,A,H--151744858(+) CCACCG/AGTGCC 1 -- int111Minor allele frequency- A:0.46NA WA CSA EA 373
    rs1825034841,2
    --151744900(+) AATTTG/TGAGAA 1 -- int10--------
    rs24953961,2
    C,F,A,H--151744928(-) TGGCAA/GCTATA 1 -- int117Minor allele frequency- G:0.33NS EA NA WA 1726
    rs750259831,2
    C--151744943(+) GTATAG/TAGGTA 1 -- int10--------
    rs1860389551,2
    C--151745224(+) AGATTC/TCTCCA 1 -- int10--------
    rs1891542181,2
    --151745377(+) TTTTTA/TATGAG 1 -- int10--------
    rs1425927931,2
    --151745425(+) ACCTCC/TGCTTC 1 -- int10--------
    rs1509608461,2
    --151745440(+) GTTCAA/GGTGAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TDRKH (151742583 - 151763892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TDRKH:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717884CNV Deletion23290073
    esv2371131CNV Deletion18987734
    esv2717895CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDRKH
    DNA2.0 Custom Variant and Variant Library Synthesis for TDRKH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609501    OMIM disorders: --

    10 diseases for TDRKH:    
    About MalaCards
    myxoid chondrosarcoma    extraskeletal myxoid chondrosarcoma    chondrosarcoma    spermatogenic failure
    chronic myeloid leukemia    sarcoma    myeloid leukemia    hypoxia
    leukemia    malaria


    TDRKH for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for TDRKH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ewings sarcoma 53.9 1 8336942 (1)
    sarcoma 10.7 1 10602519 (1)
    tumors 0 1 7503813 (1)
    cancer 0 1 15917470 (1)

    Genetic Association Database (GAD): TDRKH
    Human Genome Epidemiology (HuGE) Navigator: TDRKH (1 document)

    Export disorders for TDRKH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TDRKH gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with TDRKH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains. (PubMed id 10767542)1, 2, 3 Lamb F.S....Schutte B.C. (Gene 2000)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    6. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. Tudor domains bind symmetrical dimethylated arginines. (PubMed id 15955813)1 Cote J. and Richard S. (J. Biol. Chem. 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11022 HGNC: 11713 AceView: TDRKH Ensembl:ENSG00000182134 euGenes: HUgn11022
    ECgene: TDRKH H-InvDB: TDRKH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TDRKH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TDRKH gene:
    Search GeneIP for patents involving TDRKH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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