Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TDRKH Gene

Aliases for TDRKH Gene

  • Tudor And KH Domain Containing 2 3
  • Tudor Domain-Containing Protein 2 3 4
  • TDRD2 3 4
  • Tudor And KH Domain Containing Protein 3
  • Tudor And KH Domain-Containing Protein 3
  • Putative RNA Binding Protein 3
  • Tudor Domain Containing 2 3

External Ids for TDRKH Gene

Summaries for TDRKH Gene

GeneCards Summary for TDRKH Gene

TDRKH (Tudor And KH Domain Containing) is a Protein Coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is TDRD7.

UniProtKB/Swiss-Prot for TDRKH Gene

  • Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules (By similarity).

Gene Wiki entry for TDRKH Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRKH Gene

Genomics for TDRKH Gene

Genomic Location for TDRKH Gene

Start:
151,770,107 bp from pter
End:
151,791,416 bp from pter
Size:
21,310 bases
Orientation:
Minus strand

Genomic View for TDRKH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDRKH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRKH Gene

Regulatory Elements for TDRKH Gene

Proteins for TDRKH Gene

  • Protein details for TDRKH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2W6-TDRKH_HUMAN
    Recommended name:
    Tudor and KH domain-containing protein
    Protein Accession:
    Q9Y2W6
    Secondary Accessions:
    • D3DV24
    • Q5SZR3
    • Q5SZR5
    • Q8N582
    • Q9NYV5

    Protein attributes for TDRKH Gene

    Size:
    561 amino acids
    Molecular mass:
    62046 Da
    Quaternary structure:
    • Interacts with (symmetrically methylated) PIWIL1, PIWIL2 and PIWIL4.
    SequenceCaution:
    • Sequence=AAD30971.1; Type=Erroneous termination; Positions=562; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=BC022467; Type=Erroneous termination; Positions=175; Note=Translated as Lys.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TDRKH Gene

    Alternative splice isoforms for TDRKH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRKH Gene

Proteomics data for TDRKH Gene at MOPED

Post-translational modifications for TDRKH Gene

  • Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TDRKH Gene

Domains for TDRKH Gene

Gene Families for TDRKH Gene

HGNC:
  • TDRD :Tudor domain containing

Protein Domains for TDRKH Gene

UniProtKB/Swiss-Prot:

TDRKH_HUMAN
Domain:
  • Contains 2 KH domains.:
    • Q9Y2W6
  • Contains 1 Tudor domain.:
    • Q9Y2W6
genes like me logo Genes that share domains with TDRKH: view

Function for TDRKH Gene

Molecular function for TDRKH Gene

UniProtKB/Swiss-Prot Function: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules (By similarity).

Gene Ontology (GO) - Molecular Function for TDRKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TDRKH: view
genes like me logo Genes that share phenotypes with TDRKH: view

Animal Models for TDRKH Gene

MGI Knock Outs for TDRKH:

miRNA for TDRKH Gene

miRTarBase miRNAs that target TDRKH

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TDRKH Gene

Localization for TDRKH Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRKH Gene

Cytoplasm. Mitochondrion. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TDRKH Gene COMPARTMENTS Subcellular localization image for TDRKH gene
Compartment Confidence
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TDRKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion ISS --
GO:0071546 pi-body ISS --
GO:0071547 piP-body ISS --
genes like me logo Genes that share ontologies with TDRKH: view

Pathways for TDRKH Gene

SuperPathways for TDRKH Gene

No Data Available

Gene Ontology (GO) - Biological Process for TDRKH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007140 male meiosis ISS --
GO:0007283 spermatogenesis ISS --
GO:0009566 fertilization ISS --
GO:0010467 gene expression TAS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TDRKH: view

No data available for Pathways by source for TDRKH Gene

Transcripts for TDRKH Gene

Unigene Clusters for TDRKH Gene

Tudor and KH domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDRKH Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - -
SP9: -
SP10:

ExUns: 13 ^ 14 ^ 15a · 15b · 15c ^ 16
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TDRKH Gene

GeneLoc Exon Structure for
TDRKH
ECgene alternative splicing isoforms for
TDRKH

Expression for TDRKH Gene

mRNA expression in normal human tissues for TDRKH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDRKH Gene

This gene is overexpressed in Testis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TDRKH Gene

SOURCE GeneReport for Unigene cluster for TDRKH Gene Hs.144439

genes like me logo Genes that share expressions with TDRKH: view

Orthologs for TDRKH Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRKH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRKH 36
  • 99.58 (n)
  • 99.29 (a)
TDRKH 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TDRKH 36
  • 89.12 (n)
  • 90.48 (a)
TDRKH 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TDRKH 36
  • 90.6 (n)
  • 91.96 (a)
TDRKH 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tdrkh 36
  • 89.82 (n)
  • 91.43 (a)
Tdrkh 16
Tdrkh 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRKH 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRKH 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tdrkh 36
  • 89.76 (n)
  • 92.5 (a)
chicken
(Gallus gallus)
Aves TDRKH 36
  • 62.09 (n)
  • 62.59 (a)
TDRKH 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRKH 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6287 36
tdrkh 36
  • 53.85 (n)
  • 45.36 (a)
zebrafish
(Danio rerio)
Actinopterygii tdrkh 36
  • 52.87 (n)
  • 45.84 (a)
tdrkh 37
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta papi 37
  • 23 (a)
OneToMany
Species with no ortholog for TDRKH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRKH Gene

ENSEMBL:
Gene Tree for TDRKH (if available)
TreeFam:
Gene Tree for TDRKH (if available)

Paralogs for TDRKH Gene

Paralogs for TDRKH Gene

Selected SIMAP similar genes for TDRKH Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TDRKH: view

Variants for TDRKH Gene

Sequence variations from dbSNP and Humsavar for TDRKH Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1054475 -- 151,773,759(-) CCTCA(A/G)GAAGT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1054477 -- 151,773,617(-) ATTTT(C/T)TAAAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1054479 -- 151,773,603(-) TAGTA(A/T)AATAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1054481 -- 151,773,585(-) TATAC(A/C)CACAT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1123855 -- 151,774,567(+) GCCAG(C/T)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TDRKH Gene

Variant ID Type Subtype PubMed ID
esv2371131 CNV Deletion 18987734
esv2717884 CNV Deletion 23290073
esv2717895 CNV Deletion 23290073

Relevant External Links for TDRKH Gene

HapMap Linkage Disequilibrium report
TDRKH

Disorders for TDRKH Gene

(4) Novoseek inferred disease relationships for TDRKH Gene

Disease -log(P) Hits PubMed IDs
ewings sarcoma 53.9 1
sarcoma 10.7 1
tumors 0 1
cancer 0 1

Relevant External Links for TDRKH

Genetic Association Database (GAD)
TDRKH
Human Genome Epidemiology (HuGE) Navigator
TDRKH
genes like me logo Genes that share disorders with TDRKH: view

No data available for UniProtKB/Swiss-Prot for TDRKH Gene

Publications for TDRKH Gene

  1. Complex RNA processing of TDRKH, a novel gene encoding the putative RNA-binding tudor and KH domains. (PMID: 10767542) Lamb F.S. … Schutte B.C. (Gene 2000) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for TDRKH Gene

  • Addgene plasmids for TDRKH

Sources for TDRKH Gene

Back to Top

Content