Aliases for TDRD9 Gene
External Ids for TDRD9 Gene
Previous HGNC Symbols for TDRD9 Gene
Previous GeneCards Identifiers for TDRD9 Gene
GeneCards Summary for TDRD9 Gene
TDRD9 (Tudor Domain Containing 9) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DHX34.
UniProtKB/Swiss-Prot for TDRD9 Gene
ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.