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TDRD9 Gene

protein-coding   GIFtS: 50
GCID: GC14P104394

Tudor Domain Containing 9

(Previous name: chromosome 14 open reading frame 75)
(Previous symbol: C14orf75)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tudor Domain Containing 91 2     NET542
C14orf751 2 3     Hypoxia-Inducible HIG-12
Tudor Domain-Containing Protein 92 3     Putative ATP-Dependent RNA Helicase TDRD92
Chromosome 14 Open Reading Frame 751     EC 3.6.4.133
HIG-12     EC 3.6.18

External Ids:    HGNC: 201221   Entrez Gene: 1224022   Ensembl: ENSG000001564147   UniProtKB: Q8NDG63   

Export aliases for TDRD9 gene to outside databases

Previous GC identifers: GC14P102414 GC14P103491 GC14P084574


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TDRD9 Gene:
TDRD9 (tudor domain containing 9) is a protein-coding gene. Diseases associated with TDRD9 include hypoxia, and bipolar disorder. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot: TDRD9_HUMAN, Q8NDG6
Function: Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing
transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the
piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming
complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of
transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs
metabolic process (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDRD9 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   Egr-2   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDRD9 promoter sequence
   Search Chromatin IP Primers for TDRD9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDRD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

TDRD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDRD9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P104394:  view genomic region     (about GC identifiers)

Start:
104,394,799 bp from pter      End:
104,519,004 bp from pter
Size:
124,206 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TDRD9_HUMAN, Q8NDG6 (See protein sequence)
Recommended Name: Putative ATP-dependent RNA helicase TDRD9  
Size: 1382 amino acids; 155683 Da
Subunit: Interacts with piRNA-associated proteins PIWIL1 and PIWIL4 (By similarity)
Sequence caution: Sequence=AAI28058.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI28058.1; Type=Frameshift; Positions=1159; Sequence=BAC04182.1; Type=Erroneous initiation;
Sequence=BAC05047.1; Type=Erroneous initiation; Sequence=BAC05144.1; Type=Erroneous initiation;
Sequence=BAC86372.1; Type=Erroneous initiation;
Secondary accessions: A1A4S7 Q6ZU54 Q8N7T3 Q8N827 Q8N9V5 Q96AS9
Alternative splicing: 2 isoforms:  Q8NDG6-1   Q8NDG6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TDRD9: NX_Q8NDG6

Explore proteomics data for TDRD9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys86, Lys487, Lys511, Lys570, Lys1305
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TDRD9 (Q8NDG6)
     IVVTQPR  ILSTNIAE 


    See TDRD9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694591.2  
    ENSEMBL proteins: 
     ENSP00000387303   ENSP00000451637   ENSP00000343545  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    Selected InterPro protein domains (see all 6):
     IPR007502 Helicase-assoc_dom
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q8NDG6

    ProtoNet protein and cluster: Q8NDG6

    2 Blocks protein domains:
    IPB002999 Tudor domain
    IPB008191 Maternal tudor protein


    UniProtKB/Swiss-Prot: TDRD9_HUMAN, Q8NDG6
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 Tudor domain


    TDRD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDRD9_HUMAN, Q8NDG6
    Function: Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing
    transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the
    piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming
    complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of
    transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs
    metabolic process (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004386helicase activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    TDRD9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TDRD9:
     Decreased viability with pacli 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tdrd9):
     cellular  endocrine/exocrine gland  no phenotypic analysis  reproductive system 

    TDRD9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tdrd9tm1.1Chum for TDRD9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDRD9
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    hsa-miR-589* hsa-miR-1260b hsa-miR-1299 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidTDRD9 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDRD9_HUMAN, Q8NDG6: Cytoplasm (By similarity). Nucleus (By similarity). Note=Component of the nuage, also named
    P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes
    to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to
    piP-bodies (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0071547piP-body ISS--

    TDRD9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TDRD9
    Interactions:

        Search GeneGlobe Interaction Network for TDRD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for TDRD9 (ENSP000003873034) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD51CENSP000003367014STRING: ENSP00000336701
    PIWIL2ENSP000003492084STRING: ENSP00000349208
    TDRD1ENSP000002518644STRING: ENSP00000251864
    PDCD11ENSP000003588124STRING: ENSP00000358812
    BUD31ENSP000002229694STRING: ENSP00000222969
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007140male meiosis ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis ISS--
    GO:0009566fertilization ISS--
    GO:0030154cell differentiation IEA--

    TDRD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TDRD9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TDRD9 gene: 
    NM_153046.2  

    Unigene Cluster for TDRD9:

    Tudor domain containing 9
    Hs.21454  [show with all ESTs]
    Unigene Representative Sequence: NM_153046
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409874(uc001yom.4 uc001yon.4) ENST00000496087 ENST00000554571
    ENST00000557332 ENST00000466378 ENST00000462273 ENST00000481318 ENST00000339063

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate TDRD9:
    hsa-miR-589* hsa-miR-1260b hsa-miR-1299 hsa-miR-1260
    SwitchGear 3'UTR luciferase reporter plasmidTDRD9 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TDRD9

    Additional mRNA sequence: 

    AK093483.1 AK097429.1 AK097699.1 AK125978.1 AL833915.1 BC016796.1 BC033662.1 BC042804.1 
    BC128057.1 U56244.1 

    6 DOTS entries:

    DT.97764851  DT.95163392  DT.101978981  DT.120764902  DT.91702755  DT.97834697 

    Selected AceView cDNA sequences (see all 75):

    AW612464 BM312124 CK904216 AK097429 BQ287749 NM_153046 BI544910 BQ101234 
    BM021080 AA788616 AA293832 BM264225 AA402480 AI800767 BI438744 BE169543 
    AI287250 BQ188617 CK823203 BX117728 CK904217 AI026908 BU077929 BQ100925 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TDRD9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
    SP1:              -     -     -     -     -                     
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for TDRD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDRD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCATAGCTT
    TDRD9 Expression
    About this image


    TDRD9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Pancreas (Endocrine System)
    TDRD9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDRD9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21454
        Custom PCR Arrays for TDRD9
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TDRD9 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdrd91 , 5 tudor domain containing 91, 5 82.43(n)1
    86.29(a)1
      12 (61.14 cM)5
    746911  NM_029056.11  NP_083332.11 
     1119715595 
    chicken
    (Gallus gallus)
    Aves TDRD91 tudor domain containing 9 67.99(n)
    64.47(a)
      423488  XM_004936387.1  XP_004936444.1 
    lizard
    (Anolis carolinensis)
    Reptilia TDRD96
    tudor domain containing 9
    66(a)
    1 ↔ 1
    1(5765810-5884874)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.334972 Xenopus laevis transcribed sequence with weak similarity more 71.43(n)    BJ626222.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tdrd91 tudor domain containing 9 58.21(n)
    55.33(a)
      553222  NM_001130512.1  NP_001123984.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spn-E1 spindle E 45.45(n)
    36.7(a)
      41919  NM_057393.3  NP_476741.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative helicase with limited sequence similarity...
    16(a)
    1 → many
    XII(958428-962735) YLR419W


    ENSEMBL Gene Tree for TDRD9 (if available)
    TreeFam Gene Tree for TDRD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TDRD9 gene
    DHX292  DHX302  DHX362  YTHDC22  DHX572  DHX92  
    2 SIMAP similar genes for TDRD9 using alignment to 2 protein entries:     TDRD9_HUMAN (see all proteins):
    HIG-1    DHX36

    TDRD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDRD9 (see all 2761)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826543101,2
    --104392828(+) AACCCC/TGTCTC 1 -- us2k10--------
    rs580439201,2
    C--104392855(+) ATTAGC/GCAGCC 1 -- us2k10--------
    rs1859384811,2
    --104392953(+) TATCGC/TGCCAC 1 -- us2k10--------
    rs752411111,2
    C,F--104393053(+) AAGTGG/CTTTCA 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs118501861,2
    C,F,H--104393200(+) AACATG/AActgg 1 -- us2k19Minor allele frequency- A:0.34NA CSA WA EA 371
    rs1400739471,2
    --104393346(+) TAGCCA/GGTGTG 1 -- us2k10--------
    rs1912145101,2
    --104393349(+) CCGGTA/GTGGTG 1 -- us2k10--------
    rs1830541461,2
    --104393359(+) GGTGGC/TGTGAG 1 -- us2k10--------
    rs1502807481,2
    --104393389(+) AGGAGA/GTTGTG 1 -- us2k10--------
    rs740867581,2
    C,F--104393524(+) CTTCCT/CGGCAA 1 -- us2k14Minor allele frequency- C:0.06WA NA EA 244

    HapMap Linkage Disequilibrium report for TDRD9 (104394799 - 104519004 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TDRD9 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749176CNV Deletion23290073
    esv2666705CNV Deletion23128226
    esv2749177CNV Deletion23290073
    nsv1432CNV Insertion18451855
    dgv1997n71CNV Loss21882294
    nsv84392CNV Loss16902084
    nsv902318CNV Loss21882294
    nsv902324CNV Loss21882294
    nsv820065CNV Gain19587683
    nsv526680CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    3 diseases for TDRD9:    
    About MalaCards
    hypoxia    bipolar disorder    malaria


    TDRD9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TDRD9
    Human Genome Epidemiology (HuGE) Navigator: TDRD9 (3 documents)

    Export disorders for TDRD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TDRD9 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TDRD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PubMed id 21254220)1, 4 Jiang Y. and Zhang H. (Genet. Epidemiol. 2011)
    2. Family-based association study for bipolar affective disorder. (PubMed id 20414141)1, 4 Secolin R....Lopes-Cendes I. (Psychiatr. Genet. 2010)
    3. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    4. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PubMed id 19308021)1, 4 Ollila H.M....Paunio T. (Mol. Psychiatry 2009)
    5. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 122402 HGNC: 20122 AceView: TDRD9 Ensembl:ENSG00000156414 euGenes: HUgn122402
    ECgene: TDRD9 H-InvDB: TDRD9

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TDRD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TDRD9 gene:
    Search GeneIP for patents involving TDRD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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