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Aliases for TDRD9 Gene

Aliases for TDRD9 Gene

  • Tudor Domain Containing 9 2 3
  • Tudor Domain-Containing Protein 9 3 4
  • C14orf75 3 4
  • Putative ATP-Dependent RNA Helicase TDRD9 3
  • Chromosome 14 Open Reading Frame 75 2
  • Hypoxia-Inducible HIG-1 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • HIG-1 3
  • NET54 3

External Ids for TDRD9 Gene

Previous HGNC Symbols for TDRD9 Gene

  • C14orf75

Previous GeneCards Identifiers for TDRD9 Gene

  • GC14P102414
  • GC14P103491
  • GC14P104394
  • GC14P084574

Summaries for TDRD9 Gene

GeneCards Summary for TDRD9 Gene

TDRD9 (Tudor Domain Containing 9) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ATP-dependent helicase activity. An important paralog of this gene is DHX29.

UniProtKB/Swiss-Prot for TDRD9 Gene

  • Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD9 Gene

Genomics for TDRD9 Gene

Regulatory Elements for TDRD9 Gene

Genomic Location for TDRD9 Gene

Start:
103,928,439 bp from pter
End:
104,052,667 bp from pter
Size:
124,229 bases
Orientation:
Plus strand

Genomic View for TDRD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDRD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD9 Gene

Proteins for TDRD9 Gene

  • Protein details for TDRD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDG6-TDRD9_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase TDRD9
    Protein Accession:
    Q8NDG6
    Secondary Accessions:
    • A1A4S7
    • Q6ZU54
    • Q8N7T3
    • Q8N827
    • Q8N9V5
    • Q96AS9

    Protein attributes for TDRD9 Gene

    Size:
    1382 amino acids
    Molecular mass:
    155683 Da
    Quaternary structure:
    • Interacts with piRNA-associated proteins PIWIL1 and PIWIL4.
    SequenceCaution:
    • Sequence=AAI28058.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI28058.1; Type=Frameshift; Positions=1159; Evidence={ECO:0000305}; Sequence=BAC04182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05047.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05144.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86372.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TDRD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRD9 Gene

Proteomics data for TDRD9 Gene at MOPED

Selected DME Specific Peptides for TDRD9 Gene

Post-translational modifications for TDRD9 Gene

  • Ubiquitination at Lys86, Lys487, Lys511, Lys570, and Lys1305
  • Modification sites at PhosphoSitePlus

Other Protein References for TDRD9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for TDRD9 Gene

Gene Families for TDRD9 Gene

HGNC:
  • TDRD :Tudor domain containing

Suggested Antigen Peptide Sequences for TDRD9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NDG6

UniProtKB/Swiss-Prot:

TDRD9_HUMAN :
  • Q8NDG6
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 Tudor domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily.
genes like me logo Genes that share domains with TDRD9: view

Function for TDRD9 Gene

Molecular function for TDRD9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process (By similarity).

Enzyme Numbers (IUBMB) for TDRD9 Gene

Gene Ontology (GO) - Molecular Function for TDRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TDRD9: view
genes like me logo Genes that share phenotypes with TDRD9: view

Animal Models for TDRD9 Gene

MGI Knock Outs for TDRD9:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for TDRD9 Gene

Localization for TDRD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRD9 Gene

Cytoplasm. Nucleus. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TDRD9 Gene COMPARTMENTS Subcellular localization image for TDRD9 gene
Compartment Confidence
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TDRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0043186 P granule IBA --
GO:0071547 piP-body ISS --
genes like me logo Genes that share ontologies with TDRD9: view

Pathways for TDRD9 Gene

SuperPathways for TDRD9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TDRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IBA --
GO:0007140 male meiosis ISS --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis ISS --
GO:0009566 fertilization ISS --
genes like me logo Genes that share ontologies with TDRD9: view

No data available for Pathways by source for TDRD9 Gene

Transcripts for TDRD9 Gene

Unigene Clusters for TDRD9 Gene

Tudor domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -
SP3:
SP4:

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - - - - -
SP2:
SP3:
SP4:

Relevant External Links for TDRD9 Gene

GeneLoc Exon Structure for
TDRD9
ECgene alternative splicing isoforms for
TDRD9

Expression for TDRD9 Gene

mRNA expression in normal human tissues for TDRD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDRD9 Gene

This gene is overexpressed in Testis (13.5) and Whole Blood (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TDRD9 Gene

SOURCE GeneReport for Unigene cluster for TDRD9 Gene Hs.21454

genes like me logo Genes that share expressions with TDRD9: view

No data available for mRNA Expression by UniProt/SwissProt for TDRD9 Gene

Orthologs for TDRD9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TDRD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRD9 35
  • 99.45 (n)
  • 99.35 (a)
TDRD9 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TDRD9 35
  • 81.89 (n)
  • 85.02 (a)
TDRD9 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TDRD9 35
  • 87.01 (n)
  • 88.58 (a)
TDRD9 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tdrd9 35
  • 82.43 (n)
  • 86.29 (a)
Tdrd9 16
Tdrd9 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRD9 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRD9 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tdrd9 35
  • 82.95 (n)
  • 85.65 (a)
chicken
(Gallus gallus)
Aves TDRD9 35
  • 67.99 (n)
  • 64.47 (a)
TDRD9 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRD9 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33497 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tdrd9 35
  • 66.88 (n)
  • 65.75 (a)
zebrafish
(Danio rerio)
Actinopterygii tdrd9 35
  • 58.21 (n)
  • 55.33 (a)
tdrd9 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta SPNE_ANOGA 35
  • 47 (n)
  • 38.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta spn-E 35
  • 45.45 (n)
  • 36.7 (a)
spn-E 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for TDRD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRD9 Gene

ENSEMBL:
Gene Tree for TDRD9 (if available)
TreeFam:
Gene Tree for TDRD9 (if available)

Paralogs for TDRD9 Gene

Paralogs for TDRD9 Gene

Selected SIMAP similar genes for TDRD9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TDRD9: view

Variants for TDRD9 Gene

Sequence variations from dbSNP and Humsavar for TDRD9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs877009 -- 104,038,358(-) TAGCC(A/G)GAAAA intron-variant
rs941946 -- 104,037,325(+) AATGC(A/G)CACCC intron-variant
rs941947 -- 104,041,162(+) GTATC(A/G)GTGTT intron-variant
rs1040812 -- 103,927,595(-) AATCA(A/G)CAAAG upstream-variant-2KB
rs1115148 -- 103,966,777(+) CTTCA(A/G)AAAAT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TDRD9 Gene

Variant ID Type Subtype PubMed ID
dgv658e1 CNV Complex 17122850
nsv902318 CNV Loss 21882294
nsv902319 CNV Gain 21882294
dgv1997n71 CNV Loss 21882294
nsv902324 CNV Loss 21882294
nsv526680 CNV Gain 19592680
nsv1432 CNV Insertion 18451855
esv2749176 CNV Deletion 23290073
esv2666705 CNV Deletion 23128226
nsv84392 CNV Loss 16902084
esv2749177 CNV Deletion 23290073
nsv820065 CNV Gain 19587683

Relevant External Links for TDRD9 Gene

HapMap Linkage Disequilibrium report
TDRD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD9 Gene

Disorders for TDRD9 Gene

Relevant External Links for TDRD9

Genetic Association Database (GAD)
TDRD9
Human Genome Epidemiology (HuGE) Navigator
TDRD9
genes like me logo Genes that share disorders with TDRD9: view

No data available for UniProtKB/Swiss-Prot for TDRD9 Gene

Publications for TDRD9 Gene

  1. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y. … Zhang H. (Genet. Epidemiol. 2011) 3 48
  2. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T. … Zhu X. (Hum. Genet. 2010) 3 48
  3. Family-based association study for bipolar affective disorder. (PMID: 20414141) Secolin R. … Lopes-Cendes I. (Psychiatr. Genet. 2010) 3 48
  4. Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. (PMID: 19308021) Ollila H.M. … Paunio T. (Mol. Psychiatry 2009) 3 48
  5. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) (Nature 2007) 3 48

Products for TDRD9 Gene

Sources for TDRD9 Gene

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