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TDRD7 Gene

protein-coding   GIFtS: 58
GCID: GC09P100174

Tudor Domain Containing 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tudor Domain Containing 71 2     TRAP2 5
Tudor Repeat Associator With PCTAIRE-22 3     Tudor Domain-Containing Protein 72
PCTAIRE2BP2 3     Tudor Repeat Associator With PCTAIRE 22
PCTAIRE2-Binding Protein2 3     Trap3
CATC42 5     KIAA15295
CTRCT362 5     

External Ids:    HGNC: 308311   Entrez Gene: 234242   Ensembl: ENSG000001961167   OMIM: 6112585   UniProtKB: Q8NHU63   

Export aliases for TDRD7 gene to outside databases

Previous GC identifers: GC09P095555 GC09P097253 GC09P099214 GC09P069775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TDRD7 Gene:
This gene encodes a component of cytoplasmic RNA granules which are involved in determining the fate of mRNAs.
Mutation in this gene has been associated with pediatric cataracts. Mutation of the similar gene in mice has been
associated with cataracts, glaucoma and a block in spermatogenesis. (provided by RefSeq, May 2011)

GeneCards Summary for TDRD7 Gene:
TDRD7 (tudor domain containing 7) is a protein-coding gene. Diseases associated with TDRD7 include cataract, autosomal recessive congenital 4, and cataract 36. GO annotations related to this gene include mRNA binding and protein N-terminus binding. An important paralog of this gene is TDRKH.

UniProtKB/Swiss-Prot: TDRD7_HUMAN, Q8NHU6
Function: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific
genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens
transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the
developing lens. Also required during spermatogenesis

Gene Wiki entry for TDRD7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDRD7 gene promoter:
         USF1   RP58   MyoD   Lmo2   CUTL1   NF-kappaB   AREB6   USF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDRD7 promoter sequence
   Search Chromatin IP Primers for TDRD7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDRD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.33   Ensembl cytogenetic band:  9q22.33   HGNC cytogenetic band: 9q22.33

TDRD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDRD7 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P100174:  view genomic region     (about GC identifiers)

Start:
100,174,232 bp from pter      End:
100,258,407 bp from pter
Size:
84,176 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TDRD7_HUMAN, Q8NHU6 (See protein sequence)
Recommended Name: Tudor domain-containing protein 7  
Size: 1098 amino acids; 123586 Da
Subunit: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing
CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1 (By similarity)
1 PDB 3D structure from and Proteopedia for TDRD7:
3RCO (3D)    
Secondary accessions: A6NCI6 B2RBX3 B4DG99 B4DXF7 E7EQD4 Q5VV27 Q96JT1 Q9UFF0 Q9Y2M3
Alternative splicing: 3 isoforms:  Q8NHU6-1   Q8NHU6-2   Q8NHU6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TDRD7: NX_Q8NHU6

Explore proteomics data for TDRD7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TDRD7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055105.2  
    ENSEMBL proteins: 
     ENSP00000347444   ENSP00000413608   ENSP00000440717  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    2 InterPro protein domains:
     IPR025605 OST-HTH/LOTUS_dom
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry Q8NHU6

    ProtoNet protein and cluster: Q8NHU6

    1 Blocks protein domain: IPB008191 Maternal tudor protein

    UniProtKB/Swiss-Prot: TDRD7_HUMAN, Q8NHU6
    Similarity: Belongs to the TDRD7 family
    Similarity: Contains 3 HTH OST-type domains
    Similarity: Contains 2 Tudor domains


    TDRD7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDRD7_HUMAN, Q8NHU6
    Function: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific
    genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens
    transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the
    developing lens. Also required during spermatogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003729mRNA binding IDA--
    GO:0005515protein binding IPI14603251
    GO:0047485protein N-terminus binding IEA--
         
    TDRD7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TDRD7:
     Decreased DCP1a protein expres  Large nuclei 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tdrd7):
     cellular  endocrine/exocrine gland  immune system  nervous system  reproductive system 
     vision/eye 

    TDRD7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tdrd7tm1.1Chum for TDRD7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDRD7
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TDRD7

    miRNA
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    miRTarBase miRNAs that target TDRD7:
    hsa-let-7e-5p (MIRT051693), hsa-mir-26b-5p (MIRT030170)

    Block miRNA regulation of human, mouse, rat TDRD7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TDRD7:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidTDRD7 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDRD7_HUMAN, Q8NHU6: Cytoplasm. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of
    spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also
    named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called
    intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round
    spermatids (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005759mitochondrial matrix IEA--
    GO:0030529ribonucleoprotein complex ----
    GO:0033391chromatoid body ISS--
    GO:0035770ribonucleoprotein granule IDA--

    TDRD7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TDRD7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Aurora A signaling
    Aurora A signaling


    1 BioSystems Pathway for TDRD7
        Aurora A signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TDRD7
    Interactions:

        Search GeneGlobe Interaction Network for TDRD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TDRD7 (Q8NHU61, 2, 3 ENSP000003474444) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TACC1O754101, 3, ENSP000003217034EBI-624505,EBI-624237 I2D: score=4 STRING: ENSP00000321703
    ATXN2Q997002, 3, ENSP000003668434MINT-2871018 I2D: score=3 STRING: ENSP00000366843
    CDK17Q005373, ENSP000002612114I2D: score=4 STRING: ENSP00000261211
    GABPB1Q065473, ENSP000003702594I2D: score=4 STRING: ENSP00000370259
    CABLES1Q8TDN43, ENSP000002569254I2D: score=1 STRING: ENSP00000256925
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002089lens morphogenesis in camera-type eye IMP--
    GO:0007281germ cell development IEA--
    GO:0007283spermatogenesis ISS--
    GO:0010608posttranscriptional regulation of gene expression IMP--
    GO:0070306lens fiber cell differentiation IMP--

    TDRD7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TDRD7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TDRD7 gene: 
    NM_014290.2  

    Unigene Cluster for TDRD7:

    Tudor domain containing 7
    Hs.193842  [show with all ESTs]
    Unigene Representative Sequence: NM_014290
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355295(uc004axj.3 uc011lux.2) ENST00000492428 ENST00000422139
    ENST00000540902(uc010msp.1 uc011luy.2)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate TDRD7:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmidTDRD7 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TDRD7
      QuantiFast Probe-based Assays in human, mouse, rat TDRD7

    Additional mRNA sequence: 

    AB025254.1 AK294488.1 AK301954.1 AK310227.1 AK314853.1 AL122110.1 BC028694.1 

    3 DOTS entries:

    DT.100025485  DT.97763231  DT.40305185 

    Selected AceView cDNA sequences (see all 106):

    AL122110 BM723314 BQ716290 BU685944 CA440211 BU741556 BQ637577 BM727879 
    BU738752 BM714712 BM706188 BM713914 AI923488 F07472 BU737585 BM720435 
    AI831079 AA365978 BM699769 BU740357 AI973259 Z45201 BU742771 BM676530 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TDRD7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18
    SP1:                                                  -                                         -                                 
    SP2:                                                        -                                                                     
    SP3:                                                                                                                              


    ECgene alternative splicing isoforms for TDRD7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDRD7 expression in normal human tissues (normalized intensities)      TDRD7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTGACTG
    TDRD7 Expression
    About this image


    TDRD7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Neural Tube (Nervous System)
             Diencephalic Roof Plate
     
     Testis (Reproductive System)
    TDRD7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDRD7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.193842
        Custom PCR Arrays for TDRD7
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TDRD7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdrd71 , 5 tudor domain containing 71, 5 83.61(n)1
    84.81(a)1
      4 (24.48 cM)5
    1001211  NM_146142.11  NP_666254.11 
     459653345 
    chicken
    (Gallus gallus)
    Aves TDRD71 tudor domain containing 7 62.83(n)
    55.06(a)
      430492  XM_428047.4  XP_428047.4 
    lizard
    (Anolis carolinensis)
    Reptilia TDRD76
    tudor domain containing 7
    59(a)
    1 ↔ 1
    GL343391.1(75572-141745)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.35862 Xenopus laevis transcribed sequence with weak similarity more 74.34(n)    CD256474.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi12c122 Danio rerio mRNA similar to tudor repeat associator more 76.6(n)    BC052137.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta papi6
    papi
    12(a)
    1 → many
    2L(2220750-2225544)


    ENSEMBL Gene Tree for TDRD7 (if available)
    TreeFam Gene Tree for TDRD7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TDRD7 gene
    TDRKH2  

    TDRD7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDRD7 (see all 1580)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs783308971,2
    F--69773498(+) TCACAA/GGGACG 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs727496701,2
    C--69773516(+) CATGAC/TTTCTC 1 -- us2k10--------
    rs1899628351,2
    --69773525(+) TCAAAC/GGTCCC 1 -- us2k10--------
    rs348781661,2
    C--69799086(+) GACCC-/CT    
       GT
    /TG
    TCTTA
    1 -- int10--------
    rs713082551,2
    C--69799087(-) TTAAGAGAC/-  
            
    AGGGT
    1 -- int11Minor allele frequency- -:0.50NA 2
    rs723125881,2
    C--69824918(+) GGACC-/CAAAGGTGCTC
    TATTTATTTGAGT
    CTTTC
    1 -- int10--------
    rs779640551,2
    C--69824919(+) GACCC-/AAAGGTGCTCT
    ATTTATTTGAGTC
    TTTCA
    1 -- int10--------
    rs343082571,2
    C--100182647(+) TTTTT-/GGGGGG 1 -- int11Minor allele frequency- G:0.00NA 2
    rs592180551,2
    C--100183983(+) GTGTG-/TGTG  
            
    AAGAC
    1 -- int11Minor allele frequency- TGTG:0.00NA 2
    rs3683188161,2
    C--100184677(+) AAAAA-/AAAATC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TDRD7 (100174232 - 100258407 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TDRD7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893609CNV Gain21882294

    Human Gene Mutation Database (HGMD): TDRD7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDRD7
    DNA2.0 Custom Variant and Variant Library Synthesis for TDRD7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611258   
    OMIM disorders: 613887  
    UniProtKB/Swiss-Prot: TDRD7_HUMAN, Q8NHU6
  • Cataract 36 (CTRCT36) [MIM:613887]: An opacification of the crystalline lens of the eye becoming evident
    at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often
    confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and
    dense an opacity, the greater the impact on visual function. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 11 diseases for TDRD7:    About MalaCards
    cataract, autosomal recessive congenital 4    cataract 36    cataract-glaucoma    cataracts, autosomal recessive
    glaucoma    cataract    blindness    ataxia
    multiple myeloma    myeloma    breast cancer


    TDRD7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TDRD7

    Export disorders for TDRD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TDRD7 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TDRD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. (PubMed id 21436445)1, 2, 3 Lachke S.A.... Maas R.L. (Science 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. (PubMed id 10727952)1, 2 Hirose T.... Okada M. (Eur. J. Biochem. 2000)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. OST-HTH: a novel predicted RNA-binding domain. (PubMed id 20302647)2 Anantharaman V.... Aravind L. (Biol. Direct 2010)
    9. LOTUS, a new domain associated with small RNA pathways in the germline. (PubMed id 20305267)2 Callebaut I. and Mornon J.P. (Bioinformatics 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23424 HGNC: 30831 AceView: TDRD7 Ensembl:ENSG00000196116 euGenes: HUgn23424
    ECgene: TDRD7 H-InvDB: TDRD7

    (According to HUGE)
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    HUGE: KIAA1529

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TDRD7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TDRD7 gene:
    Search GeneIP for patents involving TDRD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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