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TDRD6 Gene

protein-coding   GIFtS: 44
GCID: GC06P046702

Tudor Domain Containing 6

  See TDRD6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tudor Domain Containing 61 2     SPATA362
Cancer/Testis Antigen 41.21 2 3     TDR22
Spermatogenesis Associated 361 2     bA446F17.42
Antigen NY-CO-452 3     Tudor Domain-Containing Protein 62
CT41.22 3     Tudor Repeat 22
NY-CO-452     

External Ids:    HGNC: 213391   Entrez Gene: 2214002   Ensembl: ENSG000001801137   OMIM: 6112005   UniProtKB: O605223   

Export aliases for TDRD6 gene to outside databases

Previous GC identifers: GC06P046764 GC06P046378


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TDRD6 Gene:
TDRD6 (tudor domain containing 6) is a protein-coding gene. Diseases associated with TDRD6 include autoimmune polyendocrine syndrome type 1. An important paralog of this gene is TDRD1.

UniProtKB/Swiss-Prot: TDRD6_HUMAN, O60522
Function: Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA
expression (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDRD6 gene promoter:
         GR   Sox5   Lmo2   c-Ets-1   Max   FAC1   POU2F1   POU2F1a   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDRD6 promoter sequence
   Search Chromatin IP Primers for TDRD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDRD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

TDRD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDRD6 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P046702:  view genomic region     (about GC identifiers)

Start:
46,655,612 bp from pter      End:
46,672,056 bp from pter
Size:
16,445 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TDRD6_HUMAN, O60522 (See protein sequence)
Recommended Name: Tudor domain-containing protein 6  
Size: 2096 amino acids; 236517 Da
Subunit: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex, at least
composed of PIWIL1, PIWIL2 and TDRD6. Interacts with DDX4 and PIWIL1 (By similarity)
Sequence caution: Sequence=AAC18034.1; Type=Frameshift; Positions=1994; Sequence=CAI45997.1; Type=Erroneous
initiation;
Secondary accessions: B3KWU2 F5H5M3 Q5HYB1 Q5VTS4 Q6ZMX5
Alternative splicing: 2 isoforms:  O60522-1   O60522-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TDRD6: NX_O60522

Explore proteomics data for TDRD6 at MOPED

Post-translational modifications: 

  • Undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis I to
    meiosis II in primary spermatocytes (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TDRD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001010870.1  NP_001161831.1  

    ENSEMBL proteins: 
     ENSP00000346065   ENSP00000397165   ENSP00000443299  

    TDRD6 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TDRD6

     
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    EMD Millipore Mono- and Polyclonal Antibodies for the study of TDRD6
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    TDRD6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TDRD6
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    Search eBioscience for ELISAs for TDRD6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    1 InterPro protein domain:
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry O60522

    ProtoNet protein and cluster: O60522

    2 Blocks protein domains:
    IPB002999 Tudor domain
    IPB008191 Maternal tudor protein


    UniProtKB/Swiss-Prot: TDRD6_HUMAN, O60522
    Similarity: Contains 8 Tudor domains


    Find genes that share domains with TDRD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDRD6_HUMAN, O60522
    Function: Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA
    expression (By similarity)

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tdrd6):

     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with TDRD6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TDRD6: Tdrd6tm1Jess Tdrd6tm1Chum

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDRD6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TDRD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TDRD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TDRD6

    miRNA
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    Block miRNA regulation of human, mouse, rat TDRD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TDRD6 (see all 17):
    hsa-miR-549 hsa-miR-607 hsa-miR-3152-3p hsa-miR-4251 hsa-miR-539 hsa-miR-4272 hsa-miR-138-2* hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidTDRD6 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDRD6_HUMAN, O60522: Cytoplasm (By similarity). Note=Present in chromatoid body (CB) of spermatids (mammalian
    counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies
    (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial
    cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in
    CB with DDX4, PIWIL1, PIWIL2, TDRD1 and TDRD7 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum IEA--
    GO:0030529ribonucleoprotein complex ----
    GO:0033391chromatoid body ISS--
    GO:0043186P granule IEA--

    Find genes that share ontologies with TDRD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TDRD6
    Interactions:

        Search GeneGlobe Interaction Network for TDRD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for TDRD6 (O605223 ENSP000003460654) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    PIWIL1Q96J943, ENSP000002452554I2D: score=1 STRING: ENSP00000245255
    MAPK6Q166593I2D: score=2 
    PIWIL2ENSP000003492084STRING: ENSP00000349208
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007281germ cell development IEA--
    GO:0007283spermatogenesis ISS--

    Find genes that share ontologies with TDRD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TDRD6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TDRD6 gene (2 alternative transcripts): 
    NM_001010870.2  NM_001168359.1  

    Unigene Cluster for TDRD6:

    Tudor domain containing 6
    Hs.656983  [show with all ESTs]
    Unigene Representative Sequence: NM_001010870
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316081 ENST00000450697 ENST00000544460(uc003oyj.3 uc010jze.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TDRD6 (see all 17):
    hsa-miR-549 hsa-miR-607 hsa-miR-3152-3p hsa-miR-4251 hsa-miR-539 hsa-miR-4272 hsa-miR-138-2* hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidTDRD6 3' UTR sequence
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TDRD6
      QuantiFast Probe-based Assays in human, mouse, rat TDRD6

    Additional mRNA sequence: 

    AF039442.1 AK125838.1 AK131455.1 BX648686.1 CR936792.1 EF185284.1 

    4 DOTS entries:

    DT.109680  DT.100718312  DT.103732  DT.97769279 

    24 AceView cDNA sequences:

    AK125838 AK131455 AL044109 AL043594 AI695269 BX648686 CD244147 AA401219 
    AL044110 AL043170 AA404231 AL040037 AF039442 CD108053 AL043169 AL705423 
    BG210710 CD557142 BG186209 AL040021 BG184238 BG183719 BG182170 BG190601 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDRD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCAGATTG
    TDRD6 Expression
    About this image

    TDRD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDRD6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656983
        Custom PCR Arrays for TDRD6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TDRD6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdrd61 , 5 tudor domain containing 61, 5 75.68(n)1
    73.02(a)1
      17 (19.75 cM)5
    2105101  NM_001161367.11  NP_001154839.11 
     436153395 
    chicken
    (Gallus gallus)
    Aves TDRD66
    tudor domain containing 6
    33(a)
    1 ↔ 1
    3(109447790-109456799)
    lizard
    (Anolis carolinensis)
    Reptilia TDRD66
    tudor domain containing 6
    44(a)
    1 ↔ 1
    1(138580940-138585978)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xtr2 tudor protein 72.99(n)    AB066588.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005361021 tudor domain-containing protein 6-like 43.29(n)
    30.24(a)
      100536102  XM_003200303.2  XP_003200351.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta qin6
    tud6
    tudor
    13(a)
    12(a)
    many ↔ many
    many ↔ many
    3R(14416749-14475859)
    2R(17070937-17079903)


    ENSEMBL Gene Tree for TDRD6 (if available)
    TreeFam Gene Tree for TDRD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TDRD6 gene
    TDRD12  TDRD152  RNF172  TDRD52  

    Find genes that share paralogs with TDRD6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDRD6 (see all 600)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814395551,2
    --46653713(+) CAGAAA/CAAACT 2 -- us2k10--------
    rs94728191,2
    C,F,H--46653789(+) GATTCG/AGATCA 2 -- us2k128Minor allele frequency- A:0.12NS EA NA WA CSA 2770
    rs1439075711,2
    C--46653824(+) CCTGAC/TGTCCT 2 -- us2k10--------
    rs1864606791,2
    --46653839(+) TTAAGG/TCCATG 2 -- us2k10--------
    rs109482991,2
    C,F,A,H--46653858(+) AAGGAG/TGTTGG 2 -- us2k112Minor allele frequency- T:0.38NS EA NA 1024
    rs1904934641,2
    --46654001(+) TCAAGG/TGATCA 2 -- us2k10--------
    rs1481947521,2
    --46654049(+) AAAGGC/TCATAG 2 -- us2k10--------
    rs800519921,2
    F--46654052(+) GGCCAT/CAGTGT 2 -- us2k11Minor allele frequency- C:0.06WA 118
    rs762625991,2
    C,F--46654174(+) TGTGGC/AAAACA 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs350289911,2
    C--46654214(+) TATGT-/AAAAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TDRD6 (46655612 - 46672056 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TDRD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523148CNV Loss19592680
    nsv885868CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDRD6
    DNA2.0 Custom Variant and Variant Library Synthesis for TDRD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611200    OMIM disorders: --

    1 disease for TDRD6:    
    About MalaCards
    autoimmune polyendocrine syndrome type 1


    Find genes that share disorders with TDRD6           About GenesLikeMe


    Export disorders for TDRD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TDRD6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TDRD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J.... Old L.J. (Int. J. Cancer 1998)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (PLoS ONE 2010)
    5. Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1. (PubMed id 17215373)1 Bensing S.... Kampe O. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221400 HGNC: 21339 AceView: TDRD6 Ensembl:ENSG00000180113 euGenes: HUgn221400
    ECgene: TDRD6 H-InvDB: TDRD6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TDRD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TDRD6 gene:
    Search GeneIP for patents involving TDRD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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