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Aliases for TDRD6 Gene

Aliases for TDRD6 Gene

  • Tudor Domain Containing 6 2 3
  • Cancer/Testis Antigen 41.2 2 3 4
  • Spermatogenesis Associated 36 2 3
  • Antigen NY-CO-45 3 4
  • CT41.2 3 4
  • Tudor Domain-Containing Protein 6 3
  • Tudor Repeat 2 3
  • BA446F17.4 3
  • NY-CO-45 3
  • SPATA36 3
  • TDR2 3

External Ids for TDRD6 Gene

Previous GeneCards Identifiers for TDRD6 Gene

  • GC06P046702
  • GC06P046764
  • GC06P046378

Summaries for TDRD6 Gene

GeneCards Summary for TDRD6 Gene

TDRD6 (Tudor Domain Containing 6) is a Protein Coding gene. Diseases associated with TDRD6 include autoimmune polyendocrine syndrome type 1. An important paralog of this gene is TDRD5.

UniProtKB/Swiss-Prot for TDRD6 Gene

  • Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD6 Gene

Genomics for TDRD6 Gene

Regulatory Elements for TDRD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TDRD6 Gene

46,687,875 bp from pter
46,704,319 bp from pter
16,445 bases
Plus strand

Genomic View for TDRD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDRD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD6 Gene

Proteins for TDRD6 Gene

  • Protein details for TDRD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tudor domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • B3KWU2
    • F5H5M3
    • Q5HYB1
    • Q5VTS4
    • Q6ZMX5

    Protein attributes for TDRD6 Gene

    2096 amino acids
    Molecular mass:
    236517 Da
    Quaternary structure:
    • Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex, at least composed of PIWIL1, PIWIL2 and TDRD6. Interacts with DDX4 and PIWIL1 (By similarity).
    • Sequence=AAC18034.1; Type=Frameshift; Positions=1994; Evidence={ECO:0000305}; Sequence=CAI45997.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TDRD6 Gene


neXtProt entry for TDRD6 Gene

Proteomics data for TDRD6 Gene at MOPED

Post-translational modifications for TDRD6 Gene

  • Undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis I to meiosis II in primary spermatocytes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRD6 Gene

No data available for DME Specific Peptides for TDRD6 Gene

Domains for TDRD6 Gene

Gene Families for TDRD6 Gene

Protein Domains for TDRD6 Gene


Suggested Antigen Peptide Sequences for TDRD6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 Tudor domains.
  • Contains 8 Tudor domains.
genes like me logo Genes that share domains with TDRD6: view

Function for TDRD6 Gene

Molecular function for TDRD6 Gene

UniProtKB/Swiss-Prot Function:
Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression.

Gene Ontology (GO) - Molecular Function for TDRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TDRD6: view
genes like me logo Genes that share phenotypes with TDRD6: view

Animal Models for TDRD6 Gene

MGI Knock Outs for TDRD6:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TDRD6 Gene

Localization for TDRD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRD6 Gene

Cytoplasm. Note=Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in CB with DDX4, PIWIL1, PIWIL2, TDRD1 and TDRD7 (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TDRD6 Gene COMPARTMENTS Subcellular localization image for TDRD6 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TDRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum IEA --
GO:0030529 ribonucleoprotein complex --
GO:0033391 chromatoid body ISS --
GO:0043186 P granule IEA --
genes like me logo Genes that share ontologies with TDRD6: view

Pathways for TDRD6 Gene

SuperPathways for TDRD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TDRD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007281 germ cell development IEA --
GO:0007283 spermatogenesis ISS --
GO:0010467 gene expression TAS --
GO:0034587 piRNA metabolic process TAS --
genes like me logo Genes that share ontologies with TDRD6: view

No data available for Pathways by source for TDRD6 Gene

Transcripts for TDRD6 Gene

Unigene Clusters for TDRD6 Gene

Tudor domain containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD6 Gene

No ASD Table

Relevant External Links for TDRD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TDRD6 Gene

mRNA expression in normal human tissues for TDRD6 Gene

mRNA differential expression in normal tissues according to GTEx for TDRD6 Gene

This gene is overexpressed in Testis (13.2), Brain - Cerebellum (6.1), and Brain - Cerebellar Hemisphere (4.8).

Protein differential expression in normal tissues for TDRD6 Gene

This gene is overexpressed in Ovary (37.4), Testis (22.6), and Platelet (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TDRD6 Gene

SOURCE GeneReport for Unigene cluster for TDRD6 Gene Hs.656983

genes like me logo Genes that share expressions with TDRD6: view

Expression partners for TDRD6 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TDRD6 Gene

Orthologs for TDRD6 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TDRD6 35
  • 82.92 (n)
  • 76.82 (a)
TDRD6 36
  • 77 (a)
(Canis familiaris)
Mammalia TDRD6 35
  • 85.22 (n)
  • 80.11 (a)
TDRD6 36
  • 80 (a)
(Mus musculus)
Mammalia Tdrd6 35
  • 75.68 (n)
  • 73.02 (a)
Tdrd6 16
Tdrd6 36
  • 71 (a)
(Pan troglodytes)
Mammalia TDRD6 35
  • 99.59 (n)
  • 99.38 (a)
TDRD6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tdrd6 35
  • 76.39 (n)
  • 74.16 (a)
(Monodelphis domestica)
Mammalia TDRD6 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TDRD6 36
  • 48 (a)
(Gallus gallus)
Aves TDRD6 36
  • 33 (a)
(Anolis carolinensis)
Reptilia TDRD6 36
  • 44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xtr 35
(Danio rerio)
Actinopterygii LOC100536102 35
  • 43.29 (n)
  • 30.24 (a)
tdrd6 36
  • 29 (a)
TDRD6 (2 of 2) 36
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta qin 36
  • 13 (a)
tud 36
  • 12 (a)
Species with no ortholog for TDRD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRD6 Gene

Gene Tree for TDRD6 (if available)
Gene Tree for TDRD6 (if available)

Paralogs for TDRD6 Gene

Paralogs for TDRD6 Gene

genes like me logo Genes that share paralogs with TDRD6: view

Variants for TDRD6 Gene

Sequence variations from dbSNP and Humsavar for TDRD6 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs974670 -- 46,699,606(+) GTCTA(C/T)GCTAG intron-variant
rs1024915 -- 46,696,551(+) tatat(A/G)tgtgt intron-variant
rs1024916 -- 46,696,575(+) tgtgt(A/G)tgtgt intron-variant
rs1421370 -- 46,699,077(+) GCTCA(A/G)GGGCA intron-variant
rs1421371 -- 46,703,085(+) CGCCA(C/T)CAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TDRD6 Gene

Variant ID Type Subtype PubMed ID
nsv885868 CNV Gain 21882294
nsv523148 CNV Loss 19592680

Relevant External Links for TDRD6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD6 Gene

Disorders for TDRD6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TDRD6 Gene in MalaCards »

(1) Disease for TDRD6 Gene

genes like me logo Genes that share disorders with TDRD6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TDRD6 Gene

Publications for TDRD6 Gene

  1. Characterization of human colon cancer antigens recognized by autologous antibodies. (PMID: 9610721) Scanlan M.J. … Old L.J. (Int. J. Cancer 1998) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1. (PMID: 17215373) Bensing S. … Kampe O. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3
  5. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3

Products for TDRD6 Gene

Sources for TDRD6 Gene

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