TDRD6 Gene
protein-coding GIFtS: 43
GCID: GC06P046702
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|
tudor domain containing 6
| |
Aliases
for TDRD6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tudor Domain Containing 61 2 | | Cancer/Testis Antigen 41.22 3 | | CT41.21 2 3 | | TDR22 | | NY-CO-451 2 | | Spermatogenesis Associated 362 | | SPATA361 2 | | Tudor Domain-Containing Protein 62 | | BA446F17.41 | | Tudor Repeat 22 | | Antigen NY-CO-452 3 | | |
Export aliases for TDRD6 gene to outside databasesPrevious GC identifers: GC06P046764 GC06P046378 |
Summaries
for TDRD6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TDRD6_HUMAN, O60522Function: Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression(By similarity)
|
Genomic Views
for TDRD6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TDRD6 gene promoter:
GR Sox5 Lmo2 c-Ets-1 Max FAC1 POU2F1 POU2F1a GR-alpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TDRD6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDRD6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12.3 Ensembl cytogenetic band: 6p12.3 HGNC cytogenetic band: 6p12.3TDRD6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P046702: view genomic region
(about GC identifiers)
Start:
|
46,655,612 bp from pter |
End:
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46,672,056 bp from pter |
Size:
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16,445 bases |
Orientation:
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plus strand |
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Proteins
for TDRD6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TDRD6_HUMAN, O60522 (See
protein sequence)Recommended Name: Tudor domain-containing protein 6 Size: 2096 amino acids; 236517 Da
Subunit: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex, at leastcomposed of PIWIL1, PIWIL2 and TDRD6. Interacts with DDX4 and PIWIL1 (By similarity)
Subcellular location: Cytoplasm (By similarity). Note=Present in chromatoid body (CB) of spermatids (mammaliancounterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies(P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) inpachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in CB with DDX4,PIWIL1, PIWIL2, TDRD1 and TDRD7 (By similarity)
Sequence caution: Sequence=AAC18034.1; Type=Frameshift; Positions=1994; Sequence=CAI45997.1; Type=Erroneous initiation;
Secondary accessions: B3KWU2 F5H5M3 Q5HYB1 Q5VTS4 Q6ZMX5Alternative splicing: 2 isoforms: O60522-1 O60522-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TDRD6: NX_O60522
Post-translational modifications:
Undergoes proteolytic cleavage near the C-terminal by an unknown protease during the transition from meiosis I tomeiosis II in primary spermatocytes (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60522
TDRD6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001010870.1 NP_001161831.1
ENSEMBL proteins: ENSP00000346065 ENSP00000397165 ENSP00000443299
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TDRD6 for ontologies About GeneDecksing
TDRD6 Antibody Products:
Assay Products for TDRD6: |
Protein
Domains /
Families
for TDRD6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TDRD6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60522ProtoNet protein and cluster: O60522 2 Blocks protein families: IPB002999 Tudor domain IPB008191 Maternal tudor protein
UniProtKB/Swiss-Prot: TDRD6_HUMAN, O60522Similarity: Contains 8 Tudor domains |
Function
for TDRD6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TDRD6_HUMAN, O60522Function: Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression(By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD6 |
Animal Models:
Mouse knock-outs for TDRD6: Tdrd6tm1Jess Tdrd6tm1Chum
3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tdrd6):
TDRD6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TDRD6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TDRD6
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for TDRD6 (O605223 ENSP000003460654) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007281 | germ cell development |
IEA | -- | | GO:0007283 | spermatogenesis |
ISS | -- |
TDRD6 for ontologies About GeneDecksing
|
Drugs & Compounds
for TDRD6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TDRD6
Search CenterWatch for drugs/clinical trials and news about TDRD6
|
Transcripts
for TDRD6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TDRD6 gene (2 alternative transcripts): NM_001010870.2 NM_001168359.1 Unigene Cluster for TDRD6: Tudor domain containing 6 Hs.656983 [show with all ESTs]Unigene Representative Sequence: NM_0010108703 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316081 ENST00000450697 ENST00000544460(uc003oyj.3 uc010jze.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD6 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TDRD6 (NM_001010870) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TDRD6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD6 |
Additional cDNA sequence: AF039442.1 AK125838.1 AK131455.1 BX648686.1 CR936792.1 EF185284.1 4 DOTS entries: DT.109680 DT.100718312 DT.103732 DT.97769279 24 AceView cDNA sequences: AI695269 BX648686 AL044109 CD244147 AK131455 AA401219 AK125838 AL043594 AL043170 AL044110 AF039442 AA404231 AL040037 CD108053 AL043169 AL705423 BG186209 BG210710 CD557142 BG184238 AL040021 BG183719 BG182170 BG190601
GeneLoc Exon Structure
|
Expression
for TDRD6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TDRD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCAGATTG
About this image
See TDRD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TDRD6
SOURCE GeneReport for Unigene cluster: Hs.656983
SABiosciences Custom PCR Arrays for TDRD6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDRD6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TDRD6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDRD6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDRD6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD6 |
Orthologs
for TDRD6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TDRD6 gene from 4/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TDRD66 |
Uncharacterized protein |
43(a) |
1 ↔ 1 |
3(112644647-112647067) |
lizard
(Anolis carolinensis) |
Reptilia |
TDRD66 |
-- |
41(a) |
1 ↔ 1 |
1(138580940-138585978) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xtr2 |
tudor protein |
72.99(n) |
|
AB066588.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC1005350411 |
tudor domain-containing protein 6-like |
48.29(n)
37.29(a) |
|
100535041 XM_003200730.1 XP_003200778.1 |
ENSEMBL Gene Tree for TDRD6 (if available)
TreeFam Gene Tree for TDRD6 (if available) |
Paralogs
for TDRD6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TDRD6 gene
- TDRD12 TDRD152 RNF172
TDRD6 for paralogs About GeneDecksing
|
Genomic Variants
for TDRD6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TDRD6 (46655612 - 46672056 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TDRD6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDRD6 |
|
Disorders
/ Diseases
for TDRD6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TDRD6 for disorders About GeneDecksing
OMIM gene information: 611200
OMIM disorders: --
4  diseases for TDRD6: About MalaCardssertoli cell-only syndrome autoimmune polyendocrine syndrome type 1 autoimmune polyendocrine syndrome colon cancer
Export disorders for TDRD6 gene to outside databases
|
Publications
for TDRD6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TDRD6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TDRD6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of human colon cancer antigens recognized by autologous antibodies. (PubMed id 9610721)1, 2, 3 Scanlan M.J....Old L.J. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
- Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1. (PubMed id 17215373)1 Bensing S.... Kampe O. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for TDRD6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TDRD6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TDRD6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TDRD6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TDRD6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TDRD6 gene:
Search GeneIP for patents involving TDRD6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TDRD6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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 | | | TDRD6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD6 |
|  |  |  | | | | Search ThermoFisher Antibodies for TDRD6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD6 |
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