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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TDRD5 Gene

protein-coding GIFtS: 44
GCID: GC01P179560

tudor domain containing 5

Explore 2 diseases affiliated with
TDRD5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tudor Domain Containing 5¹ ²
TUDOR3¹ ²
FLJ34823¹
RP11-427G13.1²
Tudor Domain-Containing Protein 5²

External Ids:	HGNC: 20614¹	Entrez Gene: 163589²	Ensembl: ENSG00000162782⁷	UniProtKB: Q8NAT2³

Export aliases for TDRD5 gene to outside databases

Previous GC identifers: GC01P174993 GC01P176085 GC01P176814 GC01P176800 GC01P176292 GC01P177827 GC01P150787

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TDRD5_HUMAN, Q8NAT2

Function: Required during spermiogenesis to participate in the repression transposable elements and prevent their

mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which

mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi

proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB)

assembly (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TDRD5 gene promoter:
MAZR POU6F1 (c2) AP-2gamma HNF-1A Egr-2 Ik-2 HNF-1 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TDRD5 promoter sequence

Search SABiosciences Chromatin IP Primers for TDRD5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDRD5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2 Ensembl cytogenetic band: 1q25.2 HGNC cytogenetic band: 1q24.2

TDRD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDRD5 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P179560: view genomic region (about GC identifiers)

Start:	179,560,748 bp from pter	End:	179,660,407 bp from pter
Size:	99,660 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TDRD5_HUMAN, Q8NAT2 (See protein sequence)

Recommended Name: Tudor domain-containing protein 5

Size: 981 amino acids; 109737 Da

Subcellular location: Cytoplasm (By similarity). Note=Localizes to chromatoid body (CB) and pi-body (also called

intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis

(By similarity)

Sequence caution: Sequence=BAC03815.1; Type=Frameshift; Positions=819;

1 PDB 3D structure from and Proteopedia for TDRD5:

3S93 (3D)

Secondary accessions: A1L4G5 B7ZLV0 Q5EBN4 Q5VTV0 Q6ZSK2

Alternative splicing: 2 isoforms: Q8NAT2-3 Q8NAT2-1

Explore the universe of human proteins at neXtProt for TDRD5: NX_Q8NAT2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NAT2

TDRD5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001186014.1 NP_001186018.1 NP_001186020.1 NP_001186021.1 NP_775804.2

ENSEMBL proteins:

ENSP00000356586 ENSP00000294848 ENSP00000410744 ENSP00000406052

Human Recombinant Protein Products:

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	Novus Biologicals TDRD5 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TDRD5

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0033391	chromatoid body	ISS	--
GO:0071546	pi-body	ISS	--

TDRD5 for ontologies About GeneDecksing

TDRD5 Antibody Products:

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	Novus Biologicals TDRD5 Antibodies
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	Uscn Antibodies for TDRD5
	Search ThermoFisher Antibodies for TDRD5

Assay Products for TDRD5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TDRD5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TDRD5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TDRD5 for domains About GeneDecksing

2 InterPro domains/families:

IPR025605 OST-HTH/LOTUS_dom

IPR002999 Tudor

Graphical View of Domain Structure for InterPro Entry Q8NAT2

ProtoNet protein and cluster: Q8NAT2

1 Blocks protein family: IPB008191 Maternal tudor protein

UniProtKB/Swiss-Prot: TDRD5_HUMAN, Q8NAT2

Similarity: Belongs to the TDRD5 family

Similarity: Contains 3 HTH OST-type domains

Similarity: Contains 1 Tudor domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TDRD5_HUMAN, Q8NAT2

Function: Required during spermiogenesis to participate in the repression transposable elements and prevent their

mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which

mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi

proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB)

assembly (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: TDRD5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDRD5
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TDRD5:
		hsa-miR-374a* hsa-miR-433
		SwitchGear 3'UTR luciferase reporter plasmid: TDRD5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDRD5 (see all 7) OriGene shRNA RFP: TDRD5 OriGene siRNA: TDRD5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDRD5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TDRD5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD5 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): TDRD5 (NM_001199092)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDRD5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TDRD5
		Search LifeMap BioReagents cell lines for TDRD5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD5

Animal Models:
Mouse knock-out Tdrd5^tm1Sait for TDRD5
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tdrd5):

cellular

endocrine/exocrine gland

reproductive system

TDRD5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TDRD5

1 Interacting protein for TDRD5 (Q8NAT2³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBR7	Q8N806³	I2D: score=2

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007286	spermatid development	ISS	--
GO:0030719	P granule organization	ISS	--
GO:0043046	DNA methylation involved in gamete generation	ISS	--

TDRD5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TDRD5
Search CenterWatch for drugs/clinical trials and news about TDRD5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TDRD5 gene (5 alternative transcripts):

NM_001199085.1 NM_001199089.1 NM_001199091.1 NM_001199092.1 NM_173533.3

Unigene Cluster for TDRD5:

Tudor domain containing 5

Hs.197354 [show with all ESTs]

Unigene Representative Sequence: NM_001199085

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367614(uc021pfm.1) ENST00000294848(uc001gnf.2 uc001gnh.2)

ENST00000417329 ENST00000444136(uc010pnp.2 uc021pfn.1)

miRNA Products:		OriGene 3'-UTR Clone: TDRD5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDRD5
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate TDRD5:
		hsa-miR-374a* hsa-miR-433
		SwitchGear 3'UTR luciferase reporter plasmid: TDRD5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDRD5 (see all 7) OriGene shRNA RFP: TDRD5 OriGene siRNA: TDRD5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDRD5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD5 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD5 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 5): TDRD5 (NM_001199092)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDRD5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDRD5 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDRD5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDRD5

Additional cDNA sequence:

AK092142.1 AK126889.1 AK127370.1 BC043368.1 BC065707.1 BC089387.1 BC130532.1 BC144058.1

7 DOTS entries:

DT.40297531 DT.121345022 DT.95232844 DT.99978871 DT.121345030 DT.121345031 DT.91683930

24/26 AceView cDNA sequences (see all 26):

AW452292 BE674279 AI630765 BE217803 AK127370 BC043368 BE673670 NM_173533

AX747378 BI520089 BX112064 AK126889 AW589750 BG055328 AI702961 BC065707

CD557653 AK092142 BU852780 AW341780 AA931671 CD706642 BF335791 BF512009

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TDRD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGATAAAT

About this image

TDRD5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Podocyte Layer

Presumptive Podocytes

Kidney

Kidney

Ovary

Ovary

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Kidney

Kidney

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Primordial germ cell-like cells (Reconstitution of mo...)

Epiblast-like cells (Reconstitution of mo...)

See TDRD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TDRD5

SOURCE GeneReport for Unigene cluster: Hs.197354

SABiosciences Custom PCR Arrays for TDRD5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDRD5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat TDRD5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDRD5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDRD5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TDRD5 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TDRD5¹	tudor domain containing 5	53.6(n) 43.19(a)		424421 XM_422264.3 XP_422264.2
lizard (Anolis carolinensis)	Reptilia	TDRD5⁶	--	49(a)	1 ↔ 1	4(70978455-71007156)
zebrafish (Danio rerio)	Actinopterygii	tdrd5¹	tudor domain containing 5	46.39(n) 36.52(a)		557999 NM_001044850.1 NP_001038315.1
honey bee (Apis mellifera)	Insecta	--	--	17(a)	possible ortholog	GroupUn.2273(1500-7289)

ENSEMBL Gene Tree for TDRD5 (if available)
TreeFam Gene Tree for TDRD5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TDRD5 gene

TDRD7² TDRKH²

TDRD5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145798073^1,2	C,	other	179604984(+)	`AGGGAT/CTCGTC`	10	/D	syn¹		1		NA	4550
rs141675295^1,2		--	179558962(+)	`TGATCA/GCCACA`	3	--	us2k¹		0	--	--	--	--
rs117954289^1,2	F,	--	179559166(+)	`ATAAAT/GAAGAA`	4	--	us2k¹		1		EA	120
rs12405014^1,2	H	--	179559322(+)	`TCTCAG/AGCCCT`	4	--	us2k¹		4		NS EA	386
rs4652417^1,2	C,F,A,H,	--	179559456(+)	`CACCTC/TTCTTA`	4	--	us2k¹		21		NA NS EA WA CSA	1549
rs138582336^1,2		--	179559508(+)	`AGTTGA/GGATAA`	4	--	us2k¹		0	--	--	--	--
rs10753199^1,2	C,F,A,H,	--	179559632(+)	`CTTGTC/TAAAAT`	4	--	us2k¹		27		NS EA NA WA	2774
rs114862051^1,2	F,	--	179559802(+)	`CCTTAC/TGAAGG`	4	--	us2k¹		1		WA	118
rs73035949^1,2	C,F,	--	179559856(+)	`CAGACG/AACCTT`	4	--	us2k¹		3		WA CSA	122
rs138391621^1,2	C,	--	179559967(+)	`AACAT-/AGTC AGCCA`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TDRD5 (179560748 - 179660407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for TDRD5
4 CNVs: 97567 84682 34739 84683
12 Indels: 44473 74798 74795 74794 43187 97568 84685 65316 84684 74797 74796 84686

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDRD5

DNA2.0 Custom Variant and Variant Library Synthesis for TDRD5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TDRD5 for disorders About GeneDecksing

2 diseases for TDRD5: About MalaCards

essential hypertension hypertension

Human Genome Epidemiology (HuGE) Navigator: TDRD5 (3 documents)

Export disorders for TDRD5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TDRD5 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TDRD5)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
OST-HTH: a novel predicted RNA-binding domain. (PubMed id 20302647)² Anantharaman V.... Aravind L. (2010)
LOTUS, a new domain associated with small RNA pathways in the germline. (PubMed id 20305267)² Callebaut I. and Mornon J.P. (2010)
Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)¹ Ehret G.B....Chakravarti A. (2009)
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)¹ Uhl G.R....Lerman C. (2008)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)¹ Olsen J.V....Mann M. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 163589	HGNC: 20614	AceView: TDRD5	Ensembl:ENSG00000162782	euGenes: HUgn163589
ECgene: TDRD5	H-InvDB: TDRD5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TDRD5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TDRD5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TDRD5 gene:
Search GeneIP for patents involving TDRD5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TDRD5
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	Regulatory tfbs in TDRD5 promoter
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TDRD5 gene at Home site.

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TDRD5 Gene

tudor domain containing 5

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TDRD5 Gene

tudor domain containing 5

Aliasesfor TDRD5 gene

Summariesfor TDRD5 gene

Genomic Viewsfor TDRD5 gene

Proteinsfor TDRD5 gene

Protein Domains /Familiesfor TDRD5 gene

Functionfor TDRD5 gene

Pathways & Interactionsfor TDRD5 gene

Drugs & Compoundsfor TDRD5 gene

Transcriptsfor TDRD5 gene

Expression for TDRD5 gene

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Genomic Variantsfor TDRD5 gene

Disorders / Diseasesfor TDRD5 gene

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Genome Databases showing TDRD5 gene

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for TDRD5 gene

Genomic Views
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for TDRD5 gene

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for TDRD5 gene

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Expression
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Orthologs
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Genomic Variants
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Disorders / Diseases
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for TDRD5 gene

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for TDRD5 gene