Aliases for TDRD3 Gene
External Ids for TDRD3 Gene
- HGNC: 20612
- Entrez Gene: 81550
- Ensembl: ENSG00000083544
- OMIM: 614392
- UniProtKB: Q9H7E2
Previous GeneCards Identifiers for TDRD3 Gene
- GC13P054966
- GC13P059907
- GC13P058768
- GC13P058769
- GC13P059868
- GC13P060970
- GC13P041662
Summaries for TDRD3 Gene
GeneCards Summary for TDRD3 Gene
TDRD3 (Tudor Domain Containing 3) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is RMI1.
UniProtKB/Swiss-Prot for TDRD3 Gene
-
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD3 Gene
Genomics for TDRD3 Gene
GeneHancer (GH) Regulatory Elements for TDRD3 Gene
Promoters and enhancers for TDRD3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH13I060395 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 583.6 | +1.2 | 1245 | 4.2 | PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF213 | TDRD3 DIAPH3 GC13M060411 | |
| GH13I060409 | Promoter/Enhancer | 1 | EPDnew ENCODE | 583.4 | +13.6 | 13570 | 1.1 | SOX13 ZNF766 IKZF1 ZNF133 CEBPG HNF4A | TDRD3 GC13M060411 | |
| GH13I060161 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE | 13.2 | -232.6 | -232583 | 5 | PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 | DIAPH3 LOC105370227 TDRD3 GC13M060165 DIAPH3-AS2 | |
| GH13I060582 | Enhancer | 1 | Ensembl ENCODE | 24.1 | +188.2 | 188169 | 3.8 | PKNOX1 TAF9B SIN3A ZBTB40 ETS1 ZNF766 CAVIN1 ZBTB11 HDAC8 ZNF592 | TDRD3 RNA5SP31 GC13P060445 | |
| GH13I060426 | Enhancer | 0.5 | ENCODE | 32.8 | +31.1 | 31060 | 1.3 | SMAD1 IKZF1 NBN IKZF2 RUNX3 RELA | TDRD3 GC13M060411 GC13P060445 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TDRD3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for TDRD3 Gene
Genomic Locations for TDRD3 Gene
- chr13:60,396,457-60,573,879
- (GRCh38/hg38)
- Size:
- 177,423 bases
- Orientation:
- Plus strand
- chr13:60,970,591-61,148,013
- (GRCh37/hg19)
Genomic View for TDRD3 Gene
Genes around TDRD3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q21.2 by Ensembl
- 13q21.2 by Entrez Gene
- 13q21.2 by HGNC
TDRD3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TDRD3 Gene
Proteins for TDRD3 Gene
-
Protein details for TDRD3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H7E2-TDRD3_HUMAN
- Recommended name:
- Tudor domain-containing protein 3
- Protein Accession:
- Q9H7E2
- B2MWP9
- Q53XA6
- Q6P992
Protein attributes for TDRD3 Gene
- Size:
- 651 amino acids
- Molecular mass:
- 73185 Da
- Quaternary structure:
-
- Component of mRNA stress granules. Interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 and DDX3X or DDX3Y, and with the small nuclear ribonucleoprotein-associated proteins SNRPB and SNRPN. Interacts with Lys-48-linked tetra-ubiquitin, but not with monoubiquitin or Lys-63-linked ubiquitin chains. May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A. Interacts with POLR2A (via the C-terminal domain (CTD)).
Three dimensional structures from OCA and Proteopedia for TDRD3 Gene
Protein Expression for TDRD3 Gene
Post-translational modifications for TDRD3 Gene
No Post-translational modifications
Other Protein References for TDRD3 Gene
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-
Abcam antibodies for TDRD3
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-
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- antibodies-online: Search results for 3 available TDRD3 Proteins ranked by validation data
- Compare Top TDRD3 Proteins
-
Quality Products:
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Assay Products
No data available for DME Specific Peptides for TDRD3 Gene
Domains & Families for TDRD3 Gene
Gene Families for TDRD3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TDRD3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TDRD3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H7E2UniProtKB/Swiss-Prot:
TDRD3_HUMAN :- The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 Arg-17 (H3R17me2a) and histones H4 Arg-3, 2 tags for epigenetic transcriptional activation.
- Domain:
-
- The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 Arg-17 (H3R17me2a) and histones H4 Arg-3, 2 tags for epigenetic transcriptional activation.
Function for TDRD3 Gene
Molecular function for TDRD3 Gene
- UniProtKB/Swiss-Prot Function:
- Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Phenotypes From GWAS Catalog for TDRD3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA | 21172665 |
| GO:0003713 | transcription coactivator activity | IDA | 21172665 |
| GO:0003723 | RNA binding | HDA,IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 26700805 |
| GO:0035064 | methylated histone binding | IDA | 21172665 |
Phenotypes for TDRD3 Gene
- MGI mutant phenotypes for TDRD3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TDRD3:
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-
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-
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miRNA for TDRD3 Gene
- miRTarBase miRNAs that target TDRD3
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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ViGene Biosciences adenoviral particle packaged cDNA for TDRD3 gene
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TDRD3 Gene
Localization for TDRD3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TDRD3 Gene
- Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules. {ECO:0000269 PubMed:18632687, ECO:0000269 PubMed:18664458}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| cytoskeleton | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Golgi apparatus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 21172665 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for TDRD3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chromatin Regulation / Acetylation | ||
| 2 | Translational Control | ||
Pathways by source for TDRD3 Gene
2 Cell Signaling Technology pathways for TDRD3 Gene
Interacting Proteins for TDRD3 Gene
Selected Interacting proteins:
ENSP00000440190
Q9H7E2-TDRD3_HUMAN
for TDRD3 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016569 | covalent chromatin modification | IEA | -- |
| GO:1903506 | regulation of nucleic acid-templated transcription | IEA | -- |
No data available for SIGNOR curated interactions for TDRD3 Gene
Transcripts for TDRD3 Gene
mRNA/cDNA for TDRD3 Gene
- (8) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (250) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TDRD3 Gene
- Tudor domain containing 3:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TDRD3
- genomics-online: gRNA clones - Search results for 121 available TDRD3 gene related products
- Overview of 121 available TDRD3 gene related products
- Applied Biological Materials CRISPR for TDRD3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TDRD3
- GenScript: Design CRISPR guide RNA sequences for TDRD3
miRNA Products
- Search ViGene Biosciences for TDRD3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TDRD3
- Browse OriGene Inhibitory RNA Products For TDRD3
- genomics-online: shRNA clones - Search results for 121 available TDRD3 gene related products
- Overview of 121 available TDRD3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TDRD3 gene
Clone Products
-
OriGene ORF clones in human for TDRD3
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TDRD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TDRD3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TDRD3
- Applied Biological Materials Clones for TDRD3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
Expression for TDRD3 Gene
This gene is overexpressed in Fetal gut (28.0) and Fetal Liver (27.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TDRD3 Gene
NURSA nuclear receptor signaling pathways regulating expression of TDRD3 Gene:
TDRD3SOURCE GeneReport for Unigene cluster for TDRD3 Gene:
Hs.525061mRNA Expression by UniProt/SwissProt for TDRD3 Gene:
Q9H7E2-TDRD3_HUMAN
Tissue specificity:
Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Primer Products
-
OriGene qPCR primer pairs for TDRD3
-
OriGene qPCR primer pairs and template standards for TDRD3
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TDRD3 Gene
Orthologs for TDRD3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TDRD3 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TDRD3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TDRD3 33 |
|
||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Tdrd3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tdrd3 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TDRD3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TDRD3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TDRD3 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | TDRD3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tdrd3 33 |
|
||
| MGC76148 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8087 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tdrd3 33 34 |
|
||
| Dr.16828 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG13472 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | Y50D4C.3 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3026 34 |
|
OneToOne |
- Species where no ortholog for TDRD3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TDRD3 Gene
Variants for TDRD3 Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013214 | -- | 60,414,576(+) | T/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000038966 | -- | 60,569,628(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000069730 | -- | 60,510,902(+) | G/C/T | intron_variant | |
| rs1000127480 | -- | 60,516,269(+) | T/G | intron_variant | |
| rs1000135090 | -- | 60,504,832(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3184n54 | CNV | loss | 21841781 |
| esv29450 | CNV | gain | 19812545 |
| esv3331016 | CNV | insertion | 20981092 |
| esv3580686 | CNV | loss | 25503493 |
| esv3580687 | CNV | loss | 25503493 |
| nsv1070590 | CNV | deletion | 25765185 |
| nsv1144680 | CNV | deletion | 24896259 |
| nsv455903 | CNV | loss | 19166990 |
| nsv523359 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.15;
75.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TDRD3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TDRD3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD3 Gene
Disorders for TDRD3 Gene
Additional Disease Information for TDRD3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TDRD3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRD3 Gene
Publications for TDRD3 Gene
- SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. (PMID: 26700805) Zhao DY … Greenblatt JF (Nature 2016) 3 4 58
- Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 44 58
- TDRD3 is an effector molecule for arginine-methylated histone marks. (PMID: 21172665) Yang Y … Bedford MT (Molecular cell 2010) 3 4 58
- SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. (PMID: 20930030) Kashima I … Izaurralde E (Genes & development 2010) 3 4 58
- Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. (PMID: 18664458) Linder B … Fischer U (Human molecular genetics 2008) 3 4 58
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for TDRD3
- VectorBuilder custom plasmid, inducible vectors for TDRD3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TDRD3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TDRD3
- antibodies-online: Search results for 16 available TDRD3 Antibodies ranked by validation data
- Compare Top TDRD3 Antibodies
- antibodies-online: Search results for available TDRD3 related products ranked by validation data
- antibodies-online: Search results for 3 available TDRD3 Proteins ranked by validation data
- Compare Top TDRD3 Proteins
- Quality Products:
- Search GeneTex for Antibodies for TDRD3
- Search GeneTex for Proteins for TDRD3
- ViGene Biosciences adenoviral particle packaged cDNA for TDRD3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TDRD3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TDRD3 gene
- Search ViGene Biosciences for TDRD3
- Horizon Cell Lines for TDRD3
- genomics-online: cdna clones - Search results for 121 available TDRD3 gene related products
- Overview of 121 available TDRD3 gene related products
- orf clones - Search results for 121 available TDRD3 gene related products
- Overview of 121 available TDRD3 gene related products
- genomics-online: gRNA clones - Search results for 121 available TDRD3 gene related products
- Overview of 121 available TDRD3 gene related products
- genomics-online: primer clones - Search results for 121 available TDRD3 gene related products
- Overview of 121 available TDRD3 gene related products
- genomics-online: shRNA clones - Search results for 121 available TDRD3 gene related products
- Overview of 121 available TDRD3 gene related products
Sources for TDRD3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew