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Aliases for TDRD3 Gene

Aliases for TDRD3 Gene

  • Tudor Domain Containing 3 2 3

External Ids for TDRD3 Gene

Previous GeneCards Identifiers for TDRD3 Gene

  • GC13P054966
  • GC13P059907
  • GC13P058768
  • GC13P058769
  • GC13P059868
  • GC13P060970
  • GC13P041662

Summaries for TDRD3 Gene

GeneCards Summary for TDRD3 Gene

TDRD3 (Tudor Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and methylated histone binding. An important paralog of this gene is RMI1.

UniProtKB/Swiss-Prot for TDRD3 Gene

  • Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

Gene Wiki entry for TDRD3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD3 Gene

Genomics for TDRD3 Gene

Regulatory Elements for TDRD3 Gene

Genomic Location for TDRD3 Gene

Start:
60,396,457 bp from pter
End:
60,573,879 bp from pter
Size:
177,423 bases
Orientation:
Plus strand

Genomic View for TDRD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD3 Gene

Proteins for TDRD3 Gene

  • Protein details for TDRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7E2-TDRD3_HUMAN
    Recommended name:
    Tudor domain-containing protein 3
    Protein Accession:
    Q9H7E2
    Secondary Accessions:
    • B2MWP9
    • Q53XA6
    • Q6P992

    Protein attributes for TDRD3 Gene

    Size:
    651 amino acids
    Molecular mass:
    73185 Da
    Quaternary structure:
    • Component of mRNA stress granules. Interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 and DDX3X or DDX3Y, and with the small nuclear ribonucleoprotein-associated proteins SNRPB and SNRPN. Interacts with Lys-48-linked tetra-ubiquitin, but not with monoubiquitin or Lys-63-linked ubiquitin chains. May interact with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A.

    Three dimensional structures from OCA and Proteopedia for TDRD3 Gene

    Alternative splice isoforms for TDRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRD3 Gene

Proteomics data for TDRD3 Gene at MOPED

Post-translational modifications for TDRD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TDRD3 Gene

Domains for TDRD3 Gene

Gene Families for TDRD3 Gene

HGNC:
  • TDRD :Tudor domain containing

Protein Domains for TDRD3 Gene

Suggested Antigen Peptide Sequences for TDRD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7E2

UniProtKB/Swiss-Prot:

TDRD3_HUMAN :
  • Q9H7E2
Domain:
  • The Tudor domain specifically recognizes and binds asymmetric dimethylation of histone H3 Arg-17 (H3R17me2a) and histones H4 Arg-3, 2 tags for epigenetic transcriptional activation.
  • Contains 1 Tudor domain.
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with TDRD3: view

Function for TDRD3 Gene

Molecular function for TDRD3 Gene

UniProtKB/Swiss-Prot Function: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.

Gene Ontology (GO) - Molecular Function for TDRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 21172665
GO:0003713 transcription coactivator activity IDA 21172665
GO:0003723 RNA binding --
GO:0005515 protein binding --
GO:0035064 methylated histone binding IDA 21172665
genes like me logo Genes that share ontologies with TDRD3: view
genes like me logo Genes that share phenotypes with TDRD3: view

miRNA for TDRD3 Gene

miRTarBase miRNAs that target TDRD3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TDRD3 Gene

Localization for TDRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRD3 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TDRD3 Gene COMPARTMENTS Subcellular localization image for TDRD3 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TDRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21172665
GO:0005737 cytoplasm IEA --
GO:0035145 colocalizes_with exon-exon junction complex IDA 20930030
genes like me logo Genes that share ontologies with TDRD3: view

Pathways for TDRD3 Gene

SuperPathways for TDRD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TDRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing --
GO:0016568 chromatin modification IEA --
GO:1903506 regulation of nucleic acid-templated transcription IDA 21172665
GO:2001141 regulation of RNA biosynthetic process --
genes like me logo Genes that share ontologies with TDRD3: view

No data available for Pathways by source for TDRD3 Gene

Transcripts for TDRD3 Gene

Unigene Clusters for TDRD3 Gene

Tudor domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5:
SP6:
SP7:
SP8: -

Relevant External Links for TDRD3 Gene

GeneLoc Exon Structure for
TDRD3
ECgene alternative splicing isoforms for
TDRD3

Expression for TDRD3 Gene

mRNA expression in normal human tissues for TDRD3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TDRD3 Gene

SOURCE GeneReport for Unigene cluster for TDRD3 Gene Hs.525061

mRNA Expression by UniProt/SwissProt for TDRD3 Gene

Q9H7E2-TDRD3_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with TDRD3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TDRD3 Gene

Orthologs for TDRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRD3 35
  • 99.6 (n)
  • 99.33 (a)
TDRD3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TDRD3 35
  • 91.51 (n)
  • 91.27 (a)
TDRD3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
TDRD3 35
  • 91.22 (n)
  • 91.36 (a)
mouse
(Mus musculus)
Mammalia Tdrd3 35
  • 85.6 (n)
  • 85.06 (a)
Tdrd3 16
Tdrd3 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRD3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRD3 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tdrd3 35
  • 86.53 (n)
  • 86.18 (a)
chicken
(Gallus gallus)
Aves TDRD3 35
  • 77 (n)
  • 76.59 (a)
TDRD3 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRD3 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8087 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76148 35
tdrd3 35
  • 68.59 (n)
  • 64.53 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.16828 35
tdrd3 35
  • 57.79 (n)
  • 55.24 (a)
tdrd3 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13472 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y50D4C.3 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3026 36
  • 37 (a)
OneToOne
Species with no ortholog for TDRD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TDRD3 Gene

ENSEMBL:
Gene Tree for TDRD3 (if available)
TreeFam:
Gene Tree for TDRD3 (if available)

Paralogs for TDRD3 Gene

Paralogs for TDRD3 Gene

genes like me logo Genes that share paralogs with TDRD3: view

Variants for TDRD3 Gene

Sequence variations from dbSNP and Humsavar for TDRD3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs951058 -- 60,401,154(-) AACCT(C/T)AAAAA intron-variant
rs952805 -- 60,405,371(+) AACAT(A/G)CTGCA intron-variant
rs1033854 -- 60,573,986(-) TTGTA(A/G)GGGGA downstream-variant-500B
rs1341840 -- 60,411,058(+) GCAAA(A/G)TGGCC intron-variant
rs1341841 -- 60,411,174(+) TAGCT(A/G)TGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TDRD3 Gene

Variant ID Type Subtype PubMed ID
nsv455903 CNV Loss 19166990
nsv523359 CNV Loss 19592680
esv29450 CNV Gain 19812545

Relevant External Links for TDRD3 Gene

HapMap Linkage Disequilibrium report
TDRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD3 Gene

Disorders for TDRD3 Gene

(1) University of Copenhagen DISEASES for TDRD3 Gene

Relevant External Links for TDRD3

Genetic Association Database (GAD)
TDRD3
genes like me logo Genes that share disorders with TDRD3: view

No data available for UniProtKB/Swiss-Prot for TDRD3 Gene

Publications for TDRD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L. … Lunetta K.L. (Nat. Genet. 2012) 3 48
  4. TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PMID: 18632687) Goulet I. … Cote J. (Hum. Mol. Genet. 2008) 3 4
  5. Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. (PMID: 18664458) Linder B. … Fischer U. (Hum. Mol. Genet. 2008) 3 4

Products for TDRD3 Gene

Sources for TDRD3 Gene

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