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Aliases for TDRD15 Gene

Aliases for TDRD15 Gene

  • Tudor Domain Containing 15 2 3 5

External Ids for TDRD15 Gene

Previous GeneCards Identifiers for TDRD15 Gene

  • GC02P021348

Summaries for TDRD15 Gene

GeneCards Summary for TDRD15 Gene

TDRD15 (Tudor Domain Containing 15) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity, acting on ester bonds. An important paralog of this gene is TDRD6.

Additional gene information for TDRD15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD15 Gene

Genomics for TDRD15 Gene

Regulatory Elements for TDRD15 Gene

Enhancers for TDRD15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H021095 0.9 ENCODE 0.4 -9.0 -9011 4 FOXA2 MLX ZSCAN9 RAD21 YY1 CREM MIXL1 SP5 CEBPB MXD4 APOB TDRD15 GC02M021043
GH02H021069 1 ENCODE 0.3 -36.0 -35982 2 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 FOS ZHX2 APOB GC02M021043 TDRD15
GH02H021102 0.3 FANTOM5 0.7 -4.2 -4189 0 APOB TDRD15 GC02M021043
GH02H021046 0.9 ENCODE 0.2 -59.4 -59401 2 ELF3 FOXA2 MLX ZSCAN4 ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 APOB GC02M021043 TDRD15
GH02H021067 0.5 ENCODE 0.3 -38.4 -38400 0 SAP130 KDM1A ZSCAN9 APOB GC02M021043 TDRD15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TDRD15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TDRD15 Gene

Chromosome:
2
Start:
21,106,652 bp from pter
End:
21,147,393 bp from pter
Size:
40,742 bases
Orientation:
Plus strand

Genomic View for TDRD15 Gene

Genes around TDRD15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRD15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD15 Gene

Proteins for TDRD15 Gene

  • Protein details for TDRD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B5MCY1-TDR15_HUMAN
    Recommended name:
    Tudor domain-containing protein 15
    Protein Accession:
    B5MCY1

    Protein attributes for TDRD15 Gene

    Size:
    1934 amino acids
    Molecular mass:
    221722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TDRD15 Gene

Post-translational modifications for TDRD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRD15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TDRD15 Gene

Domains & Families for TDRD15 Gene

Gene Families for TDRD15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TDRD15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TDRD15: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TDRD15 Gene

Function for TDRD15 Gene

Phenotypes From GWAS Catalog for TDRD15 Gene

Phenotypes for TDRD15 Gene

GenomeRNAi human phenotypes for TDRD15:
genes like me logo Genes that share phenotypes with TDRD15: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TDRD15 Gene

Localization for TDRD15 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TDRD15 Gene

Pathways & Interactions for TDRD15 Gene

SuperPathways for TDRD15 Gene

No Data Available

Interacting Proteins for TDRD15 Gene

Gene Ontology (GO) - Biological Process for TDRD15 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TDRD15 Gene

Drugs & Compounds for TDRD15 Gene

No Compound Related Data Available

Transcripts for TDRD15 Gene

mRNA/cDNA for TDRD15 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD15 Gene

No ASD Table

Relevant External Links for TDRD15 Gene

GeneLoc Exon Structure for
TDRD15
ECgene alternative splicing isoforms for
TDRD15

Expression for TDRD15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TDRD15 Gene

mRNA differential expression in normal tissues according to GTEx for TDRD15 Gene

This gene is overexpressed in Testis (x33.2) and Liver (x11.8).

Protein differential expression in normal tissues from HIPED for TDRD15 Gene

This gene is overexpressed in Amniocyte (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TDRD15 Gene



NURSA nuclear receptor signaling pathways regulating expression of TDRD15 Gene:

TDRD15

Evidence on tissue expression from TISSUES for TDRD15 Gene

  • Blood(2.1)
genes like me logo Genes that share expression patterns with TDRD15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TDRD15 Gene

Orthologs for TDRD15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRD15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRD15 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TDRD15 34
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRD15 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRD15 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TDRD15 34
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRD15 34
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TDRD15 34
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta qin 34
  • 14 (a)
ManyToMany
tud 34
  • 12 (a)
ManyToMany
Species where no ortholog for TDRD15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRD15 Gene

ENSEMBL:
Gene Tree for TDRD15 (if available)
TreeFam:
Gene Tree for TDRD15 (if available)

Paralogs for TDRD15 Gene

Paralogs for TDRD15 Gene

Pseudogenes.org Pseudogenes for TDRD15 Gene

genes like me logo Genes that share paralogs with TDRD15: view

Variants for TDRD15 Gene

Sequence variations from dbSNP and Humsavar for TDRD15 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000178960 -- 21,127,435(+) ATACA(G/T)TTAGT intron-variant
rs1000509049 -- 21,130,373(+) CCCTG(A/G)CTTAC intron-variant
rs1000600682 -- 21,135,385(+) AGGAT(A/G)GGTTA intron-variant
rs1000871815 -- 21,145,654(+) ACGGA(-/T)TAGTA intron-variant
rs1001034727 -- 21,135,571(+) CAGAA(A/G)CTATT intron-variant

Variation tolerance for TDRD15 Gene

Gene Damage Index Score: 4.49; 64.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TDRD15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TDRD15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TDRD15 Gene

Disorders for TDRD15 Gene

Relevant External Links for TDRD15

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TDRD15

No disorders were found for TDRD15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRD15 Gene

Publications for TDRD15 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60
  3. LDL-cholesterol concentrations: a genome-wide association study. (PMID: 18262040) Sandhu MS … Mooser V (Lancet (London, England) 2008) 3 60
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 60

Products for TDRD15 Gene

Sources for TDRD15 Gene

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