TDRD12 Gene
protein-coding GIFtS: 41
GCID: GC19P033210
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tudor domain containing 12
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Aliases
for TDRD12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tudor Domain Containing 121 2 | | ECAT81 2 3 | | ES Cell-Associated Transcript 8 Protein2 3 | | FLJ130721 | | ES Cell Associated Transcript 82 | | Tudor Domain-Containing Protein 122 |
Export aliases for TDRD12 gene to outside databasesPrevious GC identifers: GC19P037903 GC19P029713 |
Summaries
for TDRD12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TDRD12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TDRD12 gene promoter:
HOXA9 HOXA9B NRSF form 1 STAT5A NRSF form 2 Evi-1 TFIID Meis-1a Pax-4a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TDRD12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDRD12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.11TDRD12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P033210: view genomic region
(about GC identifiers)
Start:
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33,210,659 bp from pter |
End:
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33,320,483 bp from pter |
Size:
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109,825 bases |
Orientation:
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plus strand |
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Proteins
for TDRD12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TDR12_HUMAN, Q587J7 (See
protein sequence)Recommended Name: Tudor domain-containing protein 12 Size: 1177 amino acids; 132578 Da
Sequence caution: Sequence=BAD95490.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Alternative splicing: 2 isoforms: Q587J7-1 Q587J7-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TDRD12: NX_Q587J7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q587J7
TDRD12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001104292.1
ENSEMBL proteins: ENSP00000416248 ENSP00000390621 ENSP00000457498
Human Recombinant Protein Products for TDRD12:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
TDRD12 for ontologies About GeneDecksing
TDRD12 Antibody Products:
Assay Products for TDRD12: |
Protein
Domains /
Families
for TDRD12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TDRD12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q587J7ProtoNet protein and cluster: Q587J7 1 Blocks protein family: IPB008191 Maternal tudor protein
UniProtKB/Swiss-Prot: TDR12_HUMAN, Q587J7Similarity: Contains 1 Tudor domain |
Function
for TDRD12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TDRD12 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TDRD12 (NM_001110822) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TDRD12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD12 |
|
Pathways & Interactions
for TDRD12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TDRD12
5/50 Interacting proteins for TDRD12 (Q587J72) via UniProtKB, MINT, STRING, and/or I2D (see all 50)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TDRD12 for ontologies About GeneDecksing
|
Drugs & Compounds
for TDRD12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TDRD12
Search CenterWatch for drugs/clinical trials and news about TDRD12 / TDR12
|
Transcripts
for TDRD12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TDRD12 gene (2 alternative transcripts): NM_001015890.1 NM_001110822.1 Unigene Clusters for TDRD12: Tudor domain containing 12 Hs.646351 [show with all ESTs], Hs.729739 [show with all ESTs]Unigene Representative Sequences: BC049000, AK0231343 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444215(uc002ntr.4 uc002ntq.2) ENST00000421545 ENST00000564769(uc002nts.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD12 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TDRD12 (NM_001110822) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TDRD12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD12 |
Additional cDNA sequence: AK023134.1 3 DOTS entries: DT.75166698 DT.40221128 DT.40128441 15 AceView cDNA sequences: AU152849 AA482523 BC049000 AK023134 BX281663 BQ927023 AI610791 AI005674 AL041342 BI769394 AU131012 AI539427 BU655807 BE614078 BI831323
GeneLoc Exon Structure
|
Expression
for TDRD12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TDRD12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTAGTTGTG
About this image
See TDRD12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TDRD12
SOURCE GeneReport for Unigene clusters: Hs.646351 Hs.729739
SABiosciences Custom PCR Arrays for TDRD12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDRD12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TDRD12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDRD12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDRD12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD12 |
Orthologs
for TDRD12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TDRD12 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for TDRD12 (if available)
TreeFam Gene Tree for TDRD12 (if available) |
Paralogs
for TDRD12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TDRD12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TDRD12 (33210659 - 33320483 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TDRD12
1 CNV: 73354
2 Indels: 26263 73353 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDRD12 |
|
Disorders
/ Diseases
for TDRD12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TDRD12 for disorders About GeneDecksing
1  disease for TDRD12: About MalaCardskidney disease
1 disease from the University of Copenhagen DISEASES database for TDRD12:Adenoid cystic carcinoma Export disorders for TDRD12 gene to outside databases
|
Publications
for TDRD12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TDRD12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TDRD12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PubMed id 12787504)1, 2 Mitsui K.... Yamanaka S. (2003)
- Human chromosome 19 and related regions in mouse: con servative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (2001)
- New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (2010)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TDRD12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TDRD12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TDRD12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TDRD12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TDRD12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TDRD12 gene:
Search GeneIP for patents involving TDRD12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TDRD12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TDRD12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDRD12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDRD12 | | | OriGene Protein Over-expression Lysate for TDRD12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TDRD12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDRD12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TDRD12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDRD12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDRD12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDRD12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDRD12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDRD12 |
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| | | | Search Tocris compounds for TDRD12 |
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 | | | TDRD12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD12 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TDRD12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD12 |
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