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Aliases for TDRD12 Gene

Aliases for TDRD12 Gene

  • Tudor Domain Containing 12 2 3 5
  • ES Cell-Associated Transcript 8 Protein 3 4
  • Tudor Domain-Containing Protein 12 3 4
  • ECAT8 3 4
  • ES Cell Associated Transcript 8 3
  • EC 3.6.4.13 4

External Ids for TDRD12 Gene

Previous GeneCards Identifiers for TDRD12 Gene

  • GC19P037903
  • GC19P033210
  • GC19P029713

Summaries for TDRD12 Gene

GeneCards Summary for TDRD12 Gene

TDRD12 (Tudor Domain Containing 12) is a Protein Coding gene. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for TDRD12 Gene

  • Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD12 Gene

Genomics for TDRD12 Gene

Regulatory Elements for TDRD12 Gene

Genomic Location for TDRD12 Gene

Chromosome:
19
Start:
32,719,753 bp from pter
End:
32,829,580 bp from pter
Size:
109,828 bases
Orientation:
Plus strand

Genomic View for TDRD12 Gene

Genes around TDRD12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRD12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRD12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD12 Gene

Proteins for TDRD12 Gene

  • Protein details for TDRD12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q587J7-TDR12_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase TDRD12
    Protein Accession:
    Q587J7

    Protein attributes for TDRD12 Gene

    Size:
    1177 amino acids
    Molecular mass:
    132578 Da
    Quaternary structure:
    • Component of a mRNP complex containing PIWIL2, TDRD1 and piRNAs. Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs.
    SequenceCaution:
    • Sequence=BAD95490.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TDRD12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRD12 Gene

Proteomics data for TDRD12 Gene at MOPED

Post-translational modifications for TDRD12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRD12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TDRD12 Gene

Domains & Families for TDRD12 Gene

Gene Families for TDRD12 Gene

Protein Domains for TDRD12 Gene

Suggested Antigen Peptide Sequences for TDRD12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q587J7

UniProtKB/Swiss-Prot:

TDR12_HUMAN :
  • Contains 1 helicase ATP-binding domain.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 2 Tudor domains.
genes like me logo Genes that share domains with TDRD12: view

Function for TDRD12 Gene

Molecular function for TDRD12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs.

Enzyme Numbers (IUBMB) for TDRD12 Gene

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TDRD12 Gene

Localization for TDRD12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TDRD12 Gene COMPARTMENTS Subcellular localization image for TDRD12 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TDRD12 Gene

Pathways & Interactions for TDRD12 Gene

genes like me logo Genes that share pathways with TDRD12: view

Pathways by source for TDRD12 Gene

Gene Ontology (GO) - Biological Process for TDRD12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007140 male meiosis IEA,ISS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA,ISS --
GO:0010501 RNA secondary structure unwinding IBA --
GO:0031047 gene silencing by RNA IEA,ISS --
genes like me logo Genes that share ontologies with TDRD12: view

No data available for SIGNOR curated interactions for TDRD12 Gene

Drugs & Compounds for TDRD12 Gene

No Compound Related Data Available

Transcripts for TDRD12 Gene

mRNA/cDNA for TDRD12 Gene

Unigene Clusters for TDRD12 Gene

Tudor domain containing 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD12 Gene

No ASD Table

Relevant External Links for TDRD12 Gene

GeneLoc Exon Structure for
TDRD12
ECgene alternative splicing isoforms for
TDRD12

Expression for TDRD12 Gene

mRNA expression in normal human tissues for TDRD12 Gene

mRNA differential expression in normal tissues according to GTEx for TDRD12 Gene

This gene is overexpressed in Testis (x17.8).

Protein differential expression in normal tissues from HIPED for TDRD12 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TDRD12 Gene



SOURCE GeneReport for Unigene cluster for TDRD12 Gene Hs.646351

genes like me logo Genes that share expression patterns with TDRD12: view

Protein tissue co-expression partners for TDRD12 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TDRD12 Gene

Orthologs for TDRD12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDRD12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRD12 35
  • 99.58 (n)
  • 98.98 (a)
TDRD12 36
  • 33 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TDRD12 36
  • 24 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TDRD12 36
  • 24 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRD12 36
  • 17 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tdrd12 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
OneToMany
-- 36
OneToMany
chicken
(Gallus gallus)
Aves TDRD12 36
  • 14 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRD12 36
  • 1 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TDRD12 36
  • 8 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToOne
Species with no ortholog for TDRD12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRD12 Gene

ENSEMBL:
Gene Tree for TDRD12 (if available)
TreeFam:
Gene Tree for TDRD12 (if available)

Paralogs for TDRD12 Gene

No data available for Paralogs for TDRD12 Gene

Variants for TDRD12 Gene

Sequence variations from dbSNP and Humsavar for TDRD12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs508455 -- 32,725,686(+) gtgtc(A/C/G/T)tggct intron-variant
rs755691 -- 32,767,911(-) ggtag(C/T)acaaa intron-variant
rs1071306 -- 32,785,334(-) aatca(A/C/G/T)aacaa intron-variant
rs1071482 -- 32,785,321(-) tgtct(A/C)tcaga intron-variant
rs1071483 -- 32,785,342(-) ataac(A/T)gaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TDRD12 Gene

Variant ID Type Subtype PubMed ID
nsv911575 CNV Loss 21882294
nsv458535 CNV Loss 19166990
esv2670459 CNV Deletion 23128226
nsv511617 CNV Loss 21212237
esv24839 CNV Gain 19812545
esv1422310 CNV Deletion 17803354
esv2718461 CNV Deletion 23290073
dgv559e201 CNV Deletion 23290073
esv2718464 CNV Deletion 23290073
esv29523 CNV Loss 19812545
esv2718466 CNV Deletion 23290073
esv2527998 CNV Deletion 19546169
nsv911576 CNV Loss 21882294
nsv518446 CNV Loss 19592680

Variation tolerance for TDRD12 Gene

Gene Damage Index Score: 9.00; 87.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TDRD12 Gene

HapMap Linkage Disequilibrium report
TDRD12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD12 Gene

Disorders for TDRD12 Gene

Relevant External Links for TDRD12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TDRD12

No disorders were found for TDRD12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRD12 Gene

Publications for TDRD12 Gene

  1. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PMID: 12787504) Mitsui K. … Yamanaka S. (Cell 2003) 3 4 67
  2. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 2 3
  3. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3
  4. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TDRD12 Gene

Sources for TDRD12 Gene

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