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TDRD12 Gene

protein-coding   GIFtS: 43
GCID: GC19P033210

Tudor Domain Containing 12

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tudor Domain Containing 121 2     ES Cell Associated Transcript 82
Tudor Domain-Containing Protein 122 3     Putative ATP-Dependent RNA Helicase TDRD122
ECAT82 3     EC 3.6.4.133
ES Cell-Associated Transcript 8 Protein2 3     

External Ids:    HGNC: 250441   Entrez Gene: 916462   Ensembl: ENSG000001738097   UniProtKB: Q587J73   

Export aliases for TDRD12 gene to outside databases

Previous GC identifers: GC19P037903 GC19P029713


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TDRD12 Gene:
TDRD12 (tudor domain containing 12) is a protein-coding gene. Diseases associated with TDRD12 include adenoiditis, and adenoid cystic carcinoma. GO annotations related to this gene include ATP-dependent helicase activity and nucleic acid binding.

UniProtKB/Swiss-Prot: TDR12_HUMAN, Q587J7
Function: Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and
preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic
process, which mediates the repression of transposable elements during meiosis by forming complexes composed of
piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the
secondary piRNAs metabolic process (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDRD12 gene promoter:
         HOXA9   HOXA9B   NRSF form 1   STAT5A   NRSF form 2   Evi-1   TFIID   Meis-1a   Pax-4a   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TDRD12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDRD12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

TDRD12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDRD12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P033210:  view genomic region     (about GC identifiers)

Start:
33,210,659 bp from pter      End:
33,320,483 bp from pter
Size:
109,825 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TDR12_HUMAN, Q587J7 (See protein sequence)
Recommended Name: Putative ATP-dependent RNA helicase TDRD12  
Size: 1177 amino acids; 132578 Da
Subunit: Component of a mRNP complex containing PIWIL2, TDRD1 and piRNAs (By similarity)
Sequence caution: Sequence=BAD95490.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Alternative splicing: 2 isoforms:  Q587J7-1   Q587J7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TDRD12: NX_Q587J7

Explore proteomics data for TDRD12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TDRD12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001104292.1  
    ENSEMBL proteins: 
     ENSP00000416248   ENSP00000390621   ENSP00000457498  

    TDRD12 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for TDRD12

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    3 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry Q587J7

    ProtoNet protein and cluster: Q587J7

    1 Blocks protein domain: IPB008191 Maternal tudor protein

    UniProtKB/Swiss-Prot: TDR12_HUMAN, Q587J7
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 2 Tudor domains


    TDRD12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDR12_HUMAN, Q587J7
    Function: Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and
    preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic
    process, which mediates the repression of transposable elements during meiosis by forming complexes composed of
    piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the
    secondary piRNAs metabolic process (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Number (IUBMB): EC 3.6.4.131

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding IEA--
    GO:0005524ATP binding IEA--
    GO:0008026ATP-dependent helicase activity IEA--
         
    TDRD12 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tdrd12):
     endocrine/exocrine gland  reproductive system 

    TDRD12 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDRD12
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TDRD12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TDRD12

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    GenScript: all cDNA clones in your preferred vector: TDRD12 (NM_001110822)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD12

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    TDRD12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TDRD12
    Interactions:

        Search GeneGlobe Interaction Network for TDRD12

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for TDRD12 (Q587J72 ENSP000003906214) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG2O958162MINT-8415355
    BAG6P463792MINT-8415355
    CCDC8Q9H0W52MINT-8415355
    CCT2P783712MINT-8415355
    CCT3P493682MINT-8415355
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007140male meiosis ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis ISS--
    GO:0008150biological_process ND--
    GO:0009566fertilization ISS--

    TDRD12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TDRD12 (TDR12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TDRD12 gene (2 alternative transcripts): 
    NM_001015890.1  NM_001110822.1  

    Unigene Cluster for TDRD12:

    Tudor domain containing 12
    Hs.646351  [show with all ESTs]
    Unigene Representative Sequence: BC049000
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000444215(uc002ntr.4 uc002ntq.2) ENST00000421545 ENST00000564769(uc002nts.1)

    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate TDRD12
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TDRD12
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TDRD12
      QuantiFast Probe-based Assays in human, mouse, rat TDRD12

    Additional mRNA sequence: 

    AB211063.1 BC049000.1 

    2 DOTS entries:

    DT.40221128  DT.40128441 

    15 AceView cDNA sequences:

    BC049000 AU152849 AA482523 AK023134 BX281663 BI769394 BQ927023 AI610791 
    AU131012 AI005674 AL041342 BU655807 AI539427 BE614078 BI831323 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDRD12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAGTTGTG
    TDRD12 Expression
    About this image


    TDRD12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Colon (Gastrointestinal Tract)
    TDRD12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDRD12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.646351
        Custom PCR Arrays for TDRD12
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDRD12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TDRD12 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdrd125 tudor domain containing 12   --   7 (21.37 cM) 35493612 
    chicken
    (Gallus gallus)
    Aves TDRD126
    tudor domain containing 12
    14(a)
    1 ↔ 1
    11(9402911-9424291)
    lizard
    (Anolis carolinensis)
    Reptilia TDRD126
    tudor domain containing 12
    1(a)
    1 ↔ 1
    GL343483.1(128101-151055)
    zebrafish
    (Danio rerio)
    Actinopterygii TDRD126
    tudor domain containing 12
    8(a)
    1 ↔ 1
    25(38188881-38213579) ENSDARG00000075217


    ENSEMBL Gene Tree for TDRD12 (if available)
    TreeFam Gene Tree for TDRD12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDRD12 (see all 1465)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1112727991,2
    C,F--33208679(+) GACTGT/ACCAGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1505986711,2
    --33208701(+) CCACCA/GAGGCT 1 -- us2k10--------
    rs1405879251,2
    C--33208716(+) GCTCAC/TAGCGT 1 -- us2k10--------
    rs1837266191,2
    --33208939(+) CCAGGC/TGTGGT 1 -- us2k10--------
    rs1428394541,2
    --33208989(+) ATGGAA/GGATCA 1 -- us2k10--------
    rs1885350251,2
    --33209130(+) TGCCCA/GCTGCC 1 -- us2k10--------
    rs1479883211,2
    C--33209141(+) TAGAC-/AGAGCCA 1 -- us2k10--------
    rs1918540951,2
    --33209200(+) AGCCGA/GCTGTG 1 -- us2k10--------
    rs1474026071,2
    C--33209231(+) ATTACC/TCAAAT 1 -- us2k10--------
    rs1408285121,2
    --33209246(+) CTCTCC/TGAGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TDRD12 (33210659 - 33320483 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TDRD12 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718466CNV Deletion23290073
    esv2670459CNV Deletion23128226
    esv2718464CNV Deletion23290073
    dgv559e201CNV Deletion23290073
    esv2718461CNV Deletion23290073
    esv1422310CNV Deletion17803354
    esv2527998CNV Deletion19546169
    nsv518446CNV Loss19592680
    nsv458535CNV Loss19166990
    nsv911576CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDRD12
    DNA2.0 Custom Variant and Variant Library Synthesis for TDRD12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for TDRD12:    
    About MalaCards
    adenoiditis    adenoid cystic carcinoma    kidney disease

    1 disease from the University of Copenhagen DISEASES database for TDRD12:
    Adenoid cystic carcinoma

    TDRD12 for disorders           About GeneDecksing


    Export disorders for TDRD12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TDRD12 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TDRD12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. (PubMed id 12787504)1, 2 Mitsui K.... Yamanaka S. (Cell 2003)
    2. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PubMed id 11441184)1, 3 Dehal P....Stubbs L. (Science 2001)
    3. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91646 HGNC: 25044 AceView: FLJ13072 Ensembl:ENSG00000173809 euGenes: HUgn91646
    ECgene: TDRD12 H-InvDB: TDRD12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TDRD12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TDRD12 gene:
    Search GeneIP for patents involving TDRD12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TDRD12  
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     Block miRNA regulation of human, mouse, rat TDRD12 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TDRD12
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDRD12 Predesigned siRNA for gene silencing in human, mouse, rat TDRD12
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     Search Tocris compounds for TDRD12 (TDR12)
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for TDRD12
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     Search ThermoFisher Antibodies for TDRD12
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDRD12
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDRD12
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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