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Aliases for TDRD10 Gene

Aliases for TDRD10 Gene

  • Tudor Domain Containing 10 2 3 5

External Ids for TDRD10 Gene

Previous GeneCards Identifiers for TDRD10 Gene

  • GC01P151307
  • GC01P152741
  • GC01P125838

Summaries for TDRD10 Gene

GeneCards Summary for TDRD10 Gene

TDRD10 (Tudor Domain Containing 10) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD10 Gene

Genomics for TDRD10 Gene

Regulatory Elements for TDRD10 Gene

Enhancers for TDRD10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154489 1.6 FANTOM5 Ensembl ENCODE 23.1 -8.4 -8419 8.0 ATF1 PKNOX1 YY1 GATA2 ZNF548 FOS JUNB ZNF488 REST TBX21 SLC27A3 TDRD10 CHTOP KRTCAP2 SHE THBS3 DCST1 UBE2Q1-AS1 UBE2Q1 ENSG00000272030
GH01F154546 1 Ensembl ENCODE 23.5 +44.7 44672 1.0 ELF3 CTCF SAP130 ARID4B ZBTB40 RAD21 ZNF316 ZNF143 SMC3 MAFK TDRD10 SHE UBE2Q1-AS1 PIR57366
GH01F154417 1.8 FANTOM5 Ensembl ENCODE 11.7 -80.5 -80547 7.9 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS ZNF263 IL6R TDRD10 CRTC2 ADAR UBAP2L KRTCAP2 S100A1 GATAD2B C1orf43 PSMD8P1
GH01F154461 1.2 Ensembl ENCODE 16.7 -37.2 -37168 6.3 TBP HDGF PKNOX1 RAD21 GATA2 FOS ETV6 EGR2 CBFB CEBPB TDRD10 IL6R ENSG00000273110 PSMD8P1
GH01F154935 1.5 FANTOM5 ENCODE 11.3 +435.4 435433 3.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LOC101928120 KRTCAP2 ASH1L RAB13 TDRD10 ENSG00000272654 RPS27 MSTO2P ASH1L-AS1 KIAA0907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TDRD10 on UCSC Golden Path with GeneCards custom track

Promoters for TDRD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TDRD10 Gene

154,502,219 bp from pter
154,548,147 bp from pter
45,929 bases
Plus strand

Genomic View for TDRD10 Gene

Genes around TDRD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDRD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDRD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD10 Gene

Proteins for TDRD10 Gene

  • Protein details for TDRD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tudor domain-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • A4FU09
    • B0QZ53
    • B4DXV4
    • Q3ZCP1
    • Q3ZCS7
    • Q5SXY7
    • Q6UXV2
    • Q8TCN3

    Protein attributes for TDRD10 Gene

    366 amino acids
    Molecular mass:
    40941 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH44864.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00896.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00897.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00898.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI00899.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAQ88562.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD28538.1; Type=Frameshift; Positions=93, 242; Evidence={ECO:0000305}; Sequence=CAH72850.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16182.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16188.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ08365.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAQ10669.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TDRD10 Gene


neXtProt entry for TDRD10 Gene

Post-translational modifications for TDRD10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TDRD10 Gene

Domains & Families for TDRD10 Gene

Protein Domains for TDRD10 Gene

Suggested Antigen Peptide Sequences for TDRD10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 Tudor domain.
genes like me logo Genes that share domains with TDRD10: view

Function for TDRD10 Gene

Gene Ontology (GO) - Molecular Function for TDRD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with TDRD10: view
genes like me logo Genes that share phenotypes with TDRD10: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TDRD10 Gene

Localization for TDRD10 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDRD10 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TDRD10 Gene

Pathways & Interactions for TDRD10 Gene

SuperPathways for TDRD10 Gene

No Data Available

Interacting Proteins for TDRD10 Gene

Selected Interacting proteins: Q5VZ19-TDR10_HUMAN for TDRD10 Gene via IID

Gene Ontology (GO) - Biological Process for TDRD10 Gene


No data available for Pathways by source and SIGNOR curated interactions for TDRD10 Gene

Transcripts for TDRD10 Gene

Unigene Clusters for TDRD10 Gene

Tudor domain containing 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD10 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for TDRD10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TDRD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TDRD10 Gene

mRNA differential expression in normal tissues according to GTEx for TDRD10 Gene

This gene is overexpressed in Testis (x13.8).

Protein differential expression in normal tissues from HIPED for TDRD10 Gene

This gene is overexpressed in Prostate (58.4) and Ovary (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDRD10 Gene

Protein tissue co-expression partners for TDRD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TDRD10 Gene:


SOURCE GeneReport for Unigene cluster for TDRD10 Gene:

genes like me logo Genes that share expression patterns with TDRD10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TDRD10 Gene

Orthologs for TDRD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDRD10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TDRD10 34 35
  • 95.1 (n)
(Bos Taurus)
Mammalia TDRD10 34 35
  • 81.73 (n)
(Monodelphis domestica)
Mammalia TDRD10 35
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490913 34
  • 51.3 (n)
Species where no ortholog for TDRD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TDRD10 Gene

Gene Tree for TDRD10 (if available)
Gene Tree for TDRD10 (if available)

Paralogs for TDRD10 Gene

No data available for Paralogs for TDRD10 Gene

Variants for TDRD10 Gene

Sequence variations from dbSNP and Humsavar for TDRD10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10465961 -- 154,514,878(+) tattt(A/T)ttttt intron-variant
rs10534175 -- 154,525,403(+) AAGAA(-/GAA)TTTAT intron-variant
rs10568950 -- 154,522,694(+) TCAAA(-/CT)CTTTC intron-variant
rs10654618 -- 154,507,181(+) GACAC(-/AT)GTTTC intron-variant
rs10752642 -- 154,509,148(+) GCAGT(C/T)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TDRD10 Gene

Variant ID Type Subtype PubMed ID
nsv547957 CNV loss 21841781
nsv547954 CNV loss 21841781
nsv547942 CNV gain+loss 21841781
nsv521887 CNV gain 19592680
nsv506960 OTHER sequence alteration 20534489
nsv160554 CNV deletion 16902084
esv23279 CNV loss 19812545
dgv585n54 CNV gain 21841781
dgv584n54 CNV gain 21841781

Variation tolerance for TDRD10 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.69; 78.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TDRD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDRD10 Gene

Disorders for TDRD10 Gene

Relevant External Links for TDRD10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TDRD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TDRD10 Gene

Publications for TDRD10 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients. (PMID: 24423473) Galora S. … Giusti B. (J. Vasc. Surg. 2014) 3 64

Products for TDRD10 Gene

Sources for TDRD10 Gene

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