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TDRD1 Gene

protein-coding   GIFtS: 53
GCID: GC10P115929

Tudor Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tudor Domain Containing 11 2
Cancer/Testis Antigen 41.11 2 3
CT41.12 3
Tudor Domain Containing Protein 12
Tudor Domain-Containing Protein 12

External Ids:    HGNC: 117121   Entrez Gene: 561652   Ensembl: ENSG000000956277   OMIM: 6057965   UniProtKB: Q9BXT43   

Export aliases for TDRD1 gene to outside databases

Previous GC identifers: GC10P114870 GC10P115172 GC10P116070 GC10P115627 GC10P115603 GC10P109566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TDRD1 Gene:
This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript
variants have been described but their full length sequences have not been determined. (provided by RefSeq, Jul
2008)

GeneCards Summary for TDRD1 Gene:
TDRD1 (tudor domain containing 1) is a protein-coding gene. An important paralog of this gene is TDRD6.

UniProtKB/Swiss-Prot: TDRD1_HUMAN, Q9BXT4
Function: Plays a central role during spermatogenesis by participating in the repression transposable elements and
preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic
process, which mediates the repression of transposable elements during meiosis by forming complexes composed of
piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the
localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry
of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA
pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry
of transcripts and piRNAs into Piwi proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDRD1 gene promoter:
         Egr-3   ISGF-3   Gfi-1   FOXL1   RORalpha1   Egr-2   Max   ARP-1   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDRD1 promoter sequence
   Search Chromatin IP Primers for TDRD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.3   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q26.11

TDRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDRD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P115929:  view genomic region     (about GC identifiers)

Start:
115,939,029 bp from pter      End:
115,992,063 bp from pter
Size:
53,035 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TDRD1_HUMAN, Q9BXT4 (See protein sequence)
Recommended Name: Tudor domain-containing protein 1  
Size: 1180 amino acids; 132024 Da
Subunit: Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with MAEL.
Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues). Interacts with TDRD12 (By
similarity)
Sequence caution: Sequence=AAH35010.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence;
Sequence=AAK31985.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAK31985.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence; Sequence=BAB14982.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAB14982.1; Type=Miscellaneous discrepancy; Note=Potential
poly-A sequence;
Secondary accessions: A6NEN3 A6NMN2 B3KVI4 B4E2L5 D3DRC2 Q4G0Y8 Q6P518 Q9H7B3
Alternative splicing: 4 isoforms:  Q9BXT4-1   Q9BXT4-2   Q9BXT4-3   Q9BXT4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TDRD1: NX_Q9BXT4

Explore proteomics data for TDRD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TDRD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_942090.1  
    ENSEMBL proteins: 
     ENSP00000358288   ENSP00000358286   ENSP00000251864   ENSP00000358287   ENSP00000402794  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TDRD: Tudor domain containing

    2 InterPro protein domains:
     IPR002893 Znf_MYND
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry Q9BXT4

    ProtoNet protein and cluster: Q9BXT4

    2 Blocks protein domains:
    IPB002999 Tudor domain
    IPB008191 Maternal tudor protein


    UniProtKB/Swiss-Prot: TDRD1_HUMAN, Q9BXT4
    Domain: Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor
    binder due to an impaired aromatic cage (By similarity)
    Similarity: Belongs to the TDRD1 family
    Similarity: Contains 1 MYND-type zinc finger
    Similarity: Contains 4 Tudor domains


    Find genes that share domains with TDRD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDRD1_HUMAN, Q9BXT4
    Function: Plays a central role during spermatogenesis by participating in the repression transposable elements and
    preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic
    process, which mediates the repression of transposable elements during meiosis by forming complexes composed of
    piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the
    localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry
    of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA
    pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry
    of transcripts and piRNAs into Piwi proteins (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TDRD1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tdrd1):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with TDRD1           About GenesLikeMe

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDRD1_HUMAN, Q9BXT4: Cytoplasm (By similarity). Note=Component of the meiotic nuage, also named P granule, a
    germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid
    body (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0030529ribonucleoprotein complex ----
    GO:0033391chromatoid body IEA--
    GO:0043186P granule ISS--
    GO:0071546pi-body ISS--

    Find genes that share ontologies with TDRD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TDRD1
    Interactions:

        Search GeneGlobe Interaction Network for TDRD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TDRD1 (Q9BXT42, 3 ENSP000002518644) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8111595 I2D: score=3 STRING: ENSP00000357656
    PLCG1P191742, 3, ENSP000002440074MINT-8112831 I2D: score=3 STRING: ENSP00000244007
    MAELQ96JY03, ENSP000003568464I2D: score=1 STRING: ENSP00000356846
    PPME1Q9Y5703, ENSP000003814614I2D: score=1 STRING: ENSP00000381461
    PIWIL1Q96J943, ENSP000002452554I2D: score=2 STRING: ENSP00000245255
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007126meiotic nuclear division IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007281germ cell development ISS--
    GO:0007283spermatogenesis ISS--
    GO:0031047gene silencing by RNA ISS--

    Find genes that share ontologies with TDRD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for TDRD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TDRD1 gene: 
    NM_198795.1  

    Unigene Cluster for TDRD1:

    Tudor domain containing 1
    Hs.333132  [show with all ESTs]
    Unigene Representative Sequence: NM_198795
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369282 ENST00000369280(uc001lbi.1 uc010qsc.2 uc001lbj.3)
    ENST00000251864(uc001lbg.1 uc001lbh.1) ENST00000369281(uc001lbf.3)
    ENST00000422662
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    Additional mRNA sequence: 

    AF285606.1 AK024735.1 AK122916.1 AK304331.1 AL833340.1 BC035010.2 BC063133.1 BX648664.1 

    4 DOTS entries:

    DT.425526  DT.101981701  DT.95177594  DT.101981702 

    22 AceView cDNA sequences:

    AL044913 BX648664 NM_198795 AK122916 AI692786 BC035010 AK024735 BC063133 
    BP370743 AL833340 BV180537 BG771552 CA453178 BU561773 AF285606 AL044914 
    BQ882979 CB136029 AA531597 AW973066 AA531454 BU561753 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TDRD1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:                          -                                                                                                                                 
    SP2:                    -     -                                                                                                                 -               
    SP3:                                                                                                                                                            
    SP4:                          -                                                                             -                       -                           

    ExUns: 23 ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27
    SP1:                                -         
    SP2:                                          
    SP3:                                          
    SP4:                                          


    ECgene alternative splicing isoforms for TDRD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACATATTCT
    TDRD1 Expression
    About this image


    TDRD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
             Bone Marrow
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Secondary Spermatocyte Seminiferous Tubules
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Short-term differentiated embryoid bodies
    TDRD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDRD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333132

    UniProtKB/Swiss-Prot: TDRD1_HUMAN, Q9BXT4
    Tissue specificity: Testis and ovary specific. Also expressed in several cancers

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TDRD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdrd11 , 5 tudor domain containing 11, 5 76.68(n)1
    72.17(a)1
      19 (52.00 cM)5
    835611  NM_001002238.21  NP_001002238.11 
     568262095 
    chicken
    (Gallus gallus)
    Aves TDRD11 tudor domain containing 1 59.43(n)
    48.37(a)
      423906  XM_421768.4  XP_421768.4 
    lizard
    (Anolis carolinensis)
    Reptilia TDRD16
    tudor domain containing 1
    41(a)
    1 ↔ 1
    GL343204.1(72570-135908)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1002162611 uncharacterized LOC100216261 51.24(n)
    40.19(a)
      100216261  XM_004919373.1  XP_004919430.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tdrd11 tudor domain containing 1 50.88(n)
    40.37(a)
      553522  NM_001164028.1  NP_001157500.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tud6
    qin6
    qin
    7(a)
    11(a)
    many ↔ many
    many ↔ many
    2R(17070937-17079903)
    3R(14416749-14475859)


    ENSEMBL Gene Tree for TDRD1 (if available)
    TreeFam Gene Tree for TDRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TDRD1 gene
    TDRD62  TDRD152  RNF172  TDRD52  
    1 SIMAP similar gene for TDRD1 using alignment to 5 protein entries:     TDRD1_HUMAN (see all proteins):
    CBFA2T1

    Find genes that share paralogs with TDRD1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TDRD1
    PGOHUM00000246002


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDRD1 (see all 1224)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832492481,2
    --115937205(+) TAACCC/TGTAAC 1 -- us2k10--------
    rs1381730901,2
    --115937273(+) AAGGCC/TTGAGA 1 -- us2k10--------
    rs1865050871,2
    --115937387(+) TCCTGA/CTGAGA 1 -- us2k10--------
    rs1914424061,2
    --115937539(+) GAAACC/GATGTG 1 -- us2k10--------
    rs1848756251,2
    --115937567(+) GTACAG/TCACCT 1 -- us2k10--------
    rs341897561,2
    C--115937594(+) TTTTC-/TTTTTT 1 -- us2k10--------
    rs1897142011,2
    --115937618(+) GACAGC/TCTTGC 1 -- us2k10--------
    rs1930844351,2
    --115937621(+) AGTCTC/TGCTCT 1 -- us2k10--------
    rs1181916891,2
    C,F--115937665(+) TGGCTC/TGGTGA 1 -- us2k11Minor allele frequency- T:0.05EA 120
    rs1850433111,2
    --115937677(+) ACCTCC/TGCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TDRD1 (115939029 - 115992063 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TDRD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7211OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for TDRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605796    OMIM disorders: --


    Find genes that share disorders with TDRD1           About GenesLikeMe

    Genetic Association Database (GAD): TDRD1
    Human Genome Epidemiology (HuGE) Navigator: TDRD1 (1 document)

    Export disorders for TDRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TDRD1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TDRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (Nat. Genet. 2001)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer. (PubMed id 23319146)1 Boormans J.L....Trapman J. (Int. J. Cancer 2013)
    5. ERG induces epigenetic activation of Tudor domain-containing protein 1 (TDRD1) in ERG rearrangement-positive prostate cancer. (PubMed id 23555854)1 Kacprzyk L.A....SA1ltmann H. (PLoS ONE 2013)
    6. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. An integrated workflow for charting the human interaction proteome: insights into the PP2A system. (PubMed id 19156129)1 Glatter T....Gstaiger M. (Mol. Syst. Biol. 2009)
    9. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)
    10. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56165 HGNC: 11712 AceView: TDRD1 Ensembl:ENSG00000095627 euGenes: HUgn56165
    ECgene: TDRD1 H-InvDB: TDRD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TDRD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TDRD1 gene:
    Search GeneIP for patents involving TDRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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