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Aliases for TDRD1 Gene

Aliases for TDRD1 Gene

  • Tudor Domain Containing 1 2 3
  • Cancer/Testis Antigen 41.1 2 3 4
  • CT41.1 3 4
  • Tudor Domain Containing Protein 1 3
  • Tudor Domain-Containing Protein 1 3

External Ids for TDRD1 Gene

Summaries for TDRD1 Gene

Entrez Gene Summary for TDRD1 Gene

  • This gene is similar to a mouse gene that encodes a tudor domain protein. Alternatively spliced transcript variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TDRD1 Gene

TDRD1 (Tudor Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is TDRD6.

UniProtKB/Swiss-Prot for TDRD1 Gene

  • Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDRD1 Gene

Genomics for TDRD1 Gene

Genomic Location for TDRD1 Gene

Start:
114,179,256 bp from pter
End:
114,232,666 bp from pter
Size:
53,411 bases
Orientation:
Plus strand

Genomic View for TDRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDRD1 Gene

Regulatory Elements for TDRD1 Gene

Proteins for TDRD1 Gene

  • Protein details for TDRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXT4-TDRD1_HUMAN
    Recommended name:
    Tudor domain-containing protein 1
    Protein Accession:
    Q9BXT4
    Secondary Accessions:
    • A6NEN3
    • A6NMN2
    • B3KVI4
    • B4E2L5
    • D3DRC2
    • Q4G0Y8
    • Q6P518
    • Q9H7B3

    Protein attributes for TDRD1 Gene

    Size:
    1180 amino acids
    Molecular mass:
    132024 Da
    Quaternary structure:
    • Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with MAEL. Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues). Interacts with TDRD12 (By similarity).
    SequenceCaution:
    • Sequence=AAH35010.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAK31985.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK31985.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305}; Sequence=BAB14982.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14982.1; Type=Miscellaneous discrepancy; Note=Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for TDRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDRD1 Gene

Proteomics data for TDRD1 Gene at MOPED

Post-translational modifications for TDRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TDRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TDRD1 Gene

Domains for TDRD1 Gene

Gene Families for TDRD1 Gene

HGNC:
  • TDRD :Tudor domain containing

Protein Domains for TDRD1 Gene

UniProtKB/Swiss-Prot:

TDRD1_HUMAN
Domain:
  • Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage.:
    • Q9BXT4
  • Contains 4 Tudor domains.:
    • Q9BXT4
Family:
  • Belongs to the TDRD1 family.:
    • Q9BXT4
Similarity:
  • Contains 1 MYND-type zinc finger.:
    • Q9BXT4
genes like me logo Genes that share domains with TDRD1: view

Function for TDRD1 Gene

Molecular function for TDRD1 Gene

UniProtKB/Swiss-Prot Function: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity).

Gene Ontology (GO) - Molecular Function for TDRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TDRD1: view
genes like me logo Genes that share phenotypes with TDRD1: view

Animal Models for TDRD1 Gene

MGI Knock Outs for TDRD1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TDRD1 Gene

Localization for TDRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDRD1 Gene

Cytoplasm. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TDRD1 Gene COMPARTMENTS Subcellular localization image for TDRD1 gene
Compartment Confidence
nucleus 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TDRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0030529 ribonucleoprotein complex --
GO:0033391 chromatoid body IEA --
GO:0043186 P granule ISS --
GO:0071546 pi-body ISS --
genes like me logo Genes that share ontologies with TDRD1: view

Pathways for TDRD1 Gene

SuperPathways for TDRD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TDRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007281 germ cell development ISS --
GO:0007283 spermatogenesis ISS --
GO:0010467 gene expression TAS --
GO:0031047 gene silencing by RNA ISS --
genes like me logo Genes that share ontologies with TDRD1: view

No data available for Pathways by source for TDRD1 Gene

Transcripts for TDRD1 Gene

Unigene Clusters for TDRD1 Gene

Tudor domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDRD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
SP1: -
SP2: - - -
SP3:
SP4: - - -

ExUns: 23 ^ 24 ^ 25 ^ 26a · 26b · 26c ^ 27
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for TDRD1 Gene

GeneLoc Exon Structure for
TDRD1
ECgene alternative splicing isoforms for
TDRD1

Expression for TDRD1 Gene

mRNA expression in normal human tissues for TDRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDRD1 Gene

This gene is overexpressed in Testis (30.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TDRD1 Gene

SOURCE GeneReport for Unigene cluster for TDRD1 Gene Hs.333132

mRNA Expression by UniProt/SwissProt for TDRD1 Gene

Q9BXT4-TDRD1_HUMAN
Tissue specificity: Testis and ovary specific. Also expressed in several cancers.
genes like me logo Genes that share expressions with TDRD1: view

Orthologs for TDRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TDRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TDRD1 36
  • 99.52 (n)
  • 99.24 (a)
TDRD1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC536516 36
  • 84.75 (n)
  • 79.23 (a)
TDRD1 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TDRD1 36
  • 86.76 (n)
  • 80.53 (a)
TDRD1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tdrd1 36
  • 76.68 (n)
  • 72.17 (a)
Tdrd1 16
Tdrd1 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TDRD1 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TDRD1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tdrd1 36
  • 76.68 (n)
  • 73.14 (a)
chicken
(Gallus gallus)
Aves TDRD1 36
  • 59.43 (n)
  • 48.37 (a)
TDRD1 37
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TDRD1 37
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216261 36
  • 51.24 (n)
  • 40.19 (a)
zebrafish
(Danio rerio)
Actinopterygii tdrd1 36
  • 50.88 (n)
  • 40.37 (a)
tdrd1 37
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta qin 37
  • 11 (a)
ManyToMany
tud 37
  • 7 (a)
ManyToMany
Species with no ortholog for TDRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDRD1 Gene

ENSEMBL:
Gene Tree for TDRD1 (if available)
TreeFam:
Gene Tree for TDRD1 (if available)

Paralogs for TDRD1 Gene

Paralogs for TDRD1 Gene

Selected SIMAP similar genes for TDRD1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TDRD1 Gene

genes like me logo Genes that share paralogs with TDRD1: view

Variants for TDRD1 Gene

Sequence variations from dbSNP and Humsavar for TDRD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs642602 -- 114,218,670(+) CATTT(C/T)GTGTG intron-variant
rs665581 -- 114,230,857(+) cccag(A/G)agttt intron-variant
rs666429 -- 114,231,024(+) ATGGC(A/G)CCACT intron-variant
rs687157 -- 114,221,717(-) GGACA(C/T)TTCTG intron-variant
rs687200 -- 114,231,885(-) ctgta(A/C)ccttg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TDRD1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855

Relevant External Links for TDRD1 Gene

HapMap Linkage Disequilibrium report
TDRD1

Disorders for TDRD1 Gene

Relevant External Links for TDRD1

Genetic Association Database (GAD)
TDRD1
Human Genome Epidemiology (HuGE) Navigator
TDRD1
genes like me logo Genes that share disorders with TDRD1: view

No data available for UniProtKB/Swiss-Prot for TDRD1 Gene

Publications for TDRD1 Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for TDRD1 Gene

Sources for TDRD1 Gene

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