TDP2 Gene
protein-coding GIFtS: 52
GCID: GC06M024651
|
|
tyrosyl-DNA phosphodiesterase 2(Previous name: TRAF and TNF receptor associated protein )
(Previous symbol: TTRAP)
| |
Aliases
for TDP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tyrosyl-DNA Phosphodiesterase 21 2 | | ETS1-Associated Protein 22 3 | | TTRAP1 2 3 5 | | ETS1-Associated Protein II2 3 | | TRAF And TNF Receptor Associated Protein1 2 | | HTDP21 | | Tyr-DNA Phosphodiesterase 22 3 | | TRAF And TNF Receptor-Associated Protein2 3 | | Tyrosyl-RNA Phosphodiesterase2 3 | | VPg Unlinkase2 3 | | 5'-Tyr-DNA Phosphodiesterase2 3 | | AD0222 | | 5'-Tyrosyl-DNA Phosphodiesterase2 3 | | DJ30M3.31 | | EAP22 3 | | EC 3.1.4.-3 | | EAPII2 3 | | |
Export aliases for TDP2 gene to outside databases |
Summaries
for TDP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TDP2:
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded proteinassociates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), andinhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1endonuclease, which is involved in both DNA repair and the activation of transcription factors. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: TYDP2_HUMAN, O95551Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexesbetween DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNAphosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creatinga 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplexDNA with a 4 base pair overhang as substrate. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficientlyand much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as a5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and actsby specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps ofa picornavirus infection, without impairing the integrity of viral RNA. Also acts as an adapter by participating tothe specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-betareceptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved innon-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibitNF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress
Gene Wiki entry for TDP2 (TTRAP)
|
Genomic Views
for TDP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TDP2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TDP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p22.3-p22.1 Ensembl cytogenetic band: 6p22.3 HGNC cytogenetic band: 6p22.3-p22.1TDP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M024651: view genomic region
(about GC identifiers)
Start:
|
24,650,205 bp from pter |
End:
|
24,667,261 bp from pter |
Size:
|
17,057 bases |
Orientation:
|
minus strand |
|
Proteins
for TDP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TYDP2_HUMAN, O95551 (See
protein sequence)Recommended Name: Tyrosyl-DNA phosphodiesterase 2 Size: 362 amino acids; 40930 Da
Cofactor: Magnesium. Can use other divalent cations as cofactor in vitro, such as manganese
Subunit: Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1,SMAD3 and ACVR1B/ALK4
Subcellular location: Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavitiesfollowing stress; localization to nucleolus is dependent on PML protein. In case of infection by picornavirus,relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication orencapsidation
Sequence caution: Sequence=BAG59230.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAD92510.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DKL8 B4DQ95 Q2TBE2 Q5JYM0 Q7Z6U5 Q9NUK5 Q9NYY9Alternative splicing: 3 isoforms: O95551-1 O95551-2 O95551-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TDP2: NX_O95551
Post-translational modifications:
Ubiquitinated by TRAF61
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95551
TDP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057698.2
ENSEMBL proteins: ENSP00000367440 ENSP00000345345 ENSP00000437637
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TDP2 for ontologies About GeneDecksing
TDP2 Antibody Products:
Assay Products for TDP2: |
Protein
Domains /
Families
for TDP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TDP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O95551ProtoNet protein and cluster: O95551 UniProtKB/Swiss-Prot: TYDP2_HUMAN, O95551Similarity: Belongs to the CCR4/nocturin family |
Function
for TDP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TYDP2_HUMAN, O95551Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexesbetween DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNAphosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creatinga 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has preference for single-stranded DNA or duplexDNA with a 4 base pair overhang as substrate. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficientlyand much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as a5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and actsby specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps ofa picornavirus infection, without impairing the integrity of viral RNA. Also acts as an adapter by participating tothe specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-betareceptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved innon-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibitNF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stressBiophysicochemical properties: Kinetic parameters: KM=8 uM for single-stranded 5'-tyrosyl DNA; Note=kcat is 3 sec(-1)with single-stranded 5'-tyrosyl DNA as substrate;Enzyme Number (IUBMB): EC 3.1.4.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TDP2 (NM_016614) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TDP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDP2 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
TDP2 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tdp2):
TDP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TDP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | CD40/CD40L signaling | |
1  BioSystems Pathway for TDP2
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TDP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/37 Interacting proteins for TDP2 (O955512, 3 ENSP000003674404) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006302 | double-strand break repair |
IMP | -- | | GO:0007166 | cell surface receptor signaling pathway |
TAS | 10764746 |
TDP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TDP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TDP2
Search CenterWatch for drugs/clinical trials and news about TDP2 / TYDP2
|
Transcripts
for TDP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TDP2 gene: NM_016614.2 Unigene Cluster for TDP2: Tyrosyl-DNA phosphodiesterase 2 Hs.403010 [show with all ESTs]Unigene Representative Sequence: BC0175536 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378198(uc003nej.3) ENST00000341060 ENST00000478507 ENST00000478285
ENST00000480495 ENST00000545995(uc010jpu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDP2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDP2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TDP2 (NM_016614) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TDP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDP2 |
Additional cDNA sequence: AF201687.1 AF223469.1 AJ269473.1 AK002168.1 AK296623.1 AK298699.1 AK308836.1 BC017553.2 BC110375.1 JN104587.1 14 DOTS entries: DT.216332 DT.100818415 DT.121363900 DT.100818416 DT.95194872 DT.121363950 DT.70101915 DT.40222287 DT.92443705 DT.92443706 DT.95153612 DT.92443720 DT.100715402 DT.92443715 24/313 AceView cDNA sequences (see all 313): BI908925 H53454 CR597293 AA622205 BP379659 AI636852 AA931115 BI754101 AI636151 AA259127 NM_016614 CR601303 AI690729 AI766732 CR602029 AU279894 CR592636 AI699159 BM980338 AI524416 AA304024 AU185972 AA746345 CA777140
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TDP2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | | | - | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TDP2
|
Expression
for TDP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TDP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAGACATA
About this image
See TDP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TDP2
SOURCE GeneReport for Unigene cluster: Hs.403010
UniProtKB/Swiss-Prot: TYDP2_HUMAN, O95551Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for TDP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TDP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDP2 |
Orthologs
for TDP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TDP2 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tdp21 , 5 |
tyrosyl-DNA phosphodiesterase 21, 5 |
78.87(n)1
69.16(a)1 |
|
13 (10.70 cM)5
561961 NM_019551.21 NP_062424.11
248316795 |
chicken
(Gallus gallus) |
Aves |
TDP21 |
tyrosyl-DNA phosphodiesterase 2 |
67.81(n)
64.67(a) |
|
421007 XM_419093.3 XP_419093.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TDP26 |
-- |
61(a) |
1 ↔ 1 |
4(53966481-53977804) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.80252 |
Xenopus laevis transcribed sequence with weak similarity more |
75.61(n) |
|
BX846715.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AL722584.12 |
-- |
73.62(n) |
|
AL722584.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_Y63D3A.41 |
Protein Y63D3A.4 |
44.85(n)
33.55(a) |
|
173276 NM_061060.2 NP_493461.1 |
ENSEMBL Gene Tree for TDP2 (if available)
TreeFam Gene Tree for TDP2 (if available) |
Paralogs
for TDP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TDP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TDP2 (24650205 - 24667261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TDP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDP2 |
|
Disorders
/ Diseases
for TDP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TDP2 for disorders About GeneDecksing
OMIM gene information: 605764
OMIM disorders: --
3  diseases for TDP2: About MalaCardsdyslexia parkinson's disease lung cancer
1 disease from the University of Copenhagen DISEASES database for TDP2:Dyslexia Human Genome Epidemiology (HuGE) Navigator: TDP2 (0 documents)
Export disorders for TDP2 gene to outside databases
|
Publications
for TDP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TDP2 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with TDP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation. (PubMed id 10764746)1, 2, 9 Pype S.... Remacle J.E. (2000)
- Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction. (PubMed id 22405347)1, 2 Adhikari S.... Uren A. (2012)
- An RNA virus hijacks an incognito function of a DNA repair enzyme. (PubMed id 22908287)1, 2 Virgen-Slane R....Semler B.L. (2012)
- The PML nuclear bodies-associated protein TTRAP regula tes ribosome biogenesis in nucleolar cavities upon proteasome inhibition. (PubMed id 21921940)1, 2 Vilotti S....Gustincich S. (2012)
- Biochemical characterization of human Tyrosyl DNA Phosphodiesterase 2 (TDP2/TTRAP): a Mg2+/Mn2+-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes. (PubMed id 22822062)1, 2 Gao R.... Pommier Y. (2012)
- TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiester ase activity in vertebrate cells and is critical for cellular resistance to top oisomerase II-induced DNA damage. (PubMed id 21030584)1, 2 Zeng Z....Caldecott K.W. (2011)
- A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase- mediated DNA damage. (PubMed id 19794497)1, 2 Ledesma F.C.... Caldecott K.W. (2009)
- Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. (PubMed id 18039968)1, 2 Esguerra C.V....Huylebroeck D. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for TDP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TDP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TDP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TDP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TDP2 | Pharmacogenomics, SNPs, Pathways | | SeattleSNPs | http://pga.gs.washington.edu/data/ttrap/ |
|
| | |
About This Section
| Patent Information for TDP2 gene:
Search GeneIP for patents involving TDP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TDP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for TDP2 | | OriGene shRNA RFP for TDP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDP2 | | | OriGene Protein Over-expression Lysate for TDP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TDP2 | | OriGene 3'-UTR Clone for TDP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TDP2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TDP2 | | OriGene Custom Protein Services for TDP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TDP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDP2 |
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| | | | Search Tocris compounds for TDP2 |
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 | | | TDP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDP2 |
|  |  |  | | | | ThermoFisher Antibodies for TDP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDP2 |
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