Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TDP1 Gene

protein-coding   GIFtS: 66
GCID: GC14P090422

Tyrosyl-DNA Phosphodiesterase 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tyrosyl-DNA Phosphodiesterase 11 2
Tyr-DNA Phosphodiesterase 12 3
EC 3.1.4.-3
EC 3.1.48

External Ids:    HGNC: 188841   Entrez Gene: 557752   Ensembl: ENSG000000420887   OMIM: 6071985   UniProtKB: Q9NUW83   

Export aliases for TDP1 gene to outside databases

Previous GC identifers: GC14P087927 GC14P084237 GC14P088411 GC14P088412 GC14P089492 GC14P070596


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TDP1 Gene:
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the
hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate
of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate,
suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the
phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with
the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist
for this gene, the full-length natures of only two have been described to date. These two represent the major
variants of this gene and encode the same isoform. (provided by RefSeq, Jul 2008)

GeneCards Summary for TDP1 Gene:
TDP1 (tyrosyl-DNA phosphodiesterase 1) is a protein-coding gene. Diseases associated with TDP1 include spinocerebellar ataxia with axonal neuropathy, autosomal recessive, and spinocerebellar degeneration. GO annotations related to this gene include double-stranded DNA binding and exonuclease activity.

UniProtKB/Swiss-Prot: TYDP1_HUMAN, Q9NUW8
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a
3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end
complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on
protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on
blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a
single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity
towards DNA or RNA with a 3'phosphate

Gene Wiki entry for TDP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDP1 gene promoter:
         AML1a   HSF1 (long)   MyoD   CUTL1   Nkx2-5   CBF-C   CBF-A   HSF1short   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TDP1 promoter sequence
   Search Chromatin IP Primers for TDP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.11   Ensembl cytogenetic band:  14q32.11   HGNC cytogenetic band: 14q32.11

TDP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDP1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P090422:  view genomic region     (about GC identifiers)

Start:
90,421,283 bp from pter      End:
90,511,108 bp from pter
Size:
89,826 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TYDP1_HUMAN, Q9NUW8 (See protein sequence)
Recommended Name: Tyrosyl-DNA phosphodiesterase 1  
Size: 608 amino acids; 68420 Da
Subunit: Monomer
Selected PDB 3D structures from and Proteopedia for TDP1 (see all 12):
1JY1 (3D)        1MU7 (3D)        1MU9 (3D)        1NOP (3D)        1QZQ (3D)        1RFF (3D)    
Secondary accessions: Q2HXX4 Q96BK7 Q9NZM7 Q9NZM8

Explore the universe of human proteins at neXtProt for TDP1: NX_Q9NUW8

Explore proteomics data for TDP1 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and/or threonine residues, but not on tyrosine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TDP1 (Q9NUW8)
     FGTHHTKM  PHIKTYMR 


    See TDP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008744.1  NP_060789.2  

    ENSEMBL proteins: 
     ENSP00000452042   ENSP00000377098   ENSP00000450872   ENSP00000377099   ENSP00000450708  
     ENSP00000337353   ENSP00000452279   ENSP00000451358   ENSP00000452333   ENSP00000444587  
     ENSP00000452363   ENSP00000452183   ENSP00000450628   ENSP00000451767   ENSP00000450795  
     ENSP00000349952  
    Reactome Protein details: Q9NUW8

    TDP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TDP1
    OriGene Protein Over-expression Lysate for TDP1
    OriGene MassSpec for TDP1
    OriGene Custom Protein Services for TDP1
    GenScript Custom Purified and Recombinant Proteins Services for TDP1
    Novus Biologicals TDP1 Proteins
    Novus Biologicals TDP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TDP1
    Cloud-Clone Corp. Proteins for TDP1

    TDP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TDP1
    OriGene Custom Antibody Services for TDP1
    Novus Biologicals TDP1 Antibodies
    Abcam antibodies for TDP1
    Cloud-Clone Corp. Antibodies for TDP1
    ThermoFisher Antibody for TDP1
    LSBio Antibodies in human, mouse, rat for TDP1

    TDP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TDP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TDP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TDP1
    Cloud-Clone Corp. CLIAs for TDP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR010347 Tdp1
     IPR027415 TDP_C

    Graphical View of Domain Structure for InterPro Entry Q9NUW8

    ProtoNet protein and cluster: Q9NUW8

    1 Blocks protein domain: IPB010347 Tyrosyl-DNA phosphodiesterase

    UniProtKB/Swiss-Prot: TYDP1_HUMAN, Q9NUW8
    Similarity: Belongs to the tyrosyl-DNA phosphodiesterase family


    TDP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYDP1_HUMAN, Q9NUW8
    Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a
    3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end
    complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on
    protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on
    blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a
    single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity
    towards DNA or RNA with a 3'phosphate
    Biophysicochemical properties: Kinetic parameters: KM=0.08 uM for 14-mer single-stranded oligo with a 3'-
    phosphotyrosine; Note=kcat is 7 sec(-1) with single-stranded 5'-tyrosyl DNA as substrate;

         Enzyme Numbers (IUBMB): EC 3.1.4.-1 EC 3.1.42

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003690double-stranded DNA binding IDA15811850
    GO:0003697single-stranded DNA binding IDA15811850
    GO:0004527exonuclease activity IEA--
    GO:0005515protein binding IPI15744309
    GO:0008081phosphoric diester hydrolase activity ----
         
    TDP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TDP1:
     Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tdp1):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system 

    TDP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TDP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TDP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TDP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TDP1:
    hsa-mir-320a (MIRT044817), hsa-mir-215-5p (MIRT024260), hsa-mir-1 (MIRT002780), hsa-mir-193b-3p (MIRT041491), hsa-mir-192-5p (MIRT026291)

    Block miRNA regulation of human, mouse, rat TDP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TDP1:
    hsa-miR-548t hsa-miR-581 hsa-miR-3658 hsa-miR-513a-3p hsa-miR-3653 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidTDP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TDP1
    Predesigned siRNA for gene silencing in human, mouse, rat TDP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TDP1

    Clone
    Products:
         
    OriGene clones in human, mouse for TDP1 (see all 12)
    OriGene ORF clones in mouse, rat for TDP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TDP1 (NM_001202504)
    Sino Biological Human cDNA Clone for TDP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TDP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TDP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TYDP1_HUMAN, Q9NUW8: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA17948061

    TDP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TDP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Homologous Recombination Repair
    Double-Strand Break Repair0.70
    Nonhomologous End-joining (NHEJ)0.00
    Processing of DNA ends prior to end rejoining0.00
    2DNA Repair
    DNA Repair0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TDP1
        Processing of DNA ends prior to end rejoining



    TDP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TDP1
    Interactions:

        GeneGlobe Interaction Network for TDP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TDP1 (Q9NUW82, 3 ENSP000003373534) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    H2AFXP161042, 3, ENSP000003643104MINT-7543405 MINT-7543888 MINT-7542699 I2D: score=1 STRING: ENSP00000364310
    ATMQ133152, 3, ENSP000002786164MINT-7543535 I2D: score=2 STRING: ENSP00000278616
    XRCC1P188872, 3, ENSP000002628874MINT-7543877 I2D: score=1 STRING: ENSP00000262887
    LIG3P499163, ENSP000003677874I2D: score=3 STRING: ENSP00000367787
    TOP1P113873, ENSP000003545224I2D: score=1 STRING: ENSP00000354522
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000012single strand break repair IMP17600775
    GO:0006281DNA repair IDA17948061
    GO:0006302double-strand break repair IDA12023295
    GO:0008219cell death IEA--

    TDP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TDP1 (TYDP1)

    7 Novoseek inferred chemical compound relationships for TDP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tdp-1 99.4 298 19883083 (10), 20097655 (9), 16141202 (9), 17576665 (9) (see all 36)
    phosphonate 83.8 10 15333697 (1), 15811850 (1), 12618186 (1), 15494395 (1) (see all 9)
    camptothecin 80 17 15920477 (3), 16935573 (2), 16793421 (1), 16751265 (1) (see all 7)
    phosphodiester 76.7 9 20097655 (2), 14967139 (1), 12470949 (1), 11839309 (1) (see all 8)
    vanadate 57.3 9 14761185 (3), 12618186 (2), 12470949 (2), 19963390 (1)
    tyrosine 39.1 13 14761185 (3), 12618186 (2), 15333697 (1), 15647511 (1) (see all 9)
    oligonucleotide 19.5 3 12618186 (1), 14761185 (1)



    TDP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TDP1 gene (2 alternative transcripts): 
    NM_001008744.1  NM_018319.3  

    Unigene Cluster for TDP1:

    Tyrosyl-DNA phosphodiesterase 1
    Hs.209945  [show with all ESTs]
    Unigene Representative Sequence: NM_018319
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554976 ENST00000393452 ENST00000554180 ENST00000393454 ENST00000553617
    ENST00000335725(uc010atm.3 uc001xxy.3 uc001xxz.3 uc010atn.3 uc001xya.3 uc001xyb.3)
    ENST00000555565 ENST00000556867 ENST00000553569 ENST00000553527 ENST00000553989
    ENST00000545686 ENST00000555178 ENST00000556498 ENST00000555880 ENST00000557782
    ENST00000556063(uc001xyd.1) ENST00000357382

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TDP1 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TDP1:
    hsa-miR-548t hsa-miR-581 hsa-miR-3658 hsa-miR-513a-3p hsa-miR-3653 hsa-miR-548n
    SwitchGear 3'UTR luciferase reporter plasmidTDP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TDP1
    Predesigned siRNA for gene silencing in human, mouse, rat TDP1
    Clone
    Products:
         
    OriGene clones in human, mouse for TDP1 (see all 12)
    OriGene ORF clones in mouse, rat for TDP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TDP1 (NM_001202504)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TDP1
    OriGene qSTAR qPCR primer pairs in human, mouse for TDP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TDP1
      QuantiTect SYBR Green Assays in human, mouse, rat TDP1
      QuantiFast Probe-based Assays in human, mouse, rat TDP1

    Additional mRNA sequence: 

    AF182002.1 AF182003.1 AK001952.1 AK023514.1 AK093235.1 AK315549.1 AL832288.1 BC006083.1 
    BC015474.1 BC107877.1 BX161451.1 

    17 DOTS entries:

    DT.100792498  DT.212817  DT.100774287  DT.100792501  DT.120784327  DT.91761821  DT.95375417  DT.100792497 
    DT.100737228  DT.100809028  DT.100661909  DT.40277777  DT.100736927  DT.104142  DT.100018747  DT.91761819 
    DT.95141859 

    Selected AceView cDNA sequences (see all 192):

    BQ214685 BU738356 NM_018319 BX357935 CR602214 AA620407 AK093235 AA479654 
    AA609339 BX352942 CR622999 CR618058 AA769506 BQ049211 BE613472 BC006083 
    AW849814 AA514317 BM789444 BQ233509 BU185781 BU171697 BX388603 CR605014 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TDP1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                    -     -     -           -                       -                                   -     -                       -                     
    SP2:                                            -                       -                                   -                                                   
    SP3:        -     -     -     -     -           -                                                                 -                       -                     
    SP4:                    -     -     -     -     -                       -                                   -     -                       -                     
    SP5:                                            -                       -                                   -     -                       -                     

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
    SP1:                          -               
    SP2:              -           -               
    SP3:              -           -               
    SP4:              -           -               
    SP5:              -           -               


    ECgene alternative splicing isoforms for TDP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TDP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCTCTTC
    TDP1 Expression
    About this image

    TDP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDP1 Protein Expression

    Genevestigator expression for TDP1

    SOURCE GeneReport for Unigene cluster: Hs.209945

    UniProtKB/Swiss-Prot: TYDP1_HUMAN, Q9NUW8
    Tissue specificity: Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain,
    amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital
    lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased
    expression in testis and thymus

        Custom PCR Arrays for TDP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TDP1
    OriGene qSTAR qPCR primer pairs in human, mouse for TDP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TDP1
    QuantiTect SYBR Green Assays in human, mouse, rat TDP1
    QuantiFast Probe-based Assays in human, mouse, rat TDP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TDP1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdp11 , 5 tyrosyl-DNA phosphodiesterase 11, 5 81.25(n)1
    81.58(a)1
      12 (50.43 cM)5
    1048841  NM_028354.41  NP_082630.21 
     998845175 
    chicken
    (Gallus gallus)
    Aves TDP11 tyrosyl-DNA phosphodiesterase 1 68.94(n)
    70.22(a)
      423403  XM_004941859.1  XP_004941916.1 
    lizard
    (Anolis carolinensis)
    Reptilia TDP16
    tyrosyl-DNA phosphodiesterase 1
    64(a)
    1 ↔ 1
    1(12789082-12816502)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168782 Xenopus laevis transcribed sequence with weak similarity more 75.24(n)    BU905625.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tdp11 tyrosyl-DNA phosphodiesterase 1 61.71(n)
    60.17(a)
      571485  XM_695082.5  XP_700174.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta gkt1 glaikit 48.05(n)
    39.61(a)
      33530  NM_078741.4  NP_523465.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F52C12.11 , 3 F52C12.11 34(a)3
    46.93(n)1
    38.57(a)1
      IV(1959862-1963128)3
    1769961  NM_067748.41  NP_500149.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TDP11 TDP1 48.85(n)
    39.87(a)
      831369  NM_121521.3  NP_197021.2 
    rice
    (Oryza sativa)
    Liliopsida Os.99872 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.69(n)    AK069279.1 


    ENSEMBL Gene Tree for TDP1 (if available)
    TreeFam Gene Tree for TDP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TDP1 (see all 2064)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0171444
    Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy (SCAN1)4--see VAR_0171442 H R mis40--------
    rs1194670031,2
    Cpathogenic171445194(+) GCCACA/GTATTA 4 H R mis10--------
    rs349117161,2
    C,F--71405716(+) AGCAGT/CTTTAA 2 -- us2k14Minor allele frequency- C:0.01NA WA 4742
    rs37368601,2
    C,F,H--71405726(+) AAGTCC/TTCTCT 2 -- us2k126Minor allele frequency- T:0.05EA NA NS WA EU 9947
    rs1883397331,2
    C--71405752(+) GTGATA/CTTCAT 2 -- us2k10--------
    rs344865811,2
    C,F--71405757(+) CTTCAT/CCACAT 2 -- us2k18Minor allele frequency- C:0.02NS CSA WA NA 4852
    rs345765331,2
    C,F--71405827(+) TTTATT/CACTAG 2 -- us2k15Minor allele frequency- C:0.00NS 188
    rs344957171,2
    C,F--71406078(+) GTGAGG/ACAAAG 2 -- us2k15Minor allele frequency- A:0.00NS 188
    rs355115291,2
    C,F--71406110(+) AGAGAT/CGCAGA 2 -- us2k15Minor allele frequency- C:0.00NS 188
    rs1880225531,2
    --71406197(+) GCCAGA/GAGCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TDP1 (90421283 - 90511108 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TDP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1392CNV Loss18451855
    nsv521779CNV Loss19592680
    nsv832853CNV Gain17160897
    nsv832854CNV Gain17160897

    Human Gene Mutation Database (HGMD): TDP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TDP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607198   
    OMIM disorders: 607250  
    UniProtKB/Swiss-Prot: TYDP1_HUMAN, Q9NUW8
  • Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy (SCAN1) [MIM:607250]: Spinocerebellar
    ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive
    incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the
    cerebellum with variable involvement of the brainstem and spinal cord. SCAN1 is an autosomal recessive cerebellar
    ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus
    and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 18 diseases for TDP1:    About MalaCards
    spinocerebellar ataxia with axonal neuropathy, autosomal recessive    spinocerebellar degeneration    axonal neuropathy    ollier disease
    hereditary ataxia    spinocerebellar ataxia    neuropathy    ataxia
    cerebellar ataxia    ataxia telangiectasia    muscular atrophy    neutropenia
    meningioma    cerebritis    lung cancer    multiple myeloma
    myeloma    malaria

    3 diseases from the University of Copenhagen DISEASES database for TDP1:
    Axonal neuropathy     Spinocerebellar ataxia     Ollier disease

    TDP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for TDP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    scan1 98.9 25 17600775 (4), 15920477 (4), 15647511 (3), 15744309 (3) (see all 7)
    spinocerebellar ataxias 87.3 17 16141202 (2), 16793421 (1), 17600775 (1), 20009512 (1) (see all 11)
    spinocerebellar degenerations 78.3 5 16793421 (1), 20009512 (1), 15920477 (1), 18473723 (1)
    neurodegenerative diseases 43.4 5 15744309 (1), 17045754 (1), 16141202 (1), 19794497 (1)
    cancer 2.73 2 19883083 (1), 15494395 (1)
    tumors 0 1 15379698 (1)

    GeneTests: TDP1
    GeneReviews: TDP1
    Genetic Association Database (GAD): TDP1
    Human Genome Epidemiology (HuGE) Navigator: TDP1 (3 documents)

    Export disorders for TDP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TDP1 gene, integrated from 10 sources (see all 71):
    (articles sorted by number of sources associating them with TDP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1. (PubMed id 11839309)1, 2, 3, 9 Davies D.R.... Hol W.G.J. (Structure 2002)
    2. Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy. (PubMed id 12244316)1, 2, 3 Takashima H.... Lupski J.R. (Nat. Genet. 2002)
    3. Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages. (PubMed id 16141202)1, 2, 9 Interthal H.... Champoux J.J. (J. Biol. Chem. 2005)
    4. Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1). (PubMed id 15811850)1, 2, 9 Raymond A.C.... Burgin A.B. Jr. (J. Biol. Chem. 2005)
    5. SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity. (PubMed id 15920477)1, 2, 9 Interthal H....Champoux J.J. (EMBO J. 2005)
    6. Deficiency in 3'-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1). (PubMed id 15647511)1, 2, 9 Zhou T....Povirk L.F. (Nucleic Acids Res. 2005)
    7. Insights into substrate binding and catalytic mechanism of human tyrosyl-DNA phosphodiesterase (Tdp1) from vanadate and tungstate- inhibited structures. (PubMed id 12470949)1, 2, 9 Davies D.R.... Hol W.G.J. (J. Mol. Biol. 2002)
    8. Explorations of peptide and oligonucleotide binding sites of tyrosyl- DNA phosphodiesterase using vanadate complexes. (PubMed id 14761185)1, 2, 9 Davies D.R.... Hol W.G.J. (J. Med. Chem. 2004)
    9. Crystal structure of a transition state mimic for TDP1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide. (PubMed id 12618186)1, 2, 9 Davies D.R.... Hol W.G.J. (Chem. Biol. 2003)
    10. Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues. (PubMed id 15111055)1, 2, 9 Raymond A.C.... Burgin A.B. Jr. (J. Mol. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55775 HGNC: 18884 AceView: TDP1 Ensembl:ENSG00000042088 euGenes: HUgn55775
    ECgene: TDP1 H-InvDB: TDP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TDP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TDP1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tdp1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TDP1 gene:
    Search GeneIP for patents involving TDP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TDP1   OriGene RNAi products in human, mouse, rat for TDP1  
     OriGene qPCR primer pairs and template standards for TDP1   OriGene Protein Over-expression Lysate for TDP1  
     OriGene MassSpec something-or-other for TDP1   OriGene clones in human, mouse for TDP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TDP1   OriGene Purified Protein for TDP1  
     OriGene ORF clones in mouse, rat for TDP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TDP1   OriGene Custom Protein Services for TDP1  

     
     
     Block miRNA regulation of human, mouse, rat TDP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TDP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDP1 Predesigned siRNA for gene silencing in human, mouse, rat TDP1
     QuantiFast Probe-based Assays in human, mouse, rat TDP1 QuantiTect SYBR Green Assays in human, mouse, rat TDP1
     Custom PCR Arrays for TDP1 Search Chromatin IP Primers for TDP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TDP1  GeneGlobe Interaction Network for TDP1
     Regulatory tfbs in TDP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TDP1 GenScript cDNA clones with any tag delivered in your preferred vector for TDP1
     GenScript Custom Assay Services for TDP1 GenScript Custom overexpressing Cell Line Services for TDP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TDP1 (TYDP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TDP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TDP1 antibodies
     TDP1 proteins
     TDP1 lysates
     Antibodies for TDP1
     See all of Abcam's Antibodies, Kits and Proteins for TDP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TDP1
     Proteins for TDP1
     Antibodies for TDP1
     ELISAs for TDP1
     CLIAs for TDP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TDP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDP1
     SwitchGear 3'UTR luciferase reporter plasmids for TDP1
     SwitchGear Promoter luciferase reporter plasmids for TDP1
     ThermoFisher Antibody for TDP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TDP1
     LSBio Antibodies in human, mouse, rat for TDP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TDP1 gene at Home site.
    Version: 3.12.130 7 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4