Aliases for TDO2 Gene
External Ids for TDO2 Gene
Previous GeneCards Identifiers for TDO2 Gene
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
GeneCards Summary for TDO2 Gene
TDO2 (Tryptophan 2,3-Dioxygenase) is a Protein Coding gene. Diseases associated with TDO2 include photoparoxysmal response 1 and swayback. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include heme binding and amino acid binding.
UniProtKB/Swiss-Prot for TDO2 Gene
Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).