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TDO2 Gene

protein-coding   GIFtS: 66
GCID: GC04P156824

Tryptophan 2,3-Dioxygenase

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tryptophan 2,3-Dioxygenase1 2     TO2 3
TRPO2 3 5     EC 1.13.11.113 8
Tryptamin 2,3-Dioxygenase2 3     TPH22 5
Tryptophan Oxygenase2 3     tryptophanase2
Tryptophan Pyrrolase2 3     Tryptophanase3
TDO2 3     

External Ids:    HGNC: 117081   Entrez Gene: 69992   Ensembl: ENSG000001517907   OMIM: 1910705   UniProtKB: P487753   

Export aliases for TDO2 gene to outside databases

Previous GC identifers: GC04P157712 GC04P157252 GC04P157402 GC04P157182 GC04P157044 GC04P152563


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TDO2 Gene:
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and
rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine
production may also play a role in cancer through the suppression of antitumor immune responses, and single
nucleotide polymorphisms in this gene may be associated with autism. (provided by RefSeq, Feb 2012)

GeneCards Summary for TDO2 Gene:
TDO2 (tryptophan 2,3-dioxygenase) is a protein-coding gene. Diseases associated with TDO2 include swayback, and photosensitivity disease. GO annotations related to this gene include amino acid binding and heme binding.

UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
Function: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and
derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)

Gene Wiki entry for TDO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDO2 gene promoter:
         Bach1   TBP   Pbx1a   CUTL1   NF-kappaB   GATA-1   FOXJ2 (long isoform)   NF-kappaB2   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDO2 promoter sequence
   Search Chromatin IP Primers for TDO2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31-q32   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31-q32

TDO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDO2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156824:  view genomic region     (about GC identifiers)

Start:
156,775,890 bp from pter      End:
156,841,558 bp from pter
Size:
65,669 bases      Orientation:
plus strand

1 alternative location:
Chr4+,NW_003315914 68,318-85,021     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T23O_HUMAN, P48775 (See protein sequence)
Recommended Name: Tryptophan 2,3-dioxygenase  
Size: 406 amino acids; 47872 Da
Cofactor: Binds 2 heme groups per tetramer (By similarity)
Subunit: Homotetramer (By similarity)
Secondary accessions: A8K053

Explore the universe of human proteins at neXtProt for TDO2: NX_P48775

Explore proteomics data for TDO2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TDO2 (P48775) (see all 17)
     HDEHLFI  PASGFQS  SDRYKVF  GFNFWGK 


    See TDO2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005642.1  
    ENSEMBL proteins: 
     ENSP00000423394   ENSP00000424384   ENSP00000444788  
    Reactome Protein details: P48775

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004981 Trp_2_3_dOase

    Graphical View of Domain Structure for InterPro Entry P48775

    ProtoNet protein and cluster: P48775

    1 Blocks protein domain: IPB004981 Tryptophan 2,3-dioxygenase

    UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
    Similarity: Belongs to the tryptophan 2,3-dioxygenase family


    TDO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T23O_HUMAN, P48775
    Function: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and
    derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)
    Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine

         Genatlas biochemistry entry for TDO2:
    tryptophan 2-3 dioxygenase

         Enzyme Number (IUBMB): EC 1.13.11.111 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004833tryptophan 2,3-dioxygenase activity TAS--
    GO:0016597amino acid binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IBA--
    GO:0046872metal ion binding IEA--
         
    TDO2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tdo2):
     behavior/neurological  cellular  homeostasis/metabolism  integument  nervous system 
     pigmentation  vision/eye 

    TDO2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tdo2tm1Tnak for TDO2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDO2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    peroxisome2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    TDO2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TDO2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan catabolism0.00
    Tryptophan metabolism0.46
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    tryptophan degradation via kynurenine0.00
    4tryptophan utilization II
    tryptophan utilization II0.71
    NAD de novo biosynthesis0.00
    tryptophan utilization I0.71
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde0.00
    tryptophan degradation0.00
    5Nicotinate and nicotinamide metabolism
    NAD metabolism0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TDO2
        NAD metabolism

    Selected BioSystems Pathways for TDO2 (see all 8)
        NAD de novo biosynthesis
    Monoamine Transport
    tryptophan degradation via kynurenine
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    Tryptophan metabolism


    1 Reactome Pathway for TDO2
        Tryptophan catabolism


    2 Kegg Pathways  (Kegg details for TDO2):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
    Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan:
    step 1/2


    TDO2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TDO2: 

              Amino Acid Metabolism I in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TDO2

    3 Interacting proteins for TDO2 (P487752, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASMTLO956713I2D: score=4 
    GALEQ143763I2D: score=1 
    --Q5JQ522MINT-66349
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006568tryptophan metabolic process ----
    GO:0006569tryptophan catabolic process TAS--
    GO:0019441tryptophan catabolic process to kynurenine IEA--
    GO:0019442tryptophan catabolic process to acetyl-CoA IBA--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    TDO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for TDO2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FebuxostatXanthine oxidase inhibitor[144060-53-7]
    680C91 Potent and selective inhibitor of tryptophan 2,3-dioxygenase [163239-22-3]
    MDL 72527Polyamine oxidase (PAO) inhibitor[93565-01-6]

    5 HMDB Compounds for TDO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    L-Tryptophan(-)-tryptophan (see all 53)73-22-3--
    N'-Formylkynurenine3-(N-formylanthraniloyl)-Alanine (see all 9)1022-31-7--
    OxygenOxygen (see all 5)7782-44-7--
    ValdecoxibBextra (see all 6)181695-72-7--

    3 DrugBank Compounds for TDO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3enzymesubstrate19290871
    Nalidixic Acid-- 389-08-2enzymeinhibitor108253
    TolmetinTolmetin Sodium (see all 5)26171-23-3enzymeinhibitor16952380

    Selected Novoseek inferred chemical compound relationships for TDO2 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indoleamine 88 16 17430112 (1), 19021508 (1), 19275153 (1), 15056470 (1) (see all 14)
    kynurenine 85.8 14 16897051 (2), 19021508 (1), 19759277 (1), 12871129 (1) (see all 10)
    l-tryptophan 84.1 21 19218188 (3), 19582219 (3), 20047315 (2), 19021508 (1) (see all 13)
    indole 81.8 20 16091039 (1), 18608755 (1), 17924666 (1), 16557313 (1) (see all 15)
    n-formylkynurenine 81.4 5 19275153 (1), 18370410 (1), 19218188 (1), 20047315 (1)
    pyridoxal 5-phosphate 54.7 6 17937401 (1), 9565551 (1), 11904229 (1), 9551100 (1)
    bifidobacterium 44.7 1 9875515 (1)
    quinolinic acid 37.6 1 1664036 (1)
    haem 34.6 2 19290871 (1), 19218188 (1)
    melatonin 33.1 9 9379342 (5), 9949305 (1)



    TDO2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TDO2 gene: 
    NM_005651.3  

    Unigene Cluster for TDO2:

    Tryptophan 2,3-dioxygenase
    Hs.183671  [show with all ESTs]
    Unigene Representative Sequence: BX647341
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503634 ENST00000506181 ENST00000506072 ENST00000507590 ENST00000509738
    ENST00000536354(uc003ipf.1) ENST00000512584 ENST00000510293
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK289418.1 AK307741.1 BC005355.1 BX647341.1 U32989.1 

    6 DOTS entries:

    DT.313977  DT.91771370  DT.91771367  DT.91771368  DT.95265276  DT.95339128 

    Selected AceView cDNA sequences (see all 100):

    BG744666 AV681870 AA344430 CD107651 BG569675 BG616881 W20466 U32989 
    BG562454 NM_005651 BX113653 BG564876 R00392 BF063812 BG617602 BG616785 
    BG562641 BG563303 BE379581 BG565053 BG564329 BG617121 BG617332 BX495753 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TDO2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -                             -                                                   
    SP2:                                                              -     -                                             
    SP3:                                -                                                                                 
    SP4:                          -     -     -                                                                           
    SP5:                          -     -     -                       -                                                   


    ECgene alternative splicing isoforms for TDO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCACAGAA
    TDO2 Expression
    About this image


    TDO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 4 entries
             Immature hepatocytes
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Endothelium (Cardiovascular System)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Extraembryonic Angioblasts Extraembryonic Capillary Plexus
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    TDO2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDO2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183671
        Pathway & Disease-focused RT2 Profiler PCR Array including TDO2: 
              Amino Acid Metabolism I in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TDO2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdo21 , 5 tryptophan 2,3-dioxygenase1, 5 83.58(n)1
    88.67(a)1
      3 (35.97 cM)5
    567201  NM_019911.21  NP_064295.21 
     819570905 
    chicken
    (Gallus gallus)
    Aves TDO21 tryptophan 2,3-dioxygenase 78.33(n)
    83.74(a)
      422409  XM_420377.4  XP_420377.3 
    lizard
    (Anolis carolinensis)
    Reptilia TDO26
    tryptophan 2,3-dioxygenase
    83(a)
    1 ↔ 1
    5(129446586-129468797)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.307112 Xenopus laevis transcribed sequence with moderate similarity more 79.13(n)    48039745 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi30d082 wufi30d08 73.74(n)   334082  BC055123.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta v1 , 3 ommochrome biosynthesis tryptophan 2,3
    dioxygenase3
    vermilion1
    56(a)3
    60.11(n)1
    58.49(a)1
      1 9F113
    320261  NM_078558.31  NP_511113.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.111 C28H8.11 56.28(n)
    53.27(a)
      175836  NM_065883.4  NP_498284.1 


    ENSEMBL Gene Tree for TDO2 (if available)
    TreeFam Gene Tree for TDO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDO2 (see all 477)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437643901,2
    --156822860(+) AAATGA/TTGACC 1 -- us2k10--------
    rs1867012251,2
    --156822929(+) TGTATA/GGGGGC 1 -- us2k10--------
    rs1468500481,2
    C--156822946(+) CTGTAA/GTTACT 1 -- us2k10--------
    rs623284311,2
    C,F--156822993(+) CTTGCA/GGTTTC 1 -- us2k12Minor allele frequency- G:0.06NA 122
    rs173799131,2
    C,F,H--156823004(+) TCTGAT/CGCCCC 1 -- us2k18Minor allele frequency- C:0.02NA NS EA 656
    rs1408541451,2
    --156823007(+) GATGCC/TCCAAA 1 -- us2k10--------
    rs1905435211,2
    --156823104(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs1830981741,2
    --156823222(+) TTAAAA/GAGAGT 1 -- us2k10--------
    rs1877402261,2
    --156823259(+) TGTAAA/TCACGT 1 -- us2k10--------
    rs1925475421,2
    --156823295(+) AAGAGA/GGGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TDO2 (156775890 - 156841558 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TDO2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830121CNV Gain17160897

    Human Gene Mutation Database (HGMD): TDO2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDO2
    DNA2.0 Custom Variant and Variant Library Synthesis for TDO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191070    OMIM disorders: --

    Selected diseases for TDO2 (see all 22):    
    About MalaCards
    swayback    photosensitivity disease    dental enamel hypoplasia    paronychia
    eosinophilia-myalgia syndrome    pellagra    acute intermittent porphyria    constipation
    substance abuse    pervasive developmental disorder    gilles de la tourette syndrome    porphyria
    otitis media    eosinophilia    attention deficit hyperactivity disorder    bipolar disorder
    schizophrenia    influenza    hepatitis b    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for TDO2:
    Pellagra     Gilles de la Tourette syndrome

    TDO2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TDO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 23 1 2004780 (1)
    schizophrenia 17.7 10 16448631 (4), 16897051 (1), 15056470 (1), 18328600 (1)
    psychiatric disorder 13.6 3 8666386 (1), 10580097 (1), 8873217 (1)

    Genetic Association Database (GAD): TDO2
    Human Genome Epidemiology (HuGE) Navigator: TDO2 (3 documents)

    Export disorders for TDO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TDO2 gene, integrated from 10 sources (see all 123):
    (articles sorted by number of sources associating them with TDO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat. (PubMed id 8666386)1, 2, 9 Comings D.E.... Forest G.L. (Genomics 1995)
    2. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PubMed id 19786962)1, 4 Roeske D....Schulte-KAPrne G. (Mol. Psychiatry 2011)
    3. Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder. (PubMed id 19502010)1, 4 Miller C.L....Leonard S. (Schizophr. Res. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. (PubMed id 11140838)1, 4 Comings D.E....MacMurray J.P. (Clin. Genet. 2000)
    6. Antimicrobial and immunoregulatory properties of human tryptophan 2,3-dioxygenase. (PubMed id 19637229)1, 9 Schmidt S.K....DAoubener W. (Eur. J. Immunol. 2009)
    7. Association of tryptophan 2,3 dioxygenase gene polymorphism with autism. (PubMed id 14755447)1, 9 Nabi R....Huq A.H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    8. Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders. (PubMed id 2004780)1, 9 Comings D.E....Donlon T. (Genomics 1991)
    9. Cooperative binding of L-trp to human tryptophan 2,3-dioxygenase: resonance Raman spectroscopic analysis. (PubMed id 19218188)1, 9 Fukumura E....Shiro Y. (J. Biochem. 2009)
    10. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels. (PubMed id 16952380)7, 9 Dairam A....Daya S. (Life Sci. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6999 HGNC: 11708 AceView: TDO2 Ensembl:ENSG00000151790 euGenes: HUgn6999
    ECgene: TDO2 Kegg: 6999 H-InvDB: TDO2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TDO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TDO2 gene:
    Search GeneIP for patents involving TDO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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