Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TDO2 Gene

protein-coding   GIFtS: 67
GCID: GC04P156824

tryptophan 2,3-dioxygenase
 Explore 28 diseases affiliated with
TDO2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TDO2    

Aliases
for TDO2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tryptophan 2,3-Dioxygenase1 2     Tryptophan Pyrrolase2 3
TDO1 2 3     TO2 3
TPH21 2 5     EC 1.13.11.113 8
TRPO2 3 5     Tryptophanase3
Tryptamin 2,3-Dioxygenase2 3     Tryptophanase3
Tryptophan Oxygenase2 3     

External Ids:    HGNC: 117081   Entrez Gene: 69992   Ensembl: ENSG000001517907   OMIM: 1910705   UniProtKB: P487753   

Export aliases for TDO2 gene to outside databases

Previous GC identifers: GC04P157712 GC04P157252 GC04P157402 GC04P157182 GC04P157044 GC04P152563


Summaries
for TDO2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TDO2:
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and
rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine
production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide
polymorphisms in this gene may be associated with autism. (provided by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
Function: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and
derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)

Gene Wiki entry for TDO2


Genomic Views
for TDO2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TDO2 gene promoter:
         Bach1   TBP   Pbx1a   CUTL1   NF-kappaB   GATA-1   FOXJ2 (long isoform)   NF-kappaB2   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TDO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TDO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31-q32   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31-q32

TDO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDO2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156824:  view genomic region     (about GC identifiers)

Start:
 156,775,890 bp from pter      End:
 156,841,558 bp from pter
Size:
 65,669 bases      Orientation:
 plus strand

1 alternative location:
Chr4+,PATCHES 156,818,522-156,835,225     

Proteins
for TDO2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: T23O_HUMAN, P48775 (See protein sequence)
Recommended Name: Tryptophan 2,3-dioxygenase  
Size: 406 amino acids; 47872 Da
Cofactor: Binds 2 heme groups per tetramer (By similarity)
Subunit: Homotetramer (By similarity)
Secondary accessions: A8K053

Explore the universe of human proteins at neXtProt for TDO2: NX_P48775

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48775

    • 4/17 DME Specific Peptides for TDO2 (P48775) (see all 17)
     HDEHLFI  PASGFQS  SDRYKVF  GFNFWGK 

    TDO2 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_005642.1  
    ENSEMBL proteins: 
     ENSP00000423394   ENSP00000424384   ENSP00000444788  
    Reactome Protein details: P48775
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for TDO2
    OriGene Purified Protein: TDO2
    OriGene Protein Over-expression Lysate: TDO2
    OriGene Custom Protein Services for TDO2 
    GenScript Custom Purified and Recombinant Proteins Services for TDO2
    Novus Biologicals TDO2 Proteins
    Novus Biologicals TDO2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TDO2
    Uscn Proteins for TDO2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005829cytosol TAS--


    TDO2 for ontologies           About GeneDecksing



    TDO2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 4): TDO2
    OriGene Custom Antibody Services for TDO2 
    GenScript Custom Superior Antibodies Services for TDO2
    Novus Biologicals TDO2 Antibodies
    Search for Antibodies for TDO2 at Abcam  
    Uscn Antibodies for TDO2
    Search ThermoFisher Antibodies for TDO2

    Assay Products for TDO2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TDO2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TDO2

    Protein Domains /
    Families
    for TDO2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TDO2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004981 Trp_2_3_dOase

    Graphical View of Domain Structure for InterPro Entry P48775

    ProtoNet protein and cluster: P48775

    1 Blocks protein family: IPB004981 Tryptophan 2,3-dioxygenase

    UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
    Similarity: Belongs to the tryptophan 2,3-dioxygenase family


    Function
    for TDO2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
    Function: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and
    derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)
    Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine

         Genatlas biochemistry entry for TDO2:
    tryptophan 2-3 dioxygenase

    Enzyme Number (IUBMB): EC 1.13.11.111 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: TDO2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDO2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TDO2
    SwitchGear 3'UTR luciferase reporter plasmid: TDO2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDO2 (see all 7)
    OriGene shRNA RFP: TDO2
    OriGene siRNA: TDO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDO2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TDO2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDO2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDO2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TDO2 (NM_005651)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDO2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TDO2
    Search LifeMap BioReagents cell lines for TDO2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDO2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004833tryptophan 2,3-dioxygenase activity TAS--
    GO:0005506iron ion binding IEA--
    GO:0016597amino acid binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IBA--


    TDO2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Tdo2tm1Tnak for TDO2
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Tdo2):
     behavior/neurological  cellular  homeostasis/metabolism  integument  nervous system 
     pigmentation  vision/eye 

    TDO2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TDO2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    		tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde1.00
    		Tryptophan catabolism0.45
    		NAD biosynthesis II (from tryptophan)0.50
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3NAD metabolism
    		NAD metabolism1.00
    		NAD metabolism1.00
    4Tryptophan metabolism
    		Tryptophan metabolism1.00
    		Tryptophan metabolism0.47
    5Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for TDO2
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for TDO2
        NAD metabolism

    5 BioSystems Pathways for TDO2 
        Monoamine Transport
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    Tryptophan metabolism
    tryptophan degradation III (eukaryotic)
    NAD biosynthesis II (from tryptophan)

    3        Reactome Pathways for TDO2
        Tryptophan catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for TDO2):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
    Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step
    1/2


    TDO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TDO2

    3 Interacting proteins for TDO2 (P487752, 3) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASMTLO956713I2D: score=4 
    GALEQ143763I2D: score=1 
    --Q5JQ522MINT-66349
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006568tryptophan metabolic process ----
    GO:0006569tryptophan catabolic process TAS--
    GO:0019441tryptophan catabolic process to kynurenine IEA--
    GO:0019442tryptophan catabolic process to acetyl-CoA IBA--
    GO:0034641cellular nitrogen compound metabolic process TAS--


    TDO2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TDO2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TDO2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TDO2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    680C91 Potent and selective inhibitor of tryptophan 2,3-dioxygenase [163239-22-3]

    5 HMDB Compounds for TDO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    L-Tryptophan(-)-tryptophan (see all 53)73-22-3--
    N'-Formylkynurenine3-(N-formylanthraniloyl)-Alanine (see all 9)1022-31-7--
    OxygenOxygen (see all 5)7782-44-7--
    ValdecoxibBextra (see all 6)181695-72-7--

    2 DrugBank Compounds for TDO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3enzymesubstrate19290871
    Nalidixic Acid-- 389-08-2enzymeinhibitor108253

    10/29 Novoseek chemical compound relationships for TDO2 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indoleamine 88 16 17430112 (1), 19021508 (1), 19275153 (1), 15056470 (1) (see all 14)
    kynurenine 85.8 14 16897051 (2), 19021508 (1), 19759277 (1), 12871129 (1) (see all 10)
    l-tryptophan 84.1 21 19218188 (3), 19582219 (3), 20047315 (2), 19021508 (1) (see all 13)
    indole 81.8 20 16091039 (1), 18608755 (1), 17924666 (1), 16557313 (1) (see all 15)
    n-formylkynurenine 81.4 5 19275153 (1), 18370410 (1), 19218188 (1), 20047315 (1)
    pyridoxal 5-phosphate 54.7 6 17937401 (1), 9565551 (1), 11904229 (1), 9551100 (1)
    bifidobacterium 44.7 1 9875515 (1)
    quinolinic acid 37.6 1 1664036 (1)
    haem 34.6 2 19290871 (1), 19218188 (1)
    melatonin 33.1 9 9379342 (5), 9949305 (1)

    Search CenterWatch for drugs/clinical trials and news about TDO2 / T23O 

    Transcripts
    for TDO2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TDO2 gene: 
    NM_005651.3  

    Unigene Cluster for TDO2:

    Tryptophan 2,3-dioxygenase
    Hs.183671  [show with all ESTs]
    Unigene Representative Sequence: BX647341
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503634 ENST00000506181 ENST00000506072 ENST00000507590 ENST00000509738
    ENST00000536354(uc003ipf.1) ENST00000512584 ENST00000510293

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TDO2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDO2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TDO2
    SwitchGear 3'UTR luciferase reporter plasmid: TDO2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDO2 (see all 7)
    OriGene shRNA RFP: TDO2
    OriGene siRNA: TDO2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDO2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDO2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDO2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TDO2 (NM_005651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDO2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDO2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDO2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TDO2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDO2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDO2

    Additional cDNA sequence: 

    AK289418.1 AK307741.1 BC005355.1 BX647341.1 U32989.1 

    6 DOTS entries:

    DT.313977  DT.91771370  DT.91771367  DT.91771368  DT.95265276  DT.95339128 

    24/100 AceView cDNA sequences (see all 100):

    BX113653 BG616881 NM_005651 BF063812 BG744666 BG569675 BG562454 W20466 
    AA344430 U32989 R00392 BG564876 AV681870 CD107651 BG617121 BG562709 
    BG568577 BI833613 BG564329 BG563207 BG565743 BG562641 BE728670 BG545282 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TDO2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -                             -                                                   
    SP2:                                                              -     -                                             
    SP3:                                -                                                                                 
    SP4:                          -     -     -                                                                           
    SP5:                          -     -     -                       -                                                   


    ECgene alternative splicing isoforms for TDO2

    Expression
    for TDO2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TDO2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCACAGAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TDO2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Hepatocyte-like cells (Functional hepatocyt...)
    Immature hepatocytes (Functional, immature...)
    Immature hepatocyte-like cells (Generation of hepato...)

    Genevestigator expression for TDO2

    SOURCE GeneReport for Unigene cluster: Hs.183671
        SABiosciences Expression via Pathway-Focused PCR Array including TDO2: 
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDO2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TDO2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDO2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDO2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDO2

    Orthologs
    for TDO2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TDO2 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tdo21 , 5 tryptophan 2,3-dioxygenase1, 5 83.58(n)1
    88.67(a)1    		   3 (35.97 cM)5
    567201  NM_019911.21  NP_064295.21 
     819570905 
    chicken
    (Gallus gallus)    		 Aves TDO21 tryptophan 2,3-dioxygenase 78.33(n)
    83.74(a)    		   422409  XM_420377.3  XP_420377.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TDO26
    		 --
    		 83(a)
    		 1 ↔ 1
    		 5(129447912-129468562)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.307112 Xenopus laevis transcribed sequence with moderate similarity more 79.13(n)    48039745 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi30d082 wufi30d08 73.74(n)   334082  BC055123.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta v3 ommochrome biosynthesis tryptophan 2,3
    dioxygenase    		 56(a)   1 9F11   --
    worm
    (Caenorhabditis elegans)    		 Secernentea C28H8.111 Protein C28H8.11 56.26(n)
    53.4(a)    		   175836  NM_065883.3  NP_498284.1 


    ENSEMBL Gene Tree for TDO2 (if available)
    TreeFam Gene Tree for TDO2 (if available) 

    Paralogs
    for TDO2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for TDO2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): TDO2
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDO2
    DNA2.0 Custom Variant and Variant Library Synthesis for TDO2

    Disorders / Diseases
    for TDO2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TDO2 for disorders           About GeneDecksing

    OMIM gene information: 191070    OMIM disorders: --

    20/28 diseases for TDO2 (see all 28):    About MalaCards
    gilles de la tourette syndrome    eosinophilia-myalgia syndrome    dental enamel hypoplasia    attention deficit hyperactivity disorder
    pervasive developmental disorder    acute intermittent porphyria    substance abuse    otitis media
    swayback    paronychia    tourette syndrome    haemophilus influenzae
    pellagra    porphyria    photosensitivity disease    bipolar disorder
    constipation    eosinophilia    paralysis    adhd

    1 disease from the University of Copenhagen DISEASES database for TDO2:
    Pellagra

    3 Novoseek disease relationships for TDO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 23 1 2004780 (1)
    schizophrenia 17.7 10 16448631 (4), 16897051 (1), 15056470 (1), 18328600 (1)
    psychiatric disorder 13.6 3 8666386 (1), 10580097 (1), 8873217 (1)

    Genetic Association Database (GAD): TDO2
    Human Genome Epidemiology (HuGE) Navigator: TDO2 (3 documents)

    Export disorders for TDO2 gene to outside databases

    Publications
    for TDO2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TDO2 gene, integrated from 9 sources (see all 121):
    (articles sorted by number of sources associating them with TDO2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat. (PubMed id 8666386)1, 2, 9 Comings D.E.... Forest G.L. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Antimicrobial and immunoregulatory properties of huma n tryptophan 2,3-dioxygenase. (PubMed id 19637229)1, 9 Schmidt S.K....DAoubener W. (2009)
    4. Association of tryptophan 2,3 dioxygenase gene polymorphism with autism. (PubMed id 14755447)1, 9 Nabi R....Huq A.H. (2004)
    5. Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders. (PubMed id 2004780)1, 9 Comings D.E....Donlon T. (1991)
    6. Cooperative binding of L-trp to human tryptophan 2,3-dioxygenase: resonance Raman spectroscopic analysis. (PubMed id 19218188)1, 9 Fukumura E....Shiro Y. (2009)
    7. Exon and intron variants in the human tryptophan 2,3-dioxygenase gene: potential association with Tourette syndrome, substance abuse and other disorders. (PubMed id 8873217)4, 9 Comings D.E....MacMurray J.P. (1996)
    8. Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase. (PubMed id 19290871)7, 9 Rafice S.A....Raven E.L. (2009)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. Reversal of tumoral immune resistance by inhibition o f tryptophan 2,3-dioxygenase. (PubMed id 22308364)1 Pilotte L....Van den Eynde B.J. (2012)

    External Searches for TDO2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TDO2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6999 HGNC: 11708 AceView: TDO2 Ensembl:ENSG00000151790 euGenes: HUgn6999
    ECgene: TDO2 Kegg: 6999 H-InvDB: TDO2

    Other Databases showing TDO2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TDO2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TDO2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TDO2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TDO2 gene:
    Search GeneIP for patents involving TDO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TDO2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for TDO2   OriGene shRNA RFP for TDO2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDO2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDO2  
     OriGene Protein Over-expression Lysate for TDO2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TDO2   OriGene 3'-UTR Clone for TDO2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDO2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDO2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TDO2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TDO2   OriGene Custom Protein Services for TDO2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TDO2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDO2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDO2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDO2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDO2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDO2
     GenScript Custom Purified and Recombinant Proteins Services for TDO2 GenScript cDNA clones with any tag delivered in your preferred vector for TDO2
     GenScript Custom Assay Services for TDO2 GenScript Custom Superior Antibodies Services for TDO2
     GenScript Custom overexpressing Cell Line Services for TDO2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TDO2 promoter
     Search Chromatin IP Primers for TDO2
     RT2 qPCR Primer Assay in human, mouse, rat TDO2
     Search GNC Networks for TDO2
     SABiosciences PCR Arrays including human, mouse, rat TDO2
     Tocris compounds for TDO2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for TDO2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TDO2 antibodies
     TDO2 proteins
     TDO2 lysates
     Search for Antibodies for TDO2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TDO2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TDO2




     TDO2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TDO2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDO2
     SwitchGear 3'UTR luciferase reporter plasmids for TDO2
     SwitchGear Promoter luciferase reporter plasmids for TDO2
     Search ThermoFisher Antibodies for TDO2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDO2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TDO2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4