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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TDO2 Gene

protein-coding   GIFtS: 67
GCID: GC04P156824

Tryptophan 2,3-Dioxygenase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tryptophan 2,3-Dioxygenase1 2     TO2 3
TRPO2 3 5     EC 1.13.11.113 8
Tryptamin 2,3-Dioxygenase2 3     TPH22 5
Tryptophan Oxygenase2 3     tryptophanase2
Tryptophan Pyrrolase2 3     Tryptophanase3
TDO2 3     

External Ids:    HGNC: 117081   Entrez Gene: 69992   Ensembl: ENSG000001517907   OMIM: 1910705   UniProtKB: P487753   

Export aliases for TDO2 gene to outside databases

Previous GC identifers: GC04P157712 GC04P157252 GC04P157402 GC04P157182 GC04P157044 GC04P152563


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TDO2 Gene:
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and
rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine
production may also play a role in cancer through the suppression of antitumor immune responses, and single
nucleotide polymorphisms in this gene may be associated with autism. (provided by RefSeq, Feb 2012)

GeneCards Summary for TDO2 Gene: 
TDO2 (tryptophan 2,3-dioxygenase) is a protein-coding gene. Diseases associated with TDO2 include swayback, and photosensitivity disease, and among its related super-pathways are tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde and Tryptophan metabolism. GO annotations related to this gene include iron ion binding and oxygen binding.

UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
Function: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and
derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)

Gene Wiki entry for TDO2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TDO2 gene promoter:
         Bach1   TBP   Pbx1a   CUTL1   NF-kappaB   GATA-1   FOXJ2 (long isoform)   NF-kappaB2   STAT3   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TDO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31-q32   Ensembl cytogenetic band:  4q32.1   HGNC cytogenetic band: 4q31-q32

TDO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDO2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P156824:  view genomic region     (about GC identifiers)

Start:
156,775,890 bp from pter      End:
156,841,558 bp from pter
Size:
65,669 bases      Orientation:
plus strand

1 alternative location:
Chr4+,NW_003315914 68,318-85,021     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T23O_HUMAN, P48775 (See protein sequence)
Recommended Name: Tryptophan 2,3-dioxygenase  
Size: 406 amino acids; 47872 Da
Cofactor: Binds 2 heme groups per tetramer (By similarity)
Subunit: Homotetramer (By similarity)
Secondary accessions: A8K053

Explore the universe of human proteins at neXtProt for TDO2: NX_P48775

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P48775

  • 4/17 DME Specific Peptides for TDO2 (P48775) (see all 17)
     HDEHLFI  PASGFQS  SDRYKVF  GFNFWGK 

    TDO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_005642.1  
    ENSEMBL proteins: 
     ENSP00000423394   ENSP00000424384   ENSP00000444788  
    Reactome Protein details: P48775
    Human Recombinant Protein Products for TDO2: 
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    ProSpec Recombinant Protein for TDO2
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    TDO2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004981 Trp_2_3_dOase

    Graphical View of Domain Structure for InterPro Entry P48775

    ProtoNet protein and cluster: P48775

    1 Blocks protein domain: IPB004981 Tryptophan 2,3-dioxygenase

    UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
    Similarity: Belongs to the tryptophan 2,3-dioxygenase family


    TDO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T23O_HUMAN, P48775
    Function: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and
    derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity)
    Catalytic activity: L-tryptophan + O(2) = N-formyl-L-kynurenine

         Genatlas biochemistry entry for TDO2:
    tryptophan 2-3 dioxygenase

         Enzyme Number (IUBMB): EC 1.13.11.111 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004833tryptophan 2,3-dioxygenase activity TAS--
    GO:0016597amino acid binding IEA--
    GO:0019825oxygen binding IEA--
    GO:0020037heme binding IBA--
    GO:0046872metal ion binding IEA--
         
    TDO2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tdo2):
     behavior/neurological  cellular  homeostasis/metabolism  integument  nervous system 
     pigmentation  vision/eye 

    TDO2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tdo2tm1Tnak for TDO2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TDO2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TDO2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TDO2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TDO2 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde0.50
    NAD biosynthesis II (from tryptophan)0.50
    tryptophan degradation III (eukaryotic)0.50
    Tryptophan catabolism0.45
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4tryptophan utilization II
    tryptophan utilization II0.70
    tryptophan utilization I0.70
    5NAD metabolism
    NAD metabolism0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TDO2
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for TDO2
        NAD metabolism

    5/7 BioSystems Pathways for TDO2 (see all 7)
        Monoamine Transport
    tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
    Tryptophan metabolism
    NAD biosynthesis II (from tryptophan)
    tryptophan degradation III (eukaryotic)


    3        Reactome Pathways for TDO2
        Tryptophan catabolism
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for TDO2):
        Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: T23O_HUMAN, P48775
    Pathway: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan:
    step 1/2


    TDO2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TDO2

    3 Interacting proteins for TDO2 (P487752, 3) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASMTLO956713I2D: score=4 
    GALEQ143763I2D: score=1 
    --Q5JQ522MINT-66349
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006568tryptophan metabolic process ----
    GO:0006569tryptophan catabolic process TAS--
    GO:0019441tryptophan catabolic process to kynurenine IEA--
    GO:0019442tryptophan catabolic process to acetyl-CoA IBA--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    TDO2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TDO2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TDO2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FebuxostatXanthine oxidase inhibitor[144060-53-7]
    680C91 Potent and selective inhibitor of tryptophan 2,3-dioxygenase [163239-22-3]
    MDL 72527Polyamine oxidase (PAO) inhibitor[93565-01-6]

    5 HMDB Compounds for TDO2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Heme(protoporphyrinato)iron (see all 19)14875-96-8--
    L-Tryptophan(-)-tryptophan (see all 53)73-22-3--
    N'-Formylkynurenine3-(N-formylanthraniloyl)-Alanine (see all 9)1022-31-7--
    OxygenOxygen (see all 5)7782-44-7--
    ValdecoxibBextra (see all 6)181695-72-7--

    3 DrugBank Compounds for TDO2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Tryptophan(-)-Tryptophan (see all 14)73-22-3enzymesubstrate19290871
    Nalidixic Acid-- 389-08-2enzymeinhibitor108253
    TolmetinTolmetin Sodium (see all 5)26171-23-3enzymeinhibitor16952380

    10/29 Novoseek inferred chemical compound relationships for TDO2 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    indoleamine 88 16 17430112 (1), 19021508 (1), 19275153 (1), 15056470 (1) (see all 14)
    kynurenine 85.8 14 16897051 (2), 19021508 (1), 19759277 (1), 12871129 (1) (see all 10)
    l-tryptophan 84.1 21 19218188 (3), 19582219 (3), 20047315 (2), 19021508 (1) (see all 13)
    indole 81.8 20 16091039 (1), 18608755 (1), 17924666 (1), 16557313 (1) (see all 15)
    n-formylkynurenine 81.4 5 19275153 (1), 18370410 (1), 19218188 (1), 20047315 (1)
    pyridoxal 5-phosphate 54.7 6 17937401 (1), 9565551 (1), 11904229 (1), 9551100 (1)
    bifidobacterium 44.7 1 9875515 (1)
    quinolinic acid 37.6 1 1664036 (1)
    haem 34.6 2 19290871 (1), 19218188 (1)
    melatonin 33.1 9 9379342 (5), 9949305 (1)

    Search CenterWatch for drugs/clinical trials and news about TDO2 / T23O

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
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    About This Section

    REFSEQ mRNAs for TDO2 gene: 
    NM_005651.3  

    Unigene Cluster for TDO2:

    Tryptophan 2,3-dioxygenase
    Hs.183671  [show with all ESTs]
    Unigene Representative Sequence: BX647341
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503634 ENST00000506181 ENST00000506072 ENST00000507590 ENST00000509738
    ENST00000536354(uc003ipf.1) ENST00000512584 ENST00000510293
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK289418.1 AK307741.1 BC005355.1 BX647341.1 U32989.1 

    6 DOTS entries:

    DT.313977  DT.91771370  DT.91771367  DT.91771368  DT.95265276  DT.95339128 

    24/100 AceView cDNA sequences (see all 100):

    R00392 AA344430 BX113653 BG616881 BG562454 BG744666 CD107651 U32989 
    BG569675 W20466 NM_005651 AV681870 BF063812 BG564876 BG545119 BG568953 
    BG565518 BI772258 BG120892 BG616664 BG567109 BX506600 BG568315 BG618475 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TDO2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -                             -                                                   
    SP2:                                                              -     -                                             
    SP3:                                -                                                                                 
    SP4:                          -     -     -                                                                           
    SP5:                          -     -     -                       -                                                   


    ECgene alternative splicing isoforms for TDO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TDO2 expression in normal human tissues (normalized intensities)      TDO2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCACAGAA
    TDO2 Expression
    About this image


    TDO2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Hepatocyte-like cells ( Functional hepatocyte generation from human embryonic stem...
             Human Hepatocyte (HH)   
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Lower Urinary Tract (Urinary System)
             Human Urothelial Cells (HUC)   
     
     Epithelium (Uncategorized)
             Human Urothelial Cells (HUC)   
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter

    Genevestigator expression for TDO2

    SOURCE GeneReport for Unigene cluster: Hs.183671
        SABiosciences Expression via Pathway-Focused PCR Array including TDO2: 
              Amino Acid Metabolism I in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TDO2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdo21 , 5 tryptophan 2,3-dioxygenase1, 5 83.58(n)1
    88.67(a)1
      3 (35.97 cM)5
    567201  NM_019911.21  NP_064295.21 
     819570905 
    chicken
    (Gallus gallus)
    Aves TDO21 tryptophan 2,3-dioxygenase 78.33(n)
    83.74(a)
      422409  XM_420377.3  XP_420377.2 
    lizard
    (Anolis carolinensis)
    Reptilia TDO26
    Uncharacterized protein
    83(a)
    1 ↔ 1
    5(129446586-129468797)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.307112 Xenopus laevis transcribed sequence with moderate similarity more 79.13(n)    48039745 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi30d082 wufi30d08 73.74(n)   334082  BC055123.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta v3 ommochrome biosynthesis tryptophan 2,3
    dioxygenase
    56(a)   1 9F11   --
    worm
    (Caenorhabditis elegans)
    Secernentea C28H8.111 Protein C28H8.11 56.26(n)
    53.4(a)
      175836  NM_065883.3  NP_498284.1 


    ENSEMBL Gene Tree for TDO2 (if available)
    TreeFam Gene Tree for TDO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/477 SNPs in TDO2 are shown (see all 477)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437643901,2
    --156822860(+) AAATGA/TTGACC 1 -- us2k10--------
    rs1867012251,2
    --156822929(+) TGTATA/GGGGGC 1 -- us2k10--------
    rs1468500481,2
    C--156822946(+) CTGTAA/GTTACT 1 -- us2k10--------
    rs623284311,2
    C,F--156822993(+) CTTGCA/GGTTTC 1 -- us2k12Minor allele frequency- G:0.06NA 122
    rs173799131,2
    C,F,H--156823004(+) TCTGAT/CGCCCC 1 -- us2k18Minor allele frequency- C:0.02NA NS EA 656
    rs1408541451,2
    --156823007(+) GATGCC/TCCAAA 1 -- us2k10--------
    rs1905435211,2
    --156823104(+) AAAAAA/TTTTTT 1 -- us2k10--------
    rs1830981741,2
    --156823222(+) TTAAAA/GAGAGT 1 -- us2k10--------
    rs1877402261,2
    --156823259(+) TGTAAA/TCACGT 1 -- us2k10--------
    rs1925475421,2
    --156823295(+) AAGAGA/GGGCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TDO2 (156775890 - 156841558 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TDO2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830121CNV Gain17160897


    Human Gene Mutation Database (HGMD): TDO2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TDO2
    DNA2.0 Custom Variant and Variant Library Synthesis for TDO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191070    OMIM disorders: --

    20/26 diseases for TDO2 (see all 26):    About MalaCards
    swayback    photosensitivity disease    paronychia    dental enamel hypoplasia
    eosinophilia-myalgia syndrome    pellagra    acute intermittent porphyria    substance abuse
    constipation    pervasive developmental disorder    gilles de la tourette syndrome    porphyria
    otitis media    eosinophilia    paralysis    attention deficit hyperactivity disorder
    influenza    schizophrenia    bipolar disorder    alcoholism

    2 diseases from the University of Copenhagen DISEASES database for TDO2:
    Pellagra     Gilles de la Tourette syndrome

    TDO2 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TDO2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 23 1 2004780 (1)
    schizophrenia 17.7 10 16448631 (4), 16897051 (1), 15056470 (1), 18328600 (1)
    psychiatric disorder 13.6 3 8666386 (1), 10580097 (1), 8873217 (1)

    Genetic Association Database (GAD): TDO2
    Human Genome Epidemiology (HuGE) Navigator: TDO2 (3 documents)

    Export disorders for TDO2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TDO2 gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with TDO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat. (PubMed id 8666386)1, 2, 9 Comings D.E.... Forest G.L. (1995)
    2. Two complex genotypes relevant to the kynurenine path way and melanotropin function show association with schizophrenia and bipolar d isorder. (PubMed id 19502010)1, 4 Miller C.L....Leonard S. (2009)
    3. First genome-wide association scan on neurophysiologi cal endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic chi ldren. (PubMed id 19786962)1, 4 Roeske D....Schulte-KAPrne G. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. (PubMed id 11140838)1, 4 Comings D.E....MacMurray J.P. (2000)
    6. Antimicrobial and immunoregulatory properties of huma n tryptophan 2,3-dioxygenase. (PubMed id 19637229)1, 9 Schmidt S.K....DAoubener W. (2009)
    7. Association of tryptophan 2,3 dioxygenase gene polymorphism with autism. (PubMed id 14755447)1, 9 Nabi R....Huq A.H. (2004)
    8. Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders. (PubMed id 2004780)1, 9 Comings D.E....Donlon T. (1991)
    9. Cooperative binding of L-trp to human tryptophan 2,3-dioxygenase: resonance Raman spectroscopic analysis. (PubMed id 19218188)1, 9 Fukumura E....Shiro Y. (2009)
    10. Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels. (PubMed id 16952380)7, 9 Dairam A....Daya S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6999 HGNC: 11708 AceView: TDO2 Ensembl:ENSG00000151790 euGenes: HUgn6999
    ECgene: TDO2 Kegg: 6999 H-InvDB: TDO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TDO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TDO2 gene:
    Search GeneIP for patents involving TDO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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