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Aliases for TDH Gene

Aliases for TDH Gene

  • L-Threonine Dehydrogenase (Pseudogene) 2 3
  • SDR14E1P 3 4
  • Short Chain Dehydrogenase/Reductase Family 14E, Member 1 (Pseudogene) 3
  • Short Chain Dehydrogenase/Reductase Family 14E Member 1 Pseudogene 4
  • Short Chain Dehydrogenase/Reductase Family 14E 2
  • L-Threonine Dehydrogenase 2
  • Member 1 (Pseudogene) 2

External Ids for TDH Gene

Previous GeneCards Identifiers for TDH Gene

  • GC00U990976
  • GC08P011076
  • GC08P011242
  • GC08P011234
  • GC08P011198
  • GC08P010127

Summaries for TDH Gene

Entrez Gene Summary for TDH Gene

  • This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human, the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins. This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the possible protein product provides any functional role. [provided by RefSeq, Jul 2008]

GeneCards Summary for TDH Gene

TDH (L-Threonine Dehydrogenase (Pseudogene)) is a Pseudogene. Diseases associated with TDH include keratolytic winter erythema. GO annotations related to this gene include coenzyme binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDH Gene

Genomics for TDH Gene

Regulatory Elements for TDH Gene

Genomic Location for TDH Gene

Chromosome:
8
Start:
11,339,637 bp from pter
End:
11,368,452 bp from pter
Size:
28,816 bases
Orientation:
Plus strand

Genomic View for TDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDH Gene

Proteins for TDH Gene

  • Protein details for TDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZJ6-TDH_HUMAN
    Recommended name:
    Inactive L-threonine 3-dehydrogenase, mitochondrial
    Protein Accession:
    Q8IZJ6
    Secondary Accessions:
    • Q8IZJ5
    • Q96LV6

    Protein attributes for TDH Gene

    Size:
    230 amino acids
    Molecular mass:
    25407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TDH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TDH Gene

Proteomics data for TDH Gene at MOPED

Post-translational modifications for TDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TDH Gene

Domains & Families for TDH Gene

Protein Domains for TDH Gene

Suggested Antigen Peptide Sequences for TDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZJ6

UniProtKB/Swiss-Prot:

TDH_HUMAN :
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Family:
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family.
genes like me logo Genes that share domains with TDH: view

Function for TDH Gene

Gene Ontology (GO) - Molecular Function for TDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0050662 coenzyme binding IEA --
genes like me logo Genes that share ontologies with TDH: view

Animal Model Products

miRNA for TDH Gene

miRTarBase miRNAs that target TDH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TDH

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for TDH Gene

Localization for TDH Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDH Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for TDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with TDH: view

No data available for Subcellular locations from COMPARTMENTS for TDH Gene

Pathways & Interactions for TDH Gene

SuperPathways for TDH Gene

No Data Available

Interacting Proteins for TDH Gene

Selected Interacting proteins: Q8IZJ6-TDH_HUMAN for TDH Gene via I2D

Symbol External ID(s) Details
ADD1

Gene Ontology (GO) - Biological Process for TDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TDH: view

No data available for Pathways by source and SIGNOR curated interactions for TDH Gene

Drugs & Compounds for TDH Gene

(2) Drugs for TDH Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra 0
threonine Nutra 16

(2) Additional Compounds for TDH Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-amino-3-ketobutyrate
Oligonucleotide
genes like me logo Genes that share compounds with TDH: view

Transcripts for TDH Gene

Unigene Clusters for TDH Gene

L-threonine dehydrogenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for TDH Gene

GeneLoc Exon Structure for
TDH
ECgene alternative splicing isoforms for
TDH

Expression for TDH Gene

mRNA expression in normal human tissues for TDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDH Gene

This gene is overexpressed in Pancreas (x19.0).

Protein differential expression in normal tissues from HIPED for TDH Gene

This gene is overexpressed in Adrenal (49.0) and Ovary (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TDH Gene



SOURCE GeneReport for Unigene cluster for TDH Gene Hs.583896

mRNA Expression by UniProt/SwissProt for TDH Gene

Q8IZJ6-TDH_HUMAN
Tissue specificity: Expressed in all tissues examined. Detected in most cell types examined, but not observed in endothelial cells, glioma cell lines and some leukemia cell lines.
genes like me logo Genes that share expression patterns with TDH: view

Protein tissue co-expression partners for TDH Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for TDH Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TDH Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tdh 16
Species with no ortholog for TDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TDH Gene

ENSEMBL:
Gene Tree for TDH (if available)
TreeFam:
Gene Tree for TDH (if available)

Paralogs for TDH Gene

No data available for Paralogs for TDH Gene

Variants for TDH Gene

Sequence variations from dbSNP and Humsavar for TDH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs956662 -- 11,338,132(-) CAGGA(C/T)GCTAA upstream-variant-2KB
rs956663 -- 11,338,123(-) AAATT(C/T)TGAGT upstream-variant-2KB
rs1369366 -- 11,342,316(+) aactc(A/G)ctaga intron-variant
rs1435272 -- 11,363,237(-) ctgca(A/G)ccctg intron-variant
rs1435273 -- 11,351,990(-) tgtat(A/G)ttgta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TDH Gene

Variant ID Type Subtype PubMed ID
nsv831233 CNV Gain 17160897
nsv890354 CNV Gain 21882294
esv34097 CNV Loss 18971310
esv2658364 CNV Deletion 23128226
dgv7703n71 CNV Loss 21882294
esv2661653 CNV Deletion 23128226
esv273248 CNV Insertion 20981092
esv269551 CNV Insertion 20981092

Relevant External Links for TDH Gene

HapMap Linkage Disequilibrium report
TDH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TDH Gene

Disorders for TDH Gene

MalaCards: The human disease database

(1) MalaCards diseases for TDH Gene - From: GeneCards

Disorder Aliases PubMed IDs
keratolytic winter erythema
  • erythrokeratolysis hiemalis ichthyosis
- elite association
Search TDH in MalaCards View complete list of genes associated with diseases

Relevant External Links for TDH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TDH
genes like me logo Genes that share disorders with TDH: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TDH Gene

Publications for TDH Gene

  1. The human L-threonine 3-dehydrogenase gene is an expressed pseudogene. (PMID: 12361482) Edgar A.J. (BMC Genet. 2002) 2 23 67
  2. [Etiologic and molecular characteristics of Vibrio parahaemolyticus strains isolated from diarrheal patients in Shenzhen, in 2007 - 2008]. (PMID: 20302699) Wang Y. … Yang Z.R. (Zhonghua Liu Xing Bing Xue Za Zhi 2010) 23 67
  3. [Type III secretion system of Vibrio parahaemolyticus--a review]. (PMID: 19873746) Yu Y. … Fang W. (Wei Sheng Wu Xue Bao 2009) 23 67
  4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 67
  5. Characteristics of a pandemic clone of O3 : K6 and O4 : K68 Vibrio parahaemolyticus isolated in Beira, Mozambique. (PMID: 19018020) Ansaruzzaman M. … Kim D.W. (J. Med. Microbiol. 2008) 23 67

Products for TDH Gene

Sources for TDH Gene

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