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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TDH Gene

pseudogene GIFtS: 40
GCID: GC08P011198

L-threonine dehydrogenase

Explore 10 diseases affiliated with
TDH via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
L-Threonine Dehydrogenase¹ ²
SDR14E1P¹ ²
FLJ25033¹
LYRIC⁵
MAEG1⁵

External Ids:	HGNC: 15547¹	Entrez Gene: 157739²	Ensembl: ENSG00000154316⁷	OMIM: 610323⁵	UniProtKB: Q8IZJ6³

ORGUL members:
	NONCODE:n370150 n385350 n385351

Export aliases for TDH gene to outside databases

Previous GC identifers: GC00U990976 GC08P011076 GC08P011242 GC08P011234 GC08P010127

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TDH:

This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and

eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human,

the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted

protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins.

This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and

alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the

possible protein product provides any functional role. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_077531.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TDH gene promoter:
GR C/EBPbeta AML1a p53 Ik-3 GATA-1 E47 Hand1 GR-alpha Pax-4a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TDH

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDH

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23.1 Ensembl cytogenetic band: 8p23.1 HGNC cytogenetic band: 8p23.1

TDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDH gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P011198: view genomic region (about GC identifiers)

Start:	11,197,146 bp from pter	End:	11,225,961 bp from pter
Size:	28,816 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TDH

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TDH_HUMAN, Q8IZJ6 (See protein sequence)

Recommended Name: Inactive L-threonine 3-dehydrogenase, mitochondrial precursor

Size: 230 amino acids; 25407 Da

Subcellular location: Mitochondrion (By similarity)

Caution: According to PubMed:12361482, the human TDH gene is an expressed pseudogene encoding non-functional truncated

proteins that are unable to make appropriate contacts with the substrates, L-threonine and NAD(+). Although all exons

expected to encode a functional L-threonine 3-dehydrogenase of 369 residues are present in the human genome, all

transcripts described encode truncated proteins that result from mutations within the gene causing the loss of

acceptor splice site preceding exon 4 and exon 6

Secondary accessions: Q8IZJ5 Q96LV6

Alternative splicing: 3 isoforms: Q8IZJ6-1 Q8IZJ6-2 Q8IZJ6-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TDH: NX_Q8IZJ6

TDH Protein expression data from MOPED and PaxDb: --

Human Recombinant Protein Products for TDH:

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	Uscn Proteins for TDH

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

TDH for ontologies About GeneDecksing

TDH Antibody Products:

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Assay Products for TDH:

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	Uscn ELISAs and CLIAs for TDH

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TDH for domains About GeneDecksing

2 InterPro domains/families:

IPR001509 Epimerase_deHydtase

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry Q8IZJ6

ProtoNet protein and cluster: Q8IZJ6

UniProtKB/Swiss-Prot: TDH_HUMAN, Q8IZJ6

Similarity: Belongs to the sugar epimerase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003824	catalytic activity	IEA	--
GO:0050662	coenzyme binding	IEA	--

TDH for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TDH

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDH
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TDH
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDH (see all 6) Browse OriGene siRNA
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TDH
			Sirion Biotech Customized adenovirus for overexpression of TDH Sirion Biotech Customized adenovirus for potent knockdown of TDH

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDH (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TDH (NM_178812)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDH
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TDH

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TDH
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		Sirion Biotech Customized stable knockdown cell line services for TDH Sirion Biotech Customized inducible knockdown cell line services for TDH Sirion Biotech Customized stable overexpressing cell line services for TDH Sirion Biotech Customized inducible overexpressing cell line services for TDH

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDH

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TDH

1 Interacting protein for TDH (Q8IZJ6³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADD1	P35611³	I2D: score=4

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0044237	cellular metabolic process	IEA	--

TDH for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TDH for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TDH

2 HMDB Compounds for TDH About this table

Compound	Synonyms	CAS #	PubMed Ids
2-Hydroxybutyric acid	(RS)-2-Hydroxybutyrate (see all 29)	600-15-7	11731084
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--

4 Novoseek chemical compound relationships for TDH gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2-amino-3-ketobutyrate	92.6	1	8439306 (1)
threonine	36	9	12867457 (4), 12361482 (2), 10476630 (1), 8439306 (1)
nadh	23.8	1	12361482 (1)
oligonucleotide	20	2	8126441 (1), 10379807 (1)

Search CenterWatch for drugs/clinical trials and news about TDH

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for TDH:

L-threonine dehydrogenase

Hs.583896 [show with all ESTs]

Unigene Representative Sequence: AK057762

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000525246(uc003wtt.1 uc003wtq.1) ENST00000534302(uc003wts.1)

ENST00000531764 ENST00000525664 ENST00000326605

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDH
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TDH
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDH (see all 6) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDH
		Sirion Biotech Custom design and validation of potent shRNA sequences against TDH

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDH (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TDH (NM_178812)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDH
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TDH

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDH Browse OriGene validated miRNA SYBR primer pairs
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		Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDH
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDH

Additional cDNA sequence:

AJ301562.1 AJ301563.1 AK057762.1 AY101186.1 AY101187.1 BC074983.2 BC080558.1 NR_001578.1

NR_026814.1

7 DOTS entries:

DT.97841330 DT.70104426 DT.95103741 DT.91750010 DT.100019866 DT.95265121 DT.99948767

24/43 AceView cDNA sequences (see all 43):

BQ059744 BQ062075 BQ063270 BQ055552 BQ642283 BQ057711 AJ301563 AY101186

NR_001578 AJ301562 NM_054017 BQ063907 AI474649 BQ056232 BF953738 BM817654

AY101187 BQ065932 BE267834 BM909520 BI225106 BI224741 BE514180 BM051842

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TDH About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13
SP1:			-		-														-		-								-
SP2:															-				-		-
SP3:															-						-
SP4:

ECgene alternative splicing isoforms for TDH

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TDH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATATATTCCT

About this image

TDH expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for TDH

SOURCE GeneReport for Unigene cluster: Hs.583896

UniProtKB/Swiss-Prot: TDH_HUMAN, Q8IZJ6

Tissue specificity: Expressed in all tissues examined. Detected in most cell types examined, but not observed in

endothelial cells, glioma cell lines and some leukemia cell lines

SABiosciences Custom PCR Arrays for TDH

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TDH gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tdh⁵	L-threonine dehydrogenase	--		14 (33.31 cM) 63492347

ENSEMBL Gene Tree for TDH (if available)
TreeFam Gene Tree for TDH (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73663103^1,2	C	--	10133286(+)	`AGGCAG/ATGTCA`	1	--	ds500¹		1		WA	2
rs4841523^1,2	C,F	--	10133772(+)	`TTGGCC/TCTGAC`	1	--	nc-transcript-variant		3		WA NA EA	358
rs34424291^1,2	C	--	10134526(+)	`CCCGT-/CCCCCC`	1	--	int¹		0	--	--	--	--
rs78091483^1,2		--	10134705(+)	`CCCCAC/GAGATG`	1	--	int¹		0	--	--	--	--
rs2043511^1,2	F	--	10135822(-)	`GAGGTC/GTGACT`	1	--	us2k¹		3		EA WA	298
rs35291885^1,2	C	--	10135939(+)	`AGTTT-/AAAAAA`	2	--	us2k¹ int¹		2		NA	4
rs78797594^1,2		--	10136162(+)	`CGACCC/ACCTGG`	1	--	us2k¹		1		WA	118
rs76950829^1,2	C	--	10136302(+)	`TCGGGG/CTGGTG`	1	--	us2k¹		2		NA	122
rs76579019^1,2	F	--	10136314(+)	`AAGTAG/CAGGGT`	1	--	us2k¹		1		WA	118
rs73663104^1,2	C	--	10136728(+)	`GTTGTA/GAACTG`	1	--	us2k¹		2		WA	120

HapMap Linkage Disequilibrium report for TDH (11197146 - 11225961 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for TDH
1 CNV: 47971
15/16 Inversions (see all 16): 37318 37316 37307 37317 37311 37319 37320 37315 37312 37321 37304 37313 37314 37305 37306

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDH

DNA2.0 Custom Variant and Variant Library Synthesis for TDH

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TDH for disorders           About GeneDecksing

OMIM gene information: 610323    OMIM disorders: --

10 diseases for TDH:    About MalaCards

keratolytic winter erythema acalculous cholecystitis congenital diaphragmatic hernia cholecystitis

gastroenteritis hernia diarrhea cholera

breast cancer leukemia

2 Novoseek disease relationships for TDH gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gastroenteritis	59.8	1	8126441 (1)
poisoning	25.2	3	15182493 (2), 8593076 (1)

Export disorders for TDH gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TDH gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with TDH)

Utopia: connect your pdf to the dynamic
world of online information

The human L-threonine 3-dehydrogenase gene is an expressed pseudogene. (PubMed id 12361482)^{1, 2, 3, 9} Edgar A.J. (2002)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (2009)
Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PubMed id 11896452)^{1, 3} Appel S.... Rosenthal A. (2002)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Inhibition and regulation of rat liver L-threonine de hydrogenase by different fatty acids and their derivatives. (PubMed id 11731084)⁶ Guerranti R....Marinello E. (2001)
Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production. (PubMed id 3536927)¹ Tressel T....Davis L. (1986)
The thermostable direct hemolysin gene (tdh) of Vibri o hollisae is dissimilar in prevalence to and phylogenetically distant from the tdh genes of other vibrios: implications in the horizontal transfer of the tdh gene. (PubMed id 8871530)⁹ Nishibuchi M....Ezaki T. (1996)
Detection of a functional insertion sequence responsi ble for deletion of the thermostable direct hemolysin gene (tdh) in Vibrio para haemolyticus. (PubMed id 18598741)⁹ Kamruzzaman M....Nishibuchi M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 157739	HGNC: 15547	AceView: C8orf12	Ensembl:ENSG00000154316	euGenes: HUgn157739
ECgene: TDH	H-InvDB: TDH

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TDH	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TDH gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TDH gene:
Search GeneIP for patents involving TDH

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDH		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDH
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		Browse 3'-UTR reporter clones for miRNA target validation
	Browse OriGene untagged cDNA clones in CMV expression vector		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDH
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TDH		OriGene Custom Protein Services for TDH
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TDH
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDH
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDH
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDH
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDH
	Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDH

	GenScript Custom Purified and Recombinant Proteins Services for TDH		GenScript cDNA clones with any tag delivered in your preferred vector for TDH
	GenScript Custom Assay Services for TDH		GenScript Custom Superior Antibodies Services for TDH
	GenScript Custom overexpressing Cell Line Services for TDH		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in TDH promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
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	Search for Antibodies for TDH at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TDH
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Browse ProSpec Recombinant Proteins

TDH Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TDH

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDH

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TDH
	Browse SwitchGear Promoter luciferase reporter plasmids for TDH

Search ThermoFisher Antibodies for TDH

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TDH

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TDH

Sirion Biotech Customized:

	stable knockdown cell line services for TDH
	inducible knockdown cell line services for TDH
	design and validation of potent shRNA sequences against TDH
	adenovirus for potent knockdown of TDH
	adenovirus for overexpression of TDH
	stable overexpressing cell line services for TDH
	inducible overexpressing cell line services for TDH

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TDH gene at Home site.

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TDH Gene

L-threonine dehydrogenase

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TDH Gene

L-threonine dehydrogenase

Aliasesfor TDH gene

Summariesfor TDH gene

Genomic Viewsfor TDH gene

Proteinsfor TDH gene

Protein Domains /Familiesfor TDH gene

Functionfor TDH gene

Pathways & Interactionsfor TDH gene

Drugs & Compoundsfor TDH gene

Transcriptsfor TDH gene

Expression for TDH gene

Orthologsfor TDH gene

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Genomic Variantsfor TDH gene

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Genome Databases showing TDH gene

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for TDH gene

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for TDH gene

Genomic Views
for TDH gene

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for TDH gene

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Families
for TDH gene

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for TDH gene

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for TDH gene

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for TDH gene

Transcripts
for TDH gene

Expression
for TDH gene

Orthologs
for TDH gene

Paralogs
for TDH gene

Genomic Variants
for TDH gene

Disorders / Diseases
for TDH gene

Publications
for TDH gene

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for TDH gene

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for TDH gene