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Aliases for TDH Gene

Aliases for TDH Gene

  • L-Threonine Dehydrogenase (Pseudogene) 2 3
  • SDR14E1P 3 4
  • Short Chain Dehydrogenase/Reductase Family 14E, Member 1 (Pseudogene) 3
  • Short Chain Dehydrogenase/Reductase Family 14E Member 1 Pseudogene 4
  • Short Chain Dehydrogenase/Reductase Family 14E 2
  • L-Threonine Dehydrogenase 2
  • Member 1 (Pseudogene) 2

External Ids for TDH Gene

Previous GeneCards Identifiers for TDH Gene

  • GC00U990976
  • GC08P011076
  • GC08P011242
  • GC08P011234
  • GC08P011198
  • GC08P010127

Summaries for TDH Gene

Entrez Gene Summary for TDH Gene

  • This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human, the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins. This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the possible protein product provides any functional role. [provided by RefSeq, Jul 2008]

GeneCards Summary for TDH Gene

TDH (L-Threonine Dehydrogenase (Pseudogene)) is a Pseudogene. Diseases associated with TDH include acalculous cholecystitis and keratolytic winter erythema. GO annotations related to this gene include coenzyme binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDH Gene

Genomics for TDH Gene

Regulatory Elements for TDH Gene

Genomic Location for TDH Gene

11,339,637 bp from pter
11,368,452 bp from pter
28,816 bases
Plus strand

Genomic View for TDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDH Gene

Proteins for TDH Gene

  • Protein details for TDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive L-threonine 3-dehydrogenase, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q8IZJ5
    • Q96LV6

    Protein attributes for TDH Gene

    230 amino acids
    Molecular mass:
    25407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TDH Gene


neXtProt entry for TDH Gene

Proteomics data for TDH Gene at MOPED

Post-translational modifications for TDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TDH Gene

Domains for TDH Gene

Gene Families for TDH Gene

  • SDRE :Short chain dehydrogenase/reductase superfamily / Extended SDR fold

Protein Domains for TDH Gene

Suggested Antigen Peptide Sequences for TDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IZJ6
  • Belongs to the NAD(P)-dependent epimerase/dehydratase family.
genes like me logo Genes that share domains with TDH: view

Function for TDH Gene

Gene Ontology (GO) - Molecular Function for TDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0050662 coenzyme binding IEA --
genes like me logo Genes that share ontologies with TDH: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TDH Gene

Localization for TDH Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDH Gene


Subcellular locations from

Jensen Localization Image for TDH Gene COMPARTMENTS Subcellular localization image for TDH gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with TDH: view

Pathways for TDH Gene

SuperPathways for TDH Gene

No Data Available

Interacting Proteins for TDH Gene

Selected Interacting proteins: Q8IZJ6-TDH_HUMAN for TDH Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TDH: view

No data available for Pathways by source for TDH Gene

Compounds for TDH Gene

(2) HMDB Compounds for TDH Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxybutyric acid
  • (RS)-2-Hydroxybutyrate
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate

(4) Novoseek inferred chemical compound relationships for TDH Gene

Compound -log(P) Hits PubMed IDs
2-amino-3-ketobutyrate 92.6 1
threonine 36 8
nadh 23.8 1
oligonucleotide 20 2
genes like me logo Genes that share compounds with TDH: view

Transcripts for TDH Gene

Unigene Clusters for TDH Gene

L-threonine dehydrogenase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TDH

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TDH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - -
SP2: - - -
SP3: - -

Relevant External Links for TDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TDH Gene

mRNA expression in normal human tissues for TDH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDH Gene

This gene is overexpressed in Pancreas (19.0).

Protein differential expression in normal tissues for TDH Gene

This gene is overexpressed in Adrenal (49.0) and Ovary (20.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TDH Gene

SOURCE GeneReport for Unigene cluster for TDH Gene Hs.583896

mRNA Expression by UniProt/SwissProt for TDH Gene

Tissue specificity: Expressed in all tissues examined. Detected in most cell types examined, but not observed in endothelial cells, glioma cell lines and some leukemia cell lines.
genes like me logo Genes that share expressions with TDH: view

Expression partners for TDH Gene

In Situ Assay Products

Orthologs for TDH Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TDH Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tdh 16
Species with no ortholog for TDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TDH Gene

Gene Tree for TDH (if available)
Gene Tree for TDH (if available)

Paralogs for TDH Gene

No data available for Paralogs for TDH Gene

Variants for TDH Gene

Sequence variations from dbSNP and Humsavar for TDH Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs956662 -- 11,338,132(-) CAGGA(C/T)GCTAA upstream-variant-2KB
rs956663 -- 11,338,123(-) AAATT(C/T)TGAGT upstream-variant-2KB
rs1369366 -- 11,342,316(+) aactc(A/G)ctaga intron-variant
rs1435272 -- 11,363,237(-) ctgca(A/G)ccctg intron-variant
rs1435273 -- 11,351,990(-) tgtat(A/G)ttgta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TDH Gene

Variant ID Type Subtype PubMed ID
nsv831233 CNV Gain 17160897
nsv890354 CNV Gain 21882294
esv34097 CNV Loss 18971310
esv2658364 CNV Deletion 23128226
dgv7703n71 CNV Loss 21882294
esv2661653 CNV Deletion 23128226
esv273248 CNV Insertion 20981092
esv269551 CNV Insertion 20981092

Relevant External Links for TDH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDH Gene

Disorders for TDH Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TDH Gene in MalaCards »

(2) Diseases for TDH Gene including...

(1) University of Copenhagen DISEASES for TDH Gene

(2) Novoseek inferred disease relationships for TDH Gene

Disease -log(P) Hits PubMed IDs
gastroenteritis 59.8 1
poisoning 25.2 3
genes like me logo Genes that share disorders with TDH: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for TDH Gene

Publications for TDH Gene

  1. The human L-threonine 3-dehydrogenase gene is an expressed pseudogene. (PMID: 12361482) Edgar A.J. (BMC Genet. 2002) 2 3 4 23
  2. Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. (PMID: 11896452) Appel S. … Rosenthal A. (Eur. J. Hum. Genet. 2002) 2 3
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4

Products for TDH Gene

Sources for TDH Gene

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