Aliases for TDGF1 Gene
External Ids for TDGF1 Gene
Previous GeneCards Identifiers for TDGF1 Gene
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for TDGF1 Gene
TDGF1 (Teratocarcinoma-Derived Growth Factor 1) is a Protein Coding gene. Diseases associated with TDGF1 include Septopreoptic Holoprosencephaly and Midline Interhemispheric Variant Of Holoprosencephaly. Among its related pathways are p70S6K Signaling and TGF-beta Signaling Pathway (sino). GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is CFC1B.
UniProtKB/Swiss-Prot for TDGF1 Gene
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.