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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TDGF1 Gene

protein-coding   GIFtS: 61
GCID: GC03P046616

Teratocarcinoma-Derived Growth Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Teratocarcinoma-Derived Growth Factor 11 2
Cripto-1 Growth Factor2 3
Epidermal Growth Factor-Like Cripto Protein CR12 3
CRGF2 3
CRIPTO2 3
CR2

External Ids:    HGNC: 117011   Entrez Gene: 69972   Ensembl: ENSG000002411867   OMIM: 1873955   UniProtKB: P133853   

Export aliases for TDGF1 gene to outside databases

Previous GC identifers: GC03P045859 GC03P046435 GC03P046579 GC03P046594


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TDGF1 Gene:
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain.
The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in
embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes
of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for TDGF1 Gene: 
TDGF1 (teratocarcinoma-derived growth factor 1) is a protein-coding gene. Diseases associated with TDGF1 include teratocarcinoma, and congenital heart defect, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include growth factor activity and receptor binding. An important paralog of this gene is CFC1B.

UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385
Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the
mesoderm

Gene Wiki entry for TDGF1 (Teratocarcinoma-derived growth factor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TDGF1 gene promoter:
         RREB-1   Bach2   FOXO3   CUTL1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   LCR-F1   FOXL1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDGF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TDGF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDGF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

TDGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDGF1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046616:  view genomic region     (about GC identifiers)

Start:
46,616,045 bp from pter      End:
46,668,033 bp from pter
Size:
51,989 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385 (See protein sequence)
Recommended Name: Teratocarcinoma-derived growth factor 1 precursor  
Size: 188 amino acids; 21169 Da
Subunit: Interacts with the activin type-1 receptor ACVR1B
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q8TCC1

Explore the universe of human proteins at neXtProt for TDGF1: NX_P13385

Explore proteomics data for TDGF1 at MOPED 

TDGF1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TDGF1 Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001167607.1  NP_003203.1  

ENSEMBL proteins: 
 ENSP00000296145   ENSP00000446375  
Reactome Protein details: P13385
Human Recombinant Protein Products for TDGF1: 
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R&D Systems Recombinant & Natural Proteins for TDGF1 (Cripto)
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OriGene Protein Over-expression Lysate for TDGF1
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Novus Biologicals TDGF1 Proteins
Novus Biologicals TDGF1 Lysates
Sino Biological Recombinant Protein for TDGF1
Sino Biological Cell Lysate for TDGF1 
ProSpec Recombinant Protein for TDGF1
Cloud-Clone Corp. Proteins for TDGF1 

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space IDA17720976
GO:0005634nucleus IEA--
GO:0005737cytoplasm ----
GO:0005794Golgi apparatus IEA--
GO:0009986cell surface IDA12925698

TDGF1 for ontologies           About GeneDecksing



TDGF1 Antibody Products: 
EMD Millipore Mono- and Polyclonal Antibodies for the study of TDGF1
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Novus Biologicals TDGF1 Antibodies
Abcam antibodies for TDGF1
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Search LSBio for Antibodies for TDGF1 

Assay Products for TDGF1: 
Browse Kits and Assays available from EMD Millipore
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R&D Systems ELISAs for TDGF1 (Cripto)         (see all)
GenScript Custom Assay Services for TDGF1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for TDGF1 
Cloud-Clone Corp. CLIAs for TDGF1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR019011 Cryptic/Cripto_CFC-dom
 IPR000742 EG-like_dom
 IPR013032 EGF-like_CS
 IPR017047 Cripto_growth_factor

Graphical View of Domain Structure for InterPro Entry P13385

ProtoNet protein and cluster: P13385

1 Blocks protein domain: IPB006210 Type I EGF

UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385
Similarity: Contains 1 EGF-like domain


TDGF1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TDGF1_HUMAN, P13385
Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the
mesoderm

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005102receptor binding IDA11909953
GO:0005515protein binding IPI12919325
GO:0008083growth factor activity IDA12925698
     
TDGF1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TDGF1:
 Decreased DCP1a protein expres 

     7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Tdgf1):
 cardiovascular system  cellular  embryogenesis  mortality/aging  nervous system 
 normal  vision/eye 

TDGF1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for TDGF1: Tdgf1tm2.1Mms Tdgf1tm1Eda

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TDGF1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TDGF1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TDGF1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TDGF1 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDGF1
5 QIAGEN miScript miRNA Assays for microRNAs that regulate TDGF1:
hsa-miR-299-5p hsa-miR-338-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-888
SwitchGear 3'UTR luciferase reporter plasmidTDGF1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for TDGF1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDGF1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for TDGF1
Sirion Biotech Customized adenovirus for overexpression of TDGF1

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for TDGF1 (see all 9)
OriGene ORF clones in mouse, rat for TDGF1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): TDGF1 (NM_003212)
Sino Biological Human cDNA Clone for TDGF1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDGF1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDGF1
Sirion Biotech Customized lentivirus for stable overexpression of TDGF1 
                     Customized lentivirus expression plasmids for stable overexpression of TDGF1 

Cell Line
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GenScript Custom overexpressing Cell Line Services for TDGF1
Search LifeMap BioReagents cell lines for TDGF1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDGF1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TDGF1 About   (see all 19)                                                                                              See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Apoptotic Pathways in Synovial Fibroblasts
Mitochondrial Apoptosis0.85
Rac1 Pathway0.65
Cellular Apoptosis Pathway0.85
Glioma Invasiveness0.64
Apoptotic Pathways in Synovial Fibroblasts0.84
Actin-Based Motility by Rho Family GTPases0.62
p53 Mediated Apoptosis0.84
ERK5 Signaling0.61
2GPCR Pathway
Ras Pathway0.73
Breast Cancer Regulation by Stathmin10.58
Paxillin Interactions0.73
NFAT in Immune Response0.58
GPCR Pathway0.62
Estrogen Pathway0.55
Pancreatic Adenocarcinoma0.59
3Rho Family GTPases
Rho Family GTPases0.61
Molecular Mechanisms of Cancer0.51
ERK Signaling0.61
ILK Signaling0.49
MAPK Signaling0.58
4Nanog in Mammalian ESC Pluripotency
Nanog in Mammalian ESC Pluripotency0.61
14-3-3 Induced Intracellular Signaling0.59
GSK3 Signaling0.61
eNOS Signaling0.48
5TGF-Beta Pathway
TGF-Beta Pathway0.60
JAK-STAT Pathway0.57
MAPK Family Pathway0.60
JNK Pathway0.51

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TDGF1 (see all 56)
    Nuclear Receptor Activation by Vitamin-A
Paxillin Interactions
Telomerase Components in Cell Signaling
Mitochondrial Apoptosis
Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for TDGF1
    Wnt / Hedgehog / Notch
Angiogenesis

1 BioSystems Pathway for TDGF1
    Glypican 1 network

1 Sino Biological Pathway for TDGF1 
    TGF-beta Signaling Pathway

3        Reactome Pathways for TDGF1
    Developmental Biology
Signaling by NODAL
Regulation of Signaling by NODAL



TDGF1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TDGF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/33 Interacting proteins for TDGF1 (P133852, 3 ENSP000002961454) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
InteractantInteraction Details
GeneCardExternal ID(s)
BAG6P463792, 3MINT-63466 I2D: score=4 
ENSG00000096155P463792, 3MINT-63466 I2D: score=4 
ENSG00000227761P463792, 3MINT-63466 I2D: score=4 
ENSG00000228760P463792, 3MINT-63466 I2D: score=4 
ENSG00000229524P463792, 3MINT-63466 I2D: score=4 
About this table

Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000187activation of MAPK activity IDA9013573
GO:0001570vasculogenesis IEA--
GO:0001701in utero embryonic development IEA--
GO:0001763morphogenesis of a branching structure TAS10070255
GO:0001954positive regulation of cell-matrix adhesion IEA--

TDGF1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TDGF1 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TDGF1

4 Novoseek inferred chemical compound relationships for TDGF1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
heparin 5.03 3 11218236 (2), 9650567 (1)
threonine 3.58 1 17504756 (1)
serine 0.166 2 12919325 (1)
tyrosine 0 1 12532421 (1)

Search CenterWatch for drugs/clinical trials and news about TDGF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TDGF1 gene (2 alternative transcripts): 
NM_001174136.1  NM_003212.3  

Unigene Cluster for TDGF1:

Teratocarcinoma-derived growth factor 1
Hs.385870  [show with all ESTs]
Unigene Representative Sequence: NM_003212
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000296145(uc003cpv.3) ENST00000493282 ENST00000471721 ENST00000459867
ENST00000505797 ENST00000444264(uc003cpw.1) ENST00000542931(uc021wxd.1)

miRNA
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5 QIAGEN miScript miRNA Assays for microRNAs that regulate TDGF1:
hsa-miR-299-5p hsa-miR-338-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-888
SwitchGear 3'UTR luciferase reporter plasmidTDGF1 3' UTR sequence
Inhib. RNA
Products:
     
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Clone
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OriGene ORF clones in mouse, rat for TDGF1
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GenScript: all cDNA clones in your preferred vector (see all 2): TDGF1 (NM_003212)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDGF1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDGF1
Sirion Biotech Customized lentivirus for stable overexpression of TDGF1 
                     Customized lentivirus expression plasmids for stable overexpression of TDGF1 
Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDGF1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDGF1

Additional mRNA sequence: 

AK313319.1 BC022393.1 BC067844.1 X14253.1 

5 DOTS entries:

DT.100725583  DT.213859  DT.120853654  DT.120853660  DT.102830280 

24/46 AceView cDNA sequences (see all 46):

AU124747 AI827894 CD651946 AL697438 AA101474 AA218548 BX105218 CD642565 
AU125077 AA218549 AA101473 NM_003212 BC022393 BC067844 BI598827 AI969787 
AA227015 AU125451 CD247314 X14253 BG429460 AA216755 AA205710 BI596538 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TDGF1 expression in normal human tissues (normalized intensities)      TDGF1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAATTCTACC
TDGF1 Expression
About this image


TDGF1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/9 selected tissues (see all 9) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 27 entries
         Inner Cell Mass Cells Inner Cell Mass
         CA2
 
 Epiblast (Early Embryonic Tissues)    fully expand to see all 5 entries
         Early Epiblast Cells Epiblast
         Epiblast Stem Cell line 5
 
 Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
         Primitive Streak Cells Primitive Streak
         Primitive Streak
 
 Peripheral Nervous System (Nervous System)
         PERIPHERAL NERVOUS SYSTEM   
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

See TDGF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TDGF1

SOURCE GeneReport for Unigene cluster: Hs.385870

UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385
Tissue specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal
counterparts. Expressed in breast and lung

    SABiosciences Expression via Pathway-Focused PCR Arrays including TDGF1 (see all 6): 
          Growth Factors in human mouse rat
          Stem Cell Transcription Factors in human mouse rat
          Angiogenic Growth Factors in human mouse rat
          TGFB/BMP Signaling Pathway in human mouse rat
          Embryonic Stem Cells in human mouse rat

Primer
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OriGene qPCR primer pairs and template standards for TDGF1
OriGene qSTAR qPCR primer pairs in human, mouse for TDGF1
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDGF1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDGF1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDGF1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TDGF1 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tdgf11 , 5 teratocarcinoma-derived growth factor 11, 5 79.19(n)1
72.12(a)1
  9 (60.79 cM)5
216671  NM_011562.21  NP_035692.21 
 1109396105 
chicken
(Gallus gallus)
Aves CFC16
Cryptic protein
26(a)
1 → many
Z(42279475-42284756)
lizard
(Anolis carolinensis)
Reptilia --
--
--
28(a)
24(a)
many → 1
possible ortholog
2(39715410-39727241)
2(39802641-39806113)
zebrafish
(Danio rerio)
Actinopterygii cripto2 cripto 97.47(n)   57932  AF151352.1 


ENSEMBL Gene Tree for TDGF1 (if available)
TreeFam Gene Tree for TDGF1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TDGF1 gene
CFC1B2  CFC12  
1 SIMAP similar gene for TDGF1 using alignment to 3 protein entries:     TDGF1_HUMAN (see all proteins):
TDGF1P3

TDGF1 for paralogs           About GeneDecksing


5/6 Pseudogenes.org Pseudogenes for TDGF1 (see all 6)
PGOHUM00000234686 PGOHUM00000240543 PGOHUM00000238206 PGOHUM00000260147 PGOHUM00000249665


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/267 SNPs in TDGF1 are shown (see all 267)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1219095011,2
Cpathogenic146552039(+) GCTGCC/TCAAGA 4 P L mis10--------
rs351851301,2
C--46614166(+) GAGAC-/GGGGGC 1 -- us2k10--------
rs1880171551,2
--46614173(+) GGGCTC/TCACTG 1 -- us2k10--------
rs1926879111,2
--46614204(+) ATCTCA/CTGACC 1 -- us2k10--------
rs622478581,2
C,F--46614299(+) TAACAA/GGTTGC 1 -- us2k16Minor allele frequency- G:0.23NA WA CSA EA 364
rs1409832681,2
--46614319(+) AGCCCA/GGAATA 1 -- us2k10--------
rs1844664881,2
C--46614338(+) GGTTTA/GGGTTA 1 -- us2k10--------
rs1905782751,2
C--46614345(+) GTTACA/GTATTT 1 -- us2k10--------
rs1924086031,2
--46614369(+) TTTCCA/CTTCTT 1 -- us2k10--------
rs791301831,2
C,F--46614499(+) GGGCTG/AAGATT 1 -- us2k11Minor allele frequency- A:0.05WA 118

HapMap Linkage Disequilibrium report for TDGF1 (46616045 - 46668033 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TDGF1: --

Human Gene Mutation Database (HGMD): TDGF1
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 187395    OMIM disorders: --

20/24 diseases for TDGF1 (see all 24):    About MalaCards
teratocarcinoma    congenital heart defect    cystadenoma    holoprosencephaly
oral squamous cell carcinoma    colon cancer    basal cell carcinoma    teratoma
gastric cancer    nasopharyngitis    inflammatory bowel disease    pancreatitis
adenoma    squamous cell carcinoma    pancreatic cancer    cervicitis
breast cancer    hepatocellular carcinoma    colorectal cancer    lung cancer

1 disease from the University of Copenhagen DISEASES database for TDGF1:
Holoprosencephaly

TDGF1 for disorders           About GeneDecksing

10/19 Novoseek inferred disease relationships for TDGF1 gene (see all 19)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cystadenoma mucinous 51 2 8144392 (1), 8986534 (1)
carcinoma embryonal 46.3 3 11857442 (1), 11553858 (1)
colon carcinoma 45.4 4 9466051 (2), 11127817 (1), 11553858 (1)
colon tumor 42.6 2 1596904 (1), 12925698 (1)
mammary tumor 42.4 4 10225449 (2), 11857442 (1), 19421146 (1)
colon cancer 39.2 1 9816209 (1)
breast carcinoma 38.4 5 9935161 (2), 11174844 (1), 11553858 (1)
colorectal tumors 34.2 2 1596904 (2)
colorectal carcinoma 26.7 3 11553858 (2), 12147741 (1)
pancreatic carcinoma 26.6 2 11857442 (1)

Genetic Association Database (GAD): TDGF1
Human Genome Epidemiology (HuGE) Navigator: TDGF1 (3 documents)

Export disorders for TDGF1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TDGF1 gene, integrated from 9 sources (see all 124):
(articles sorted by number of sources associating them with TDGF1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence. (PubMed id 1882841)1, 2, 3 Dono R....Persico M.G. (1991)
  2. The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. (PubMed id 12919325)1, 2, 9 Foley S.F.... Wen D. (2003)
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  4. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. (PubMed id 19727905)1, 4 Li G.H....Huang Q.Y. (2009)
  5. Teratocarcinoma-derived growth factor 1 (TDGF1) seque nce variants in patients with congenital heart defect. (PubMed id 19853938)1, 4 Wang B....Ma X. (2009)
  6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
  7. Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. (PubMed id 11909953)1, 2 Bianco C....Salomon D.S. (2002)
  8. Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1. (PubMed id 10393436)1, 3 Scognamiglio B....Persico M.G. (1999)
  9. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. (PubMed id 2792079)1, 2 Ciccodicola A.... Persico M.G. (1989)
  10. Cripto: a tumor growth factor and more. (PubMed id 11857442)1, 9 Adamson E.D....Salomon D.S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6997 HGNC: 11701 AceView: TDGF1 Ensembl:ENSG00000241186 euGenes: HUgn6997
ECgene: TDGF1 H-InvDB: TDGF1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TDGF1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TDGF1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TDGF1 gene:
Search GeneIP for patents involving TDGF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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