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Aliases for TDGF1 Gene

Aliases for TDGF1 Gene

  • Teratocarcinoma-Derived Growth Factor 1 2 3 5
  • Epidermal Growth Factor-Like Cripto Protein CR1 3 4
  • Cripto-1 Growth Factor 3 4
  • CRIPTO 3 4
  • CRGF 3 4
  • CR 3

External Ids for TDGF1 Gene

Previous GeneCards Identifiers for TDGF1 Gene

  • GC03P045859
  • GC03P046435
  • GC03P046579
  • GC03P046594
  • GC03P046616

Summaries for TDGF1 Gene

Entrez Gene Summary for TDGF1 Gene

  • This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for TDGF1 Gene

TDGF1 (Teratocarcinoma-Derived Growth Factor 1) is a Protein Coding gene. Diseases associated with TDGF1 include Forebrain Defects and Septopreoptic Holoprosencephaly. Among its related pathways are p70S6K Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is CFC1.

UniProtKB/Swiss-Prot for TDGF1 Gene

  • Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Gene Wiki entry for TDGF1 Gene

Additional gene information for TDGF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDGF1 Gene

Genomics for TDGF1 Gene

Regulatory Elements for TDGF1 Gene

Enhancers for TDGF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H046572 1.3 Ensembl ENCODE dbSUPER 59.3 +0.9 900 6.2 SOX13 TFAP4 ATF1 ZSCAN4 RAD21 YY1 ETS1 POLR2A NR2F6 CREM TDGF1 LRRC2
GH03H046584 0.9 ENCODE 48.3 +11.5 11483 2.6 FOXA2 MLX THRB ZSCAN9 RAD21 YY1 CREM MIXL1 CEBPB REST TDGF1 RTP3 LTF ALS2CL PRSS46 LRRC2 ENSG00000283877 PIR44476
GH03H046549 1.6 FANTOM5 ENCODE dbSUPER 15.5 -24.8 -24840 1.3 PKNOX1 ATF1 ARNT ETS1 TCF12 ZNF766 CBX5 GATA2 ATF7 NCOA1 TDGF1 RTP3 LTF LRRC2-AS1 CCR2 LOC105377070
GH03H046544 1 FANTOM5 ENCODE dbSUPER 21.7 -28.5 -28472 2.6 L3MBTL2 POLR2A ZNF24 TDGF1 LRRC2-AS1 LOC105377070
GH03H046537 1.4 Ensembl ENCODE dbSUPER 12.3 -35.5 -35465 2.4 PKNOX1 TBL1XR1 BMI1 BATF ATF7 ETV6 RUNX3 CREM IKZF2 SMARCA5 TDGF1 LRRC2 NBEAL2 LRRC2-AS1 LOC105377070
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TDGF1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TDGF1 Gene

Genomic Locations for TDGF1 Gene
7,930 bases
Plus strand

Genomic View for TDGF1 Gene

Genes around TDGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDGF1 Gene

Proteins for TDGF1 Gene

  • Protein details for TDGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Teratocarcinoma-derived growth factor 1
    Protein Accession:
    Secondary Accessions:
    • Q8TCC1

    Protein attributes for TDGF1 Gene

    188 amino acids
    Molecular mass:
    21169 Da
    Quaternary structure:
    • Interacts with the activin type-1 receptor ACVR1B.

neXtProt entry for TDGF1 Gene

Post-translational modifications for TDGF1 Gene

Other Protein References for TDGF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TDGF1 Gene

Domains & Families for TDGF1 Gene

Gene Families for TDGF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TDGF1 Gene

Suggested Antigen Peptide Sequences for TDGF1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TDGF1: view

No data available for UniProtKB/Swiss-Prot for TDGF1 Gene

Function for TDGF1 Gene

Molecular function for TDGF1 Gene

UniProtKB/Swiss-Prot Function:
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Phenotypes From GWAS Catalog for TDGF1 Gene

Gene Ontology (GO) - Molecular Function for TDGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IDA 11909953
GO:0005515 protein binding IPI 12919325
GO:0008083 growth factor activity IDA 8006041
genes like me logo Genes that share ontologies with TDGF1: view
genes like me logo Genes that share phenotypes with TDGF1: view

Animal Models for TDGF1 Gene

MGI Knock Outs for TDGF1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TDGF1 Gene

Localization for TDGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDGF1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TDGF1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for TDGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 17720976
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 12925698
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IDA 17720976
genes like me logo Genes that share ontologies with TDGF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TDGF1 Gene

Pathways & Interactions for TDGF1 Gene

genes like me logo Genes that share pathways with TDGF1: view

SIGNOR curated interactions for TDGF1 Gene


Gene Ontology (GO) - Biological Process for TDGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 9013573
GO:0001763 morphogenesis of a branching structure TAS 10070255
GO:0002042 cell migration involved in sprouting angiogenesis IMP 17720976
GO:0007173 NOT epidermal growth factor receptor signaling pathway IDA 8006041
GO:0007507 heart development IDA 9576836
genes like me logo Genes that share ontologies with TDGF1: view

Drugs & Compounds for TDGF1 Gene

(4) Drugs for TDGF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TDGF1: view

Transcripts for TDGF1 Gene

Unigene Clusters for TDGF1 Gene

Teratocarcinoma-derived growth factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TDGF1 Gene

No ASD Table

Relevant External Links for TDGF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TDGF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TDGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDGF1 Gene

This gene is overexpressed in Spleen (x10.3), Kidney - Cortex (x9.7), Adrenal Gland (x4.7), and Ovary (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of TDGF1 Gene:


SOURCE GeneReport for Unigene cluster for TDGF1 Gene:


mRNA Expression by UniProt/SwissProt for TDGF1 Gene:

Tissue specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Evidence on tissue expression from TISSUES for TDGF1 Gene

  • Kidney(4.2)
  • Nervous system(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TDGF1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeleton
Head and neck:
  • brain
  • eye
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • nose
  • pharynx
  • pituitary gland
  • skull
  • tooth
  • skin
genes like me logo Genes that share expression patterns with TDGF1: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TDGF1 Gene

Orthologs for TDGF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDGF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TDGF1 33 34
  • 99.29 (n)
(Bos Taurus)
Mammalia TDGF1 33 34
  • 83.79 (n)
-- 34
  • 78 (a)
(Canis familiaris)
Mammalia TDGF1 33
  • 82.63 (n)
(Mus musculus)
Mammalia Tdgf1 33 16 34
  • 79.19 (n)
(Rattus norvegicus)
Mammalia Tdgf1 33
  • 78.22 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tdgf1.1 33
  • 51.57 (n)
(Danio rerio)
Actinopterygii oep 34
  • 27 (a)
cripto 33
Species where no ortholog for TDGF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDGF1 Gene

Gene Tree for TDGF1 (if available)
Gene Tree for TDGF1 (if available)

Paralogs for TDGF1 Gene

Paralogs for TDGF1 Gene

(1) SIMAP similar genes for TDGF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TDGF1: view

Variants for TDGF1 Gene

Sequence variations from dbSNP and Humsavar for TDGF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121909501 Pathogenic 46,579,986(+) GCTGC(C/T)CAAGA reference, missense, utr-variant-5-prime
rs1000142928 -- 46,576,720(+) TCCTT(C/T)AGAAA intron-variant, upstream-variant-2KB
rs1000179862 -- 46,576,198(+) GGCGC(A/G)GTAGC intron-variant, upstream-variant-2KB
rs1000317020 -- 46,580,557(+) AGAAC(C/T)CTTAC intron-variant, upstream-variant-2KB
rs1000598874 -- 46,581,382(+) CATTT(C/G)CAAAA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TDGF1 Gene

Variant ID Type Subtype PubMed ID
nsv1013306 CNV gain 25217958

Variation tolerance for TDGF1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TDGF1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TDGF1 Gene

Disorders for TDGF1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TDGF1 Gene - From: HGMD, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TDGF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TDGF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TDGF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TDGF1 Gene

Publications for TDGF1 Gene

  1. The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis. (PMID: 12919325) Foley SF … Wen D (European journal of biochemistry 2003) 3 4 22 60
  2. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence. (PMID: 1882841) Dono R … Persico MG (American journal of human genetics 1991) 2 3 4 60
  3. Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. (PMID: 19853938) Wang B … Ma X (International journal of cardiology 2011) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. (PMID: 19727905) Li GH … Huang QY (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2010) 3 45 60

Products for TDGF1 Gene

Sources for TDGF1 Gene

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