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TDGF1 Gene

protein-coding   GIFtS: 59
GCID: GC03P046616

Teratocarcinoma-Derived Growth Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Teratocarcinoma-Derived Growth Factor 11 2
Cripto-1 Growth Factor2 3
Epidermal Growth Factor-Like Cripto Protein CR12 3
CRGF2 3
CRIPTO2 3
CR2

External Ids:    HGNC: 117011   Entrez Gene: 69972   Ensembl: ENSG000002411867   OMIM: 1873955   UniProtKB: P133853   

Export aliases for TDGF1 gene to outside databases

Previous GC identifers: GC03P045859 GC03P046435 GC03P046579 GC03P046594


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TDGF1 Gene:
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain.
The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in
embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes
of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2010)

GeneCards Summary for TDGF1 Gene:
TDGF1 (teratocarcinoma-derived growth factor 1) is a protein-coding gene. Diseases associated with TDGF1 include forebrain defects, and teratocarcinoma. GO annotations related to this gene include growth factor activity and receptor binding. An important paralog of this gene is CFC1B.

UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385
Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the
mesoderm

Gene Wiki entry for TDGF1 (Teratocarcinoma-derived growth factor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TDGF1 gene promoter:
         RREB-1   Bach2   FOXO3   CUTL1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   LCR-F1   FOXL1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTDGF1 promoter sequence
   Search Chromatin IP Primers for TDGF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TDGF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

TDGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TDGF1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046616:  view genomic region     (about GC identifiers)

Start:
46,616,045 bp from pter      End:
46,668,033 bp from pter
Size:
51,989 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385 (See protein sequence)
Recommended Name: Teratocarcinoma-derived growth factor 1 precursor  
Size: 188 amino acids; 21169 Da
Subunit: Interacts with the activin type-1 receptor ACVR1B
Secondary accessions: Q8TCC1

Explore the universe of human proteins at neXtProt for TDGF1: NX_P13385

Explore proteomics data for TDGF1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn79

  • See TDGF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001167607.1  NP_003203.1  

    ENSEMBL proteins: 
     ENSP00000296145   ENSP00000446375  
    Reactome Protein details: P13385

    TDGF1 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for TDGF1 (Cripto)
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    OriGene Protein Over-expression Lysate for TDGF1
    OriGene Custom MassSpec
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    Novus Biologicals TDGF1 Proteins
    Novus Biologicals TDGF1 Lysates
    Sino Biological Recombinant Protein for TDGF1
    Sino Biological Cell Lysate for TDGF1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TDGF1

    TDGF1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TDGF1
    R&D Systems Antibodies for TDGF1 (Cripto)
    OriGene Antibodies for TDGF1
    OriGene Custom Antibody Services for TDGF1
    Novus Biologicals TDGF1 Antibodies
    Search for Antibodies for TDGF1 at Abcam
    Cloud-Clone Corp. Antibodies for TDGF1
    ThermoFisher Antibody for TDGF1
    Search LSBio for Antibodies for TDGF1

    TDGF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TDGF1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TDGF1
    Cloud-Clone Corp. CLIAs for TDGF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR019011 Cryptic/Cripto_CFC-dom
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR017047 Cripto_growth_factor

    Graphical View of Domain Structure for InterPro Entry P13385

    ProtoNet protein and cluster: P13385

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385
    Similarity: Contains 1 EGF-like domain


    TDGF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDGF1_HUMAN, P13385
    Function: Could play a role in the determination of the epiblastic cells that subsequently give rise to the
    mesoderm

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IDA11909953
    GO:0005515protein binding IPI12919325
    GO:0008083growth factor activity IDA12925698
         
    TDGF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TDGF1:
     Decreased DCP1a protein expres 

         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Tdgf1):
     cardiovascular system  cellular  embryogenesis  mortality/aging  nervous system 
     normal  vision/eye 

    TDGF1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TDGF1: Tdgf1tm2.1Mms Tdgf1tm1Eda

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TDGF1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TDGF1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TDGF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TDGF1

    miRNA
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    Block miRNA regulation of human, mouse, rat TDGF1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TDGF1:
    hsa-miR-299-5p hsa-miR-338-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidTDGF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TDGF1
    Predesigned siRNA for gene silencing in human, mouse, rat TDGF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TDGF1

    Clone
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    OriGene clones in human, mouse for TDGF1 (see all 11)
    OriGene ORF clones in mouse, rat for TDGF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TDGF1 (NM_003212)
    Sino Biological Human cDNA Clone for TDGF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDGF1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TDGF1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDGF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDGF1_HUMAN, P13385: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    golgi apparatus2
    nucleus2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA17720976
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IEA--
    GO:0009986cell surface IDA12925698

    TDGF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TDGF1 About   (see all 19)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JAK-STAT Pathway0.57
    MAPK Family Pathway0.60
    JNK Pathway0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TDGF1 (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for TDGF1
        Wnt / Hedgehog / Notch
    Angiogenesis

    1 BioSystems Pathway for TDGF1
        Glypican 1 network

    1 Sino Biological Pathway for TDGF1
        TGF-beta Signaling Pathway

    3 Reactome Pathways for TDGF1
        POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
    Signaling by NODAL
    Regulation of signaling by NODAL



    TDGF1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TDGF1 (see all 6): 
              Growth Factors in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TDGF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TDGF1 (P133852, 3 ENSP000002961454) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-63466 I2D: score=4 
    ENSG00000096155P463792, 3MINT-63466 I2D: score=4 
    ENSG00000227761P463792, 3MINT-63466 I2D: score=4 
    ENSG00000228760P463792, 3MINT-63466 I2D: score=4 
    ENSG00000229524P463792, 3MINT-63466 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA9013573
    GO:0001570vasculogenesis IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001763morphogenesis of a branching structure TAS10070255
    GO:0001954positive regulation of cell-matrix adhesion IEA--

    TDGF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TDGF1

    4 Novoseek inferred chemical compound relationships for TDGF1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 5.03 3 11218236 (2), 9650567 (1)
    threonine 3.58 1 17504756 (1)
    serine 0.166 2 12919325 (1)
    tyrosine 0 1 12532421 (1)



    TDGF1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TDGF1 gene (2 alternative transcripts): 
    NM_001174136.1  NM_003212.3  

    Unigene Cluster for TDGF1:

    Teratocarcinoma-derived growth factor 1
    Hs.385870  [show with all ESTs]
    Unigene Representative Sequence: NM_003212
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296145(uc003cpv.3) ENST00000493282 ENST00000471721 ENST00000459867
    ENST00000505797 ENST00000444264(uc003cpw.1) ENST00000542931(uc021wxd.1)

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate TDGF1:
    hsa-miR-299-5p hsa-miR-338-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidTDGF1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): TDGF1 (NM_003212)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDGF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDGF1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TDGF1
      QuantiTect SYBR Green Assays in human, mouse, rat TDGF1
      QuantiFast Probe-based Assays in human, mouse, rat TDGF1

    Additional mRNA sequence: 

    AK313319.1 BC022393.1 BC067844.1 X14253.1 

    5 DOTS entries:

    DT.100725583  DT.213859  DT.120853654  DT.120853660  DT.102830280 

    Selected AceView cDNA sequences (see all 46):

    AU124747 CD642565 CD651946 AU125451 AU125077 AA101474 AA218548 BI598827 
    BX105218 CD247314 X14253 BC067844 AL697438 AA101473 AA227015 AI969787 
    AA218549 NM_003212 BC022393 AI827894 AA216757 AA227381 BG429460 BI764848 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TDGF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATTCTACC
    TDGF1 Expression
    About this image


    TDGF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 27 entries
             Inner Cell Mass Cells Inner Cell Mass
             BresaGen 03
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 7 entries
             Primitive Streak Cells Anterior Primitive Streak
             Primitive Streak
     
     Epiblast (Early Embryo)    fully expand to see all 7 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Mesendoderm Cells Anterior Primitive Streak
     
     Endoderm (Gastrulation Derivatives)
             Mesendoderm Cells Anterior Primitive Streak
    TDGF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TDGF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.385870

    UniProtKB/Swiss-Prot: TDGF1_HUMAN, P13385
    Tissue specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal
    counterparts. Expressed in breast and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TDGF1 (see all 6): 
              Growth Factors in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat TDGF1
    QuantiFast Probe-based Assays in human, mouse, rat TDGF1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDGF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TDGF1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tdgf11 , 5 teratocarcinoma-derived growth factor 11, 5 79.19(n)1
    72.12(a)1
      9 (60.79 cM)5
    216671  NM_011562.21  NP_035692.21 
     1109396105 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    many ↔ many
    2(39715410-39727241)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tdgf1.11 teratocarcinoma-derived growth factor 1, member 1 51.57(n)
    42.45(a)
      100038139  NM_001085360.1  NP_001078829.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cripto2 cripto 97.47(n)   57932  AF151352.1 


    ENSEMBL Gene Tree for TDGF1 (if available)
    TreeFam Gene Tree for TDGF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TDGF1 gene
    CFC1B2  CFC12  
    1 SIMAP similar gene for TDGF1 using alignment to 3 protein entries:     TDGF1_HUMAN (see all proteins):
    TDGF1P3

    TDGF1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for TDGF1 (see all 6)
    PGOHUM00000234686 PGOHUM00000240543 PGOHUM00000238206 PGOHUM00000260147 PGOHUM00000249665


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TDGF1 (see all 267)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219095011,2
    Cpathogenic146552039(+) GCTGCC/TCAAGA 4 P L mis10--------
    rs351851301,2
    C--46614166(+) GAGAC-/GGGGGC 1 -- us2k10--------
    rs1880171551,2
    --46614173(+) GGGCTC/TCACTG 1 -- us2k10--------
    rs1926879111,2
    --46614204(+) ATCTCA/CTGACC 1 -- us2k10--------
    rs622478581,2
    C,F--46614299(+) TAACAA/GGTTGC 1 -- us2k16Minor allele frequency- G:0.23NA WA CSA EA 364
    rs1409832681,2
    --46614319(+) AGCCCA/GGAATA 1 -- us2k10--------
    rs1844664881,2
    C--46614338(+) GGTTTA/GGGTTA 1 -- us2k10--------
    rs1905782751,2
    C--46614345(+) GTTACA/GTATTT 1 -- us2k10--------
    rs1924086031,2
    --46614369(+) TTTCCA/CTTCTT 1 -- us2k10--------
    rs791301831,2
    C,F--46614499(+) GGGCTG/AAGATT 1 -- us2k11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for TDGF1 (46616045 - 46668033 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TDGF1: --
    Human Gene Mutation Database (HGMD): TDGF1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TDGF1
    DNA2.0 Custom Variant and Variant Library Synthesis for TDGF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187395    OMIM disorders: --

    Selected diseases for TDGF1 (see all 32):    
    About MalaCards
    forebrain defects    teratocarcinoma    midline interhemispheric variant of holoprosencephaly    septopreoptic holoprosencephaly
    lobar holoprosencephaly    alobar holoprosencephaly    single median maxillary central incisor    semilobar holoprosencephaly
    congenital heart defect    cystadenoma    holoprosencephaly    ovarian endometriosis
    teratoma    basal cell carcinoma    oral squamous cell carcinoma    osteoporosis
    nasopharyngitis    inflammatory bowel disease    pancreatitis    adenoma

    1 disease from the University of Copenhagen DISEASES database for TDGF1:
    Holoprosencephaly

    TDGF1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TDGF1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cystadenoma mucinous 51 2 8144392 (1), 8986534 (1)
    carcinoma embryonal 46.3 3 11857442 (1), 11553858 (1)
    colon carcinoma 45.4 4 9466051 (2), 11127817 (1), 11553858 (1)
    colon tumor 42.6 2 1596904 (1), 12925698 (1)
    mammary tumor 42.4 4 10225449 (2), 11857442 (1), 19421146 (1)
    colon cancer 39.2 1 9816209 (1)
    breast carcinoma 38.4 5 9935161 (2), 11174844 (1), 11553858 (1)
    colorectal tumors 34.2 2 1596904 (2)
    colorectal carcinoma 26.7 3 11553858 (2), 12147741 (1)
    pancreatic carcinoma 26.6 2 11857442 (1)

    Genetic Association Database (GAD): TDGF1
    Human Genome Epidemiology (HuGE) Navigator: TDGF1 (3 documents)

    Export disorders for TDGF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TDGF1 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with TDGF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence. (PubMed id 1882841)1, 2, 3 Dono R....Persico M.G. (Am. J. Hum. Genet. 1991)
    2. The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. (PubMed id 12919325)1, 2, 9 Foley S.F.... Wen D. (Eur. J. Biochem. 2003)
    3. Teratocarcinoma-derived growth factor 1 (TDGF1) sequence variants in patients with congenital heart defect. (PubMed id 19853938)1, 4 Wang B....Ma X. (Int. J. Cardiol. 2011)
    4. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. (PubMed id 19727905)1, 4 Li G.H....Huang Q.Y. (Osteoporos Int 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. (PubMed id 11909953)1, 2 Bianco C.... Salomon D.S. (Mol. Cell. Biol. 2002)
    8. Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1. (PubMed id 10393436)1, 3 Scognamiglio B....Persico M.G. (Cytogenet. Cell Genet. 1999)
    9. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. (PubMed id 2792079)1, 2 Ciccodicola A.... Persico M.G. (EMBO J. 1989)
    10. Cripto: a tumor growth factor and more. (PubMed id 11857442)1, 9 Adamson E.D....Salomon D.S. (J. Cell. Physiol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6997 HGNC: 11701 AceView: TDGF1 Ensembl:ENSG00000241186 euGenes: HUgn6997
    ECgene: TDGF1 H-InvDB: TDGF1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TDGF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TDGF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TDGF1 gene:
    Search GeneIP for patents involving TDGF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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