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Aliases for TDGF1 Gene

Aliases for TDGF1 Gene

  • Teratocarcinoma-Derived Growth Factor 1 2 3 5
  • Epidermal Growth Factor-Like Cripto Protein CR1 3 4
  • Cripto-1 Growth Factor 3 4
  • CRIPTO 3 4
  • CRGF 3 4
  • CR 3

External Ids for TDGF1 Gene

Previous GeneCards Identifiers for TDGF1 Gene

  • GC03P045859
  • GC03P046435
  • GC03P046579
  • GC03P046594
  • GC03P046616

Summaries for TDGF1 Gene

Entrez Gene Summary for TDGF1 Gene

  • This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for TDGF1 Gene

TDGF1 (Teratocarcinoma-Derived Growth Factor 1) is a Protein Coding gene. Diseases associated with TDGF1 include Microform Holoprosencephaly and Septopreoptic Holoprosencephaly. Among its related pathways are p70S6K Signaling and ERK Signaling. GO annotations related to this gene include receptor binding and growth factor activity. An important paralog of this gene is CFC1.

UniProtKB/Swiss-Prot for TDGF1 Gene

  • Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

Gene Wiki entry for TDGF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TDGF1 Gene

Genomics for TDGF1 Gene

Regulatory Elements for TDGF1 Gene

Enhancers for TDGF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TDGF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TDGF1 Gene

46,574,555 bp from pter
46,626,543 bp from pter
51,989 bases
Plus strand

Genomic View for TDGF1 Gene

Genes around TDGF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TDGF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TDGF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TDGF1 Gene

Proteins for TDGF1 Gene

  • Protein details for TDGF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Teratocarcinoma-derived growth factor 1
    Protein Accession:
    Secondary Accessions:
    • Q8TCC1

    Protein attributes for TDGF1 Gene

    188 amino acids
    Molecular mass:
    21169 Da
    Quaternary structure:
    • Interacts with the activin type-1 receptor ACVR1B.

neXtProt entry for TDGF1 Gene

Proteomics data for TDGF1 Gene at MOPED

Post-translational modifications for TDGF1 Gene

Other Protein References for TDGF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TDGF1 Gene

Domains & Families for TDGF1 Gene

Protein Domains for TDGF1 Gene

Suggested Antigen Peptide Sequences for TDGF1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with TDGF1: view

No data available for Gene Families for TDGF1 Gene

Function for TDGF1 Gene

Molecular function for TDGF1 Gene

UniProtKB/Swiss-Prot Function:
Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
genes like me logo Genes that share phenotypes with TDGF1: view

Human Phenotype Ontology for TDGF1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TDGF1 Gene

MGI Knock Outs for TDGF1:

Animal Model Products

  • Taconic Biosciences Mouse Models for TDGF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for TDGF1 Gene

Localization for TDGF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TDGF1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for TDGF1 Gene COMPARTMENTS Subcellular localization image for TDGF1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 3
golgi apparatus 2
cytoskeleton 1
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for TDGF1 Gene

Pathways & Interactions for TDGF1 Gene

genes like me logo Genes that share pathways with TDGF1: view

SIGNOR curated interactions for TDGF1 Gene


Gene Ontology (GO) - Biological Process for TDGF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 9013573
GO:0002042 cell migration involved in sprouting angiogenesis IMP 17720976
GO:0007173 NOT epidermal growth factor receptor signaling pathway IDA 8006041
GO:0007507 heart development IDA 9576836
GO:0008284 positive regulation of cell proliferation TAS 11857442
genes like me logo Genes that share ontologies with TDGF1: view

Drugs & Compounds for TDGF1 Gene

(4) Drugs for TDGF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TDGF1: view

Transcripts for TDGF1 Gene

Unigene Clusters for TDGF1 Gene

Teratocarcinoma-derived growth factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TDGF1 Gene

No ASD Table

Relevant External Links for TDGF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TDGF1 Gene

mRNA expression in normal human tissues for TDGF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TDGF1 Gene

This gene is overexpressed in Spleen (x10.3), Kidney - Cortex (x9.7), Adrenal Gland (x4.7), and Ovary (x4.5).

SOURCE GeneReport for Unigene cluster for TDGF1 Gene Hs.385870

mRNA Expression by UniProt/SwissProt for TDGF1 Gene

Tissue specificity: Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
genes like me logo Genes that share expression patterns with TDGF1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TDGF1 Gene

Orthologs for TDGF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TDGF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TDGF1 35
  • 83.79 (n)
  • 80.11 (a)
-- 36
  • 78 (a)
TDGF1 36
  • 80 (a)
(Canis familiaris)
Mammalia TDGF1 35
  • 82.63 (n)
  • 73.05 (a)
(Mus musculus)
Mammalia Tdgf1 35
  • 79.19 (n)
  • 72.12 (a)
Tdgf1 16
Tdgf1 36
  • 69 (a)
(Pan troglodytes)
Mammalia TDGF1 35
  • 99.29 (n)
  • 98.4 (a)
TDGF1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Tdgf1 35
  • 78.22 (n)
  • 68.75 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tdgf1.1 35
  • 51.57 (n)
  • 42.45 (a)
(Danio rerio)
Actinopterygii cripto 35
oep 36
  • 27 (a)
Species with no ortholog for TDGF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TDGF1 Gene

Gene Tree for TDGF1 (if available)
Gene Tree for TDGF1 (if available)

Paralogs for TDGF1 Gene

Paralogs for TDGF1 Gene

(1) SIMAP similar genes for TDGF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TDGF1: view

Variants for TDGF1 Gene

Sequence variations from dbSNP and Humsavar for TDGF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_021903 -
VAR_024262 -
VAR_048975 -
rs1049667 -- 46,582,200(+) AAGAA(A/C)TCCCC utr-variant-3-prime
rs3189859 -- 46,582,225(+) GCATT(A/G)TAAAA utr-variant-3-prime

Variation tolerance for TDGF1 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.98; 59.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TDGF1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TDGF1 Gene

Disorders for TDGF1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for TDGF1 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TDGF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TDGF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TDGF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TDGF1 Gene

Publications for TDGF1 Gene

  1. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence. (PMID: 1882841) Dono R. … Persico M.G. (Am. J. Hum. Genet. 1991) 2 3 4 67
  2. Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. (PMID: 20385969) Williams T.A. … Mulatero P. (Hypertension 2010) 3 23
  3. Activin A, activin receptor type II, nodal, and cripto mRNA are expressed by eutopic and ectopic endometrium in women with ovarian endometriosis. (PMID: 19386982) Torres P.B. … Petraglia F. (Reprod Sci 2009) 3 23
  4. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. (PMID: 19421146) Kelber J.A. … Gray P.C. (Oncogene 2009) 3 23
  5. Expression of nodal signalling components in cycling human endometrium and in endometrial cancer. (PMID: 19874624) Papageorgiou I. … Harrison C.A. (Reprod. Biol. Endocrinol. 2009) 3 23

Products for TDGF1 Gene

Sources for TDGF1 Gene