TDGF1 Gene

Aliases
for TDGF1 gene

Previous GC identifers: GC03P045859 GC03P046435 GC03P046579 GC03P046594

Summaries
for TDGF1 gene

Genomic Views
for TDGF1 gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: TDGF1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDGF1

TDGF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P046616:  view genomic region     (about GC identifiers)

Proteins
for TDGF1 gene

Explore the universe of human proteins at neXtProt for TDGF1: NX_P13385

TDGF1 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for TDGF1 (Cripto)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TDGF1 OriGene Custom Protein Services for TDGF1
	GenScript Custom Purified and Recombinant Proteins Services for TDGF1
	Novus Biologicals TDGF1 Proteins Novus Biologicals TDGF1 Lysates
	Sino Biological Recombinant Protein for TDGF1
	ProSpec Recombinant Protein for TDGF1
	Uscn Proteins for TDGF1

Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of TDGF1
	R&D Systems Antibodies for TDGF1 (Cripto)
	OriGene Antibodies (see all 2): TDGF1 OriGene Custom Antibody Services for TDGF1
	GenScript Custom Superior Antibodies Services for TDGF1
	Novus Biologicals TDGF1 Antibodies
	Abcam antibodies for TDGF1
	Uscn Antibodies for TDGF1
	ThermoFisher Antibody for TDGF1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for TDGF1 (Cripto)         (see all)
	GenScript Custom Assay Services for TDGF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TDGF1

Protein Domains /
Families
for TDGF1 gene

ProtoNet protein and cluster: P13385

Function
for TDGF1 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TDGF1
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TDGF1:
		hsa-miR-299-5p hsa-miR-338-5p hsa-miR-516a-3p hsa-miR-516b* hsa-miR-888
		SwitchGear 3'UTR luciferase reporter plasmid: TDGF1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDGF1 (see all 4) OriGene shRNA RFP: TDGF1 OriGene siRNA: TDGF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDGF1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TDGF1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDGF1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDGF1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TDGF1 (NM_003212)
		Sino Biological Human cDNA Clone for TDGF1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TDGF1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDGF1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TDGF1
		Search LifeMap BioReagents cell lines for TDGF1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDGF1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 6 alleles) (MGI details for Tdgf1)

Pathways & Interactions
for TDGF1 gene

	Super-pathway	contained gene-specific pathways
1	Apoptotic Pathways in Synovial Fibroblasts	8/14 pathways (see all 14) Apoptotic Pathways in Synovial Fibroblasts 1.00 ERK5 Signaling 0.61 p53 Mediated Apoptosis 0.84 eIF2 Pathway 0.60 Mitochondrial Apoptosis 0.73 Rac1 Pathway 0.58 Telomerase Components in Cell Signaling 0.72 Nuclear Receptor Activation by Vitamin-A 0.57
2	GPCR Pathway	GPCR Pathway 1.00 Estrogen Pathway 0.55 Ras Pathway 0.62 Pancreatic Adenocarcinoma 0.55 Breast Cancer Regulation by Stathmin1 0.58 Paxillin Interactions 0.53 NFAT in Immune Response 0.58
3	Rho Family GTPases	Rho Family GTPases 1.00 MAPK Signaling 0.51 ERK Signaling 0.61 ILK Signaling 0.45 Molecular Mechanisms of Cancer 0.51
4	TGF-Beta Pathway	TGF-Beta Pathway 1.00 JAK-STAT Pathway 0.57 MAPK Family Pathway 0.60 JNK Pathway 0.50
5	Nanog in Mammalian ESC Pluripotency	Nanog in Mammalian ESC Pluripotency 1.00 14-3-3 Induced Intracellular Signaling 0.59 GSK3 Signaling 0.61 eNOS Signaling 0.48

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TDGF1

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

2 Cell Signaling Technology (CST) Pathways for TDGF1

	Wnt / Hedgehog / Notch
	Angiogenesis

1 BioSystems Pathway for TDGF1

Glypican 1 network

3        Reactome Pathways for TDGF1

	Developmental Biology
	Signaling by NODAL
	Regulation of Signaling by NODAL

Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

Drugs & Compounds
for TDGF1 gene

Transcripts
for TDGF1 gene

Expression
for TDGF1 gene

TDGF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATTCTACC

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EpiblastEpiblastEarly Epiblast Cells			Early Embryo
	EpiblastEpiblastEpiblast Cells			Early Embryo
	EpiblastEpiblastIntraembryonic Epiblast Cells			Early Embryo
	EpiblastEpiblastIntraembryonic Epiblast Cells			Early Embryo
	Inner Cell MassInner Cell MassInner Cell Mass Cells			Early Embryo
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/26 LifeMap Cells (see all 26)
	Name			Category
	Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)			Early Embryo, Fibroblast
	Induced pluripotent stem cells (ALS patient) (Induced Pluripotent Stem Cell)			Early Embryo, Fibroblast
	Induced pluripotent stem cells (using UTF1) (Induced Pluripotent Stem Cell)			Early Embryo, Fibroblast
	ESI-017 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	ESI-035 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	ESI-049 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	ESI-051 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	ESI-053 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	BG01V (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	CA1 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDGF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TDGF1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDGF1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDGF1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDGF1

Orthologs
for TDGF1 gene

Paralogs
for TDGF1 gene

Paralogs for TDGF1 gene

CFC1B²  CFC1²  

1 SIMAP similar gene for TDGF1 using alignment to 3 protein entries:     TDGF1_HUMAN (see all proteins):

TDGF1P3

TDGF1 for paralogs           About GeneDecksing


5/6 Pseudogenes.org Pseudogenes for TDGF1 (see all 6)
PGOHUM00000234686 PGOHUM00000240543 PGOHUM00000238206 PGOHUM00000260147 PGOHUM00000249665

Genomic Variants
for TDGF1 gene

10/203 NCBI SNPs in TDGF1 are shown (see all 203)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1219095011,2	C	pathogenic	46621476(+)	GCTGCC/TCAAGA	4	P L	mis1		0	--	--	--	--
rs1880171551,2		--	46614173(+)	GGGCTC/TCACTG	1	--	us2k1		0	--	--	--	--
rs1926879111,2		--	46614204(+)	ATCTCA/CTGACC	1	--	us2k1		0	--	--	--	--
rs622478581,2	C,F,	--	46614299(+)	TAACAA/GGTTGC	1	--	us2k1		6		NA WA CSA EA	364
rs1409832681,2		--	46614319(+)	AGCCCA/GGAATA	1	--	us2k1		0	--	--	--	--
rs1844664881,2		--	46614338(+)	GGTTTA/GGGTTA	1	--	us2k1		0	--	--	--	--
rs1905782751,2		--	46614345(+)	GTTACA/GTATTT	1	--	us2k1		0	--	--	--	--
rs1924086031,2		--	46614369(+)	TTTCCA/CTTCTT	1	--	us2k1		0	--	--	--	--
rs791301831,2	C,F,	--	46614499(+)	GGGCTG/AAGATT	1	--	us2k1		1		WA	118
rs1502268591,2		--	46614576(+)	AAACAC/TTGCAC	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for TDGF1 (46616045 - 46668033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TDGF1: --
Human Gene Mutation Database (HGMD): TDGF1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDGF1

DNA2.0 Custom Variant and Variant Library Synthesis for TDGF1

Disorders / Diseases
for TDGF1 gene

20/34 diseases for TDGF1

10/19 Novoseek disease relationships for TDGF1 gene (see all 19)    About this table

Publications
for TDGF1 gene

PubMed articles for TDGF1 gene, integrated from 9 sources (see all 121): (articles sorted by number of sources associating them with TDGF1)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence. (PubMed id 1882841)^{1, 2, 3} Dono R....Persico M.G. (1991)
2. The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. (PubMed id 12919325)^{1, 2, 9} Foley S.F.... Wen D. (2003)
3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
4. Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. (PubMed id 11909953)^{1, 2} Bianco C....Salomon D.S. (2002)
5. Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1. (PubMed id 10393436)^{1, 3} Scognamiglio B....Persico M.G. (1999)
6. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. (PubMed id 2792079)^{1, 2} Ciccodicola A.... Persico M.G. (1989)
7. Cripto: a tumor growth factor and more. (PubMed id 11857442)^{1, 9} Adamson E.D....Salomon D.S. (2002)
8. Cripto forms a complex with activin and type II activin receptors and can block activin signaling. (PubMed id 12682303)^{1, 9} Gray P.C....Vale W. (2003)
9. Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal. (PubMed id 18089557)^{1, 9} Kelber J.A....Gray P.C. (2008)
10. Blockade of Cripto binding to cell surface GRP78 inhi bits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. (PubMed id 19421146)^{1, 9} Kelber J.A....Gray P.C. (2009)

External Searches for TDGF1 gene

Genome Databases showing TDGF1 gene

Other Databases showing TDGF1 gene

Specialized Databases showing TDGF1 gene

Products
for TDGF1 gene