TDG Gene
protein-coding GIFtS: 67
GCID: GC12P104359
|
|
thymine-DNA glycosylase
| |
Aliases
for TDG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thymine-DNA Glycosylase1 2 3 | | G/T Mismatch-Specific Thymine DNA Glycosylase2 | | EC 3.2.2.293 |
Export aliases for TDG gene to outside databasesPrevious GC identifers: GC12P103472 GC12P104240 GC12P102862 GC12P101419 |
Summaries
for TDG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TDG:
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removesthymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone ofDNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDGcan also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellulardefense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene mayhave a pseudogene in the p arm of chromosome 12. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TDG_HUMAN, Q13569Function: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formationof G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogenbond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can removethymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinicsites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also removeuracil and 5-bromouracil from mispairs with guanine
Gene Wiki entry for TDG (Thymine-DNA glycosylase)
|
Genomic Views
for TDG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TDG gene promoter:
ER-alpha Pax-5 p300 Pax-2a Evi-1 RORalpha1 FAC1 FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TDG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.1 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q24.1TDG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P104359: view genomic region
(about GC identifiers)
Start:
|
104,359,582 bp from pter |
End:
|
104,382,656 bp from pter |
Size:
|
23,075 bases |
Orientation:
|
plus strand |
|
Proteins
for TDG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TDG_HUMAN, Q13569 (See
protein sequence)Recommended Name: G/T mismatch-specific thymine DNA glycosylase Size: 410 amino acids; 46053 Da
Subcellular location: Nucleus
6/7 PDB 3D structures from  and Proteopedia  for TDG (see all 7):1WYW (3D)
2D07 (3D)
2RBA (3D)
3UFJ (3D)
3UO7 (3D)
3UOB (3D)
Secondary accessions: Q8IUZ6 Q8IZM3Explore the universe of human proteins at neXtProt for TDG: NX_Q13569
Post-translational modifications:
Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13569
TDG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003202.3
ENSEMBL proteins: ENSP00000376611 ENSP00000390167 ENSP00000266775 ENSP00000445899 ENSP00000439825 ENSP00000445716 ENSP00000439054 Reactome Protein details: Q13569
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TDG for ontologies About GeneDecksing
TDG Antibody Products:
Assay Products for TDG: |
Protein
Domains /
Families
for TDG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TDG for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13569ProtoNet protein and cluster: Q13569 1 Blocks protein family: IPB005122 Uracil-DNA glycosylase superfamily
UniProtKB/Swiss-Prot: TDG_HUMAN, Q13569Similarity: Belongs to the TDG/mug DNA glycosylase family |
Function
for TDG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TDG_HUMAN, Q13569Function: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formationof G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogenbond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can removethymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinicsites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also removeuracil and 5-bromouracil from mispairs with guanineCatalytic activity: Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine Genatlas biochemistry entry for TDG:DNA glycosylase,thymine,46-55 kDa,nuclear G/T mismatch,also active toward 3,N-ethenocysteine adducts,specific,baseexcision repair,with delimited role in pancreatic ductal carcinogenesis
Enzyme Number (IUBMB): EC 3.2.2.291
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDG (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TDG (NM_003211) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TDG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDG |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity |
IEA | -- | | GO:0003684 | damaged DNA binding |
TAS | 9489705 | | GO:0005515 | protein binding |
IPI | -- | | GO:0008263 | pyrimidine-specific mismatch base pair DNA N-glycosylase activity |
TAS | 8662714 | | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds |
-- | -- |
TDG for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Tdgtm1.1Abc for TDG
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tdg):
TDG for phenotypes About GeneDecksing
|
Pathways & Interactions
for TDG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Base-Excision Repair, AP Site Formation | | | 2 | Resolution of Abasic Sites (AP sites) | | | 3 | Transcription_P53 signaling pathway | | | 4 | Fluoropyrimidine Activity | | | 5 | Nucleotide Excision Repair | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TDG
1  GeneGo (Thomson Reuters) Pathway for TDG
1  BioSystems Pathway for TDG
5/12 
Reactome Pathways for TDG (see all 12)
1  PharmGKB Pathway for TDG
1 
Kegg Pathway (Kegg details for TDG):
TDG for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TDG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for TDG (Q135691, 2, 3 ENSP000003766114) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0006281 | DNA repair |
TAS | -- | | GO:0006284 | base-excision repair |
TAS | -- | | GO:0006285 | base-excision repair, AP site formation |
TAS | -- | | GO:0006298 | mismatch repair |
IEA | -- |
TDG for ontologies About GeneDecksing
|
Drugs & Compounds
for TDG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TDG for compounds About GeneDecksing
 Browse Tocris compounds for TDG
1 HMDB Compound for TDG About this table
10 Novoseek chemical compound relationships for TDG gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| 3,n(4)-ethenocytosine |
95.3 |
23 |
12493755 (6), 17270163 (4), 10767625 (1), 10995256 (1) (see all 5) |
| thymine |
92.2 |
156 |
9867812 (7), 12493755 (6), 9685338 (5), 11554300 (4) (see all 45) |
| 5-methylcytosine |
90.8 |
17 |
12493755 (2), 10767625 (1), 11889051 (1), 9299239 (1) (see all 9) |
| cytosine |
79.8 |
11 |
11889051 (1), 17270163 (1), 18512959 (1), 10938281 (1) (see all 6) |
| guanine |
69.9 |
7 |
12954776 (1), 16984202 (1), 18789404 (1), 11554300 (1) (see all 6) |
| adenine |
57.3 |
3 |
12954776 (1), 16984202 (1), 17270163 (1) |
| purine |
38.1 |
1 |
12711670 (1) |
| 5fluorouracil |
25.2 |
12 |
19402749 (6), 18054558 (1) |
| atp |
0 |
3 |
15157103 (1), 11376160 (1) |
| estrogen |
0 |
3 |
19652917 (2), 12874288 (1) |
Search CenterWatch for drugs/clinical trials and news about TDG
|
Transcripts
for TDG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TDG gene (2 alternative transcripts): NM_003211.4 NM_001008411.1 Unigene Cluster for TDG: Thymine-DNA glycosylase Hs.584809 [show with all ESTs]Unigene Representative Sequence: NM_00321111 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000392872(uc001tkg.3 uc009zuk.3 uc010swi.2 uc010swj.2)
ENST00000436021 ENST00000545698 ENST00000266775 ENST00000544861 ENST00000537100
ENST00000544060(uc010swh.1) ENST00000542926 ENST00000540956 ENST00000536395
ENST00000542036
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDG (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDG (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TDG (NM_003211) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TDG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDG |
Additional cDNA sequence: AK295387.1 AK299832.1 AK303631.1 AK309792.1 AK311673.1 AK313234.1 BC001307.1 BC010945.1 BC019925.1 BC037557.1 BC071714.1 BC104477.1 DQ786320.1 XR_133016.3 22 DOTS entries: DT.100773293 DT.100824974 DT.313550 DT.95203205 DT.121182756 DT.101977448 DT.100835319 DT.100824975 DT.121182982 DT.121182926 DT.92469593 DT.121182693 DT.121182927 DT.100710034 DT.449388 DT.100024114 DT.100705623 DT.121182704 DT.95356374 DT.120703001 DT.455637 DT.75112079 24/213 AceView cDNA sequences (see all 213): AW590228 AI521526 BF195990 BM915474 AA316331 F04833 AV708234 CK430453 AA808472 BM986950 AI263844 AI669972 BM459353 AA748478 F08625 AI285792 AI332786 BX492385 BU187359 T34101 AA477864 AI769788 BM682174 Z39321
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TDG (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TDG
|
Expression
for TDG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TDG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAGATGAGT
About this image
See TDG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TDG
SOURCE GeneReport for Unigene cluster: Hs.584809
SABiosciences Expression via Pathway-Focused PCR Array including TDG:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TDG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDG |
Orthologs
for TDG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TDG gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Tdg1 , 5 |
thymine DNA glycosylase1, 5 |
83.21(n)1
88.51(a)1 |
|
10 (39.72 cM)5
216651 NM_172552.31 NP_766140.21
826298285 |
chicken
(Gallus gallus) |
Aves |
TDG1 |
thymine-DNA glycosylase |
78.11(n)
80.35(a) |
|
395510 NM_204750.1 NP_990081.1 |
lizard
(Anolis carolinensis) |
Reptilia |
TDG6 |
-- |
76(a) |
1 ↔ 1 |
5(18199852-18205856) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.235732 |
Xenopus laevis, Similar to hypothetical protein E13 more |
78.82(n) |
|
BC041496.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
tdg1 |
thymine-DNA glycosylase |
62.33(n)
62.5(a) |
|
553789 NM_001020751.1 NP_001018587.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Thd13 |
nucleotide-excision repair
pyrimidine-specific more |
50(a) |
|
102C2 -- |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
mug6 |
G/U mismatch-specific DNA glycosylase; xanthine DN... |
31(a) |
1 ↔ 1 |
Chromosome(3212989-3213495) |
ENSEMBL Gene Tree for TDG (if available)
TreeFam Gene Tree for TDG (if available) |
Paralogs
for TDG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TDG gene
TDG for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TDG
PGOHUM00000239708
|
Genomic Variants
for TDG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TDG (104359582 - 104382656 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for TDG
6 CNVs: 5689 39116 43837 39115 43836 39114
5 Indels: 44962 39930 39931 63046 39932 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDG |
|
Disorders
/ Diseases
for TDG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TDG for disorders About GeneDecksing
OMIM gene information: 601423
OMIM disorders: --
20/22  diseases for TDG (see all 22): About MalaCardsxeroderma pigmentosum, group c xeroderma pigmentosum graft versus host disease toxic diffuse goiter
plummer's disease pancreatic ductal adenocarcinoma goiter familial colorectal cancer
multiple myeloma multiple sclerosis colorectal cancer myeloma
choroiditis colon cancer gastric cancer meningioma
lung cancer adenocarcinoma pancreatitis retinitis
2 diseases from the University of Copenhagen DISEASES database for TDG:Toxic diffuse goiter Dissociative disorder 3 Novoseek disease relationships for TDG gene About this table
Genetic Association Database (GAD): TDG
Human Genome Epidemiology (HuGE) Navigator: TDG (11 documents)
Export disorders for TDG gene to outside databases
|
Publications
for TDG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TDG gene, integrated from 9 sources (see all 115):
(articles sorted by number of sources associating them with TDG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase. (PubMed id 8662714)1, 2, 3, 9 Neddermann P.... Jiricny J. (1996)
- Crystal structure of SUMO-3-modified thymine-DNA glycosylase. (PubMed id 16626738)1, 2, 9 Baba D.... Shirakawa M. (2006)
- Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. (PubMed id 11889051)1, 2, 9 Hardeland U.... Schaer P. (2002)
- Polymorphisms in TDG and MGMT genes - epidemiological and functional study in lung cancer patients from Poland. (PubMed id 15225156)1, 4, 9 Krzesniak M....Rusin M. (2004)
- Crystal structure of thymine DNA glycosylase conjugated to SUMO-1. (PubMed id 15959518)1, 2, 9 Baba D.... Shirakawa M. (2005)
- Chromosomal localizations and molecular analysis of TDG gene-related sequences. (PubMed id 9299239)1, 3, 9 Sard L....Radice P. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Efficient removal of uracil from G.U mispairs by the mismatch- specific thymine DNA glycosylase from HeLa cells. (PubMed id 8127859)1, 2 Neddermann P. and Jiricny J. (1994)
- The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. (PubMed id 8407958)1, 2 Neddermann P. and Jiricny J. (1993)
- Substrate specificity of human thymine-DNA glycosylase on exocyclic cytosine adducts. (PubMed id 17270163)1, 9 Hang B. and Guliaev A.B. (2007)
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External Searches for TDG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TDG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TDG gene
(According to HUGE)
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Specialized Databases showing TDG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for TDG gene:
Search GeneIP for patents involving TDG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TDG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TDG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TDG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TDG | | | OriGene Protein Over-expression Lysate for TDG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TDG | | OriGene 3'-UTR Clone for TDG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TDG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TDG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TDG | | OriGene Custom Protein Services for TDG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TDG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TDG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TDG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TDG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TDG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TDG |
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| | | | Search Tocris compounds for TDG |
| |  |  |  |  | | | | | | Recombinant Protein for TDG |
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 | | | TDG Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TDG |
|  |  |  | | | | ThermoFisher Antibodies for TDG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TDG |
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