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TCTN3 Gene

protein-coding   GIFtS: 51
GCID: GC10M097414

Tectonic Family Member 3

(Previous name: chromosome 10 open reading frame 61)
(Previous symbol: C10orf61)
  See TCTN3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tectonic Family Member 31 2     OFD42 5
C10orf611 2 3 5     Chromosome 10 Open Reading Frame 611
TECT32 3 5     tectonic-32
JBTS182 5     

External Ids:    HGNC: 245191   Entrez Gene: 261232   Ensembl: ENSG000001199777   OMIM: 6138475   UniProtKB: Q6NUS63   

Export aliases for TCTN3 gene to outside databases

Previous GC identifer: GC10M091050


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCTN3 Gene:
This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and
development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and
Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for
this gene. (provided by RefSeq, Sep 2012)

GeneCards Summary for TCTN3 Gene:
TCTN3 (tectonic family member 3) is a protein-coding gene. Diseases associated with TCTN3 include orofaciodigital syndrome, and joubert syndrome 18. An important paralog of this gene is TCTN1.

UniProtKB/Swiss-Prot: TECT3_HUMAN, Q6NUS6
Function: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate
ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal
transduction through the sonic hedgehog (Shh) signaling pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCTN3 gene promoter:
         SRF   GATA-3   SRF (504 AA)   MEF-2   Brachyury   CUTL1   GATA-1   E47   MEF-2A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCTN3 promoter sequence
   Search Chromatin IP Primers for TCTN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.1   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q24.1

TCTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCTN3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M097414:  view genomic region     (about GC identifiers)

Start:
97,423,153 bp from pter      End:
97,453,900 bp from pter
Size:
30,748 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TECT3_HUMAN, Q6NUS6 (See protein sequence)
Recommended Name: Tectonic-3 precursor  
Size: 607 amino acids; 66157 Da
Subunit: Part of the tectonic-like complex (also named B9 complex) (By similarity)
Sequence caution: Sequence=AAH68449.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=ABB90564.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC11567.1;
Type=Frameshift; Positions=238; Sequence=BAC87634.1; Type=Erroneous initiation; Note=Translation N-terminally
shortened; Sequence=CAI16768.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NIC8 B0QZ90 B4DR81 Q6P7P3 Q6UW27 Q6ZQQ0 Q8N7K1 Q8NBQ0 Q96GF7 Q9Y3U1
Alternative splicing: 5 isoforms:  Q6NUS6-1   Q6NUS6-2   Q6NUS6-3   Q6NUS6-4   Q6NUS6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCTN3: NX_Q6NUS6

Explore proteomics data for TCTN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys220
  • Glycosylation2 at Asn78, Asn179, Asn347

  • See TCTN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137445.1  NP_056446.4  

    ENSEMBL proteins: 
     ENSP00000360261   ENSP00000265993   ENSP00000387567   ENSP00000360253  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TCTN: Tectonic proteins

    1 InterPro protein domain:
     IPR011677 DUF1619

    Graphical View of Domain Structure for InterPro Entry Q6NUS6

    ProtoNet protein and cluster: Q6NUS6

    UniProtKB/Swiss-Prot: TECT3_HUMAN, Q6NUS6
    Similarity: Belongs to the tectonic family


    Find genes that share domains with TCTN3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TECT3_HUMAN, Q6NUS6
    Function: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate
    ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal
    transduction through the sonic hedgehog (Shh) signaling pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TCTN3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TCTN3:
     Decreased Wnt reporter activit 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TCTN3

    miRNA
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    miRTarBase miRNAs that target TCTN3:
    hsa-mir-339-5p (MIRT042807)

    Block miRNA regulation of human, mouse, rat TCTN3 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TCTN3:
    hsa-miR-579 hsa-miR-4328 hsa-miR-449c*
    SwitchGear 3'UTR luciferase reporter plasmidTCTN3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TECT3_HUMAN, Q6NUS6: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane2
    cytoskeleton1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TCTN3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCTN3
    Interactions:

        Search GeneGlobe Interaction Network for TCTN3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TCTN3 (ENSP000002659934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B9D1ENSP000002614994STRING: ENSP00000261499
    TCTN2ENSP000003049414STRING: ENSP00000304941
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007224smoothened signaling pathway IMP--
    GO:0060271cilium morphogenesis ISS--

    Find genes that share ontologies with TCTN3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCTN3 (TECT3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCTN3 gene (2 alternative transcripts): 
    NM_001143973.1  NM_015631.5  

    Unigene Cluster for TCTN3:

    Tectonic family member 3
    Hs.438991  [show with all ESTs]
    Unigene Representative Sequence: AK128834
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371217 ENST00000265993(uc001klb.4) ENST00000430368(uc010qoi.2)
    ENST00000371209(uc001kld.3) ENST00000497399 ENST00000478245
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TCTN3:
    hsa-miR-579 hsa-miR-4328 hsa-miR-449c*
    SwitchGear 3'UTR luciferase reporter plasmidTCTN3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TCTN3
      QuantiFast Probe-based Assays in human, mouse, rat TCTN3

    Additional mRNA sequence: 

    AK075357.1 AK128834.1 AK299141.1 AL050022.1 AY359022.1 BC009494.2 BC061582.1 BC068449.1 
    DQ278872.1 

    Selected DOTS entries (see all 26):

    DT.100795314  DT.100723751  DT.100795315  DT.100795313  DT.80101860  DT.121262394  DT.100027070  DT.101984682 
    DT.121262475  DT.95159258  DT.121262626  DT.70101173  DT.100805088  DT.100795317  DT.121262430  DT.40125600 
    DT.40206293  DT.91798933  DT.92013965  DT.92017021  DT.92447851  DT.92447854  DT.95159257  DT.95159259 

    Selected AceView cDNA sequences (see all 343):

    AL548528 BQ129369 AA508694 BQ183548 NM_015631 AW069180 BC009494 CA426847 
    BM850724 BE766771 AW008086 AI363208 AA256514 AA300594 AA039653 Z39224 
    AI868215 AA622048 BQ019017 BQ058846 BE617041 T35186 BM728527 AA442426 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TCTN3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                                      -                                         -           -                                             
    SP2:                                      -                       -                             -                                             
    SP3:                                      -                                         -     -     -                                             
    SP4:                                      -     -                                                                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for TCTN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCAGAGAGC
    TCTN3 Expression
    About this image


    TCTN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Thyroid (Endocrine System)
    TCTN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCTN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438991
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TCTN3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tctn31 , 5 tectonic family member 31, 5 79.46(n)1
    73.78(a)1
      19 (34.25 cM)5
    675901  NM_026260.21  NP_080536.21 
     405964465 
    chicken
    (Gallus gallus)
    Aves LOC1008574121 tectonic-3-like 61.11(n)
    50.45(a)
      100857412  XM_003641533.2  XP_003641581.2 
    lizard
    (Anolis carolinensis)
    Reptilia TCTN36
    tectonic family member 3
    40(a)
    1 ↔ 1
    3(38038553-38054766)


    ENSEMBL Gene Tree for TCTN3 (if available)
    TreeFam Gene Tree for TCTN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCTN3 gene
    TCTN12  

    Find genes that share paralogs with TCTN3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCTN3 (see all 663)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0688234
    Joubert syndrome 18 (JBTS18)4--see VAR_0688232 G R mis40--------
    rs3733561521,2
    C--91067785(+) CAGCT-/CTTG  
     GAAGCAA
    CACTT
    2 -- int10--------
    rs106101571,2
    C--91067786(+) CAGCT-/CACTTTA 2 -- int10--------
    rs786747041,2
    C--91067791(+) CACTTG/TAAACA 2 -- int10--------
    rs745153751,2
    C--91067792(+) ACTTTA/GAACAA 2 -- int10--------
    rs778849961,2
    C--91067795(+) TTAAAC/GAAACA 2 -- int10--------
    rs758925701,2
    C--91067796(+) TAAACA/CAACAT 2 -- int10--------
    rs1434485271,2
    C--91068182(+) GGAAG-/AACACA 2 -- int10--------
    rs1115132701,2
    C,F--91068379(+) CCACAC/ACTAAT 2 -- int12Minor allele frequency- A:0.04CSA NA 122
    rs614000571,2
    C--91075856(+) AAAAA-/A/A   
      AAAAAA
    GAAAA
    2 -- int11NA 2

    HapMap Linkage Disequilibrium report for TCTN3 (97423153 - 97453900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TCTN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662211CNV Deletion23128226
    nsv526761CNV Loss19592680
    nsv526180CNV Gain19592680

    Human Gene Mutation Database (HGMD): TCTN3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCTN3
    DNA2.0 Custom Variant and Variant Library Synthesis for TCTN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613847   
    OMIM disorders: 258860  614815  
    UniProtKB/Swiss-Prot: TECT3_HUMAN, Q6NUS6
  • Orofaciodigital syndrome 4 (OFD4) [MIM:258860]: A form of orofaciodigital syndrome, a group of
    heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated
    phenotypic abnormalities that lead to the delineation of various subtypes. OFD4 patients have tongue nodules,
    multiple frenulae, broad flat nose, hypertelorism, and short rib polydactyly with tibial dysplasia (Majewski
    syndrome). The presence of severe tibial aplasia differentiates OFD4 from OFD1. Additional features of cystic
    dysplastic kidneys and brain malformation, including occipital encephalocele, are observed in severely affected
    patients. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Joubert syndrome 18 (JBTS18) [MIM:614815]: A form of Joubert syndrome, a disorder presenting with
    cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay.
    Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented
    superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar
    tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal
    disease. JBTS18 patients have vermis agenesis and the molar tooth sign as well as severe kyphoscoliosis. Other
    features include intrauterine growth retardation, oral anomalies, micrognathism, polydactyly and camptodactyly,
    joint laxity, horseshoe kidney, and ventricular septal defect. Note=The disease is caused by mutations affecting
    the gene represented in this entry. TCTN3-mutated fibroblasts from JBTS18 patients fail to respond to Shh
    agonists suggesting that at least some of the defects in affected individuals may be secondary to reduced Shh
    signaling (PubMed:22883145)

  • 5 diseases for TCTN3:    
    About MalaCards
    orofaciodigital syndrome    joubert syndrome 18    orofaciodigital syndrome 4    joubert syndrome 22
    joubert syndrome and related disorders

    1 disease from the University of Copenhagen DISEASES database for TCTN3:
    Polydactyly

    Find genes that share disorders with TCTN3           About GenesLikeMe

    Genetic Association Database (GAD): TCTN3
    Human Genome Epidemiology (HuGE) Navigator: TCTN3 (1 document)

    Export disorders for TCTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCTN3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with TCTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. TCTN3 mutations cause Mohr-Majewski syndrome. (PubMed id 22883145)1, 2 Thomas S.... Attie-Bitach T. (Am. J. Hum. Genet. 2012)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. (PubMed id 16357211)1, 2 Reiter J.F. and Skarnes W.C. (Genes Dev. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    9. Identification of novel regulators of apoptosis using a high- throughput cell-based screen. (PubMed id 17464193)2 Park K.M.... Kim S.J. (Mol. Cells 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26123 HGNC: 24519 AceView: C10orf61 Ensembl:ENSG00000119977 euGenes: HUgn26123
    ECgene: TCTN3 H-InvDB: TCTN3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TCTN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCTN3 gene:
    Search GeneIP for patents involving TCTN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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