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TCTN2 Gene

protein-coding   GIFtS: 50
GCID: GC12P124155

Tectonic Family Member 2

(Previous name: chromosome 12 open reading frame 38)
(Previous symbol: C12orf38)
  See TCTN2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tectonic Family Member 21 2     Chromosome 12 Open Reading Frame 381
C12orf381 2 3     Meckel Syndrome1
TECT22 3 5     Type 81
MKS82 5     tectonic-22

External Ids:    HGNC: 257741   Entrez Gene: 798672   Ensembl: ENSG000001687787   OMIM: 6138465   UniProtKB: Q96GX13   

Export aliases for TCTN2 gene to outside databases

Previous GC identifers: GC12P122723 GC12P121116


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCTN2 Gene:
This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this
protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are
associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms
have been found for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for TCTN2 Gene:
TCTN2 (tectonic family member 2) is a protein-coding gene. Diseases associated with TCTN2 include tctn2-related meckel syndrome, and meckel syndrome 8.

UniProtKB/Swiss-Prot: TECT2_HUMAN, Q96GX1
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and
acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
Required for hedgehog signaling transduction (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCTN2 gene promoter:
         FOXF2   NRSF form 1   Nkx2-5   NRSF form 2   E4BP4   C/EBPalpha   HEN1   Msx-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCTN2 promoter sequence
   Search Chromatin IP Primers for TCTN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCTN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

TCTN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCTN2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P124155:  view genomic region     (about GC identifiers)

Start:
124,155,660 bp from pter      End:
124,192,948 bp from pter
Size:
37,289 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TECT2_HUMAN, Q96GX1 (See protein sequence)
Recommended Name: Tectonic-2 precursor  
Size: 697 amino acids; 76871 Da
Subunit: Part of the tectonic-like complex (also named B9 complex) (By similarity)
Sequence caution: Sequence=BAB14370.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K7Y8 B3KPW5 Q9H966
Alternative splicing: 2 isoforms:  Q96GX1-1   Q96GX1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCTN2: NX_Q96GX1

Explore proteomics data for TCTN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys443
  • Glycosylation2 at Asn146, Asn156, Asn372, Asn391, Asn497, Asn636
  • Modification sites at PhosphoSitePlus

  • See TCTN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137322.1  NP_079085.2  

    ENSEMBL proteins: 
     ENSP00000437644   ENSP00000395171   ENSP00000304941  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TCTN: Tectonic proteins

    1 InterPro protein domain:
     IPR011677 DUF1619

    Graphical View of Domain Structure for InterPro Entry Q96GX1

    ProtoNet protein and cluster: Q96GX1

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: TECT2_HUMAN, Q96GX1
    Similarity: Belongs to the tectonic family


    Find genes that share domains with TCTN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TECT2_HUMAN, Q96GX1
    Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and
    acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
    Required for hedgehog signaling transduction (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TCTN2           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tctn2):
     cardiovascular system  craniofacial  digestive/alimentary  embryogenesis  growth/size/body 
     limbs/digits/tail  nervous system  vision/eye 

    Find genes that share phenotypes with TCTN2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tctn2tm1.1Reit for TCTN2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCTN2
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    miRNA
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    miRTarBase miRNAs that target TCTN2:
    hsa-mir-26b-5p (MIRT029239)

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    3 qRT-PCR Assays for microRNAs that regulate TCTN2:
    hsa-miR-579 hsa-miR-1283 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidTCTN2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TECT2_HUMAN, Q96GX1: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm, cytoskeleton, cilium
    basal body (By similarity). Note=Localizes at the transition zone, a region between the basal body and the
    ciliary axoneme (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton2
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0016021integral component of membrane IEA--
    GO:0036038TCTN-B9D complex ISS--

    Find genes that share ontologies with TCTN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCTN2
    Interactions:

        Search GeneGlobe Interaction Network for TCTN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for TCTN2 (ENSP000003049414) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AHI1ENSP000003567744STRING: ENSP00000356774
    CC2D2AENSP000003983914STRING: ENSP00000398391
    CEP290ENSP000003080214STRING: ENSP00000308021
    TCTN1ENSP000003807794STRING: ENSP00000380779
    TMEM17ENSP000003350944STRING: ENSP00000335094
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007224smoothened signaling pathway ISS--
    GO:0042384cilium assembly ISS--
    GO:0060271cilium morphogenesis ISS--

    Find genes that share ontologies with TCTN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCTN2 (TECT2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCTN2 gene (2 alternative transcripts): 
    NM_001143850.2  NM_024809.4  

    Unigene Cluster for TCTN2:

    Tectonic family member 2
    Hs.167165  [show with all ESTs]
    Unigene Representative Sequence: DQ278870
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541523 ENST00000426174 ENST00000303372(uc001ufp.3 uc009zya.3)
    ENST00000543998
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TCTN2:
    hsa-miR-579 hsa-miR-1283 hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidTCTN2 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCTN2
      QuantiTect SYBR Green Assays in human, mouse, rat TCTN2
      QuantiFast Probe-based Assays in human, mouse, rat TCTN2

    Additional mRNA sequence: 

    AK023037.1 AK056924.1 AK127396.1 AK292153.1 BC009112.1 DQ278870.1 

    6 DOTS entries:

    DT.102884  DT.40108273  DT.100742129  DT.91744815  DT.91912614  DT.100747084 

    Selected AceView cDNA sequences (see all 180):

    BF439825 AI690142 NM_024809 BQ936928 AA436101 BC009112 AA341774 BQ050095 
    BI012296 AW850281 CA436808 CA454893 BF508078 AA983190 AI700211 BC068531 
    AW444520 BQ935563 BX280509 BE465357 CB117213 AW274828 AW850381 AI820609 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TCTN2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:              -                                                                             -                 -                           
    SP2:                                                                                                                                          
    SP3:              -                                                                                                                           
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for TCTN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCTN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCTGTA
    TCTN2 Expression
    About this image


    TCTN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Brain (Nervous System)
             Hypothalamus
    TCTN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCTN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.167165
        Custom PCR Arrays for TCTN2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TCTN2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tctn21 , 5 tectonic family member 21, 5 74.9(n)1
    68.64(a)1
      5 (63.68 cM)5
    679781  NM_026486.31  NP_080762.11 
     1245987495 
    chicken
    (Gallus gallus)
    Aves TCTN21 tectonic family member 2 60.31(n)
    48.35(a)
      100857705  XM_003642191.2  XP_003642239.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tctn21 tectonic family member 2 54.89(n)
    45.06(a)
      733954  NM_001045666.1  NP_001039131.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tctn21 tectonic family member 2 48.17(n)
    39.6(a)
      563835  XM_687198.5  XP_692290.5 


    ENSEMBL Gene Tree for TCTN2 (if available)
    TreeFam Gene Tree for TCTN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCTN2 (see all 981)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865664171,2
    --123968430(+) TTTGAG/TACCAG 2 -- us2k10--------
    rs72968041,2
    C,F,A--123968490(+) ccgggT/Cgtggt 2 -- us2k17Minor allele frequency- C:0.38NA CSA 132
    rs789883261,2
    C--123968551(+) CAGAAG/TTTTGA 2 -- us2k10--------
    rs1130986281,2
    C,F--123968607(+) GTGACA/CGAGTG 2 -- us2k12Minor allele frequency- C:0.08CSA WA 119
    rs1898367281,2
    --123968663(+) ACATTC/TACTTG 2 -- us2k10--------
    rs1480361841,2
    --123968927(+) ACAGCG/TGAGAA 2 -- us2k10--------
    rs1823984861,2
    --123969005(+) CAAGCC/TGTGAC 2 -- us2k10--------
    rs734162981,2
    C--123969073(+) GAATTT/CTGATT 2 -- us2k14Minor allele frequency- C:0.10WA CSA NA 241
    rs116123581,2
    C,H--123969116(+) TCTTGT/CGTGTT 2 -- us2k16Minor allele frequency- C:0.00NS EA NA 420
    rs1395177511,2
    C--123969157(+) AGCTC-/TGTGTGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCTN2 (124155660 - 124192948 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TCTN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832534CNV Loss17160897
    nsv519344CNV Gain19592680
    nsv524660CNV Gain19592680
    esv35148CNV Gain17911159
    nsv455733CNV Gain19166990
    nsv442292CNV CNV18776908
    dgv530e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): TCTN2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCTN2
    DNA2.0 Custom Variant and Variant Library Synthesis for TCTN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613846   
    OMIM disorders: 613885  
    UniProtKB/Swiss-Prot: TECT2_HUMAN, Q96GX1
  • Meckel syndrome 8 (MKS8) [MIM:613885]: A disorder characterized by a combination of renal cysts and
    variably associated features including developmental anomalies of the central nervous system (typically
    encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • Note=Defects in TCTN2 may be a cause of Joubert syndrome, a disorder presenting with cerebellar ataxia,
    oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is
    characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles,
    and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar
    tooth sign). Additional variable features include retinal dystrophy and renal disease

  • 6 diseases for TCTN2:    
    About MalaCards
    tctn2-related meckel syndrome    meckel syndrome 8    tctn2-related joubert syndrome    joubert syndrome 21
    meckel syndrome 1    joubert syndrome and related disorders


    Find genes that share disorders with TCTN2           About GenesLikeMe


    Export disorders for TCTN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCTN2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TCTN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A TCTN2 mutation defines a novel Meckel Gruber syndrome locus. (PubMed id 21462283)1, 2, 3 Shaheen R....Alkuraya F.S. (Hum. Mutat. 2011)
    2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1, 2 Sang L.... Jackson P.K. (Cell 2011)
    3. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. (PubMed id 16357211)1, 2 Reiter J.F. and Skarnes W.C. (Genes Dev. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79867 HGNC: 25774 AceView: ATP6V0A2andFLJ12975 Ensembl:ENSG00000168778 euGenes: HUgn79867
    ECgene: TCTN2 H-InvDB: TCTN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCTN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCTN2 gene:
    Search GeneIP for patents involving TCTN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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