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TCTN1 Gene

protein-coding   GIFtS: 48
GCID: GC12P111051

Tectonic Family Member 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tectonic Family Member 11 2
TECT12 3 5
JBTS132 5
tectonic-12

External Ids:    HGNC: 261131   Entrez Gene: 796002   Ensembl: ENSG000002048527   OMIM: 6098635   UniProtKB: Q2MV583   

Export aliases for TCTN1 gene to outside databases

Previous GC identifers: GC12P109537 GC12P108069


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCTN1 Gene:
This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in
mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to
modulate hedgehog signal transduction. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TCTN1 Gene:
TCTN1 (tectonic family member 1) is a protein-coding gene. Diseases associated with TCTN1 include tctn1-related joubert syndrome, and joubert syndrome 15. An important paralog of this gene is TCTN3.

UniProtKB/Swiss-Prot: TECT1_HUMAN, Q2MV58
Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and
acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of
the neural tube. During neural tube development, it is required for formation of the most ventral cell types and
for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence
of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction
downstream of SMO and RAB23 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCTN1 gene promoter:
         PPAR-alpha   ATF-2   Pax-2   Sox9   Pax-2a   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCTN1 promoter sequence
   Search Chromatin IP Primers for TCTN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

TCTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCTN1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P111051:  view genomic region     (about GC identifiers)

Start:
111,051,832 bp from pter      End:
111,087,235 bp from pter
Size:
35,404 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TECT1_HUMAN, Q2MV58 (See protein sequence)
Recommended Name: Tectonic-1 precursor  
Size: 587 amino acids; 63570 Da
Subunit: Part of the tectonic-like complex (also named B9 complex) (By similarity)
Secondary accessions: A8MX11 Q49A60 Q6P5X1 Q6UXW2 Q8NAE9 Q96N72 Q9H798
Alternative splicing: 6 isoforms:  Q2MV58-1   Q2MV58-2   Q2MV58-3   Q2MV58-4   Q2MV58-5   Q2MV58-6   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TCTN1: NX_Q2MV58

Explore proteomics data for TCTN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn36, Asn295, Asn528
  • Modification sites at PhosphoSitePlus

  • See TCTN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001076006.1  NP_001076007.1  NP_001167446.1  NP_001167447.1  NP_078825.2  

    ENSEMBL proteins: 
     ENSP00000473789   ENSP00000448735   ENSP00000474343   ENSP00000474525   ENSP00000436044  
     ENSP00000380776   ENSP00000436673   ENSP00000474291   ENSP00000380775   ENSP00000473743  
     ENSP00000473903   ENSP00000474208   ENSP00000380779   ENSP00000435027   ENSP00000437196  
     ENSP00000448188   ENSP00000450154   ENSP00000366882  

    TCTN1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TCTN: Tectonic proteins

    1 InterPro protein domain:
     IPR011677 DUF1619

    Graphical View of Domain Structure for InterPro Entry Q2MV58

    ProtoNet protein and cluster: Q2MV58

    UniProtKB/Swiss-Prot: TECT1_HUMAN, Q2MV58
    Similarity: Belongs to the tectonic family


    TCTN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TECT1_HUMAN, Q2MV58
    Function: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and
    acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes.
    Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of
    the neural tube. During neural tube development, it is required for formation of the most ventral cell types and
    for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence
    of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction
    downstream of SMO and RAB23 (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TCTN1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tctn1):
     cellular  embryogenesis  limbs/digits/tail  mortality/aging  nervous system 

    TCTN1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCTN1
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    miRNA
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    miRTarBase miRNAs that target TCTN1:
    hsa-mir-324-3p (MIRT042925)

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    Sino Biological Human cDNA Clone for TCTN1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TECT1_HUMAN, Q2MV58: Cytoplasm, cytoskeleton, cilium basal body (By similarity). Secreted (Potential).
    Note=Despite the presence of a signal sequence, the full length protein might not be secreted (By similarity).
    Localizes at the transition zone, a region between the basal body and the ciliary axoneme (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytoskeleton2
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0016020membrane IEA--
    GO:0035869ciliary transition zone ----

    TCTN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCTN1
    Interactions:

        Search GeneGlobe Interaction Network for TCTN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for TCTN1 (ENSP000003807794) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP290ENSP000003080214STRING: ENSP00000308021
    TCTN2ENSP000003049414STRING: ENSP00000304941
    TMEM17ENSP000003350944STRING: ENSP00000335094
    TMEM216ENSP000003819504STRING: ENSP00000381950
    TMEM67ENSP000003899984STRING: ENSP00000389998
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001841neural tube formation IEA--
    GO:0008589regulation of smoothened signaling pathway IEA--
    GO:0021523somatic motor neuron differentiation IEA--
    GO:0021537telencephalon development IEA--

    TCTN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCTN1 (TECT1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCTN1 gene (5 alternative transcripts): 
    NM_001082537.2  NM_001082538.2  NM_001173975.1  NM_001173976.1  NM_024549.5  

    Unigene Cluster for TCTN1:

    Tectonic family member 1
    Hs.211511  [show with all ESTs]
    Unigene Representative Sequence: AK128417
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000550703 ENST00000551590(uc001trn.4 uc009zvs.3 uc001trp.4)
    ENST00000552318 ENST00000498072 ENST00000490514(uc001trm.3) ENST00000397656(uc010syc.2)
    ENST00000495659(uc001trj.2) ENST00000481720 ENST00000397655 ENST00000546643
    ENST00000471804 ENST00000478122(uc010syb.2 uc001tri.3) ENST00000547868
    ENST00000397659 ENST00000464809(uc001trk.4) ENST00000480648 ENST00000552762
    ENST00000551555
    miRNA
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    hsa-miR-3163 hsa-miR-4282 hsa-miR-216a
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    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCTN1
      QuantiTect SYBR Green Assays in human, mouse, rat TCTN1
      QuantiFast Probe-based Assays in human, mouse, rat TCTN1

    Additional mRNA sequence: 

    AK024780.1 AK055891.1 AK092775.1 AK128417.1 AK295514.1 AK301732.1 AY358184.1 BC030993.1 
    BC033811.1 BC040113.1 BC062611.1 DQ278868.1 

    22 DOTS entries:

    DT.75103620  DT.95144753  DT.100819665  DT.40210339  DT.100819661  DT.100819663  DT.100753676  DT.100819660 
    DT.91750822  DT.92015288  DT.95308633  DT.121127327  DT.121127356  DT.95171711  DT.121127440  DT.218115 
    DT.40118106  DT.40132288  DT.423012  DT.95320836  DT.100029442  DT.100638827 

    Selected AceView cDNA sequences (see all 250):

    CD244565 AI560519 BM712333 AA602626 CR623429 BU949651 AV708490 CR624567 
    BC062611 BM473124 BM745821 R53623 AW193317 CR608794 CA311763 AI151414 
    AA764832 AA731411 BI966896 AI421262 AY358184 AI217787 AA437118 BF038378 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCTN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGACTGGG
    TCTN1 Expression
    About this image

    TCTN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCTN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211511
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TCTN1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tctn11 , 5 tectonic family member 11, 5 75.34(n)1
    71.88(a)1
      5 (62.25 cM)5
    6544701  NM_001039153.21  NP_001034242.21 
     1222412875 
    chicken
    (Gallus gallus)
    Aves TCTN11 tectonic family member 1 65.04(n)
    60.15(a)
      416870  XM_415162.4  XP_415162.3 
    lizard
    (Anolis carolinensis)
    Reptilia TCTN16
    tectonic family member 1
    46(a)
    1 ↔ 1
    GL343423.1(356942-372787)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL880167.22   -- 72.82(n)    AL880167.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tctn11 tectonic family member 1 52.74(n)
    42.24(a)
      100007222  XM_001920807.4  XP_001920842.4 


    ENSEMBL Gene Tree for TCTN1 (if available)
    TreeFam Gene Tree for TCTN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCTN1 gene
    TCTN32  

    TCTN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCTN1 (see all 667)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792504111,2
    F--110847820(+) TTACAC/TATTTG 5 -- us2k11Minor allele frequency- T:0.01NA 120
    rs747982111,2
    --110847951(+) GACATC/TCTTTT 5 -- us2k10--------
    rs1427475151,2
    --110848025(+) TGCAGC/TGGCAC 5 -- us2k10--------
    rs1506953551,2
    C--110848269(+) TACTTC/TGACAT 5 -- us2k10--------
    rs802367571,2
    F--110848382(+) AAATCG/TTAGGG 5 -- us2k11Minor allele frequency- T:0.01NA 120
    rs123021421,2
    H--110848385(+) TCGTAG/CGGTCT 5 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs1849949181,2
    --110848553(+) TGAGGC/TGGGAG 5 -- us2k10--------
    rs1399508651,2
    --110848637(+) AAGGTA/TTTAAG 5 -- us2k10--------
    rs1448442241,2
    --110848694(+) GGCAAC/TCTTGT 5 -- us2k10--------
    rs1898774181,2
    C--110848904(+) GAGTGG/TTGGCT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for TCTN1 (111051832 - 111087235 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TCTN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv885CNV Insertion18451855

    Human Gene Mutation Database (HGMD): TCTN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCTN1
    DNA2.0 Custom Variant and Variant Library Synthesis for TCTN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609863   
    OMIM disorders: 614173  
    UniProtKB/Swiss-Prot: TECT1_HUMAN, Q2MV58
  • Joubert syndrome 13 (JBTS13) [MIM:614173]: A disorder presenting with cerebellar ataxia, oculomotor
    apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is
    characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles,
    and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar
    tooth sign). Additional variable features include retinal dystrophy and renal disease. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 14 diseases for TCTN1:    
    About MalaCards
    tctn1-related joubert syndrome    joubert syndrome 15    joubert syndrome and related disorders    joubert syndrome
    apraxia    was-related disorders    polydactyly    cerebellar ataxia
    hypotonia    ataxia    retinitis    multiple myeloma
    myeloma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for TCTN1:
    Polydactyly

    TCTN1 for disorders           About GeneDecksing


    Export disorders for TCTN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCTN1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCTN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. (PubMed id 16357211)1, 2, 3 Reiter J.F. and Skarnes W.C. (Genes Dev. 2006)
    2. A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. (PubMed id 21725307)1, 2 Garcia-Gonzalo F.R....Reiter J.F. (Nat. Genet. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Joubert Syndrome and Related Disorders (PubMed id 20301500)1 Pagon R.A....Stephens K. (1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79600 HGNC: 26113 AceView: FLJ21127 Ensembl:ENSG00000204852 euGenes: HUgn79600
    ECgene: TCTN1 H-InvDB: TCTN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TCTN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCTN1 gene:
    Search GeneIP for patents involving TCTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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