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Aliases for TCTEX1D4 Gene

Aliases for TCTEX1D4 Gene

  • Tctex1 Domain Containing 4 2 3 5
  • Novel Tctex-1 Family Domain-Containing Protein 2 3
  • Protein N22.1 3 4
  • Tctex-2-Beta 3 4
  • Tctex1 Domain-Containing Protein 4 3
  • Tctex2 Beta 3

External Ids for TCTEX1D4 Gene

Previous GeneCards Identifiers for TCTEX1D4 Gene

  • GC01M045045
  • GC01M045271
  • GC01M043385

Summaries for TCTEX1D4 Gene

GeneCards Summary for TCTEX1D4 Gene

TCTEX1D4 (Tctex1 Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include protein phosphatase 1 binding. An important paralog of this gene is TCTEX1D2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTEX1D4 Gene

Genomics for TCTEX1D4 Gene

Regulatory Elements for TCTEX1D4 Gene

Enhancers for TCTEX1D4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F044829 0.7 Ensembl 12.9 -23.7 -23659 3.4 TBP ARID4B THRB DNMT3B RAD21 RARA CREM MIXL1 CEBPB KAT8 BEST4 BTBD19 TCTEX1D4 PLK3 RPS8 RNU5D-1 KIF2C EIF2B3 ENSG00000232369 UROD
GH01F044835 1.3 Ensembl ENCODE 12.8 -28.6 -28560 0.8 ELF3 HDAC1 ATF1 PKNOX1 CBX3 TBL1XR1 ARNT KLF17 ARID4B RAD21 UROD BTBD19 TCTEX1D4 PLK3 BEST4 RNU5D-1 KIF2C EIF2B3 ENSG00000232369 PTCH2
GH01F044833 0.6 Ensembl 12.8 -26.9 -26859 1.0 ELF3 CTCF HDAC1 CBX3 CREB3L1 ARID4B BACH1 UBTF CEBPG RAD21 BEST4 BTBD19 TCTEX1D4 PLK3 UROD RNU5D-1 KIF2C EIF2B3 ENSG00000232369 PTCH2
GH01F044860 0.7 Ensembl ENCODE 10.8 -53.4 -53360 1.2 CTCF TAF1 CEBPG YY1 ZNF121 POLR2A ZHX1 ZNF687 RFX1 HCFC1 BTBD19 TCTEX1D4 PLK3 EIF2B3 ENSG00000232369 BEST4 ENSG00000226499 RNA5SP47
GH01F044858 0.6 FANTOM5 10.8 -50.6 -50642 0.0 CREB3 MEF2D ESRRA NR2F1 ZBTB11 ID3 KAT8 BTBD19 TCTEX1D4 PLK3 EIF2B3 ENSG00000232369 ENSG00000226499 RNA5SP47
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TCTEX1D4 on UCSC Golden Path with GeneCards custom track

Promoters for TCTEX1D4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001744450 -1058 201 BRD4 HDGF HDAC1 MXI1 SAP130 NFRKB ZNF175 PYGO2 RARA RELA

Genomic Location for TCTEX1D4 Gene

Chromosome:
1
Start:
44,805,908 bp from pter
End:
44,807,442 bp from pter
Size:
1,535 bases
Orientation:
Minus strand

Genomic View for TCTEX1D4 Gene

Genes around TCTEX1D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTEX1D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTEX1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTEX1D4 Gene

Proteins for TCTEX1D4 Gene

  • Protein details for TCTEX1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JR98-TC1D4_HUMAN
    Recommended name:
    Tctex1 domain-containing protein 4
    Protein Accession:
    Q5JR98

    Protein attributes for TCTEX1D4 Gene

    Size:
    221 amino acids
    Molecular mass:
    23353 Da
    Quaternary structure:
    • Interacts with ENG/endoglin, TGFBR2 and TGFBR3.

neXtProt entry for TCTEX1D4 Gene

Post-translational modifications for TCTEX1D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTEX1D4 Gene

No data available for DME Specific Peptides for TCTEX1D4 Gene

Domains & Families for TCTEX1D4 Gene

Protein Domains for TCTEX1D4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTEX1D4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JR98

UniProtKB/Swiss-Prot:

TC1D4_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with TCTEX1D4: view

No data available for Gene Families for TCTEX1D4 Gene

Function for TCTEX1D4 Gene

Gene Ontology (GO) - Molecular Function for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21382349
GO:0008157 protein phosphatase 1 binding IDA 23789093
genes like me logo Genes that share ontologies with TCTEX1D4: view

Phenotypes for TCTEX1D4 Gene

GenomeRNAi human phenotypes for TCTEX1D4:
genes like me logo Genes that share phenotypes with TCTEX1D4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TCTEX1D4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCTEX1D4 Gene

Localization for TCTEX1D4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCTEX1D4 Gene COMPARTMENTS Subcellular localization image for TCTEX1D4 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005930 axoneme IEA --
genes like me logo Genes that share ontologies with TCTEX1D4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCTEX1D4 Gene

Pathways & Interactions for TCTEX1D4 Gene

SuperPathways for TCTEX1D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCTEX1D4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCTEX1D4 Gene

Transcripts for TCTEX1D4 Gene

mRNA/cDNA for TCTEX1D4 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCTEX1D4 Gene

Tctex1 domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTEX1D4 Gene

No ASD Table

Relevant External Links for TCTEX1D4 Gene

GeneLoc Exon Structure for
TCTEX1D4
ECgene alternative splicing isoforms for
TCTEX1D4

Expression for TCTEX1D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCTEX1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTEX1D4 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TCTEX1D4 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCTEX1D4 Gene



Protein tissue co-expression partners for TCTEX1D4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCTEX1D4 Gene:

TCTEX1D4

SOURCE GeneReport for Unigene cluster for TCTEX1D4 Gene:

Hs.585137

mRNA Expression by UniProt/SwissProt for TCTEX1D4 Gene:

Q5JR98-TC1D4_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with TCTEX1D4: view

Primer Products

Orthologs for TCTEX1D4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTEX1D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTEX1D4 34 35
  • 99.1 (n)
cow
(Bos Taurus)
Mammalia TCTEX1D4 34 35
  • 82.95 (n)
dog
(Canis familiaris)
Mammalia TCTEX1D4 34 35
  • 81.43 (n)
mouse
(Mus musculus)
Mammalia Tctex1d4 34 16 35
  • 74.43 (n)
rat
(Rattus norvegicus)
Mammalia LOC102551208 34
  • 74.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCTEX1D4 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCTEX1D4 34 35
  • 57.43 (n)
lizard
(Anolis carolinensis)
Reptilia TCTEX1D4 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tctex1d4 34
  • 46.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793976 34
  • 47.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5359 35
  • 28 (a)
ManyToMany
CG7276 35
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dylt-2 35
  • 22 (a)
OneToMany
Species where no ortholog for TCTEX1D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCTEX1D4 Gene

ENSEMBL:
Gene Tree for TCTEX1D4 (if available)
TreeFam:
Gene Tree for TCTEX1D4 (if available)

Paralogs for TCTEX1D4 Gene

Paralogs for TCTEX1D4 Gene

(1) SIMAP similar genes for TCTEX1D4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCTEX1D4: view

Variants for TCTEX1D4 Gene

Sequence variations from dbSNP and Humsavar for TCTEX1D4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs112176770 -- 44,806,917(+) CCTTG(A/C)CGACT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112588711 -- 44,808,412(+) AAGTT(A/T)TCCCT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs112786830 -- 44,806,516(+) GAGCC(C/T)CGGCG upstream-variant-2KB, reference, synonymous-codon
rs11549457 -- 44,805,601(-) CAGCT(A/C/G)CCGAA intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense, stop-gained
rs115755626 -- 44,808,586(+) GGCCA(C/T)TCCAG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TCTEX1D4 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV loss 19166990
nsv546145 CNV loss 21841781
nsv546146 CNV loss 21841781
nsv950705 CNV deletion 24416366

Variation tolerance for TCTEX1D4 Gene

Gene Damage Index Score: 1.53; 29.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCTEX1D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTEX1D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTEX1D4 Gene

Disorders for TCTEX1D4 Gene

Relevant External Links for TCTEX1D4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCTEX1D4

No disorders were found for TCTEX1D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCTEX1D4 Gene

Publications for TCTEX1D4 Gene

  1. Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. (PMID: 16982625) Meng Q.-J. … Garland J.M. (J. Biol. Chem. 2006) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa. (PMID: 24606217) Freitas M.J. … Fardilha M. (OMICS 2014) 3 64
  4. TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. (PMID: 23789093) Korrodi-GregA^rio L. … da Cruz E Silva E.F. (Biol Open 2013) 3 64
  5. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3 64

Products for TCTEX1D4 Gene

Sources for TCTEX1D4 Gene

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