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Aliases for TCTEX1D4 Gene

Aliases for TCTEX1D4 Gene

  • Tctex1 Domain Containing 4 2 3
  • Novel Tctex-1 Family Domain-Containing Protein 2 3
  • Protein N22.1 3 4
  • Tctex-2-Beta 3 4
  • Tctex1 Domain-Containing Protein 4 3
  • Tctex2 Beta 3

External Ids for TCTEX1D4 Gene

Summaries for TCTEX1D4 Gene

GeneCards Summary for TCTEX1D4 Gene

TCTEX1D4 (Tctex1 Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is TCTEX1D2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTEX1D4 Gene

Genomics for TCTEX1D4 Gene

Genomic Location for TCTEX1D4 Gene

Start:
44,805,908 bp from pter
End:
44,807,706 bp from pter
Size:
1,799 bases
Orientation:
Minus strand

Genomic View for TCTEX1D4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCTEX1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTEX1D4 Gene

Regulatory Elements for TCTEX1D4 Gene

Proteins for TCTEX1D4 Gene

  • Protein details for TCTEX1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JR98-TC1D4_HUMAN
    Recommended name:
    Tctex1 domain-containing protein 4
    Protein Accession:
    Q5JR98
    Secondary Accessions:

    Protein attributes for TCTEX1D4 Gene

    Size:
    221 amino acids
    Molecular mass:
    23353 Da
    Quaternary structure:
    • Interacts with ENG/endoglin, TGFBR2 and TGFBR3.

neXtProt entry for TCTEX1D4 Gene

Proteomics data for TCTEX1D4 Gene at MOPED

Post-translational modifications for TCTEX1D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTEX1D4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCTEX1D4 Gene

Domains for TCTEX1D4 Gene

Protein Domains for TCTEX1D4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTEX1D4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JR98

UniProtKB/Swiss-Prot:

TC1D4_HUMAN
Family:
  • Belongs to the dynein light chain Tctex-type family.:
    • Q5JR98
genes like me logo Genes that share domains with TCTEX1D4: view

No data available for Gene Families for TCTEX1D4 Gene

Function for TCTEX1D4 Gene

Gene Ontology (GO) - Molecular Function for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21382349
GO:0008157 protein phosphatase 1 binding IDA 23789093
genes like me logo Genes that share ontologies with TCTEX1D4: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TCTEX1D4 Gene

Localization for TCTEX1D4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCTEX1D4 Gene COMPARTMENTS Subcellular localization image for TCTEX1D4 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005815 microtubule organizing center IEA --
GO:0005930 axoneme IEA --
genes like me logo Genes that share ontologies with TCTEX1D4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCTEX1D4 Gene

Pathways for TCTEX1D4 Gene

SuperPathways for TCTEX1D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCTEX1D4 Gene

None

No data available for Pathways by source for TCTEX1D4 Gene

Transcripts for TCTEX1D4 Gene

mRNA/cDNA for TCTEX1D4 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCTEX1D4 Gene

Tctex1 domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCTEX1D4 Gene

No ASD Table

Relevant External Links for TCTEX1D4 Gene

GeneLoc Exon Structure for
TCTEX1D4
ECgene alternative splicing isoforms for
TCTEX1D4

Expression for TCTEX1D4 Gene

mRNA expression in normal human tissues for TCTEX1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTEX1D4 Gene

This gene is overexpressed in Whole Blood (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCTEX1D4 Gene

SOURCE GeneReport for Unigene cluster for TCTEX1D4 Gene Hs.585137

mRNA Expression by UniProt/SwissProt for TCTEX1D4 Gene

Q5JR98-TC1D4_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with TCTEX1D4: view

Orthologs for TCTEX1D4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTEX1D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTEX1D4 35
  • 99.1 (n)
  • 98.64 (a)
TCTEX1D4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TCTEX1D4 35
  • 82.95 (n)
  • 79.91 (a)
TCTEX1D4 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCTEX1D4 35
  • 81.43 (n)
  • 76.71 (a)
TCTEX1D4 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tctex1d4 35
  • 74.43 (n)
  • 70.78 (a)
Tctex1d4 16
Tctex1d4 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCTEX1D4 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC102551208 35
  • 74.43 (n)
  • 71.69 (a)
chicken
(Gallus gallus)
Aves TCTEX1D4 35
  • 57.43 (n)
  • 50.5 (a)
TCTEX1D4 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCTEX1D4 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tctex1d4 35
  • 46.55 (n)
  • 46.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC793976 35
  • 47.18 (n)
  • 39.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5359 36
  • 28 (a)
ManyToMany
CG7276 36
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dylt-2 36
  • 22 (a)
OneToMany
Species with no ortholog for TCTEX1D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCTEX1D4 Gene

ENSEMBL:
Gene Tree for TCTEX1D4 (if available)
TreeFam:
Gene Tree for TCTEX1D4 (if available)

Paralogs for TCTEX1D4 Gene

Paralogs for TCTEX1D4 Gene

Selected SIMAP similar genes for TCTEX1D4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCTEX1D4: view

Variants for TCTEX1D4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TCTEX1D4 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV Loss 19166990
nsv870815 CNV Loss 21882294
nsv871320 CNV Loss 21882294
nsv870773 CNV Loss 21882294
nsv870876 CNV Loss 21882294

Relevant External Links for TCTEX1D4 Gene

HapMap Linkage Disequilibrium report
TCTEX1D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TCTEX1D4 Gene

Disorders for TCTEX1D4 Gene

(1) University of Copenhagen DISEASES for TCTEX1D4 Gene

genes like me logo Genes that share disorders with TCTEX1D4: view

No data available for UniProtKB/Swiss-Prot for TCTEX1D4 Gene

Publications for TCTEX1D4 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. (PMID: 16982625) Meng Q.-J. … Garland J.M. (J. Biol. Chem. 2006) 3 4
  3. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3
  4. TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. (PMID: 23789093) Korrodi-GregA^rio L. … da Cruz E Silva E.F. (Biol Open 2013) 3
  5. TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa. (PMID: 24606217) Freitas M.J. … Fardilha M. (OMICS 2014) 3

Products for TCTEX1D4 Gene

Sources for TCTEX1D4 Gene

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