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Aliases for TCTEX1D1 Gene

Aliases for TCTEX1D1 Gene

  • Tctex1 Domain Containing 1 2 3 5

External Ids for TCTEX1D1 Gene

Previous GeneCards Identifiers for TCTEX1D1 Gene

  • GC01P066931
  • GC01P067218
  • GC01P065328

Summaries for TCTEX1D1 Gene

GeneCards Summary for TCTEX1D1 Gene

TCTEX1D1 (Tctex1 Domain Containing 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. An important paralog of this gene is TCTEX1D2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTEX1D1 Gene

Genomics for TCTEX1D1 Gene

Regulatory Elements for TCTEX1D1 Gene

Enhancers for TCTEX1D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G066561 1.7 FANTOM5 Ensembl ENCODE dbSUPER 20.4 -188.4 -188387 4.4 FOXA2 RARA GTF3C2 POLR3A GATA2 FOS ELK4 CEBPB ZNF398 NFIC SGIP1 TCTEX1D1 ENSG00000248458 PDE4B GC01M066494 GC01P066578
GH01G066727 0.9 ENCODE 34.4 -23.3 -23276 4.0 HDGF PKNOX1 BMI1 ZBTB40 CBX5 GATA2 FOS RELB IKZF2 SMARCA5 TCTEX1D1 ENSG00000248458 SGIP1 GC01M066741
GH01G066732 1.3 FANTOM5 Ensembl ENCODE 22.6 -19.3 -19277 2.1 CTCF PKNOX1 JUN MAFG RAD21 FOXA1 JUND GATA3 ZNF316 GATA2 TCTEX1D1 PDE4B MIER1 GC01M066741 ENSG00000248458
GH01G066757 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +5.9 5877 1.8 PKNOX1 ATF1 ARNT TCF12 GATA2 NCOA1 REST ZNF592 MEF2D SMARCA4 TCTEX1D1 SGIP1 MIER1 INSL5
GH01G066542 1.5 Ensembl ENCODE dbSUPER 17.5 -209.2 -209191 2.0 PKNOX1 FOXA2 ATF1 ARID4B FEZF1 DMAP1 ZNF2 YY1 FOS SP5 TCTEX1D1 SGIP1 GC01M066494
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCTEX1D1 on UCSC Golden Path with GeneCards custom track

Promoters for TCTEX1D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008136 -57 401 CTCF SUZ12 RBBP5 EP300 RAD21 POLR2A GATA2 HNF4A ZBTB33 EZH2

Genomic Location for TCTEX1D1 Gene

Chromosome:
1
Start:
66,752,457 bp from pter
End:
66,779,047 bp from pter
Size:
26,591 bases
Orientation:
Plus strand

Genomic View for TCTEX1D1 Gene

Genes around TCTEX1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTEX1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTEX1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTEX1D1 Gene

Proteins for TCTEX1D1 Gene

  • Protein details for TCTEX1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7M0-TC1D1_HUMAN
    Recommended name:
    Tctex1 domain-containing protein 1
    Protein Accession:
    Q8N7M0
    Secondary Accessions:
    • Q06YR9
    • Q5VYE1

    Protein attributes for TCTEX1D1 Gene

    Size:
    179 amino acids
    Molecular mass:
    20730 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCTEX1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCTEX1D1 Gene

Post-translational modifications for TCTEX1D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTEX1D1 Gene

No data available for DME Specific Peptides for TCTEX1D1 Gene

Domains & Families for TCTEX1D1 Gene

Protein Domains for TCTEX1D1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTEX1D1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7M0

UniProtKB/Swiss-Prot:

TC1D1_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with TCTEX1D1: view

No data available for Gene Families for TCTEX1D1 Gene

Function for TCTEX1D1 Gene

genes like me logo Genes that share phenotypes with TCTEX1D1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCTEX1D1 Gene

Localization for TCTEX1D1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTEX1D1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCTEX1D1 Gene

Pathways & Interactions for TCTEX1D1 Gene

genes like me logo Genes that share pathways with TCTEX1D1: view

Pathways by source for TCTEX1D1 Gene

Gene Ontology (GO) - Biological Process for TCTEX1D1 Gene

None

No data available for SIGNOR curated interactions for TCTEX1D1 Gene

Drugs & Compounds for TCTEX1D1 Gene

No Compound Related Data Available

Transcripts for TCTEX1D1 Gene

mRNA/cDNA for TCTEX1D1 Gene

Unigene Clusters for TCTEX1D1 Gene

Tctex1 domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTEX1D1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2:
SP3: - -
SP4: - - - - - -
SP5:

Relevant External Links for TCTEX1D1 Gene

GeneLoc Exon Structure for
TCTEX1D1
ECgene alternative splicing isoforms for
TCTEX1D1

Expression for TCTEX1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCTEX1D1 Gene

mRNA differential expression in normal tissues according to GTEx for TCTEX1D1 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.5) and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for TCTEX1D1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCTEX1D1 Gene



Protein tissue co-expression partners for TCTEX1D1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCTEX1D1 Gene:

TCTEX1D1

SOURCE GeneReport for Unigene cluster for TCTEX1D1 Gene:

Hs.479226
genes like me logo Genes that share expression patterns with TCTEX1D1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCTEX1D1 Gene

Orthologs for TCTEX1D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTEX1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTEX1D1 34 35
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia TCTEX1D1 34 35
  • 87.45 (n)
cow
(Bos Taurus)
Mammalia TCTEX1D1 34 35
  • 85.85 (n)
mouse
(Mus musculus)
Mammalia Tctex1d1 34 16 35
  • 81.53 (n)
rat
(Rattus norvegicus)
Mammalia Tctex1d1 34
  • 80.58 (n)
oppossum
(Monodelphis domestica)
Mammalia TCTEX1D1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCTEX1D1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCTEX1D1 35
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCTEX1D1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tctex1d1 34
  • 71.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10706 34
zebrafish
(Danio rerio)
Actinopterygii tctex1d1 34 35
  • 66.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5359 35
  • 23 (a)
ManyToMany
CG7276 35
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dylt-2 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToOne
Species where no ortholog for TCTEX1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCTEX1D1 Gene

ENSEMBL:
Gene Tree for TCTEX1D1 (if available)
TreeFam:
Gene Tree for TCTEX1D1 (if available)

Paralogs for TCTEX1D1 Gene

Paralogs for TCTEX1D1 Gene

(1) SIMAP similar genes for TCTEX1D1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCTEX1D1: view

Variants for TCTEX1D1 Gene

Sequence variations from dbSNP and Humsavar for TCTEX1D1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000030072 -- 66,757,361(+) TATAT(A/T)AAATA intron-variant
rs1000152934 -- 66,751,192(+) CATTC(C/T)ATGTT intron-variant, upstream-variant-2KB
rs1000210427 -- 66,763,310(+) ATTTA(A/G)CATAA intron-variant
rs1000342801 -- 66,759,760(+) ACCTG(A/G)TATCG intron-variant
rs1000398110 -- 66,769,849(+) AATTG(C/T)GGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCTEX1D1 Gene

Variant ID Type Subtype PubMed ID
esv1009176 CNV deletion 20482838
esv3893623 CNV gain 25118596
nsv830093 CNV gain 17160897

Variation tolerance for TCTEX1D1 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.27; 90.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCTEX1D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTEX1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTEX1D1 Gene

Disorders for TCTEX1D1 Gene

Relevant External Links for TCTEX1D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCTEX1D1

No disorders were found for TCTEX1D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCTEX1D1 Gene

Publications for TCTEX1D1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TCTEX1D1 Gene

Sources for TCTEX1D1 Gene

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