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Aliases for TCTEX1D1 Gene

Aliases for TCTEX1D1 Gene

  • Tctex1 Domain Containing 1 2 3 5

External Ids for TCTEX1D1 Gene

Previous GeneCards Identifiers for TCTEX1D1 Gene

  • GC01P066931
  • GC01P067218
  • GC01P065328

Summaries for TCTEX1D1 Gene

GeneCards Summary for TCTEX1D1 Gene

TCTEX1D1 (Tctex1 Domain Containing 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. An important paralog of this gene is TCTEX1D4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTEX1D1 Gene

Genomics for TCTEX1D1 Gene

Regulatory Elements for TCTEX1D1 Gene

Promoters for TCTEX1D1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCTEX1D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCTEX1D1 Gene

Chromosome:
1
Start:
66,752,457 bp from pter
End:
66,779,047 bp from pter
Size:
26,591 bases
Orientation:
Plus strand

Genomic View for TCTEX1D1 Gene

Genes around TCTEX1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTEX1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTEX1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTEX1D1 Gene

Proteins for TCTEX1D1 Gene

  • Protein details for TCTEX1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7M0-TC1D1_HUMAN
    Recommended name:
    Tctex1 domain-containing protein 1
    Protein Accession:
    Q8N7M0
    Secondary Accessions:
    • Q06YR9
    • Q5VYE1

    Protein attributes for TCTEX1D1 Gene

    Size:
    179 amino acids
    Molecular mass:
    20730 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCTEX1D1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCTEX1D1 Gene

Proteomics data for TCTEX1D1 Gene at MOPED

Post-translational modifications for TCTEX1D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTEX1D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TCTEX1D1 Gene

Domains & Families for TCTEX1D1 Gene

Protein Domains for TCTEX1D1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTEX1D1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7M0

UniProtKB/Swiss-Prot:

TC1D1_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with TCTEX1D1: view

No data available for Gene Families for TCTEX1D1 Gene

Function for TCTEX1D1 Gene

genes like me logo Genes that share phenotypes with TCTEX1D1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCTEX1D1 Gene

Localization for TCTEX1D1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCTEX1D1 Gene COMPARTMENTS Subcellular localization image for TCTEX1D1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCTEX1D1 Gene

Pathways & Interactions for TCTEX1D1 Gene

genes like me logo Genes that share pathways with TCTEX1D1: view

Pathways by source for TCTEX1D1 Gene

Interacting Proteins for TCTEX1D1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000282670%0d%0a9606.ENSP00000308312%0d%0a9606.ENSP00000356056%0d%0a9606.ENSP00000367841%0d%0a
Selected Interacting proteins: Q8N7M0-TC1D1_HUMAN ENSP00000282670 for TCTEX1D1 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for TCTEX1D1 Gene

None

No data available for SIGNOR curated interactions for TCTEX1D1 Gene

Drugs & Compounds for TCTEX1D1 Gene

No Compound Related Data Available

Transcripts for TCTEX1D1 Gene

mRNA/cDNA for TCTEX1D1 Gene

Unigene Clusters for TCTEX1D1 Gene

Tctex1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCTEX1D1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2:
SP3: - -
SP4: - - - - - -
SP5:

Relevant External Links for TCTEX1D1 Gene

GeneLoc Exon Structure for
TCTEX1D1
ECgene alternative splicing isoforms for
TCTEX1D1

Expression for TCTEX1D1 Gene

mRNA expression in normal human tissues for TCTEX1D1 Gene

mRNA differential expression in normal tissues according to GTEx for TCTEX1D1 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.5) and Brain - Caudate (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for TCTEX1D1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCTEX1D1 Gene



SOURCE GeneReport for Unigene cluster for TCTEX1D1 Gene Hs.479226

genes like me logo Genes that share expression patterns with TCTEX1D1: view

Protein tissue co-expression partners for TCTEX1D1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TCTEX1D1 Gene

Orthologs for TCTEX1D1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTEX1D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCTEX1D1 35
  • 85.85 (n)
  • 82.68 (a)
TCTEX1D1 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCTEX1D1 35
  • 87.45 (n)
  • 82.02 (a)
TCTEX1D1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tctex1d1 35
  • 81.53 (n)
  • 76.26 (a)
Tctex1d1 16
Tctex1d1 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCTEX1D1 35
  • 98.88 (n)
  • 97.21 (a)
TCTEX1D1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tctex1d1 35
  • 80.58 (n)
  • 71.94 (a)
oppossum
(Monodelphis domestica)
Mammalia TCTEX1D1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCTEX1D1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCTEX1D1 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCTEX1D1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tctex1d1 35
  • 71.19 (n)
  • 68.36 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10706 35
zebrafish
(Danio rerio)
Actinopterygii tctex1d1 35
  • 66.28 (n)
  • 63.58 (a)
tctex1d1 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5359 36
  • 23 (a)
ManyToMany
CG7276 36
  • 23 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dylt-2 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for TCTEX1D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCTEX1D1 Gene

ENSEMBL:
Gene Tree for TCTEX1D1 (if available)
TreeFam:
Gene Tree for TCTEX1D1 (if available)

Paralogs for TCTEX1D1 Gene

Paralogs for TCTEX1D1 Gene

(1) SIMAP similar genes for TCTEX1D1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCTEX1D1: view

Variants for TCTEX1D1 Gene

Sequence variations from dbSNP and Humsavar for TCTEX1D1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1060575 - 66,770,414(+) ATGGA(A/T)GAACC reference, missense
rs2133173 - 66,777,341(-) AATAA(G/T)TATGC reference, missense
rs488584 -- 66,754,959(-) TTAAC(A/G/T)TATCA intron-variant
rs480060 -- 66,756,695(-) GTCAA(A/G)TTACT intron-variant
rs506778 -- 66,757,251(+) TTGGT(C/T)TCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCTEX1D1 Gene

Variant ID Type Subtype PubMed ID
nsv830093 CNV Gain 17160897
esv1009176 CNV Deletion 20482838

Variation tolerance for TCTEX1D1 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.27; 90.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCTEX1D1 Gene

HapMap Linkage Disequilibrium report
TCTEX1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTEX1D1 Gene

Disorders for TCTEX1D1 Gene

Relevant External Links for TCTEX1D1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCTEX1D1

No disorders were found for TCTEX1D1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCTEX1D1 Gene

Publications for TCTEX1D1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TCTEX1D1 Gene

Sources for TCTEX1D1 Gene

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