TCTE3 Gene
protein-coding GIFtS: 51
GCID: GC06M170140
|
|
t-complex-associated-testis-expressed 3
| |
Aliases
for TCTE3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| T-Complex-Associated-Testis-Expressed 31 2 | | Tcte-33 | | TCTEX1D31 2 3 | | Tctex1 Domain Containing 32 | | T-Complex Testis-Specific Protein 32 3 | | Tctex1 Domain-Containing Protein 32 | | T-Complex-Associated Testis-Expressed Protein 32 3 | | Tcte-33 |
Export aliases for TCTE3 gene to outside databasesPrevious GC identifers: GC06U990122 GC06M169715 GC06M169896 GC06M169957 GC06M167559 |
Summaries
for TCTE3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in malesterility (By similarity)
|
Genomic Views
for TCTE3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCTE3 gene promoter:
MZF-1 Sox5 RP58 AML1a FOXJ2 (long isoform) FOXJ2 Gfi-1 RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCTE3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCTE3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27TCTE3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M170140: view genomic region
(about GC identifiers)
Start:
|
170,140,210 bp from pter |
End:
|
170,151,655 bp from pter |
Size:
|
11,446 bases |
Orientation:
|
minus strand |
|
Proteins
for TCTE3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6 (See
protein sequence)Recommended Name: Tctex1 domain-containing protein 3 Size: 198 amino acids; 23176 Da
Subunit: Interacts with CSNK2B (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable). Cytoplasmic granule (By similarity). Membrane; Peripheralmembrane protein (By similarity). Note=Found on the surface of sperm tail. Stored in cytoplasmic granules duringspermatogenesis (By similarity)Explore the universe of human proteins at neXtProt for TCTE3: NX_Q8IZS6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZS6
TCTE3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_777570.1
ENSEMBL proteins: ENSP00000355736
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TCTE3 for ontologies About GeneDecksing
TCTE3 Antibody Products:
Assay Products for TCTE3: |
Protein
Domains /
Families
for TCTE3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCTE3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IZS6ProtoNet protein and cluster: Q8IZS6 1 Blocks protein family: IPB005334 Tctex-1 family
UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6Similarity: Belongs to the dynein light chain Tctex-type family |
Function
for TCTE3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in malesterility (By similarity) Genatlas biochemistry entry for TCTE3:t-complex associated,testis expressed 3,murine homolog
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTE3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003774 | motor activity |
IEA | -- |
TCTE3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TCTE3:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tcte3):
TCTE3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TCTE3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeleton remodeling Neurofilaments | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TCTE3
TCTE3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCTE3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/37 Interacting proteins for TCTE3 (Q8IZS63 ENSP000003557364) via UniProtKB, MINT, STRING, and/or I2D (see all 37)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006810 | transport |
IEA | -- |
TCTE3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TCTE3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCTE3
Search CenterWatch for drugs/clinical trials and news about TCTE3 / TC1D3
|
Transcripts
for TCTE3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCTE3 gene: NM_174910.1 Unigene Cluster for TCTE3: T-complex-associated-testis-expressed 3 Hs.733746 [show with all ESTs]Unigene Representative Sequence: BC0634551 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000366774(uc003qxe.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TCTE3 (NM_174910) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCTE3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTE3 |
Additional cDNA sequence: AF519569.1 AK023627.1 BC043594.1 BC053352.1 BC063455.1 BC113639.1 2 DOTS entries: DT.75100561 DT.40125050 24/55 AceView cDNA sequences (see all 55): BM924598 BX098717 AW612077 BI826100 BF001512 BC043594 AF519569 BI914913 NM_174910 BC063455 BM987468 AK023627 BC053352 AW384624 AA781436 AW384602 AW384600 AU138274 AI669892 AW373107 AW372706 AW373085 BX089062 BX506473
GeneLoc Exon Structure
|
Expression
for TCTE3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCTE3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCAAAGTA
About this image
See TCTE3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCTE3
SOURCE GeneReport for Unigene cluster: Hs.733746
UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6Tissue specificity: Expressed predominantly in testis. Also expressed in brain, lung and trachea
SABiosciences Custom PCR Arrays for TCTE3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCTE3
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTE3 |
Orthologs
for TCTE3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TCTE3 gene from 3/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TCTE31 |
t-complex-associated-testis-expressed 3 |
65(n)
50.83(a) |
|
421555 XM_001231719.2 XP_001231720.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TCTE36 |
-- |
43(a) |
1 ↔ 1 |
1(223722050-223726185) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG147636 |
-- |
20(a) |
1 ↔ 1 |
2R(3854283-3855529) |
ENSEMBL Gene Tree for TCTE3 (if available)
TreeFam Gene Tree for TCTE3 (if available) |
Paralogs
for TCTE3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCTE3 gene
- TCTEX1D22 TCTEX1D42 TCTEX1D12
TCTE3 for paralogs About GeneDecksing
|
Genomic Variants
for TCTE3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCTE3 (170140210 - 170151655 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TCTE3
1 CNV: 94258
Human Gene Mutation Database (HGMD): TCTE3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCTE3 |
|
Disorders
/ Diseases
for TCTE3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCTE3 for disorders About GeneDecksing
OMIM gene information: 186977
OMIM disorders: --
6  diseases for TCTE3: About MalaCardsciliary dyskinesia primary ciliary dyskinesia congenital diaphragmatic hernia situs inversus
kartagener syndrome hernia
2 diseases from the University of Copenhagen DISEASES database for TCTE3:Primary ciliary dyskinesia Situs inversus Human Genome Epidemiology (HuGE) Navigator: TCTE3 (1 document)
Export disorders for TCTE3 gene to outside databases
|
Publications
for TCTE3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCTE3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCTE3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of the human ortholog of the T-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. (PubMed id 12584439)1, 2, 3 Neesen J.... Omran H. (2002)
- Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. (PubMed id 1505969)1, 3 Rappold G.A....Lichter P. (1992)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- A genome-wide meta-analysis of six type 1 diabetes coh orts identifies multiple associated loci. (PubMed id 21980299)1 Bradfield J.P....Hakonarson H. (2011)
- Identification of TCTE3 as a gene responsible for con genital diaphragmatic hernia using a high-resolution single-nucleotide polymorp hism array. (PubMed id 21085971)1 Teshiba R....Yamamoto K. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family. (PubMed id 11278908)2 DiBella L.M.... King S.M. (2001)
|
External Searches for TCTE3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TCTE3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCTE3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCTE3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCTE3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TCTE3 gene:
Search GeneIP for patents involving TCTE3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCTE3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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