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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCTE3 Gene

protein-coding   GIFtS: 53
GCID: GC06M170140

T-Complex-Associated-Testis-Expressed 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Complex-Associated-Testis-Expressed 31 2     T-Complex-Associated Testis-Expressed Protein 32 3
Tctex1 Domain Containing 31 2     tcte-32
TCTEX1D32 3     Tctex1 Domain-Containing Protein 32
T-Complex Testis-Specific Protein 32 3     Tcte-33

External Ids:    HGNC: 116951   Entrez Gene: 69912   Ensembl: ENSG000001847867   OMIM: 1869775   UniProtKB: Q8IZS63   

Export aliases for TCTE3 gene to outside databases

Previous GC identifers: GC06U990122 GC06M169715 GC06M169896 GC06M169957 GC06M167559


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCTE3 Gene: 
TCTE3 (t-complex-associated-testis-expressed 3) is a protein-coding gene. Diseases associated with TCTE3 include kartagener syndrome, and hernia, and among its related super-pathways are Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include motor activity.

UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6
Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in
male sterility (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCTE3 gene promoter:
         MZF-1   Sox5   RP58   AML1a   FOXJ2 (long isoform)   FOXJ2   Gfi-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCTE3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCTE3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCTE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

TCTE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCTE3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170140:  view genomic region     (about GC identifiers)

Start:
170,140,210 bp from pter      End:
170,151,655 bp from pter
Size:
11,446 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6 (See protein sequence)
Recommended Name: Tctex1 domain-containing protein 3  
Size: 198 amino acids; 23176 Da
Subunit: Interacts with CSNK2B (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable). Cytoplasmic granule (By similarity). Membrane;
Peripheral membrane protein (By similarity). Note=Found on the surface of sperm tail. Stored in cytoplasmic
granules during spermatogenesis (By similarity)

Explore the universe of human proteins at neXtProt for TCTE3: NX_Q8IZS6

Explore proteomics data for TCTE3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZS6

  • TCTE3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCTE3 Protein Expression
    REFSEQ proteins: NP_777570.1  
    ENSEMBL proteins: 
     ENSP00000355736  

    Human Recombinant Protein Products for TCTE3: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TCTE3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0016020membrane IEA--
    GO:0030286dynein complex IEA--

    TCTE3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005334 Tctex

    Graphical View of Domain Structure for InterPro Entry Q8IZS6

    ProtoNet protein and cluster: Q8IZS6

    1 Blocks protein domain: IPB005334 Tctex-1 family

    UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6
    Similarity: Belongs to the dynein light chain Tctex-type family


    TCTE3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TC1D3_HUMAN, Q8IZS6
    Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in
    male sterility (By similarity)

         Genatlas biochemistry entry for TCTE3:
    t-complex associated,testis expressed 3,murine homolog

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
         
    TCTE3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TCTE3:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tcte3):
     cellular  endocrine/exocrine gland  reproductive system 

    TCTE3 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TCTE3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TCTE3
        Cytoplasmic microtubules




    TCTE3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCTE3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/43 Interacting proteins for TCTE3 (Q8IZS63 ENSP000003557364) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703I2D: score=1 
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    ENSG00000224774P678703I2D: score=1 
    ENSG00000228875P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    TCTE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCTE3 (TC1D3)

    Search CenterWatch for drugs/clinical trials and news about TCTE3 / TC1D3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCTE3 gene: 
    NM_174910.1  

    Unigene Cluster for TCTE3:

    T-complex-associated-testis-expressed 3
    Hs.733746  [show with all ESTs]
    Unigene Representative Sequence: BC063455
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366774(uc003qxe.1)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF519569.1 AK023627.1 BC043594.1 BC053352.1 BC063455.1 BC113639.1 

    2 DOTS entries:

    DT.75100561  DT.40125050 

    24/55 AceView cDNA sequences (see all 55):

    NM_174910 AF519569 BC053352 BI826100 BM924598 AW612077 BM987468 BX098717 
    BF001512 BC063455 AK023627 BI914913 BC043594 AI669892 BU853089 AW372706 
    AI986424 BE222426 AW384624 AW384602 AW384600 AW373083 BX506473 BM754400 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCTE3 expression in normal human tissues (normalized intensities)      TCTE3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCAAAGTA
    TCTE3 Expression
    About this image


    TCTE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
             sperm   
     
     Gonad
             XY Germ Cells Testis Cord
     
     Breast (Uncategorized)
             MAMMARY GLAND   
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord

    See TCTE3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCTE3

    SOURCE GeneReport for Unigene cluster: Hs.733746

    UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6
    Tissue specificity: Expressed predominantly in testis. Also expressed in brain, lung and trachea

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCTE3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcte35
    Gm34481
    t-complex-associated testis expressed 35
    predicted gene 34481
    85.34(n)1
    82.72(a)1
      17 (8.95 cM)5
    1000416391  NM_001123367.11  NP_001116839.11 
     150271575 
    chicken
    (Gallus gallus)
    Aves TCTE31 t-complex-associated-testis-expressed 3 65(n)
    50.83(a)
      421555  XM_001231719.2  XP_001231720.2 
    lizard
    (Anolis carolinensis)
    Reptilia TCTE36
    Uncharacterized protein
    45(a)
    1 ↔ 1
    1(223722050-223726185)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72766
    CG53596
    --
    20(a)
    18(a)
    many ↔ many
    many ↔ many
    3L(15491302-15491921)
    3R(5825491-5826998)
    worm
    (Caenorhabditis elegans)
    Secernentea dylt-26
    Protein DYLT-2
    22(a)
    1 → many
    X(8939389-8940143)


    ENSEMBL Gene Tree for TCTE3 (if available)
    TreeFam Gene Tree for TCTE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/237 SNPs in TCTE3 are shown (see all 237)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904625801,2
    --170139782(+) TGGAGC/GGGGAG 1 -- ds50010--------
    rs1807263901,2
    --170139818(+) TAACAA/TCTTTC 1 -- ds50010--------
    rs572505971,2
    C,F--170139985(+) AAAATG/TATATT 1 -- ds50016Minor allele frequency- T:0.25WA CSA NA 245
    rs93835201,2
    C,F,A,H--170140184(+) AAGAAT/CATAGC 1 -- ds500120Minor allele frequency- C:0.31NA EA NS WA 2698
    rs1859834411,2
    C--170140248(+) AAGTTC/TGGAAG 1 -- ut310--------
    rs1998584941,2
    C--170140288(+) ATTCAC/TAATAA 2 Y C mis10--------
    rs2013401211,2
    --170140289(+) TTCATA/GATAAA 2 H Y mis10--------
    rs1445988091,2
    C,F--170140319(+) TGCCAC/TGTAGG 2 M V mis12Minor allele frequency- T:0.00NA EU 5873
    rs1884846531,2
    C--170140326(+) TAGGAG/TTCTGC 2 E D mis10--------
    rs1814139711,2
    --170140460(+) CTACAC/GTAGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TCTE3 (170140210 - 170151655 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCTE3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830872CNV Loss17160897
    nsv887010CNV Gain21882294


    Human Gene Mutation Database (HGMD): TCTE3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186977    OMIM disorders: --

    6 diseases for TCTE3:    About MalaCards
    kartagener syndrome    hernia    congenital diaphragmatic hernia    primary ciliary dyskinesia
    situs inversus    type 1 diabetes

    2 diseases from the University of Copenhagen DISEASES database for TCTE3:
    Primary ciliary dyskinesia     Situs inversus

    TCTE3 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TCTE3 (1 document)

    Export disorders for TCTE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCTE3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TCTE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the human ortholog of the T-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. (PubMed id 12584439)1, 2, 3 Neesen J.... Omran H. (2002)
    2. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. (PubMed id 1505969)1, 3 Rappold G.A....Lichter P. (1992)
    3. A genome-wide meta-analysis of six type 1 diabetes coh orts identifies multiple associated loci. (PubMed id 21980299)1 Bradfield J.P....Hakonarson H. (2011)
    4. Identification of TCTE3 as a gene responsible for con genital diaphragmatic hernia using a high-resolution single-nucleotide polymorp hism array. (PubMed id 21085971)1 Teshiba R....Yamamoto K. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family. (PubMed id 11278908)2 DiBella L.M.... King S.M. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6991 HGNC: 11695 AceView: TCTE3 Ensembl:ENSG00000184786 euGenes: HUgn6991
    ECgene: TCTE3 H-InvDB: TCTE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCTE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCTE3 gene:
    Search GeneIP for patents involving TCTE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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