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Aliases for TCTE3 Gene

Aliases for TCTE3 Gene

  • T-Complex-Associated-Testis-Expressed 3 2 3
  • T-Complex-Associated Testis-Expressed Protein 3 3 4
  • T-Complex Testis-Specific Protein 3 3 4
  • Tctex1 Domain Containing 3 2 3
  • TCTEX1D3 3 4
  • Tcte-3 3 4
  • Tctex1 Domain-Containing Protein 3 3

External Ids for TCTE3 Gene

Summaries for TCTE3 Gene

GeneCards Summary for TCTE3 Gene

TCTE3 (T-Complex-Associated-Testis-Expressed 3) is a Protein Coding gene. Diseases associated with TCTE3 include congenital diaphragmatic hernia. GO annotations related to this gene include motor activity. An important paralog of this gene is TCTEX1D2.

UniProtKB/Swiss-Prot for TCTE3 Gene

  • May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTE3 Gene

Genomics for TCTE3 Gene

Genomic Location for TCTE3 Gene

169,739,984 bp from pter
169,751,559 bp from pter
11,576 bases
Minus strand

Genomic View for TCTE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCTE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTE3 Gene

Regulatory Elements for TCTE3 Gene

Proteins for TCTE3 Gene

  • Protein details for TCTE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tctex1 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TCTE3 Gene

    198 amino acids
    Molecular mass:
    23176 Da
    Quaternary structure:
    • Interacts with CSNK2B.

neXtProt entry for TCTE3 Gene

Proteomics data for TCTE3 Gene at MOPED

Post-translational modifications for TCTE3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCTE3 Gene

Domains for TCTE3 Gene

Protein Domains for TCTE3 Gene



  • Belongs to the dynein light chain Tctex-type family.:
    • Q8IZS6
genes like me logo Genes that share domains with TCTE3: view

No data available for Gene Families for TCTE3 Gene

Function for TCTE3 Gene

Molecular function for TCTE3 Gene

GENATLAS Biochemistry: t-complex associated,testis expressed 3,murine homolog
UniProtKB/Swiss-Prot Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).

Gene Ontology (GO) - Molecular Function for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
genes like me logo Genes that share ontologies with TCTE3: view
genes like me logo Genes that share phenotypes with TCTE3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TCTE3 Gene

Localization for TCTE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCTE3 Gene

Cytoplasm, cytoskeleton. Cytoplasmic granule. Membrane; Peripheral membrane protein. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TCTE3 Gene COMPARTMENTS Subcellular localization image for TCTE3 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0016020 membrane IEA --
GO:0030286 dynein complex IEA --
genes like me logo Genes that share ontologies with TCTE3: view

Pathways for TCTE3 Gene

SuperPathways for TCTE3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TCTE3: view

No data available for Pathways by source for TCTE3 Gene

Transcripts for TCTE3 Gene

Unigene Clusters for TCTE3 Gene

T-complex-associated-testis-expressed 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCTE3 Gene

No ASD Table

Relevant External Links for TCTE3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCTE3 Gene

mRNA expression in normal human tissues for TCTE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTE3 Gene

This gene is overexpressed in Testis (20.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCTE3 Gene

SOURCE GeneReport for Unigene cluster for TCTE3 Gene Hs.733746

mRNA Expression by UniProt/SwissProt for TCTE3 Gene

Tissue specificity: Expressed predominantly in testis. Also expressed in brain, lung and trachea.
genes like me logo Genes that share expressions with TCTE3: view

Orthologs for TCTE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTE3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCTE3 36
  • 99.49 (n)
  • 98.48 (a)
TCTE3 37
  • 98 (a)
(Bos Taurus)
Mammalia TCTE3 36
  • 87.63 (n)
  • 89.18 (a)
TCTE3 37
  • 89 (a)
(Canis familiaris)
Mammalia TCTE3 37
  • 85 (a)
(Mus musculus)
Mammalia Gm3417 37
  • 82 (a)
Gm3448 36
  • 85.34 (n)
  • 82.72 (a)
Gm3448 37
  • 82 (a)
Tcte3 16
Tcte3 37
  • 82 (a)
(Monodelphis domestica)
Mammalia TCTE3 37
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia TCTE3 37
  • 62 (a)
(Gallus gallus)
Aves TCTE3 36
  • 65 (n)
  • 50.83 (a)
TCTE3 37
  • 43 (a)
(Anolis carolinensis)
Reptilia TCTE3 37
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5359 37
  • 21 (a)
CG7276 37
  • 23 (a)
(Caenorhabditis elegans)
Secernentea dylt-2 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
CSA.4501 37
  • 27 (a)
Species with no ortholog for TCTE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TCTE3 Gene

Gene Tree for TCTE3 (if available)
Gene Tree for TCTE3 (if available)

Paralogs for TCTE3 Gene

Paralogs for TCTE3 Gene

genes like me logo Genes that share paralogs with TCTE3: view

Variants for TCTE3 Gene

Sequence variations from dbSNP and Humsavar for TCTE3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1981068 -- 169,742,795(+) ggttt(C/T)accat intron-variant
rs1981069 -- 169,748,741(+) ACAGC(A/G)GCTTT intron-variant
rs2001592 -- 169,742,695(-) cttga(A/G)actgg intron-variant
rs2027062 -- 169,741,944(+) ACTGG(A/C/T)GGTTC intron-variant
rs2027063 - 169,744,132(+) CCATT(A/C)TATAT reference, missense, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCTE3 Gene

Variant ID Type Subtype PubMed ID
nsv887010 CNV Gain 21882294
nsv830872 CNV Loss 17160897

Relevant External Links for TCTE3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TCTE3 Gene

(2) University of Copenhagen DISEASES for TCTE3 Gene

Relevant External Links for TCTE3

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TCTE3: view

No data available for UniProtKB/Swiss-Prot for TCTE3 Gene

Publications for TCTE3 Gene

  1. Identification of the human ortholog of the T-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. (PMID: 12584439) Neesen J. … Omran H. (Cytogenet. Genome Res. 2002) 2 3 4
  2. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. (PMID: 1505969) Rappold G.A. … Lichter P. (Genomics 1992) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array. (PMID: 21085971) Teshiba R. … Yamamoto K. (Pediatr. Surg. Int. 2011) 3
  5. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield J.P. … Hakonarson H. (PLoS Genet. 2011) 3

Products for TCTE3 Gene

Sources for TCTE3 Gene

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