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TCTE3 Gene

protein-coding   GIFtS: 50
GCID: GC06M170140

T-Complex-Associated-Testis-Expressed 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Complex-Associated-Testis-Expressed 31 2     T-Complex-Associated Testis-Expressed Protein 32 3
Tctex1 Domain Containing 31 2     tcte-32
TCTEX1D32 3     Tctex1 Domain-Containing Protein 32
T-Complex Testis-Specific Protein 32 3     Tcte-33

External Ids:    HGNC: 116951   Entrez Gene: 69912   Ensembl: ENSG000001847867   OMIM: 1869775   UniProtKB: Q8IZS63   

Export aliases for TCTE3 gene to outside databases

Previous GC identifers: GC06U990122 GC06M169715 GC06M169896 GC06M169957 GC06M167559


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCTE3 Gene:
TCTE3 (t-complex-associated-testis-expressed 3) is a protein-coding gene. Diseases associated with TCTE3 include congenital diaphragmatic hernia, and kartagener syndrome. GO annotations related to this gene include motor activity. An important paralog of this gene is TCTEX1D4.

UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6
Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in
male sterility (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TCTE3 gene promoter:
         MZF-1   Sox5   RP58   AML1a   FOXJ2 (long isoform)   FOXJ2   Gfi-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCTE3 promoter sequence
   Search Chromatin IP Primers for TCTE3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCTE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

TCTE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCTE3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M170140:  view genomic region     (about GC identifiers)

Start:
170,140,210 bp from pter      End:
170,151,655 bp from pter
Size:
11,446 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6 (See protein sequence)
Recommended Name: Tctex1 domain-containing protein 3  
Size: 198 amino acids; 23176 Da
Subunit: Interacts with CSNK2B (By similarity)

Explore the universe of human proteins at neXtProt for TCTE3: NX_Q8IZS6

Explore proteomics data for TCTE3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TCTE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_777570.1  
    ENSEMBL proteins: 
     ENSP00000355736  

    TCTE3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for TCTE3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005334 Tctex

    Graphical View of Domain Structure for InterPro Entry Q8IZS6

    ProtoNet protein and cluster: Q8IZS6

    1 Blocks protein domain: IPB005334 Tctex-1 family

    UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6
    Similarity: Belongs to the dynein light chain Tctex-type family


    TCTE3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TC1D3_HUMAN, Q8IZS6
    Function: May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in
    male sterility (By similarity)

         Genatlas biochemistry entry for TCTE3:
    t-complex associated,testis expressed 3,murine homolog

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
         
    TCTE3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TCTE3:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tcte3):
     cellular  endocrine/exocrine gland  reproductive system 

    TCTE3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCTE3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCTE3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCTE3

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TCTE3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TCTE3 (NM_174910)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTE3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TC1D3_HUMAN, Q8IZS6: Cytoplasm, cytoskeleton (Probable). Cytoplasmic granule (By similarity). Membrane;
    Peripheral membrane protein (By similarity). Note=Found on the surface of sperm tail. Stored in cytoplasmic
    granules during spermatogenesis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus3
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0016020membrane IEA--
    GO:0030286dynein complex IEA--

    TCTE3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCTE3 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCTE3
    Interactions:

        Search GeneGlobe Interaction Network for TCTE3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCTE3 (Q8IZS63 ENSP000003557364) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703, ENSP000003650254I2D: score=1 STRING: ENSP00000365025
    ENSG00000206406P678703, ENSP000003829844I2D: score=1 STRING: ENSP00000382984
    ENSG00000224398P678703, ENSP000004130924I2D: score=1 STRING: ENSP00000413092
    ENSG00000224774P678703, ENSP000004156154I2D: score=1 STRING: ENSP00000415615
    ENSG00000232960P678703, ENSP000003955464I2D: score=1 STRING: ENSP00000395546
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--

    TCTE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCTE3 (TC1D3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TCTE3 gene: 
    NM_174910.1  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000366774(uc003qxe.1)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTE3
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      QuantiTect SYBR Green Assays in human, mouse, rat TCTE3
      QuantiFast Probe-based Assays in human, mouse, rat TCTE3

    Selected AceView cDNA sequences (see all 55):

    BM987468 AK023627 AF519569 BM924598 NM_174910 BX098717 BC053352 BF001512 
    BI914913 BI826100 BC063455 AW612077 BC043594 AW384600 AI796812 BE222426 
    BU853089 AW372706 AA781436 AW384602 AW373107 AI986424 AW373085 BX494945 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCTE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCAAAGTA
    TCTE3 Expression
    About this image


    TCTE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad
             XY Germ Cells Testis Cord
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
    TCTE3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCTE3 Protein Expression

    UniProtKB/Swiss-Prot: TC1D3_HUMAN, Q8IZS6
    Tissue specificity: Expressed predominantly in testis. Also expressed in brain, lung and trachea

        Custom PCR Arrays for TCTE3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TCTE3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcte35
    Gm34481
    t-complex-associated testis expressed 35
    predicted gene 34481
    85.34(n)1
    82.72(a)1
      17 (8.95 cM)5
    1000416391  NM_001123367.11  NP_001116839.11 
     150271575 
    chicken
    (Gallus gallus)
    Aves TCTE31 t-complex-associated-testis-expressed 3 65(n)
    50.83(a)
      421555  XM_001231744.2  XP_001231745.3 
    lizard
    (Anolis carolinensis)
    Reptilia TCTE36
    t-complex-associated-testis-expressed 3
    45(a)
    1 ↔ 1
    1(223722050-223726185)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72766
    CG53596
    --
    23(a)
    21(a)
    many ↔ many
    many ↔ many
    3L(15491302-15491921)
    3R(5825491-5826998)
    worm
    (Caenorhabditis elegans)
    Secernentea dylt-26
    Protein DYLT-2 (dylt-2) mRNA, complete cds
    25(a)
    1 → many
    X(8939389-8940143) WBGene00017014


    ENSEMBL Gene Tree for TCTE3 (if available)
    TreeFam Gene Tree for TCTE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCTE3 gene
    TCTEX1D42  TCTEX1D22  ENSG000002727412  TCTEX1D12  

    TCTE3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCTE3 (see all 237)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1904625801,2
    --170139782(+) TGGAGC/GGGGAG 1 -- ds50010--------
    rs1807263901,2
    --170139818(+) TAACAA/TCTTTC 1 -- ds50010--------
    rs572505971,2
    C,F--170139985(+) AAAATG/TATATT 1 -- ds50016Minor allele frequency- T:0.25WA CSA NA 245
    rs93835201,2
    C,F,A,H--170140184(+) AAGAAT/CATAGC 1 -- ds500120Minor allele frequency- C:0.31NA EA NS WA 2698
    rs1859834411,2
    C--170140248(+) AAGTTC/TGGAAG 1 -- ut310--------
    rs1998584941,2
    C--170140288(+) ATTCAC/TAATAA 2 Y C mis10--------
    rs2013401211,2
    --170140289(+) TTCATA/GATAAA 2 H Y mis10--------
    rs1445988091,2
    C,F--170140319(+) TGCCAC/TGTAGG 2 M V mis12Minor allele frequency- T:0.00NA EU 5873
    rs1884846531,2
    C--170140326(+) TAGGAG/TTCTGC 2 E D mis10--------
    rs1814139711,2
    --170140460(+) CTACAC/GTAGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TCTE3 (170140210 - 170151655 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCTE3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830872CNV Loss17160897
    nsv887010CNV Gain21882294

    Human Gene Mutation Database (HGMD): TCTE3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCTE3
    DNA2.0 Custom Variant and Variant Library Synthesis for TCTE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186977    OMIM disorders: --

    5 diseases for TCTE3:    
    About MalaCards
    congenital diaphragmatic hernia    kartagener syndrome    situs inversus    primary ciliary dyskinesia
    type 1 diabetes

    2 diseases from the University of Copenhagen DISEASES database for TCTE3:
    Primary ciliary dyskinesia     Situs inversus

    TCTE3 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TCTE3 (1 document)

    Export disorders for TCTE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCTE3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TCTE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the human ortholog of the T-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. (PubMed id 12584439)1, 2, 3 Neesen J.... Omran H. (Cytogenet. Genome Res. 2002)
    2. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. (PubMed id 1505969)1, 3 Rappold G.A....Lichter P. (Genomics 1992)
    3. Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array. (PubMed id 21085971)1 Teshiba R....Yamamoto K. (Pediatr. Surg. Int. 2011)
    4. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PubMed id 21980299)1 Bradfield J.P....Hakonarson H. (PLoS Genet. 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family. (PubMed id 11278908)2 DiBella L.M.... King S.M. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6991 HGNC: 11695 AceView: TCTE3 Ensembl:ENSG00000184786 euGenes: HUgn6991
    ECgene: TCTE3 H-InvDB: TCTE3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCTE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCTE3 gene:
    Search GeneIP for patents involving TCTE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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