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Aliases for TCTE3 Gene

Aliases for TCTE3 Gene

  • T-Complex-Associated-Testis-Expressed 3 2 3 5
  • T-Complex-Associated Testis-Expressed Protein 3 3 4
  • T-Complex Testis-Specific Protein 3 3 4
  • Tctex1 Domain Containing 3 2 3
  • TCTEX1D3 3 4
  • Tctex1 Domain-Containing Protein 3 3
  • Tcte-3 4

External Ids for TCTE3 Gene

Previous GeneCards Identifiers for TCTE3 Gene

  • GC06U990122
  • GC06M169715
  • GC06M169896
  • GC06M169957
  • GC06M170140
  • GC06M167559

Summaries for TCTE3 Gene

GeneCards Summary for TCTE3 Gene

TCTE3 (T-Complex-Associated-Testis-Expressed 3) is a Protein Coding gene. Diseases associated with TCTE3 include Congenital Diaphragmatic Hernia and Kartagener Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. GO annotations related to this gene include motor activity. An important paralog of this gene is TCTEX1D4.

UniProtKB/Swiss-Prot for TCTE3 Gene

  • May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTE3 Gene

Genomics for TCTE3 Gene

Regulatory Elements for TCTE3 Gene

Enhancers for TCTE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G169721 1.1 ENCODE 12.2 +27.4 27421 4.7 PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A C6orf120 ENSG00000266896 TCTE3 ERMARD WDR27 ENSG00000236173 ENSG00000227704
GH06G170400 0.9 ENCODE 12.1 -648.9 -648882 0.5 HDGF FOXA2 ARNT ZNF473 YBX1 PLRG1 ZBTB40 ZEB1 TCF12 ZNF366 FAM120B TBP ENSG00000266896 ENSG00000272848 TCTE3 ENSG00000232640 PSMB1 PDCD2 C6orf120 LOC101929670
GH06G170144 0.8 ENCODE 12.1 -393.5 -393512 1.0 SUZ12 MAX YBX1 RAD21 YY1 TCF12 HNF4G FOSL2 FOS PRDM10 ENSG00000273100 FAM120B LINC02519 TCTE3 ENSG00000232640 TBP RPL12P23 LOC101929614 PIR44793
GH06G170521 0.9 ENCODE dbSUPER 10.4 -772.2 -772167 3.6 CTCF RAD51 POLR2A GATA2 SMARCA4 IKZF1 USF2 RAD21 PSMB1 TBP DLL1 FAM120B TCTE3 ERMARD PDCD2 PIR55352 PIR48716
GH06G169720 0.6 Ensembl 11.7 +31.1 31087 0.2 CTCF PKNOX1 ZNF146 ZBTB33 ZNF394 RAD21 PRDM1 TCTE3 ERMARD ENSG00000227704 C6orf120
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCTE3 on UCSC Golden Path with GeneCards custom track

Promoters for TCTE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207228 49 1801 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for TCTE3 Gene

Chromosome:
6
Start:
169,725,090 bp from pter
End:
169,751,587 bp from pter
Size:
26,498 bases
Orientation:
Minus strand

Genomic View for TCTE3 Gene

Genes around TCTE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTE3 Gene

Proteins for TCTE3 Gene

  • Protein details for TCTE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZS6-TC1D3_HUMAN
    Recommended name:
    Tctex1 domain-containing protein 3
    Protein Accession:
    Q8IZS6

    Protein attributes for TCTE3 Gene

    Size:
    198 amino acids
    Molecular mass:
    23176 Da
    Quaternary structure:
    • Interacts with CSNK2B.

neXtProt entry for TCTE3 Gene

Post-translational modifications for TCTE3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCTE3 Gene

Domains & Families for TCTE3 Gene

Protein Domains for TCTE3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZS6

UniProtKB/Swiss-Prot:

TC1D3_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with TCTE3: view

No data available for Gene Families for TCTE3 Gene

Function for TCTE3 Gene

Molecular function for TCTE3 Gene

GENATLAS Biochemistry:
t-complex associated,testis expressed 3,murine homolog
UniProtKB/Swiss-Prot Function:
May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).

Gene Ontology (GO) - Molecular Function for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
genes like me logo Genes that share ontologies with TCTE3: view
genes like me logo Genes that share phenotypes with TCTE3: view

Animal Models for TCTE3 Gene

MGI Knock Outs for TCTE3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TCTE3 Gene

Localization for TCTE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCTE3 Gene

Cytoplasm, cytoskeleton. Cytoplasmic granule. Membrane; Peripheral membrane protein. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTE3 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0016020 membrane IEA --
GO:0030286 dynein complex IEA --
genes like me logo Genes that share ontologies with TCTE3: view

Pathways & Interactions for TCTE3 Gene

genes like me logo Genes that share pathways with TCTE3: view

Pathways by source for TCTE3 Gene

Interacting Proteins for TCTE3 Gene

Gene Ontology (GO) - Biological Process for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TCTE3: view

No data available for SIGNOR curated interactions for TCTE3 Gene

Drugs & Compounds for TCTE3 Gene

No Compound Related Data Available

Transcripts for TCTE3 Gene

Unigene Clusters for TCTE3 Gene

T-complex-associated-testis-expressed 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTE3 Gene

No ASD Table

Relevant External Links for TCTE3 Gene

GeneLoc Exon Structure for
TCTE3
ECgene alternative splicing isoforms for
TCTE3

Expression for TCTE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCTE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTE3 Gene

This gene is overexpressed in Testis (x20.8).

Protein differential expression in normal tissues from HIPED for TCTE3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCTE3 Gene



Protein tissue co-expression partners for TCTE3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCTE3 Gene:

TCTE3

SOURCE GeneReport for Unigene cluster for TCTE3 Gene:

Hs.733746

mRNA Expression by UniProt/SwissProt for TCTE3 Gene:

Q8IZS6-TC1D3_HUMAN
Tissue specificity: Expressed predominantly in testis. Also expressed in brain, lung and trachea.
genes like me logo Genes that share expression patterns with TCTE3: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCTE3 Gene

Orthologs for TCTE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTE3 34 35
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia TCTE3 34 35
  • 87.63 (n)
mouse
(Mus musculus)
Mammalia Tcte3 34 16 35
  • 85.34 (n)
Gm3417 35
  • 82 (a)
OneToMany
Gm3448 35
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TCTE3 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCTE3 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCTE3 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCTE3 34 35
  • 65 (n)
lizard
(Anolis carolinensis)
Reptilia TCTE3 35
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7276 35
  • 23 (a)
ManyToMany
CG5359 35
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dylt-2 35
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
OneToMany
CSA.4501 35
  • 27 (a)
OneToMany
Species where no ortholog for TCTE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TCTE3 Gene

ENSEMBL:
Gene Tree for TCTE3 (if available)
TreeFam:
Gene Tree for TCTE3 (if available)

Paralogs for TCTE3 Gene

Paralogs for TCTE3 Gene

genes like me logo Genes that share paralogs with TCTE3: view

Variants for TCTE3 Gene

Sequence variations from dbSNP and Humsavar for TCTE3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000078260 -- 169,737,011(+) TCATT(C/T)CTTTT intron-variant
rs1000126669 -- 169,744,535(+) GCATA(C/T)ATTTA intron-variant
rs1000135718 -- 169,751,822(+) GGCCT(C/G)TGTGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000232405 -- 169,726,788(+) GATAT(-/A)AAAAA intron-variant
rs1000310022 -- 169,726,293(+) TTAGG(G/T)GGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCTE3 Gene

Variant ID Type Subtype PubMed ID
nsv1032232 CNV loss 25217958
nsv605499 CNV gain 21841781
nsv830872 CNV loss 17160897

Variation tolerance for TCTE3 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.52; 85.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCTE3 Gene

Human Gene Mutation Database (HGMD)
TCTE3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTE3 Gene

Disorders for TCTE3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TCTE3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
congenital diaphragmatic hernia
  • diaphragmatic hernia
kartagener syndrome
  • kartagener's syndrome
primary ciliary dyskinesia
  • ciliary motility disorder
- elite association - COSMIC cancer census association via MalaCards
Search TCTE3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCTE3

Human Genome Epidemiology (HuGE) Navigator
TCTE3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCTE3
genes like me logo Genes that share disorders with TCTE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCTE3 Gene

Publications for TCTE3 Gene

  1. Identification of the human ortholog of the T-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. (PMID: 12584439) Neesen J. … Omran H. (Cytogenet. Genome Res. 2002) 2 3 4 64
  2. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. (PMID: 1505969) Rappold G.A. … Lichter P. (Genomics 1992) 2 3 64
  3. Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta. (PMID: 26643481) Sanchez-Castro M. … Le Caignec C. (Circ Cardiovasc Genet 2016) 3 64
  4. Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array. (PMID: 21085971) Teshiba R. … Yamamoto K. (Pediatr. Surg. Int. 2011) 3 64
  5. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield J.P. … Hakonarson H. (PLoS Genet. 2011) 3 64

Products for TCTE3 Gene

Sources for TCTE3 Gene

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