TCTE1 Gene
protein-coding GIFtS: 44
GCID: GC06M044246
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t-complex-associated-testis-expressed 1
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Aliases
for TCTE1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| T-Complex-Associated-Testis-Expressed 11 2 | | D6S461 2 | | MGC336001 | | T-Complex-Associated Testis-Expressed Protein 12 | | Tcte-13 | | Tcte-13 |
Export aliases for TCTE1 gene to outside databasesPrevious GC identifers: GC06U990121 GC06M158967 GC06M044357 GC06M043969 |
Summaries
for TCTE1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TCTE1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCTE1 gene promoter:
E2F-4 E2F-3a E2F-5 Lmo2 E2F-2 Tal-1beta E47 E2F E2F-1 POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCTE1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCTE1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.1 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6q21.1TCTE1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M044246: view genomic region
(about GC identifiers)
Start:
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44,246,480 bp from pter |
End:
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44,265,458 bp from pter |
Size:
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18,979 bases |
Orientation:
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minus strand |
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Proteins
for TCTE1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCTE1_HUMAN, Q5JU00 (See
protein sequence)Recommended Name: T-complex-associated testis-expressed protein 1 Size: 501 amino acids; 55632 Da
Secondary accessions: B4DX59 Q8IYS6Explore the universe of human proteins at neXtProt for TCTE1: NX_Q5JU00
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5JU00
TCTE1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872345.2
ENSEMBL proteins: ENSP00000360560 ENSP00000360559 ENSP00000360558
Human Recombinant Protein Products:
TCTE1 Antibody Products:
Assay Products for TCTE1: |
Protein
Domains /
Families
for TCTE1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5JU00 UniProtKB/Swiss-Prot: TCTE1_HUMAN, Q5JU00Similarity: Contains 5 LRR (leucine-rich) repeats |
Function
for TCTE1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for TCTE1:t-complex associated,testis expressed 1 (formerly D6S46)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: TCTE1 (NM_182539) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCTE1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTE1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTE1 |
1 GenomeRNAi human phenotype for TCTE1:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tcte1):
TCTE1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TCTE1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCTE1
1 Interacting protein for TCTE1 (Q5JU003) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TCTE1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCTE1
Search CenterWatch for drugs/clinical trials and news about TCTE1
|
Transcripts
for TCTE1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCTE1 gene: NM_182539.3 Unigene Cluster for TCTE1: T-complex-associated-testis-expressed 1 Hs.189183 [show with all ESTs]Unigene Representative Sequence: NM_1825393 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371505(uc003oxi.2) ENST00000371504 ENST00000371503
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TCTE1 (NM_182539) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCTE1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTE1 |
Additional cDNA sequence: AK301825.1 BC035022.1 1 DOTS entry: DT.208413 24/121 AceView cDNA sequences (see all 121): BM042314 BI789129 C01141 BI769677 BQ682453 CK821197 BQ883770 BU146586 AI806436 AI381515 CR612653 BQ642175 BI603994 BC033169 AI942297 BX112088 AI183453 BE794125 BG823136 BM563226 BG437448 BQ925080 AL536467 BG832342
GeneLoc Exon Structure
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Expression
for TCTE1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCTE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAACCATCA
About this image
See TCTE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCTE1
SOURCE GeneReport for Unigene cluster: Hs.189183
SABiosciences Custom PCR Arrays for TCTE1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCTE1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCTE1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCTE1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCTE1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTE1 |
Orthologs
for TCTE1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TCTE1 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for TCTE1 (if available)
TreeFam Gene Tree for TCTE1 (if available) |
Paralogs
for TCTE1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCTE1 gene
- LRRC342 PPP1R372 LOC4008912 LRRC452 C14orf166B2
TCTE1 for paralogs About GeneDecksing
|
Genomic Variants
for TCTE1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCTE1 (44246480 - 44265458 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCTE1: --
Human Gene Mutation Database (HGMD): TCTE1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCTE1 |
|
Disorders
/ Diseases
for TCTE1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCTE1 for disorders About GeneDecksing
OMIM gene information: 186975
OMIM disorders: --
2  diseases for TCTE1: About MalaCardscleidocranial dysplasia meningocele
2 diseases from the University of Copenhagen DISEASES database for TCTE1:Meningocele Cleidocranial dysplasia Human Genome Epidemiology (HuGE) Navigator: TCTE1 (1 document)
Export disorders for TCTE1 gene to outside databases
|
Publications
for TCTE1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCTE1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCTE1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties. (PubMed id 2568335)1, 3 Sarvetnick N....Silver L.M. (1989)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Sequence divergence within the sperm-specific polypeptide TCTE1 is correlated with species-specific differences in sperm binding to zona-intact eggs. (PubMed id 9570741)1 Juneja R....Silver L.M. (1998)
- Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. (PubMed id 8646886)3 Watanabe T.K.... Hirai Y. (1996)
- Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels. (PubMed id 1916824)1 Kwiatkowski T.J....Zoghbi H.Y. (1991)
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External Searches for TCTE1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TCTE1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCTE1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCTE1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCTE1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TCTE1 gene:
Search GeneIP for patents involving TCTE1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCTE1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TCTE1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCTE1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCTE1 | | | OriGene Protein Over-expression Lysate for TCTE1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TCTE1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCTE1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TCTE1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | TCTE1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTE1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TCTE1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTE1 |
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