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Aliases for TCTE1 Gene

Aliases for TCTE1 Gene

  • T-Complex-Associated-Testis-Expressed 1 2 3 5
  • Tcte-1 3 4
  • T-Complex-Associated Testis-Expressed Protein 1 3
  • FAP155 3
  • D6S46 3
  • DRC5 3

External Ids for TCTE1 Gene

Previous GeneCards Identifiers for TCTE1 Gene

  • GC06U990121
  • GC06M158967
  • GC06M044357
  • GC06M043969

Summaries for TCTE1 Gene

GeneCards Summary for TCTE1 Gene

TCTE1 (T-Complex-Associated-Testis-Expressed 1) is a Protein Coding gene. Diseases associated with TCTE1 include Epilepsy, Generalized, With Febrile Seizures Plus, Type 5. An important paralog of this gene is LRRC74A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTE1 Gene

Genomics for TCTE1 Gene

Regulatory Elements for TCTE1 Gene

Enhancers for TCTE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F043836 1.3 FANTOM5 Ensembl 11.8 +461.1 461120 0.4 PKNOX1 ATF1 ARNT MLX ZNF48 YY1 SLC30A9 ELK1 GATA2 FOS CAPN11 CDC5L TCTE1 VEGFA RSPH9 LRRC73 ABCC10 MAD2L1BP LOC105375069 LOC105375070
GH06F044232 1.8 FANTOM5 Ensembl ENCODE 6.1 +61.8 61844 6.4 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 POLH CAPN11 RPS2P29 NFKBIE SLC35B2 MIR4647 MRPL14 TMEM63B TMEM151B LOC101929726
GH06F043944 1 ENCODE 5.4 +352.1 352103 1.3 PKNOX1 MLX ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 MXD4 RPS2P29 RPL34P14 TCTE1 LOC105375067 GC06M043993
GH06F044701 0.5 FANTOM5 ENCODE 5.3 -404.2 -404176 0.2 TCTE1 LOC101929770 GC06M044626 GC06M044627
GH06F044283 0.4 FANTOM5 1.7 +14.0 14034 0.3 POLR2A SLC35B2 MIR4647 AARS2 SPATS1 MRPL14 TMEM63B TMEM151B TCTE1 ENSG00000272442
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCTE1 on UCSC Golden Path with GeneCards custom track

Promoters for TCTE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001217432 121 401 ATF1 ZFP64 ARID4B SIN3A ZNF48 ZNF766 GLIS2 ZNF207 KLF13 ZNF263

Genomic Location for TCTE1 Gene

Chromosome:
6
Start:
44,278,743 bp from pter
End:
44,297,721 bp from pter
Size:
18,979 bases
Orientation:
Minus strand

Genomic View for TCTE1 Gene

Genes around TCTE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTE1 Gene

Proteins for TCTE1 Gene

  • Protein details for TCTE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JU00-TCTE1_HUMAN
    Recommended name:
    T-complex-associated testis-expressed protein 1
    Protein Accession:
    Q5JU00
    Secondary Accessions:
    • B4DX59
    • Q8IYS6

    Protein attributes for TCTE1 Gene

    Size:
    501 amino acids
    Molecular mass:
    55632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCTE1 Gene

Post-translational modifications for TCTE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCTE1 Gene

Domains & Families for TCTE1 Gene

Gene Families for TCTE1 Gene

Protein Domains for TCTE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JU00

UniProtKB/Swiss-Prot:

TCTE1_HUMAN :
  • Contains 5 LRR (leucine-rich) repeats.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with TCTE1: view

Function for TCTE1 Gene

Molecular function for TCTE1 Gene

GENATLAS Biochemistry:
t-complex associated,testis expressed 1 (formerly D6S46)

Phenotypes for TCTE1 Gene

genes like me logo Genes that share phenotypes with TCTE1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCTE1 Gene

Localization for TCTE1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTE1 gene
Compartment Confidence
cytosol 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCTE1 Gene

Pathways & Interactions for TCTE1 Gene

SuperPathways for TCTE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCTE1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCTE1 Gene

Transcripts for TCTE1 Gene

mRNA/cDNA for TCTE1 Gene

Unigene Clusters for TCTE1 Gene

T-complex-associated-testis-expressed 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTE1 Gene

No ASD Table

Relevant External Links for TCTE1 Gene

GeneLoc Exon Structure for
TCTE1
ECgene alternative splicing isoforms for
TCTE1

Expression for TCTE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCTE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTE1 Gene

This gene is overexpressed in Testis (x29.0).

Protein differential expression in normal tissues from HIPED for TCTE1 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCTE1 Gene



Protein tissue co-expression partners for TCTE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCTE1 Gene:

TCTE1

SOURCE GeneReport for Unigene cluster for TCTE1 Gene:

Hs.189183
genes like me logo Genes that share expression patterns with TCTE1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TCTE1 Gene

Orthologs for TCTE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTE1 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia TCTE1 34 35
  • 87.03 (n)
cow
(Bos Taurus)
Mammalia TCTE1 34
  • 80.3 (n)
rat
(Rattus norvegicus)
Mammalia Tcte1 34
  • 78.05 (n)
mouse
(Mus musculus)
Mammalia Tcte1 34 16 35
  • 77.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCTE1 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCTE1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCTE1 34 35
  • 66.83 (n)
lizard
(Anolis carolinensis)
Reptilia TCTE1 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcte1 34
  • 63.52 (n)
zebrafish
(Danio rerio)
Actinopterygii tcte1 34 35
  • 60.98 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002751 34
  • 45.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14325 34 35
  • 43.6 (n)
Species where no ortholog for TCTE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCTE1 Gene

ENSEMBL:
Gene Tree for TCTE1 (if available)
TreeFam:
Gene Tree for TCTE1 (if available)

Paralogs for TCTE1 Gene

Paralogs for TCTE1 Gene

genes like me logo Genes that share paralogs with TCTE1: view

Variants for TCTE1 Gene

Sequence variations from dbSNP and Humsavar for TCTE1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1056092 -- 44,298,971(-) TGTAC(A/G)GCACC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1056093 -- 44,298,837(-) CCTTT(G/T)TTCCT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs111290795 -- 44,298,012(+) TCTTG(C/G)TAGCT upstream-variant-2KB, utr-variant-3-prime
rs111523346 -- 44,289,017(+) AAAAA(A/G)AAAAA intron-variant, upstream-variant-2KB
rs111552372 -- 44,282,300(+) GACGT(A/G)GGTTG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TCTE1 Gene

Variant ID Type Subtype PubMed ID
dgv10641n54 CNV loss 21841781
dgv3507e59 CNV insertion 20981092
esv3408956 CNV insertion 20981092
esv3571032 CNV loss 25503493
nsv462936 CNV loss 19166990
nsv524398 CNV loss 19592680
nsv603003 CNV gain 21841781

Variation tolerance for TCTE1 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCTE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTE1 Gene

Disorders for TCTE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCTE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epilepsy, generalized, with febrile seizures plus, type 5
  • epilepsy, idiopathic generalized, 10
- elite association - COSMIC cancer census association via MalaCards
Search TCTE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCTE1

Genetic Association Database (GAD)
TCTE1
Human Genome Epidemiology (HuGE) Navigator
TCTE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCTE1
genes like me logo Genes that share disorders with TCTE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCTE1 Gene

Publications for TCTE1 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  2. A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties. (PMID: 2568335) Sarvetnick N. … Silver L.M. (Immunogenetics 1989) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for TCTE1 Gene

Sources for TCTE1 Gene

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