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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCTE1 Gene

protein-coding   GIFtS: 45
GCID: GC06M044246

T-Complex-Associated-Testis-Expressed 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Complex-Associated-Testis-Expressed 11 2
D6S462
T-Complex-Associated Testis-Expressed Protein 12
tcte-12
Tcte-13

External Ids:    HGNC: 116931   Entrez Gene: 2025002   Ensembl: ENSG000001462217   OMIM: 1869755   UniProtKB: Q5JU003   

Export aliases for TCTE1 gene to outside databases

Previous GC identifers: GC06U990121 GC06M158967 GC06M044357 GC06M043969


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCTE1 Gene: 
TCTE1 (t-complex-associated-testis-expressed 1) is a protein-coding gene. Diseases associated with TCTE1 include meningocele, and cleidocranial dysplasia. An important paralog of this gene is LRRC34.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCTE1 gene promoter:
         E2F-4   E2F-3a   E2F-5   Lmo2   E2F-2   Tal-1beta   E47   E2F   E2F-1   POU2F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCTE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCTE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCTE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6q21.1

TCTE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCTE1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M044246:  view genomic region     (about GC identifiers)

Start:
44,246,480 bp from pter      End:
44,265,458 bp from pter
Size:
18,979 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCTE1_HUMAN, Q5JU00 (See protein sequence)
Recommended Name: T-complex-associated testis-expressed protein 1  
Size: 501 amino acids; 55632 Da
Secondary accessions: B4DX59 Q8IYS6

Explore the universe of human proteins at neXtProt for TCTE1: NX_Q5JU00

Explore proteomics data for TCTE1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JU00

  • TCTE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCTE1 Protein Expression
    REFSEQ proteins: NP_872345.2  
    ENSEMBL proteins: 
     ENSP00000360560   ENSP00000360559   ENSP00000360558  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5JU00

    UniProtKB/Swiss-Prot: TCTE1_HUMAN, Q5JU00
    Similarity: Contains 5 LRR (leucine-rich) repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for TCTE1:
    t-complex associated,testis expressed 1 (formerly D6S46)

    Phenotypes:
         1 GenomeRNAi human phenotype for TCTE1:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tcte1):
     behavior/neurological  reproductive system 

    TCTE1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCTE1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCTE1 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCTE1

    1 Interacting protein for TCTE1 (Q5JU003) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP3A4P086843I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCTE1

    Search CenterWatch for drugs/clinical trials and news about TCTE1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCTE1 gene: 
    NM_182539.3  

    Unigene Cluster for TCTE1:

    T-complex-associated-testis-expressed 1
    Hs.189183  [show with all ESTs]
    Unigene Representative Sequence: NM_182539
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371505(uc003oxi.2) ENST00000371504 ENST00000371503
    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of TCTE1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCTE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCTE1

    Additional mRNA sequence: 

    AK301825.1 BC035022.1 

    1 DOTS entry:

    DT.208413 

    24/121 AceView cDNA sequences (see all 121):

    CR612653 AI806436 BQ642175 BQ682453 CK821197 BM042314 C01141 BI769677 
    BU146586 BI789129 AI381515 BQ883770 BI603994 BM563226 BC013593 BQ933289 
    BM729180 BQ925080 BI826811 AA767214 BM545479 BC035022 BI770414 BE794125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCTE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACCATCA
    TCTE1 Expression
    About this image


    See TCTE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCTE1

    SOURCE GeneReport for Unigene cluster: Hs.189183
        SABiosciences Custom PCR Arrays for TCTE1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCTE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TCTE1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcte11 , 5 t-complex-associated testis expressed 11, 5 77.46(n)1
    77.26(a)1
      17 (22.54 cM)5
    216451  NM_013688.21  NP_038716.21 
     455234345 
    chicken
    (Gallus gallus)
    Aves TCTE11 t-complex-associated-testis-expressed 1 66.83(n)
    63.77(a)
      421437  XM_419489.3  XP_419489.3 
    lizard
    (Anolis carolinensis)
    Reptilia TCTE16
    t-complex-associated-testis-expressed 1
    62(a)
    1 ↔ 1
    1(228051397-228069648)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003316981 t-complex-associated testis-expressed protein 1-like 60.98(n)
    55.53(a)
      100331698  XM_002667353.2  XP_002667399.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143251 CG14325 43.4(n)
    30.96(a)
      42123  NM_142384.2  NP_650641.2 


    ENSEMBL Gene Tree for TCTE1 (if available)
    TreeFam Gene Tree for TCTE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCTE1 gene
    LRRC342  LOC4008912  C14orf166B2  

    TCTE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in TCTE1 are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs22748331,2
    H--44247859(+) AGCAGG/ACATGG 1 -- int1 ese34Minor allele frequency- A:0.00NS EA 412
    rs4847571,2
    C,F--44247951(-) ACCATC/AACTGC 2 /I syn1 ese318Minor allele frequency- A:0.12MN NA WA CSA EU 6530
    rs1996208381,2
    --44247956(+) TATGGC/TTGACA 2 T A mis10--------
    rs1389240821,2
    --44247963(+) GACATA/GAAGTG 2 F syn10--------
    rs1453833611,2
    C,F--44248003(+) CTTCTC/TGGTTT 2 Q R mis11Minor allele frequency- T:0.00NA 4552
    rs2001256371,2
    C--44248004(+) TTCTCA/GGTTTG 2 R * stg10--------
    rs1379453721,2
    C,F--44248037(+) GTACTC/TGCTTT 2 K E mis12Minor allele frequency- T:0.00NA EU 5875
    rs1406112801,2
    C,F--44248122(+) TTCCCA/GCCGTC 2 G syn11Minor allele frequency- G:0.00NA 4552
    rs1413827811,2
    C,F--44248124(+) CCCACC/TGTCCT 2 S G mis11Minor allele frequency- T:0.00NA 4552
    rs1457360691,2
    --44248208(+) GTAGAA/TGTGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TCTE1 (44246480 - 44265458 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TCTE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv462936CNV Loss19166990
    nsv885857CNV Loss21882294
    nsv524398CNV Loss19592680
    dgv6843n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): TCTE1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186975    OMIM disorders: --

    2 diseases for TCTE1:    About MalaCards
    meningocele    cleidocranial dysplasia

    2 diseases from the University of Copenhagen DISEASES database for TCTE1:
    Meningocele     Cleidocranial dysplasia

    TCTE1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TCTE1
    Human Genome Epidemiology (HuGE) Navigator: TCTE1 (1 document)

    Export disorders for TCTE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCTE1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TCTE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    2. A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties. (PubMed id 2568335)1, 3 Sarvetnick N....Silver L.M. (1989)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Sequence divergence within the sperm-specific polypeptide TCTE1 is correlated with species-specific differences in sperm binding to zona-intact eggs. (PubMed id 9570741)1 Juneja R....Silver L.M. (1998)
    8. Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. (PubMed id 8646886)3 Watanabe T.K.... Hirai Y. (1996)
    9. Linkage mapping and fluorescence in situ hybridization of TCTE1 on human chromosome 6p: analysis of dinucleotide polymorphisms on native gels. (PubMed id 1916824)1 Kwiatkowski T.J....Zoghbi H.Y. (1991)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 202500 HGNC: 11693 AceView: AARSLandMGC33600 Ensembl:ENSG00000146221 euGenes: HUgn202500
    ECgene: TCTE1 H-InvDB: TCTE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCTE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCTE1 gene:
    Search GeneIP for patents involving TCTE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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