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Aliases for TCTA Gene

Aliases for TCTA Gene

  • T-Cell Leukemia Translocation Altered 2 3
  • T-Cell Leukemia Translocation-Associated Gene Protein 4
  • T-Cell Leukemia Translocation Altered Gene 2

External Ids for TCTA Gene

Previous GeneCards Identifiers for TCTA Gene

  • GC03M048875
  • GC03M048951
  • GC03P049304
  • GC03P049408
  • GC03P049424

Summaries for TCTA Gene

GeneCards Summary for TCTA Gene

TCTA (T-Cell Leukemia Translocation Altered) is a Protein Coding gene. Diseases associated with TCTA include t-cell leukemia and leukemia.

UniProtKB/Swiss-Prot for TCTA Gene

  • May be required for cellular fusion during osteoclastogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTA Gene

Genomics for TCTA Gene

Regulatory Elements for TCTA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TCTA Gene

49,412,206 bp from pter
49,416,476 bp from pter
4,271 bases
Plus strand

Genomic View for TCTA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTA Gene

Proteins for TCTA Gene

  • Protein details for TCTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell leukemia translocation-altered gene protein
    Protein Accession:
    Secondary Accessions:
    • B2R4I4
    • Q6I9U4
    • Q9BSB0

    Protein attributes for TCTA Gene

    103 amino acids
    Molecular mass:
    11341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCTA Gene

Proteomics data for TCTA Gene at MOPED

Post-translational modifications for TCTA Gene

  • Glycosylation at Asn77
  • Modification sites at PhosphoSitePlus

Other Protein References for TCTA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TCTA

No data available for DME Specific Peptides for TCTA Gene

Domains for TCTA Gene

Protein Domains for TCTA Gene


Suggested Antigen Peptide Sequences for TCTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCTA family.
  • Belongs to the TCTA family.
genes like me logo Genes that share domains with TCTA: view

No data available for Gene Families for TCTA Gene

Function for TCTA Gene

Molecular function for TCTA Gene

GENATLAS Biochemistry:
T cell leukemia translocation-associated gene,involved in t(1;3)(p34;p21);see SCL,TAL1
UniProtKB/Swiss-Prot Function:
May be required for cellular fusion during osteoclastogenesis.

Phenotypes for TCTA Gene

GenomeRNAi human phenotypes for TCTA:
genes like me logo Genes that share phenotypes with TCTA: view

Animal Model Products

miRNA for TCTA Gene

miRTarBase miRNAs that target TCTA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TCTA Gene

Localization for TCTA Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCTA Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TCTA Gene COMPARTMENTS Subcellular localization image for TCTA gene
Compartment Confidence
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TCTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TCTA: view

Pathways for TCTA Gene

SuperPathways for TCTA Gene

No Data Available

Interacting Proteins for TCTA Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: P57738-TCTA_HUMAN ENSP00000273590 for TCTA Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for TCTA Gene


No data available for Pathways by source for TCTA Gene

Transcripts for TCTA Gene

Unigene Clusters for TCTA Gene

T-cell leukemia translocation altered:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCTA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTA Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: -

Relevant External Links for TCTA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCTA Gene

mRNA expression in normal human tissues for TCTA Gene

SOURCE GeneReport for Unigene cluster for TCTA Gene Hs.517962

mRNA Expression by UniProt/SwissProt for TCTA Gene

Tissue specificity: Ubiquitous. Highest level of expression in kidney. Present in monocytes, osteoclasts, macrophages, synoviocytes and synovial lining cells (at protein level).
genes like me logo Genes that share expressions with TCTA: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for TCTA Gene

Orthologs for TCTA Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCTA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TCTA 35
  • 92.23 (n)
  • 94.17 (a)
  • 92 (a)
(Canis familiaris)
Mammalia TCTA 35
  • 90.85 (n)
  • 90.2 (a)
  • 76 (a)
(Mus musculus)
Mammalia Tcta 35
  • 89 (n)
  • 92.23 (a)
Tcta 16
Tcta 36
  • 77 (a)
(Pan troglodytes)
Mammalia TCTA 35
  • 100 (n)
  • 100 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Tcta 35
  • 89.97 (n)
  • 95.15 (a)
(Monodelphis domestica)
Mammalia TCTA 36
  • 74 (a)
(Anolis carolinensis)
Reptilia TCTA 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tcta 35
  • 57.76 (n)
  • 53.47 (a)
(Danio rerio)
Actinopterygii tcta 35
  • 58 (n)
  • 53 (a)
tcta 36
  • 52 (a)
Species with no ortholog for TCTA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCTA Gene

Gene Tree for TCTA (if available)
Gene Tree for TCTA (if available)

Paralogs for TCTA Gene

No data available for Paralogs for TCTA Gene

Variants for TCTA Gene

Sequence variations from dbSNP and Humsavar for TCTA Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs13459 -- 49,416,024(+) ATCTG(A/G)ACCTG utr-variant-3-prime
rs1127329 -- 49,415,354(+) ctact(A/G)aaaat utr-variant-3-prime
rs1996874 -- 49,416,072(-) GAGAA(A/G)ATGCT utr-variant-3-prime
rs7620024 -- 49,414,258(+) Aggcc(A/G)ggcat intron-variant
rs7628872 -- 49,414,385(+) AAAAA(C/T)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCTA Gene

Variant ID Type Subtype PubMed ID
nsv834687 CNV Loss 17160897

Relevant External Links for TCTA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTA Gene

Disorders for TCTA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TCTA Gene in MalaCards »

(2) Diseases for TCTA Gene


  • Note=A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21).

(1) University of Copenhagen DISEASES for TCTA Gene

Relevant External Links for TCTA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TCTA: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for TCTA Gene

Publications for TCTA Gene

  1. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. (PMID: 7728759) Aplan P.D. … Kirsch I.R. (Cancer Res. 1995) 2 3 4 23
  2. T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. (PMID: 19560569) Kotake S. … Yamanaka H. (Bone 2009) 3 4 23
  3. [Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]. (PMID: 20046013) Kotake S. … Nanke Y. (Nihon Rinsho Meneki Gakkai Kaishi 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for TCTA Gene

Sources for TCTA Gene

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