TCTA Gene
protein-coding GIFtS: 51
GCID: GC03P049424
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T-cell leukemia translocation altered(Previous name: T-cell leukemia translocation altered gene )
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Aliases
for TCTA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| T-Cell Leukemia Translocation Altered1 2 | | T-Cell Leukemia Translocation-Associated Gene Protein2 3 | | T-Cell Leukemia Translocation Altered Gene1 | | T-Cell Leukemia Translocation-Altered Gene Protein2 |
Export aliases for TCTA gene to outside databasesPrevious GC identifers: GC03M048875 GC03M048951 GC03P049304 GC03P049408 |
Summaries
for TCTA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738Function: May be required for cellular fusion during osteoclastogenesis
|
Genomic Views
for TCTA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCTA gene promoter:
c-Fos PPAR-gamma1 AP-1 PPAR-gamma2 STAT5A c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCTA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCTA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21TCTA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P049424: view genomic region
(about GC identifiers)
Start:
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49,449,639 bp from pter |
End:
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49,453,909 bp from pter |
Size:
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4,271 bases |
Orientation:
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plus strand |
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Proteins
for TCTA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738 (See
protein sequence)Recommended Name: T-cell leukemia translocation-altered gene protein Size: 103 amino acids; 11341 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R4I4 Q6I9U4 Q9BSB0Explore the universe of human proteins at neXtProt for TCTA: NX_P57738
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57738
TCTA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071503.1
ENSEMBL proteins: ENSP00000273590
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TCTA for ontologies About GeneDecksing
TCTA Antibody Products:
Assay Products for TCTA: |
Protein
Domains /
Families
for TCTA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCTA for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P57738ProtoNet protein and cluster: P57738 UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738Similarity: Belongs to the TCTA family |
Function
for TCTA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738Function: May be required for cellular fusion during osteoclastogenesis Genatlas biochemistry entry for TCTA:T cell leukemia translocation-associated gene,involved in t(1;3)(p34;p21);see SCL,TAL1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCTA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TCTA (NM_022171) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCTA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTA |
2 GenomeRNAi human phenotypes for TCTA:
|
Pathways & Interactions
for TCTA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCTA
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TCTA (P577382, 3 ENSP000002735904) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for TCTA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCTA
Search CenterWatch for drugs/clinical trials and news about TCTA
|
Transcripts
for TCTA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCTA gene: NM_022171.2 Unigene Cluster for TCTA: T-cell leukemia translocation altered Hs.517962 [show with all ESTs]Unigene Representative Sequence: NM_0221716 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000273590(uc003cwv.4) ENST00000488385 ENST00000487432 ENST00000482193
ENST00000493381 ENST00000497786
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCTA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TCTA (NM_022171) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCTA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTA |
Additional cDNA sequence: AK000824.1 AK311839.1 BC005157.1 CR457411.1 L41143.1 17 DOTS entries: DT.86854089 DT.100796463 DT.120904063 DT.120904407 DT.95299109 DT.120904676 DT.91711307 DT.95299128 DT.95145503 DT.95299112 DT.100761784 DT.120904394 DT.120904732 DT.91895384 DT.95199339 DT.100796475 DT.95340348 24/226 AceView cDNA sequences (see all 226): BI819504 CR613604 AI918097 AI810817 AL532805 BP372955 BE832276 AI242670 CF145274 AI096424 CB155880 NM_022171 BQ064815 CR620159 AI670829 BU500996 L41143 AI745473 CR624816 BU169802 BQ225079 BQ052556 BX280807 CD106685
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TCTA (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | · | 4c | · | 4d |
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| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TCTA
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Expression
for TCTA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCTA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACAATAGG
About this image
See TCTA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCTA
SOURCE GeneReport for Unigene cluster: Hs.517962
UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738Tissue specificity: Ubiquitous. Highest level of expression in kidney. Present in monocytes, osteoclasts, macrophages,synoviocytes and synovial lining cells (at protein level)
SABiosciences Custom PCR Arrays for TCTA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCTA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TCTA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCTA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCTA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTA |
Orthologs
for TCTA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TCTA gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for TCTA (if available)
TreeFam Gene Tree for TCTA (if available) |
Paralogs
for TCTA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TCTA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCTA (49449639 - 49453909 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCTA: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCTA |
|
Disorders
/ Diseases
for TCTA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCTA for disorders About GeneDecksing
OMIM gene information: 600690
OMIM disorders: --
UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738
Note=A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL).Translocation t(1;3)(p34;p21)
4  diseases for TCTA: About MalaCardst-cell leukemia leukemia acute lymphoblastic leukemia lymphoblastic leukemia
1 disease from the University of Copenhagen DISEASES database for TCTA:T-cell leukemia Human Genome Epidemiology (HuGE) Navigator: TCTA (4 documents)
Export disorders for TCTA gene to outside databases
|
Publications
for TCTA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TCTA gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with TCTA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. (PubMed id 7728759)1, 2, 3, 9 Aplan P.D.... Kirsch I.R. (1995)
- T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. (PubMed id 19560569)1, 2, 9 Kotake S....Yamanaka H. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- [Role of T-cell leukemia translocation-associated gen e (TCTA) protein in human osteoclastogenesis] (PubMed id 20046013)1, 9 Kotake S....Nanke Y. (2009)
- The role of T-cell leukemia translocation-associated g ene protein in human tumorigenesis and osteoclastogenesis. (PubMed id 22174563)1 Kotake S....Nanke Y. (2012)
- Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)1 Guey L.T....Malats N. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
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External Searches for TCTA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TCTA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCTA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCTA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TCTA gene:
Search GeneIP for patents involving TCTA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCTA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TCTA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCTA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCTA | | | OriGene Protein Over-expression Lysate for TCTA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TCTA | | OriGene 3'-UTR Clone for TCTA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCTA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCTA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TCTA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCTA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCTA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCTA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCTA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCTA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCTA |
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 | | | TCTA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCTA |
|  |  |  | | | | Search ThermoFisher Antibodies for TCTA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCTA |
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