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TCTA Gene

protein-coding GIFtS: 51

GC03P049424

T-cell leukemia translocation altered gene
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Descriptions
T-cell leukemia translocation altered ^²
T-cell leukemia translocation altered gene ^²
T-cell leukemia translocation-associated gene protein ^³

External Ids
HGNC: 11692¹
Entrez Gene: 6988²
UniProtKB: P57738³
Ensembl: ENSG00000145022⁷

Search outside databases for aliases for TCTA gene

Previous GC identifers: GC03M048875 GC03M048951 GC03P049304 GC03P049408

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TCTA gene

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

TCTA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P049424: (about GC identifiers)

Start:	49,424,643 bp from pter
End:	49,428,913 bp from pter
Size:	4,271 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738 (See protein sequence)

Recommended Name: T-cell leukemia translocation-altered gene protein

Size: 103 amino acids; 11341 Da

Secondary accessions: B2R4I4 Q6I9U4 Q9BSB0

REFSEQ proteins: NP_071503.1

ENSEMBL proteins:

ENSP00000273590

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (TCTA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for TCTA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TCTA
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for TCTA

Assays for TCTA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P57738

ProtoNet protein and cluster: P57738

UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738

Similarity: Belongs to the TCTA family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCTA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022171

Applied Biosystems Silencer® siRNAs for TCTA

Sigma-Aldrich siRNA for TCTA

Sigma-Aldrich shRNA for TCTA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TCTA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_022171
Myc/DDK tagged cDNA clone in CMV expression vector: NM_022171
untagged cDNA clone in CMV expression vector: NM_022171

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_022171

Genatlas biochemistry entry for TCTA:

T cell leukemia translocation-associated gene,involved in t(1;3)(p34;p21);see SCL,TAL1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Interacting proteins for TCTA (ENSP00000273590³ P57738²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD4	Q13485²	MINT-61966
VWF	ENSP00000261405³	STRING (score=.886)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TCTA

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCTA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022171

Sigma-Aldrich siRNA for TCTA

Sigma-Aldrich shRNA for TCTA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_022171

REFSEQ mRNAs for TCTA gene:

NM_022171.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_022171

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022171
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_022171
                                 untagged cDNA clone in CMV expression vector: NM_022171

Additional cDNA sequence:

AK000824.1 AK311839.1 BC005157.1 CR457411.1 CR601095.1 CR604395.1 CR608503.1 CR613604.1

CR620159.1 CR624816.1 L41143.1

18 DOTS entries:

DT.86854089 DT.100796463 DT.120904063 DT.120904407 DT.95299109 DT.120904676 DT.91711307 DT.95299128

DT.91895384 DT.95145503 DT.95299112 DT.95340348 DT.100761784 DT.120904394 DT.120904732 DT.91898202

DT.95199339 DT.100796475

24/226 AceView cDNA sequences (see all 226 ):

BM692818 BU169802 AL541279 AI992063 BE832276 AI096424 L41143 CD106685

BP345200 AL532805 AI810817 BP372955 CB155880 AI918097 CR604395 BQ064815

BX280807 AI242670 CR624816 BQ052556 AI670829 BU500996 CR613604 BP367948

highest scoring ESTs for TCTA:

L41143 AA029268 AA029862 AA039562 AA148963 AA148964 AA167614 AA181568 AA318700 AA573853

Unigene Cluster for TCTA:

T-cell leukemia translocation altered gene

Hs.517962 [show with all ESTs]

Unigene Representative Sequence: NM_022171

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TCTA (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	·	1h	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c	·	3d	·	3e	^	4a	·	4b	·	4c	·	4d
SP1:													-		-		-		-		-				-		-		-		-
SP2:													-		-		-		-						-		-		-		-
SP3:													-		-		-								-		-		-		-
SP4:																	-		-		-				-		-		-		-
SP5:													-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for TCTA

1 Ensembl transcript including schematic representation:

ENST00000273590

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TCTA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TCTA

¹ / ² / ³

3 probe-sets matching TCTA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33441_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L41143	1.00	1.00	1.00	1
203054_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022171	0.60	1.00	0.82	1
203054_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCACAATAGG

SOURCE GeneReport for Unigene cluster: Hs.517962
Expression variation in blood from EXPOLDB for TCTA
UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738
Tissue specificity: Ubiquitous. Highest level of expression in kidney

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TCTA gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TCTA¹	--	T-cell leukemia translocation altered gene	90.85(n) 90.2(a)	608826 XM_845960.1 XP_851053.1
chimpanzee (Pan troglodytes)	TCTA¹	--	T-cell leukemia translocation altered gene	100(n) 100(a)	460368 XM_516458.2 XP_516458.2
cow (Bos taurus)	TCTA¹	--	T-cell leukemia translocation altered gene	92.23(n) 94.17(a)	616169 NM_001034789.1 NP_001029961.1
rat (Rattus norvegicus)	Tcta¹	--	T-cell leukemia translocation altered gene	89.97(n) 95.15(a)	306587 NM_001014005.1 NP_001014027.1
mouse (Mus musculus)	Tcta^{1, 5}	9 (60.00 cM)⁵	T-cell leukemia translocation altered gene^{1, 5}	89(n)¹ 92.23(a)¹	102791¹ NM_133986.1¹ NP_598747.1¹ AK018669⁵ AK133663⁵ (see all 11)

About this table Species with no ortholog for TCTA

ENSEMBL Gene Tree for TCTA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

6 NCBI SNPs in TCTA are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1996874^1,2	C,F,H	49428509(-)	`GAGAAG/AATGCT`	1	--	ut3¹		4		EU EA WA	418
--	rs7638750^1,2	A,C	49427961(+)	`aaaaaA/TTTTTT`	1	--	ut3¹ trp³		0	--	--	--	--
--	rs1127329^1,2	--	49427791(+)	`ctactA/Gaaaat`	1	--	ut3¹		0	--	--	--	--
	rs13459^1,2	--	49428461(+)	`ATCTGG/AACCTG`	1	--	ut3¹		1		MN	184
--	rs11713737^1,2	--	49428304(+)	`ATTACC/TTGAAG`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs11713827^1,2	--	49428610(+)	`AGTACC/TTGAAA`	1	--	ut3¹		0	--	--	--	--

About this table
The following additional 24 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs1126422	rs2177268	rs13096474	rs6446272	rs8897	rs1464568	rs6997
rs6779432	rs1464569	rs1464566	rs10640	rs34812788	rs1803637	rs11922013
rs4855873	rs1464567	rs6779524	rs940045	rs4855874	rs1522929	rs6784820
rs4855877	rs11710609	rs9814873

HapMap Linkage Disequilibrium images for TCTA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600690

UniProtKB/Swiss-Prot: TCTA_HUMAN, P57738

A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic

leukemia (T-ALL). Translocation t(1;3)(p34;p21)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for TCTA gene:

Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. (PubMed id 7728759)^{1, 2, 3, 4} Aplan P.D.... Kirsch I.R. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)³ Colland F....Gauthier J.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)³ Venter J.C....Zhu X. (2001)
Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)³ Hillier L.D....Marra M. (1996)
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis. (PubMed id 18346269)¹ Lind G.E....Lothe R.A. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6988	HGNC: 11692	AceView: TCTA	Ensembl:ENSG00000145022	euGenes: HUgn6988
ECgene: TCTA	H-InvDB: TCTA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TCTA	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TCTA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TCTA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TCTA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TCTA		Antibodies for TCTA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TCTA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TCTA)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for TCTA

Search Tocris compounds for TCTA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for TCTA

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TCTA Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for TCTA

Summaries
for TCTA

Genomic Location
for TCTA

Proteins
for TCTA

Protein Domains/
Families
for TCTA

Gene Function
for TCTA

Pathways & Interactions
for TCTA

Drugs & Compounds
for TCTA

Transcripts
for TCTA

Expression
for TCTA

Orthologs
for TCTA

Paralogs
for TCTA

SNPs/Variants
for TCTA

Disorders & Mutations
for TCTA

Medical News
for TCTA

Publications
for TCTA

Search for TCTA

Genome Databases showing TCTA

Other Databases showing TCTA

Specialized Databases showing TCTA

Licensable Technologies
for TCTA

Services
for TCTA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TCTA Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor TCTA

Summariesfor TCTA

Genomic Locationfor TCTA

Proteinsfor TCTA

Protein Domains/Familiesfor TCTA

Gene Functionfor TCTA

Pathways & Interactionsfor TCTA

Drugs & Compoundsfor TCTA

Transcriptsfor TCTA

Expression for TCTA

Orthologsfor TCTA

Paralogsfor TCTA

SNPs/Variantsfor TCTA

Disorders & Mutationsfor TCTA

Medical Newsfor TCTA

Publicationsfor TCTA

Search for TCTA

Genome Databases showing TCTA

Other Databases showing TCTA

Specialized Databases showing TCTA

Licensable Technologiesfor TCTA

Servicesfor TCTA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TCTA

Summaries
for TCTA

Genomic Location
for TCTA

Proteins
for TCTA

Protein Domains/
Families
for TCTA

Gene Function
for TCTA

Pathways & Interactions
for TCTA

Drugs & Compounds
for TCTA

Transcripts
for TCTA

Expression
for TCTA

Orthologs
for TCTA

Paralogs
for TCTA

SNPs/Variants
for TCTA

Disorders & Mutations
for TCTA

Medical News
for TCTA

Publications
for TCTA

Licensable Technologies
for TCTA

Services
for TCTA