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TRG@ Gene

gene cluster GIFtS: 31

GC07M038248

T cell receptor gamma locus
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TCRG)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
TCRG ^²
TRG ^¹, ²

Descriptions
T cell receptor gamma locus ^²
T-cell antigen receptor, gamma polypeptide ^²
T-cell rearranging gene, gamma ^²
T-cell receptor, gamma cluster ^²

External Ids
HGNC: 12271¹
Entrez Gene: 6965²
UniProtKB: P03986³
Ensembl: ENSG00000211686⁷

Search outside databases for aliases for TRG@ gene

Previous GC identifers: GC07U990097 GC07M038247

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TRG@:

T cell receptors recognize foreign antigens which have been processed as small peptides and bound

to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells

(APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and

one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the

order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional

chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and

alpha loci. This region represents the germline organization of the T cell receptor gamma locus.

The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell

development, the gamma chain is synthesized by a recombination event at the DNA level joining a V

segment with a J segment; the C segment is later joined by splicing at the RNA level.

Recombination of many different V segments with several J segments provides a wide range of

antigen recognition. Additional diversity is attained by junctional diversity, resulting from the

random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the

gamma locus are known to be incapable of encoding a protein and are considered pseudogenes.

Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T

cell leukemia and ataxia telangiectasia. [provided by RefSeq]

Gene Wiki entry for TRG@

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14 Ensembl cytogenetic band: 7p14.1 HGNC cytogenetic band: 7p14

TRG@ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M038248: (about GC identifiers)

Start:	38,246,150 bp from pter
End:	38,374,181 bp from pter
Size:	128,032 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 38,317,305-38,445,327

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TCC_HUMAN, P03986 (See protein sequence)

Recommended Name: T-cell receptor gamma chain C region PT-gamma-1/2

Size: 189 amino acids; 21554 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

PDB structures from and Proteopedia :

1HXM (3D)

ENSEMBL proteins:

ENSP00000374860

Human Recombinant Proteins

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	Recombinant Proteins from Abcam (T Cell Receptor V gamma 3, TCR gamma + TCR delta, T Cell Receptor)
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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	NAS	3458221
GO:0016020	membrane	IEA	--

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Antibodies for TRG@:

	Invitrogen Antibodies for TRG@
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	Antibodies from Abcam (T Cell Receptor V gamma 3, TCR gamma + TCR delta, T Cell Receptor), each with their Abpromise^SM
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Assays for TRG@:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P03986

ProtoNet protein and cluster: P03986

1 Blocks protein family: IPB003597 Immunoglobulin C-type

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
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Applied Biosystems Silencer® siRNAs for TRG@

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Clones:		Browse Clone Ranger at Invitrogen for clones
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Browse Origene for untagged/tagged cDNA clones in CMV expression vector

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

Browse Origene genome-wide validated SYBR primer pairs

6 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Tcrg):

digestive/alimentary	hematopoietic system	immune system	no phenotypic analysis	normal
skin/coat/nails

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	NAS	3458221

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Interacting proteins for TRG@ (ENSP00000374860³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD4	ENSP00000011653³	STRING (score=.898)
IL2	ENSP00000226730³	STRING (score=.894)
IL2RA	ENSP00000369293³	STRING (score=.863)
CD8A	ENSP00000283635³	STRING (score=.847)
CD5	ENSP00000342681³	STRING (score=.772)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	NAS	3458221

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

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Browse Tocris compounds for TRG@
1 Novoseek chemical compound relationship for TRG@ gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
polyacrylamide	40.55	2	16404354 (1), 11407983 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

Browse Origene for 29mer shRNA kit in GFP-retroviral vector

Browse siRNA at Sigma-Aldrich

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Browse Origene for untagged/tagged cDNA clones in CMV expression vector

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000390332

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TRG@ expression in normal and diseased human tissues

Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: --

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TRG@ gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Tcrg⁵	13 (10.00 cM)	T-cell receptor gamma chain	--	X04699

About this table Species with no ortholog for TRG@

ENSEMBL Gene Tree for TRG@

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 186970

10/17 Novoseek disease relationships for TRG@ gene (see all 17 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
minimal residual disease	80.43	10	10914544 (2), 14687622 (2), 12970784 (1), 16247752 (1) (see all 7)
t-all	78.53	26	10914544 (8), 8289500 (3), 10025894 (2), 10516765 (2) (see all 10)
lymphoma t-cell peripheral	73.84	1	17431414 (1)
lymphoma t-cell	69.10	1	16266900 (1)
lymphoblastic leukemia acute	65.87	3	10025893 (1), 8289500 (1), 14687622 (1)
mycosis fungoides	54.72	3	15660892 (1), 18644018 (1), 8409516 (1)
leukemia	53.33	4	10613353 (2), 10865981 (1), 7992601 (1)
lymphoma	53.22	2	10890990 (1), 8199020 (1)
lymphoma t-cell cutaneous	50.67	1	7769255 (1)
lymphoid neoplasm	46.73	1	16266900 (1)

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Genetic Association Database: TRG@

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/129 PubMed articles for TRG@ gene (see all 129 ):

Structure of a human gammadelta T-cell antigen receptor. (PubMed id 11459064)^{3, 4} Allison T.J....Garboczi D.N. (2001)
Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions. (PubMed id 2526744)^{2, 3} Lefranc M.P....Lefranc G. (1989)
Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism. (PubMed id 3102973)^{2, 3} Littman D.R....Weiss A. (1987)
Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. (PubMed id 3458221)^{3, 4} Dialynas D.P.... Strominger J.L. (1986)
Physical map of an asthma susceptibility locus in 7p15-p14 and an association study of TCRG. (PubMed id 12357338)^{1, 6} Polvi A....Laitinen T. (2002)
Characterization of the androgen-regulated prostate-specific T cell receptor gamma-chain alternate reading frame protein (TARP) promoter. (PubMed id 12865322)^{1, 3} Cheng W.S....Essand M. (2003)
Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS. (PubMed id 18495780)³ Cummings J.S....Pauza C.D. (2008)
Altered cord blood gammadelta T cell repertoire in Nigeria: possible impacts of environmental factors on neonatal immunity. (PubMed id 18440637)³ Cairo C....Pauza C.D. (2008)
Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells. (PubMed id 18624305)³ Kistowska M....De Libero G. (2008)
T-cell receptor repertoire of circulating gamma delta T-cells in Takayasu's arteritis. (PubMed id 16307908)³ Chauhan S.K....Nityanand S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6965	HGNC: 12271	Ensembl:ENSG00000211686	euGenes: HUgn6965	ECgene: TRG@
H-InvDB: TRG@

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TRG@	Genetics and Cytogenetics in Oncology and Haematology
IMGT entry for TRG@	The international ImMunoGeneTics information system® specializing in Immunoglobulins (IG), T cell receptors (TR), Major Histocompatibility Complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrate species.

Licensable Technologies for TRG@
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TRG@:

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TRG@-related products

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TRG@ Gene at Home site.
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TRG@ Gene

gene cluster GIFtS: 31

Aliases &
Descriptions
for TRG@

Summaries
for TRG@

Genomic Location
for TRG@

Proteins
for TRG@

Protein Domains/
Families
for TRG@

Gene Function
for TRG@

Pathways & Interactions
for TRG@

Drugs & Compounds
for TRG@

Transcripts
for TRG@

Expression
for TRG@

Orthologs
for TRG@

Paralogs
for TRG@

SNPs/Variants
for TRG@

Disorders & Mutations
for TRG@

Medical News
for TRG@

Publications
for TRG@

Search for TRG@

Genome Databases showing TRG@

Other Databases showing TRG@

Specialized Databases showing TRG@

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TRG@ Gene

gene cluster GIFtS: 31

Aliases & Descriptionsfor TRG@

Summariesfor TRG@

Genomic Locationfor TRG@

Proteinsfor TRG@

Protein Domains/Familiesfor TRG@

Gene Functionfor TRG@

Pathways & Interactionsfor TRG@

Drugs & Compoundsfor TRG@

Transcriptsfor TRG@

Expression for TRG@

Orthologsfor TRG@

Paralogsfor TRG@

SNPs/Variantsfor TRG@

Disorders & Mutationsfor TRG@

Medical Newsfor TRG@

Publicationsfor TRG@

Search for TRG@

Genome Databases showing TRG@

Other Databases showing TRG@

Specialized Databases showing TRG@

Licensable Technologiesfor TRG@

Servicesfor TRG@

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TRG@

Summaries
for TRG@

Genomic Location
for TRG@

Proteins
for TRG@

Protein Domains/
Families
for TRG@

Gene Function
for TRG@

Pathways & Interactions
for TRG@

Drugs & Compounds
for TRG@

Transcripts
for TRG@

Expression
for TRG@

Orthologs
for TRG@

Paralogs
for TRG@

SNPs/Variants
for TRG@

Disorders & Mutations
for TRG@

Medical News
for TRG@

Publications
for TRG@

Licensable Technologies
for TRG@

Services
for TRG@