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TCP11X2 Gene

protein-coding   GIFtS: 18
GCID: GC0XM101632

T-Complex 11 Family, X-Linked 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Complex 11 Family, X-Linked 21 2
T-Complex Protein 11 Homolog2

External Ids:    HGNC: 483351   Entrez Gene: 1009966482   Ensembl: ENSG000002150297   UniProtKB: Q5H9J93   

Export aliases for TCP11X2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCP11X2 Gene:
TCP11X2 (t-complex 11 family, X-linked 2) is a protein-coding gene. Diseases associated with TCP11X2 include mental retardation. An important paralog of this gene is TCP11X1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for TCP11X2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TCP11X2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCP11X2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  Xq22.1   HGNC cytogenetic band: Xq22.1

TCP11X2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP11X2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM101632:  view genomic region     (about GC identifiers)

Start:
101,629,549 bp from pter      End:
101,726,732 bp from pter
Size:
97,184 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T11X2_HUMAN, Q5H9J9 (See protein sequence)
Recommended Name: T-complex protein 11 X-linked protein 2  
Size: 407 amino acids; 46373 Da

Explore the universe of human proteins at neXtProt for TCP11X2: NX_Q5H9J9

Explore proteomics data for TCP11X2 at MOPED


See TCP11X2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001264352.1  
ENSEMBL proteins: 
 ENSP00000404462   ENSP00000392879  

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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR008862 Tcp11

Graphical View of Domain Structure for InterPro Entry Q5H9J9

ProtoNet protein and cluster: Q5H9J9

UniProtKB/Swiss-Prot: T11X2_HUMAN, Q5H9J9
Similarity: Belongs to the TCP11 family


TCP11X2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCP11X2
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In Situ Assay
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TCP11X2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCP11X2
Interactions:

    Search GeneGlobe Interaction Network for TCP11X2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for TCP11X2 (ENSP000003928794) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
DNAJC2ENSP000003685654STRING: ENSP00000368565
HFM1ENSP000003594544STRING: ENSP00000359454
JADE1ENSP000002263194STRING: ENSP00000226319
JADE3ENSP000002183434STRING: ENSP00000218343
UFD1LENSP000002632024STRING: ENSP00000263202
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TCP11X2 (T11X2)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TCP11X2 gene: 
NM_001277423.1  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000429905(uc004ejc.1 uc011mro.1) ENST00000453326(uc004ejd.1)
ENST00000462555
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

TCP11X2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TCP11X2 Protein Expression
    Custom PCR Arrays for TCP11X2
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In Situ
Assay Products:
 

 
Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TCP11X2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11X2 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1700008I05Rik1 RIKEN cDNA 1700008I05 gene 75.58(n)
69.8(a)
  71841  NM_027952.3  NP_082228.2 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
38(a)
1 → many
26(4119241-4126835)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
37(a)
1 → many
4(120831421-120853376)
fruit fly
(Drosophila melanogaster)
Insecta CG167216
--
21(a)
1 → many
X(5773891-5777433)
worm
(Caenorhabditis elegans)
Secernentea M05D6.26
Protein M05D6.2 (M05D6.2) mRNA, complete cds
21(a)
1 → many
II(8468109-8470160) WBGene00010875
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK16
Protein whose overexpression suppresses the growth...
9(a)
1 → many
IV(458542-461247) YDR006C


ENSEMBL Gene Tree for TCP11X2 (if available)
TreeFam Gene Tree for TCP11X2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TCP11X2 gene
TCP11X12  TCP11L12  TCP11L22  TCP112  
4 SIMAP similar genes for TCP11X2 using alignment to 2 protein entries:     T11X2_HUMAN (see all proteins):
TCP11X1    TCP11    TCP11L2    TCP11L1

TCP11X2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TCP11X2 (see all 48)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs560397261,2
C--91382429(-) TGGCTA/GATGCT 3 -- int10--------
rs37524451,2
C--91383395(-) CAAGGC/TTACCT 7 G syn1 int10--------
rs37524441,2
C--91383465(-) CATGGC/TGTGTT 8 A V mis10--------
rs2016784961,2
--91387655(-) GATAA-/TTGACA 4 -- int10--------
rs558997251,2
C--91393424(-) ATGTAC/TAATT 3 -- us2k10--------
rs562163591,2
C--101685530(+) TAATAC/TCCCTG 1 -- ds50010--------
rs6527591,2
C,F--101685636(-) AAAATG/CAGTCA 1 -- ds50013Minor allele frequency- C:0.50NA WA 4
rs1137439751,2
C--101686909(+) CCGTAA/GGGAGA 1 -- int10--------
rs4936891,2
C--101687419(+) CTGTAC/ACTTAA 1 -- int15Minor allele frequency- A:0.00NA EA WA 255
rs1125396941,2
C--101688688(-) TCTGAA/GAGAAC 2 K R mis10--------

HapMap Linkage Disequilibrium report for TCP11X2 (101629549 - 101726732 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TCP11X2: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TCP11X2
DNA2.0 Custom Variant and Variant Library Synthesis for TCP11X2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for TCP11X2:    About MalaCards
mental retardation


TCP11X2 for disorders           About GeneDecksing


Export disorders for TCP11X2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TCP11X2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TCP11X2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (Nature 2005)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. (PubMed id 11566096)1 Jun L.... Froyen G. (Curr. Biol. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100996648 HGNC: 48335 Ensembl:ENSG00000215029 euGenes: HUgn100996648 ECgene: TCP11X2
H-InvDB: TCP11X2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TCP11X2 gene:
Search GeneIP for patents involving TCP11X2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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