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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCP11L2 Gene

protein-coding   GIFtS: 44
GCID: GC12P106702

T-Complex 11, Testis-Specific-Like 2

(Previous names: t-complex 11 (mouse) like 2, t-complex 11 (mouse)-like 2)
  Search for TCP11L2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Complex 11, Testis-Specific-Like 21 2
T-Complex 11 (Mouse) Like 21
T-Complex 11 (Mouse)-Like 21
T-Complex 11-Like 22
T-Complex Protein 11-Like Protein 22

External Ids:    HGNC: 286271   Entrez Gene: 2553942   Ensembl: ENSG000001660467   UniProtKB: Q8N4U53   

Export aliases for TCP11L2 gene to outside databases

Previous GC identifers: GC12P105200 GC12P106696 GC12P103756 GC12P106698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCP11L2 Gene: 
TCP11L2 (t-complex 11, testis-specific-like 2) is a protein-coding gene. An important paralog of this gene is TCP11X1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCP11L2 gene promoter:
         NF-1   NF-1/L   Nkx2-5   Nkx5-1   AREB6   POU2F1   POU2F1a   FOXO1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCP11L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCP11L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP11L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

TCP11L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP11L2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P106702:  view genomic region     (about GC identifiers)

Start:
106,695,707 bp from pter      End:
106,740,793 bp from pter
Size:
45,087 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T11L2_HUMAN, Q8N4U5 (See protein sequence)
Recommended Name: T-complex protein 11-like protein 2  
Size: 519 amino acids; 58091 Da

Explore the universe of human proteins at neXtProt for TCP11L2: NX_Q8N4U5

Explore proteomics data for TCP11L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N4U5

  • TCP11L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCP11L2 Protein Expression
    REFSEQ proteins: NP_689985.1  
    ENSEMBL proteins: 
     ENSP00000447416   ENSP00000448952   ENSP00000299045   ENSP00000449123   ENSP00000448629  
     ENSP00000448064   ENSP00000447174   ENSP00000447457   ENSP00000449844  

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    Novus Biologicals TCP11L2 Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for TCP11L2 


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    LSBio Antibodies in human, mouse, rat for TCP11L2 

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    Cloud-Clone Corp. ELISAs for TCP11L2 
    Cloud-Clone Corp. CLIAs for TCP11L2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008862 Tcp11

    Graphical View of Domain Structure for InterPro Entry Q8N4U5

    ProtoNet protein and cluster: Q8N4U5

    UniProtKB/Swiss-Prot: T11L2_HUMAN, Q8N4U5
    Similarity: Belongs to the TCP11 family


    TCP11L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for TCP11L2:
     Decreased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCP11L2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCP11L2 
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    SwitchGear 3'UTR luciferase reporter plasmidTCP11L2 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for TCP11L2
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                         Customized lentivirus expression plasmids for stable overexpression of TCP11L2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCP11L2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCP11L2 (T11L2)

    Search CenterWatch for drugs/clinical trials and news about TCP11L2 / T11L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCP11L2 gene: 
    NM_152772.1  

    Unigene Cluster for TCP11L2:

    T-complex 11, testis-specific-like 2
    Hs.696047  [show with all ESTs]
    Unigene Representative Sequence: AF306858
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553143 ENST00000547153(uc001tlm.3) ENST00000299045(uc001tln.3)
    ENST00000546625(uc001tll.3) ENST00000553098 ENST00000549906 ENST00000551802
    ENST00000548428(uc001tlo.1) ENST00000551228 ENST00000552690
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCP11L2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TCP11L2:
    hsa-miR-3658 hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidTCP11L2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TCP11L2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP11L2
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    OriGene clones in human, mouse for TCP11L2 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: TCP11L2 (NM_152772)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCP11L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP11L2
    Sirion Biotech Customized lentivirus for stable overexpression of TCP11L2 
                         Customized lentivirus expression plasmids for stable overexpression of TCP11L2 
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    OriGene qPCR primer pairs and template standards for TCP11L2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP11L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP11L2

    Additional mRNA sequence: 

    AF306671.1 AF306673.1 AF306858.1 AK314055.1 BC017872.1 BC033617.1 

    6 DOTS entries:

    DT.75190745  DT.40129099  DT.100020168  DT.92039012  DT.91649200  DT.91956855 

    24/42 AceView cDNA sequences (see all 42):

    AL534373 NM_152772 BC033617 CR607890 AV724671 AI040691 BX099838 CB164782 
    AI040771 AF306673 BU657756 BM955989 BM083639 BX389653 BX398167 BI022651 
    AF306672 AI088346 BP371450 CB955581 BC017872 AF306858 BX501162 BF589371 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -     -     -     -     -                 -                                               -     -                           
    SP2:                    -     -     -     -     -                 -                                                                                 
    SP3:                    -     -     -           -                 -                                                                                 
    SP4:                                                                                                              -                                 
    SP5:                    -     -     -     -     -                                                                                                   


    ECgene alternative splicing isoforms for TCP11L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCP11L2 expression in normal human tissues (normalized intensities)      TCP11L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAAACCCC
    TCP11L2 Expression
    About this image


    TCP11L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             neutrophils   
     
     Bone (Muscoskeletal System)
             Stylopod Long Bone
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Oral Cavity (Gastrointestinal Tract)
             gingival epithelium   
     
     Limb (Muscoskeletal System)
             Autopod

    See TCP11L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCP11L2

    SOURCE GeneReport for Unigene cluster: Hs.696047
        SABiosciences Custom PCR Arrays for TCP11L2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TCP11L2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcp11l21 , 5 t-complex 11 (mouse) like 21, 5 83.43(n)1
    79.11(a)1
      10 (41.55 cM)5
    2161981  NM_146008.21  NP_666120.11 
     845766265 
    chicken
    (Gallus gallus)
    Aves TCP11L21 t-complex 11 (mouse)-like 2 72.79(n)
    72.92(a)
      425052  NM_001001897.1  NP_001001897.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCP11L26
    Uncharacterized protein
    70(a)
    1 ↔ 1
    5(19151951-19164318)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.200842 Xenopus laevis transcribed sequence with weak similarity more 73.41(n)    BJ056997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC063323.12   -- 73.94(n)    BC063323.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG167216
    --
    30(a)
    1 → many
    X(5773891-5777433)
    worm
    (Caenorhabditis elegans)
    Secernentea M05D6.26
    Protein M05D6.2
    23(a)
    1 → many
    II(8468105-8470160)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SOK1(YDR006C)4 Protein whose overexpression suppresses the growth more   --   4(461247-458542) 851569  NP_010289.1 


    ENSEMBL Gene Tree for TCP11L2 (if available)
    TreeFam Gene Tree for TCP11L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCP11L2 gene
    TCP11X12  TCP11L12  TCP11X22  TCP112  
    4 SIMAP similar genes for TCP11L2 using alignment to 9 protein entries:     T11L2_HUMAN (see all proteins):
    LL0XNC01-19D8.1    TCP11    TCP11L1    LOC100996648

    TCP11L2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/970 SNPs in TCP11L2 are shown (see all 970)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1455251191,2
    C--106546983(+) tttcc-/ATTttttt 1 -- int10--------
    rs348677301,2
    C--106548490(+) TTTAA-/TTTTTT 1 -- int10--------
    rs781462571,2
    C,F--106694623(+) CTTTAG/AAAGAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1886868711,2
    C--106694665(+) TCCAGG/TATAAA 1 -- us2k10--------
    rs1181633731,2
    C,F--106694698(+) TCACCT/CGCTCC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1808448591,2
    --106694731(+) AATACC/TTAAAT 1 -- us2k10--------
    rs79768461,2
    C--106694773(+) CCATGC/TGTCAT 1 -- us2k10--------
    rs766579921,2
    C,F--106694820(+) GTTCAT/CCTTTC 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs1172140031,2
    F--106694831(+) TATTGT/CGGAGT 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1153666941,2
    F--106694903(+) CTTCTG/ATCATT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for TCP11L2 (106695707 - 106740793 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCP11L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2746336CNV Deletion23290073
    esv2746335CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TCP11L2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCP11L2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TCP11L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of Tourette's syndrome. (PubMed id 22889924)1 Scharf J.M.... D.L. (2012)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255394 HGNC: 28627 AceView: MGC40368 Ensembl:ENSG00000166046 euGenes: HUgn255394
    ECgene: TCP11L2 H-InvDB: TCP11L2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCP11L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCP11L2 gene:
    Search GeneIP for patents involving TCP11L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for TCP11L2
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP11L2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TCP11L2
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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