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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCP11L2 Gene

protein-coding GIFtS: 41
GCID: GC12P106698

t-complex 11, testis-specific-like 2

(Previous names: t-complex 11 (mouse) like 2, t-complex 11 (mouse)-like...)

Search for TCP11L2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T-Complex 11, Testis-Specific-Like 2¹ ²
MGC40368¹
T-Complex 11 (Mouse) Like 2¹
T-Complex 11 (Mouse)-Like 2¹
T-Complex 11-Like 2²
T-Complex Protein 11-Like Protein 2²

External Ids:	HGNC: 28627¹	Entrez Gene: 255394²	Ensembl: ENSG00000166046⁷	UniProtKB: Q8N4U5³

Export aliases for TCP11L2 gene to outside databases

Previous GC identifers: GC12P105200 GC12P106696 GC12P103756

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCP11L2 gene promoter:
NF-1 NF-1/L Nkx2-5 Nkx5-1 AREB6 POU2F1 POU2F1a FOXO1a Pax-4a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCP11L2 promoter sequence

Search SABiosciences Chromatin IP Primers for TCP11L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP11L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3

TCP11L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP11L2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P106698: view genomic region (about GC identifiers)

Start:	106,695,707 bp from pter	End:	106,740,793 bp from pter
Size:	45,087 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T11L2_HUMAN, Q8N4U5 (See protein sequence)

Recommended Name: T-complex protein 11-like protein 2

Size: 519 amino acids; 58091 Da

Explore the universe of human proteins at neXtProt for TCP11L2: NX_Q8N4U5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N4U5

TCP11L2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689985.1

ENSEMBL proteins:

ENSP00000447416 ENSP00000448952 ENSP00000299045 ENSP00000449123 ENSP00000448629

ENSP00000448064 ENSP00000447174 ENSP00000447457 ENSP00000449844

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCP11L2 for domains About GeneDecksing

1 InterPro domain/family:

IPR008862 Tcp11

Graphical View of Domain Structure for InterPro Entry Q8N4U5

ProtoNet protein and cluster: Q8N4U5

UniProtKB/Swiss-Prot: T11L2_HUMAN, Q8N4U5

Similarity: Belongs to the TCP11 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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1 GenomeRNAi human phenotype for TCP11L2:

Decreased number of cells in m

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCP11L2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCP11L2
Search CenterWatch for drugs/clinical trials and news about TCP11L2 / T11L2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TCP11L2 gene:

NM_152772.1

Unigene Cluster for TCP11L2:

T-complex 11, testis-specific-like 2

Hs.696047 [show with all ESTs]

Unigene Representative Sequence: AF306858

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000553143 ENST00000547153(uc001tlm.3) ENST00000299045(uc001tln.3)

ENST00000546625(uc001tll.3) ENST00000553098 ENST00000549906 ENST00000551802

ENST00000548428(uc001tlo.1) ENST00000551228 ENST00000552690

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Additional cDNA sequence:

AF306671.1 AF306673.1 AF306858.1 AK314055.1 BC017872.1 BC033617.1

6 DOTS entries:

DT.75190745 DT.40129099 DT.100020168 DT.92039012 DT.91649200 DT.91956855

24/42 AceView cDNA sequences (see all 42):

AV724671 CR607890 BX099838 NM_152772 AL534373 BC033617 AI040691 CB164782

AI040771 AF306673 BX501162 AI088346 BX389654 BI022651 BU663336 BP371450

BX389653 BE646441 BF589371 BX398167 AF306671 AF306858 BU657756 CB955581

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L2 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15
SP1:							-		-		-		-		-						-																-		-
SP2:							-		-		-		-		-						-
SP3:							-		-		-				-						-
SP4:																																					-
SP5:							-		-		-		-		-

ECgene alternative splicing isoforms for TCP11L2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCP11L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAAACCCC

About this image

TCP11L2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Bone

Limb

Liver

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See TCP11L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCP11L2

SOURCE GeneReport for Unigene cluster: Hs.696047

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCP11L2 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tcp11l2^{1 , 5}	t-complex 11 (mouse) like 2^{1, 5}	83.43(n)¹ 79.11(a)¹		10 (41.55 cM)⁵ 216198¹ NM_146008.2¹ NP_666120.1¹ 84576626⁵
chicken (Gallus gallus)	Aves	TCP11L2¹	t-complex 11 (mouse)-like 2	72.79(n) 72.92(a)		425052 NM_001001897.1 NP_001001897.1
lizard (Anolis carolinensis)	Reptilia	TCP11L2⁶	--	70(a)	1 ↔ 1	5(19151951-19159727)
African clawed frog (Xenopus laevis)	Amphibia	Xl.20084²	Xenopus laevis transcribed sequence with weak similarity more	73.41(n)		BJ056997.1
zebrafish (Danio rerio)	Actinopterygii	BC063323.1²	--	73.94(n)		BC063323.1
fruit fly (Drosophila melanogaster)	Insecta	CG16721⁶	--	29(a)	1 → many	X(5773891-5777433)
worm (Caenorhabditis elegans)	Secernentea	M05D6.2⁶	--	21(a)	1 → many	II(8468054-8470109)

ENSEMBL Gene Tree for TCP11L2 (if available)
TreeFam Gene Tree for TCP11L2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCP11L2 gene

TCP11L1² LOC100996648² TCP11²

4 SIMAP similar genes for TCP11L2 using alignment to 9 protein entries: T11L2_HUMAN (see all proteins):

TCP11 LL0XNC01-19D8.1 TCP11L1 LOC100996648

TCP11L2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78146257^1,2	C,	--	106694623(+)	`CTTTAG/AAAGAA`	1	--	us2k¹		1		WA	2
rs188686871^1,2		--	106694665(+)	`TCCAGG/TATAAA`	1	--	us2k¹		0	--	--	--	--
rs118163373^1,2		--	106694698(+)	`TCACCT/CGCTCC`	1	--	us2k¹		1		NA	120
rs180844859^1,2		--	106694731(+)	`AATACC/TTAAAT`	1	--	us2k¹		0	--	--	--	--
rs7976846^1,2	C,	--	106694773(+)	`CCATGC/TGTCAT`	1	--	us2k¹		0	--	--	--	--
rs76657992^1,2	F,	--	106694820(+)	`GTTCAT/CCTTTC`	1	--	us2k¹		1		WA	118
rs117214003^1,2		--	106694831(+)	`TATTGT/CGGAGT`	1	--	us2k¹		1		NA	120
rs115366694^1,2	F,	--	106694903(+)	`CTTCTG/ATCATT`	1	--	us2k¹		1		WA	118
rs12315284^1,2		--	106694911(+)	`ATTCTC/GATTAC`	1	--	us2k¹		0	--	--	--	--
rs7964870^1,2	C,A,	--	106694974(+)	`GGGGAC/TAGCAC`	1	--	us2k¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for TCP11L2 (106695707 - 106740793 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCP11L2: --

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for TCP11L2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCP11L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCP11L2)

Utopia: connect your pdf to the dynamic
world of online information

Genome-wide association study of Tourette's syndrome. (PubMed id 22889924)¹ Scharf J.M.... D.L. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 255394	HGNC: 28627	AceView: MGC40368	Ensembl:ENSG00000166046	euGenes: HUgn255394
ECgene: TCP11L2	H-InvDB: TCP11L2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCP11L2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCP11L2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCP11L2 gene:
Search GeneIP for patents involving TCP11L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TCP11L2 gene at Home site.

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TCP11L2 Gene

t-complex 11, testis-specific-like 2

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TCP11L2 Gene

t-complex 11, testis-specific-like 2

Aliasesfor TCP11L2 gene

Summariesfor TCP11L2 gene

Genomic Viewsfor TCP11L2 gene

Proteinsfor TCP11L2 gene

Protein Domains /Familiesfor TCP11L2 gene

Functionfor TCP11L2 gene

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Expression for TCP11L2 gene

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Genome Databases showing TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

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for TCP11L2 gene

Intellectual Property
for TCP11L2 gene

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for TCP11L2 gene