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Aliases for TCP11L2 Gene

Aliases for TCP11L2 Gene

  • T-Complex 11 Like 2 2 3
  • T-Complex 11, Testis-Specific-Like 2 2 5
  • T-Complex 11 (Mouse) Like 2 2
  • T-Complex 11 (Mouse)-Like 2 2

External Ids for TCP11L2 Gene

Previous GeneCards Identifiers for TCP11L2 Gene

  • GC12P105200
  • GC12P106696
  • GC12P103756
  • GC12P106698
  • GC12P106702
  • GC12P106705

Summaries for TCP11L2 Gene

GeneCards Summary for TCP11L2 Gene

TCP11L2 (T-Complex 11 Like 2) is a Protein Coding gene. An important paralog of this gene is TCP11X2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP11L2 Gene

Genomics for TCP11L2 Gene

Regulatory Elements for TCP11L2 Gene

Promoters for TCP11L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCP11L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP11L2 Gene

Chromosome:
12
Start:
106,301,929 bp from pter
End:
106,347,587 bp from pter
Size:
45,659 bases
Orientation:
Plus strand

Genomic View for TCP11L2 Gene

Genes around TCP11L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP11L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP11L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP11L2 Gene

Proteins for TCP11L2 Gene

  • Protein details for TCP11L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4U5-T11L2_HUMAN
    Recommended name:
    T-complex protein 11-like protein 2
    Protein Accession:
    Q8N4U5
    Secondary Accessions:
    • B2RA65
    • G3V1Y9

    Protein attributes for TCP11L2 Gene

    Size:
    519 amino acids
    Molecular mass:
    58091 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCP11L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCP11L2 Gene

Proteomics data for TCP11L2 Gene at MOPED

Post-translational modifications for TCP11L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP11L2 Gene

Domains & Families for TCP11L2 Gene

Protein Domains for TCP11L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP11L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4U5

UniProtKB/Swiss-Prot:

T11L2_HUMAN :
  • Belongs to the TCP11 family.
Family:
  • Belongs to the TCP11 family.
genes like me logo Genes that share domains with TCP11L2: view

No data available for Gene Families for TCP11L2 Gene

Function for TCP11L2 Gene

genes like me logo Genes that share phenotypes with TCP11L2: view

Animal Model Products

CRISPR Products

miRNA for TCP11L2 Gene

miRTarBase miRNAs that target TCP11L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP11L2 Gene

Localization for TCP11L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCP11L2 Gene COMPARTMENTS Subcellular localization image for TCP11L2 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCP11L2 Gene

Pathways & Interactions for TCP11L2 Gene

SuperPathways for TCP11L2 Gene

No Data Available

Interacting Proteins for TCP11L2 Gene

Gene Ontology (GO) - Biological Process for TCP11L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP11L2 Gene

Drugs & Compounds for TCP11L2 Gene

No Compound Related Data Available

Transcripts for TCP11L2 Gene

Unigene Clusters for TCP11L2 Gene

T-complex 11, testis-specific-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8: - -

Relevant External Links for TCP11L2 Gene

GeneLoc Exon Structure for
TCP11L2
ECgene alternative splicing isoforms for
TCP11L2

Expression for TCP11L2 Gene

mRNA expression in normal human tissues for TCP11L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCP11L2 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for TCP11L2 Gene

This gene is overexpressed in Hair follicle (56.6) and Cervix (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCP11L2 Gene



SOURCE GeneReport for Unigene cluster for TCP11L2 Gene Hs.696047

genes like me logo Genes that share expression patterns with TCP11L2: view

Protein tissue co-expression partners for TCP11L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TCP11L2 Gene

Orthologs for TCP11L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCP11L2 35
  • 89.66 (n)
  • 90.94 (a)
TCP11L2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCP11L2 35
  • 92.3 (n)
  • 92.82 (a)
TCP11L2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcp11l2 35
  • 83.43 (n)
  • 79.11 (a)
Tcp11l2 16
Tcp11l2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCP11L2 35
  • 99.36 (n)
  • 99.04 (a)
TCP11L2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcp11l2 35
  • 83.17 (n)
  • 79.5 (a)
oppossum
(Monodelphis domestica)
Mammalia TCP11L2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCP11L2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCP11L2 35
  • 72.83 (n)
  • 72.83 (a)
TCP11L2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCP11L2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3807 35
tcp11l2 35
  • 63.87 (n)
  • 59.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.20084 35
zebrafish
(Danio rerio)
Actinopterygii tcp11l2 35
  • 59.12 (n)
  • 53.19 (a)
tcp11l2 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16721 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M05D6.2 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK1 36
  • 12 (a)
OneToMany
SOK1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for TCP11L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCP11L2 Gene

ENSEMBL:
Gene Tree for TCP11L2 (if available)
TreeFam:
Gene Tree for TCP11L2 (if available)

Paralogs for TCP11L2 Gene

Paralogs for TCP11L2 Gene

genes like me logo Genes that share paralogs with TCP11L2: view

Variants for TCP11L2 Gene

Sequence variations from dbSNP and Humsavar for TCP11L2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4964460 - 106,311,196(+) GCTTT(A/G)CAAGT reference, missense, utr-variant-5-prime
rs11837375 - 106,314,444(+) AGATT(G/T)CTGTA reference, missense
rs17218950 - 106,335,647(+) CTCTT(A/G)ATCAG downstream-variant-500B, reference, missense
rs904614 -- 106,304,556(+) TCTGC(A/C)ATTTT intron-variant
rs1134577 -- 106,331,060(-) TTAAA(A/G)ACAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP11L2 Gene

Variant ID Type Subtype PubMed ID
esv2746335 CNV Deletion 23290073
esv2746336 CNV Deletion 23290073

Variation tolerance for TCP11L2 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP11L2 Gene

HapMap Linkage Disequilibrium report
TCP11L2
Human Gene Mutation Database (HGMD)
TCP11L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP11L2 Gene

Disorders for TCP11L2 Gene

Relevant External Links for TCP11L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP11L2

No disorders were found for TCP11L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP11L2 Gene

Publications for TCP11L2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Genome-wide association study of Tourette's syndrome. (PMID: 22889924) Scharf J.M. … Pauls D.L. (Mol. Psychiatry 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TCP11L2 Gene

Sources for TCP11L2 Gene

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