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Aliases for TCP11L1 Gene

Aliases for TCP11L1 Gene

  • T-Complex 11 Like 1 2 3 5
  • T-Complex 11, Testis-Specific-Like 1 2 3
  • T-Complex Protein 11-Like Protein 1 3
  • T-Complex 11 (Mouse) Like 1 2
  • DJ85M6.3 3

External Ids for TCP11L1 Gene

Previous GeneCards Identifiers for TCP11L1 Gene

  • GC11P032755

Summaries for TCP11L1 Gene

GeneCards Summary for TCP11L1 Gene

TCP11L1 (T-Complex 11 Like 1) is a Protein Coding gene. An important paralog of this gene is TCP11L2.

Additional gene information for TCP11L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP11L1 Gene

Genomics for TCP11L1 Gene

Regulatory Elements for TCP11L1 Gene

Enhancers for TCP11L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H033059 1.1 Ensembl ENCODE 36.5 +23.1 23095 5.3 BMI1 BATF THRB RAD21 RARA YY1 ZSCAN5C ATF7 RCOR1 FOS TCP11L1 PIGCP1 LINC00294
GH11H033038 1.1 ENCODE 26.5 +0.8 770 3.1 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 CBX5 ZNF143 ZNF207 TCP11L1 PIGCP1 LINC00294
GH11H033043 1.1 Ensembl ENCODE 26.2 +5.5 5484 3.6 TBP SIN3A FEZF1 BRCA1 RFX5 ZNF366 RCOR1 KLF7 FOS CEBPB TCP11L1 PIGCP1 DEPDC7 LINC00294
GH11H033178 1.1 FANTOM5 Ensembl ENCODE 25.9 +139.5 139483 1.7 ZFHX2 NFIC POLR2A L3MBTL2 SOX6 ATF2 MGA TCP11L1 HIPK3 CSTF3 GC11M033171 ENSG00000206808 GC11M033190
GH11H033048 0.8 Ensembl ENCODE 27.2 +10.2 10210 1.7 SOX13 FOXA2 POLR3A NR3C1 TCP11L1 FBXO3 CSTF3 LINC00294
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCP11L1 on UCSC Golden Path with GeneCards custom track

Promoters for TCP11L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000038490 184 2000 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF143 ZNF207

Genomic Locations for TCP11L1 Gene

Genomic Locations for TCP11L1 Gene
66,527 bases
Plus strand

Genomic View for TCP11L1 Gene

Genes around TCP11L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP11L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP11L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP11L1 Gene

Proteins for TCP11L1 Gene

  • Protein details for TCP11L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 11-like protein 1
    Protein Accession:
    Secondary Accessions:
    • D3DR01
    • Q8IVX4

    Protein attributes for TCP11L1 Gene

    509 amino acids
    Molecular mass:
    57035 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCP11L1 Gene

Post-translational modifications for TCP11L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP11L1 Gene

Domains & Families for TCP11L1 Gene

Gene Families for TCP11L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCP11L1 Gene


Suggested Antigen Peptide Sequences for TCP11L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP11 family.
  • Belongs to the TCP11 family.
genes like me logo Genes that share domains with TCP11L1: view

Function for TCP11L1 Gene

Phenotypes From GWAS Catalog for TCP11L1 Gene

genes like me logo Genes that share phenotypes with TCP11L1: view

Animal Model Products

CRISPR Products

miRNA for TCP11L1 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP11L1 Gene

Localization for TCP11L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP11L1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
golgi apparatus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCP11L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IDA 21525035
genes like me logo Genes that share ontologies with TCP11L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCP11L1 Gene

Pathways & Interactions for TCP11L1 Gene

SuperPathways for TCP11L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP11L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TCP11L1 Gene

Drugs & Compounds for TCP11L1 Gene

No Compound Related Data Available

Transcripts for TCP11L1 Gene

Unigene Clusters for TCP11L1 Gene

T-complex 11, testis-specific-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - - - - - -
SP5: - - -

Relevant External Links for TCP11L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCP11L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP11L1 Gene

Protein differential expression in normal tissues from HIPED for TCP11L1 Gene

This gene is overexpressed in Bone (37.8) and Frontal cortex (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCP11L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCP11L1 Gene:


SOURCE GeneReport for Unigene cluster for TCP11L1 Gene:


Evidence on tissue expression from TISSUES for TCP11L1 Gene

  • Blood(4.1)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with TCP11L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP11L1 Gene

Orthologs for TCP11L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCP11L1 33 34
  • 99.48 (n)
(Canis familiaris)
Mammalia TCP11L1 33 34
  • 89.99 (n)
(Bos Taurus)
Mammalia TCP11L1 33 34
  • 87.43 (n)
(Mus musculus)
Mammalia Tcp11l1 33 16 34
  • 85.33 (n)
(Rattus norvegicus)
Mammalia Tcp11l1 33
  • 84.41 (n)
(Ornithorhynchus anatinus)
Mammalia TCP11L1 34
  • 71 (a)
(Monodelphis domestica)
Mammalia TCP11L1 34
  • 62 (a)
(Gallus gallus)
Aves TCP11L1 33 34
  • 69.11 (n)
(Anolis carolinensis)
Reptilia TCP11L1 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp11l1 33
  • 63.29 (n)
(Danio rerio)
Actinopterygii tcp11l1 33 34
  • 58.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16721 33 34
  • 45.55 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000633 33
  • 44.24 (n)
(Caenorhabditis elegans)
Secernentea CELE_M05D6.2 33
  • 44.09 (n)
M05D6.2 34
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK1 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
Species where no ortholog for TCP11L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCP11L1 Gene

Gene Tree for TCP11L1 (if available)
Gene Tree for TCP11L1 (if available)

Paralogs for TCP11L1 Gene

Paralogs for TCP11L1 Gene

genes like me logo Genes that share paralogs with TCP11L1: view

Variants for TCP11L1 Gene

Sequence variations from dbSNP and Humsavar for TCP11L1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000066821 -- 33,051,333(+) CGGCT(A/G)ATTTT intron-variant
rs1000141753 -- 33,040,111(+) GCCCC(C/T)TTTTT intron-variant, utr-variant-5-prime
rs1000212540 -- 33,039,277(+) GAGCC(A/G)CCGCC upstream-variant-2KB
rs1000486041 -- 33,061,079(+) GCCTC(C/T)CAGCT intron-variant
rs1000486281 -- 33,068,096(+) GTATT(C/T)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP11L1 Gene

Variant ID Type Subtype PubMed ID
nsv521130 CNV gain 19592680
nsv467786 CNV gain 19166990
nsv1040484 CNV gain 25217958
esv3579467 CNV loss 25503493
esv2762904 CNV gain 21179565
esv2658399 CNV deletion 23128226
dgv1742n54 CNV gain 21841781
dgv1093n100 CNV gain 25217958

Variation tolerance for TCP11L1 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP11L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP11L1 Gene

Disorders for TCP11L1 Gene

Relevant External Links for TCP11L1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TCP11L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP11L1 Gene

Publications for TCP11L1 Gene

  1. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K … National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) (The Journal of infectious diseases 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 60

Products for TCP11L1 Gene

Sources for TCP11L1 Gene

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