TCP11L1 Gene
protein-coding GIFtS : 47
GCID: GC11 P033018
t-complex 11, testis-specific-like 1 (Previous name: t-complex 11 (mouse) like 1 )
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Aliasesfor TCP11L1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases T-Complex 11, Testis-Specific-Like 1 1 2 FLJ113361 T-Complex 11 (Mouse) Like 11 DJ85M6.31 T-Complex 11-Like 12 T-Complex Protein 11-Like Protein 12
Export aliases for TCP11L1 gene to outside databases Previous GC identifer: GC11P032755
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Summariesfor TCP11L1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TCP11L1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_009237.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TCP11L1 gene promoter: LHX3b/Lhx3b POU2F1 Pax-5 LHX3a/Lhx3a Evi-1 Other transcription factors Search SABiosciences Chromatin IP Primers for TCP11L1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TCP11L1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13 TCP11L1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P033018: view genomic region
(about GC identifiers )
Start:
33,060,963 bp from pter
End:
33,127,489 bp from pter
Size:
66,527 bases
Orientation:
plus strand
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Proteinsfor TCP11L1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: T11L1_HUMAN, Q9NUJ3 (See
protein sequence )Recommended Name: T-complex protein 11-like protein 1 Size : 509 amino acids; 57035 Da
Secondary accessions : D3DR01 Q8IVX4Explore the universe of human proteins at neXtProt for TCP11L1: NX_Q9NUJ3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NUJ3 TCP11L1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001139013.1 NP_060863.3 ENSEMBL proteins: ENSP00000436428 ENSP00000335595 ENSP00000435667 ENSP00000431200 ENSP00000433067 ENSP00000435870 ENSP00000436471 ENSP00000395070 ENSP00000316279 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005874 microtubule
IDA --
TCP11L1 for ontologies About GeneDecksing TCP11L1 Antibody Products: Assay Products for TCP11L1:
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Protein
Domains / Familiesfor TCP11L1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TCP11L1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9NUJ3 ProtoNet protein and cluster: Q9NUJ3
UniProtKB/Swiss-Prot: T11L1_HUMAN, Q9NUJ3 Similarity : Belongs to the TCP11 family
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Functionfor TCP11L1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCP11L1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCP11L1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TCP11L1 (NM_001145541 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCP11L1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCP11L1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11L1
1 GenomeRNAi human phenotype for TCP11L1 :
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Pathways & Interactionsfor TCP11L1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCP11L1 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)5/7 Interacting proteins for TCP11L1 (Q9NUJ3 3 ENSP00000335595 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 7 )About this table
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Drugs & Compoundsfor TCP11L1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TCP11L1 Search CenterWatch for drugs/clinical trials and news about TCP11L1 / T11L1
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Transcriptsfor TCP11L1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TCP11L1 gene (2 alternative transcripts): NM_001145541.1 NM_018393.3 Unigene Cluster for TCP11L1:
T-complex 11, testis-specific-like 1 Hs.655341 [show with all ESTs ] Unigene Representative Sequence: BC030582 11 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000532687 ENST00000530419 ENST00000334274 (uc001mud.3 ) ENST00000527661 (uc001muf.1 )ENST00000530171 ENST00000528107 (uc009yju.3 ) ENST00000531632 ENST00000528898 ENST00000528962 ENST00000432887 (uc010rei.2 uc001mue.3 ) ENST00000324357 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCP11L1 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCP11L1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TCP11L1 (NM_001145541 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCP11L1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCP11L1
Additional cDNA sequence: AK002198.1 AK090646.1 BC030582.1 BC041696.1
9 DOTS entries : DT.406380 DT.100723760
DT.120739102 DT.91834780 DT.438827 DT.95305594 DT.97838525 DT.95075559 DT.95079212 24/52 AceView cDNA sequences (see all 52 ):
R81557 NM_018393 BX105318 BC041696 BM451702 AI803015 BM670852 AU117035 BM693709 AI074804 AI627556 BM462324 AK090646 T27081 BQ893328 AI769289 BX456983 AK021448 BU677984 BC030582 BX282710 AA182444 CB989865 AK002198 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L1 (see all 6 ) About this scheme ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b SP1 :     -   -   -     -                         SP2 :         -     -                         SP3 :         -     -                         SP4 :     -   -   -     -   -   -   -                   SP5 :     -   -   -                            
ECgene alternative splicing isoforms for TCP11L1
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Expression for TCP11L1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TCP11L1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCTCACCTC
About this image TCP11L1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TCP11L1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TCP11L1 SOURCE GeneReport for Unigene cluster: Hs.655341 SABiosciences Custom PCR Arrays for TCP11L1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCP11L1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TCP11L1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCP11L1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCP11L1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11L1
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Orthologsfor TCP11L1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for TCP11L1 gene from 5/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for TCP11L1 (if available)TreeFam Gene Tree for TCP11L1 (if available)
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Paralogsfor TCP11L1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TCP11L1 gene TCP11L2 2 LOC100996648 2 TCP11 2 5 SIMAP similar genes for TCP11L1 using alignment to 7 protein entries: T11L1_HUMAN (see all proteins ):TCP11 TCP11L2 LL0XNC01-19D8.1 RPS6KA5 LOC100996648
TCP11L1 for paralogs About GeneDecksing
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Genomic Variantsfor TCP11L1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 11 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TCP11L1 (33060963 - 33127489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for TCP11L1 1 CNV : 85716
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCP11L1
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Disorders
/ Diseasesfor TCP11L1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section TCP11L1 for disorders About MalaCards
TCP11L1 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: TCP11L1 (1 document)Export disorders for TCP11L1 gene to outside databases
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Publicationsfor TCP11L1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TCP11L1 gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with TCP11L1) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068) 1 Hutchins J.R....Peters J.M. (2010) Host determinants of HIV-1 control in African America ns. (PubMed id 20205591) 1 Pelak K....Weintrob A.C. (2010) Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747) 1 Fenner B.J....Prehn J.H. (2010) Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087) 1 Persaud A....Rotin D. (2009) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006)
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External Searches for TCP11L1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TCP11L1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TCP11L1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing TCP11L1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TCP11L1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TCP11L1 gene: Search GeneIP for patents involving TCP11L1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TCP11L1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TCP11L1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TCP11L1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TCP11L1 OriGene Protein Over-expression Lysate for TCP11L1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TCP11L1 OriGene 3'-UTR Clone for TCP11L1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TCP11L1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TCP11L1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TCP11L1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TCP11L1 OriGene Custom Protein Services for TCP11L1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCP11L1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TCP11L1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TCP11L1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TCP11L1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TCP11L1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TCP11L1
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TCP11L1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11L1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TCP11L1
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