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Aliases for TCP11L1 Gene

Aliases for TCP11L1 Gene

  • T-Complex 11 Like 1 2 3
  • T-Complex 11, Testis-Specific-Like 1 2 3 5
  • T-Complex 11 (Mouse) Like 1 2
  • T-Complex 11-Like 1 3
  • DJ85M6.3 3

External Ids for TCP11L1 Gene

Previous GeneCards Identifiers for TCP11L1 Gene

  • GC11P032755

Summaries for TCP11L1 Gene

GeneCards Summary for TCP11L1 Gene

TCP11L1 (T-Complex 11 Like 1) is a Protein Coding gene. An important paralog of this gene is TCP11X2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP11L1 Gene

Genomics for TCP11L1 Gene

Regulatory Elements for TCP11L1 Gene

Enhancers for TCP11L1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCP11L1 on UCSC Golden Path with GeneCards custom track

Promoters for TCP11L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCP11L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP11L1 Gene

Chromosome:
11
Start:
33,039,417 bp from pter
End:
33,105,943 bp from pter
Size:
66,527 bases
Orientation:
Plus strand

Genomic View for TCP11L1 Gene

Genes around TCP11L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP11L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP11L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP11L1 Gene

Proteins for TCP11L1 Gene

  • Protein details for TCP11L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUJ3-T11L1_HUMAN
    Recommended name:
    T-complex protein 11-like protein 1
    Protein Accession:
    Q9NUJ3
    Secondary Accessions:
    • D3DR01
    • Q8IVX4

    Protein attributes for TCP11L1 Gene

    Size:
    509 amino acids
    Molecular mass:
    57035 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCP11L1 Gene

Proteomics data for TCP11L1 Gene at MOPED

Post-translational modifications for TCP11L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP11L1 Gene

Domains & Families for TCP11L1 Gene

Protein Domains for TCP11L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP11L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUJ3

UniProtKB/Swiss-Prot:

T11L1_HUMAN :
  • Belongs to the TCP11 family.
Family:
  • Belongs to the TCP11 family.
genes like me logo Genes that share domains with TCP11L1: view

No data available for Gene Families for TCP11L1 Gene

Function for TCP11L1 Gene

genes like me logo Genes that share phenotypes with TCP11L1: view

Animal Model Products

CRISPR Products

miRNA for TCP11L1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP11L1 Gene

Localization for TCP11L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCP11L1 Gene COMPARTMENTS Subcellular localization image for TCP11L1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
golgi apparatus 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCP11L1 Gene

Pathways & Interactions for TCP11L1 Gene

SuperPathways for TCP11L1 Gene

No Data Available

Interacting Proteins for TCP11L1 Gene

Gene Ontology (GO) - Biological Process for TCP11L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP11L1 Gene

Drugs & Compounds for TCP11L1 Gene

No Compound Related Data Available

Transcripts for TCP11L1 Gene

Unigene Clusters for TCP11L1 Gene

T-complex 11, testis-specific-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6:

Relevant External Links for TCP11L1 Gene

GeneLoc Exon Structure for
TCP11L1
ECgene alternative splicing isoforms for
TCP11L1

Expression for TCP11L1 Gene

mRNA expression in normal human tissues for TCP11L1 Gene

Protein differential expression in normal tissues from HIPED for TCP11L1 Gene

This gene is overexpressed in Bone (37.8) and Frontal cortex (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCP11L1 Gene



SOURCE GeneReport for Unigene cluster for TCP11L1 Gene Hs.655341

genes like me logo Genes that share expression patterns with TCP11L1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TCP11L1 Gene

Orthologs for TCP11L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCP11L1 35
  • 87.43 (n)
  • 87.03 (a)
TCP11L1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCP11L1 35
  • 89.99 (n)
  • 88.54 (a)
TCP11L1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcp11l1 35
  • 85.33 (n)
  • 85.27 (a)
Tcp11l1 16
Tcp11l1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCP11L1 35
  • 99.48 (n)
  • 99.61 (a)
TCP11L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcp11l1 35
  • 84.41 (n)
  • 84.48 (a)
oppossum
(Monodelphis domestica)
Mammalia TCP11L1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCP11L1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCP11L1 35
  • 69.11 (n)
  • 71.14 (a)
TCP11L1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCP11L1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp11l1 35
  • 63.29 (n)
  • 61.26 (a)
zebrafish
(Danio rerio)
Actinopterygii tcp11l1 35
  • 58.88 (n)
  • 55.89 (a)
tcp11l1 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000633 35
  • 44.24 (n)
  • 31.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG16721 35
  • 45.55 (n)
  • 34.99 (a)
CG16721 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_M05D6.2 35
  • 44.09 (n)
  • 32.49 (a)
M05D6.2 36
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK1 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for TCP11L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCP11L1 Gene

ENSEMBL:
Gene Tree for TCP11L1 (if available)
TreeFam:
Gene Tree for TCP11L1 (if available)

Paralogs for TCP11L1 Gene

Paralogs for TCP11L1 Gene

genes like me logo Genes that share paralogs with TCP11L1: view

Variants for TCP11L1 Gene

Sequence variations from dbSNP and Humsavar for TCP11L1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs16923785 - 33,057,145(+) GTACA(G/T)AAAGC nc-transcript-variant, reference, missense
rs2273549 - 33,058,034(+) TTCCA(A/G)GCTGG nc-transcript-variant, reference, missense
rs752744 -- 33,067,608(+) GTGGG(A/G)TCCAG intron-variant
rs911175 -- 33,073,735(-) AAAAA(A/G)AAAAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs961644 -- 33,064,153(-) CTTTT(C/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP11L1 Gene

Variant ID Type Subtype PubMed ID
dgv1065n71 CNV Gain 21882294
nsv467786 CNV Gain 19166990
nsv521130 CNV Gain 19592680
esv2658399 CNV Deletion 23128226

Variation tolerance for TCP11L1 Gene

Residual Variation Intolerance Score: 27.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP11L1 Gene

HapMap Linkage Disequilibrium report
TCP11L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP11L1 Gene

Disorders for TCP11L1 Gene

Relevant External Links for TCP11L1

Genetic Association Database (GAD)
TCP11L1
Human Genome Epidemiology (HuGE) Navigator
TCP11L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP11L1

No disorders were found for TCP11L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP11L1 Gene

Publications for TCP11L1 Gene

  1. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K. … . (J. Infect. Dis. 2010) 3 48 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Genome-wide association study of proneness to anger. (PMID: 24489884) Mick E. … Goldberg R.J. (PLoS ONE 2014) 3

Products for TCP11L1 Gene

Sources for TCP11L1 Gene

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