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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCP11 Gene

protein-coding   GIFtS: 52
GCID: GC06M035240

T-Complex 11, Testis-Specific

(Previous names: t-complex 11 (a murine tcp homolog), t-complex 11 homolog...)
(Previous symbol: D6S230E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Complex 11, Testis-Specific1 2     T-Complex 11 Homolog (Mouse)1
D6S230E1 2 5     FPPR2
T-Complex 11 (A Murine Tcp Homolog)1 2     T-Complex 11 Homolog2
Fertilization-Promoting Peptide Receptor1 2     T-Complex Protein 11 Homolog2

External Ids:    HGNC: 116581   Entrez Gene: 69542   Ensembl: ENSG000001246787   OMIM: 1869825   UniProtKB: Q8WWU53   

Export aliases for TCP11 gene to outside databases

Previous GC identifers: GC06M035087 GC06M035132 GC06M035193 GC06M034807 GC06M035133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCP11 Gene: 
TCP11 (t-complex 11, testis-specific) is a protein-coding gene. Diseases associated with TCP11 include pancreatic cancer, and pancreatitis. An important paralog of this gene is TCP11X1.

UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5
Function: May play an important role in sperm function and fertility

Gene Wiki entry for TCP11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCP11 gene promoter:
         HOXA9   HOXA9B   MIF-1   Meis-1b   MEF-2A   FOXI1   POU2F1   POU2F1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCP11 promoter sequence
   Search SABiosciences Chromatin IP Primers for TCP11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

TCP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP11 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035240:  view genomic region     (about GC identifiers)

Start:
35,085,848 bp from pter      End:
35,116,387 bp from pter
Size:
30,540 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5 (See protein sequence)
Recommended Name: T-complex protein 11 homolog  
Size: 503 amino acids; 56141 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B2RCE9 B3KQ27 B7Z7B5 B7Z7G1 B7Z7H4 B7Z7S8 E7EP29 J3KNG1 Q8NF85 Q9NQZ9
Q9NR39
Alternative splicing: 7 isoforms:  Q8WWU5-1   Q8WWU5-2   Q8WWU5-3   Q8WWU5-4   Q8WWU5-5   Q8WWU5-6   Q8WWU5-7   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for TCP11: NX_Q8WWU5

Explore proteomics data for TCP11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WWU5

  • TCP11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCP11 Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001087197.1  NP_001248746.1  NP_001248747.1  NP_001248748.1  NP_001248749.1  NP_001248750.1  NP_061149.1  

    ENSEMBL proteins: 
     ENSP00000402816   ENSP00000363091   ENSP00000422105   ENSP00000421916   ENSP00000423293  
     ENSP00000399012   ENSP00000308708   ENSP00000404479   ENSP00000363085   ENSP00000425995  
     ENSP00000415320   ENSP00000415562   ENSP00000421103   ENSP00000422259   ENSP00000422774  
     ENSP00000423183   ENSP00000425849   ENSP00000421333   ENSP00000421386   ENSP00000424209  
     ENSP00000422940   ENSP00000421349   ENSP00000424332   ENSP00000244645  

    Human Recombinant Protein Products for TCP11: 
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    OriGene MassSpec for TCP11 
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    Novus Biologicals TCP11 Proteins
    Novus Biologicals TCP11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TCP11 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TCP11 for ontologies           About GeneDecksing



    TCP11 Antibody Products: 
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    ThermoFisher Antibodies for TCP11
    LSBio Antibodies in human, mouse, rat for TCP11 

    Assay Products for TCP11: 
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    Cloud-Clone Corp. ELISAs for TCP11 
    Cloud-Clone Corp. CLIAs for TCP11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008862 Tcp11

    Graphical View of Domain Structure for InterPro Entry Q8WWU5

    ProtoNet protein and cluster: Q8WWU5

    UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5
    Similarity: Belongs to the TCP11 family


    TCP11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCP11_HUMAN, Q8WWU5
    Function: May play an important role in sperm function and fertility

         Genatlas biochemistry entry for TCP11:
    T-complex 11 (murine tcp homolog)

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TCP11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCP11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCP11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TCP11 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCP11
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TCP11
    SwitchGear 3'UTR luciferase reporter plasmidTCP11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TCP11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP11

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TCP11
    Sirion Biotech Customized adenovirus for overexpression of TCP11

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TCP11 (see all 10)
    OriGene ORF clones in mouse, rat for TCP11
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    GenScript: all cDNA clones in your preferred vector (see all 2): TCP11 (NM_001093728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP11
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                         Customized lentivirus expression plasmids for stable overexpression of TCP11 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TCP11
    Search LifeMap BioReagents cell lines for TCP11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCP11

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TCP11 (Q8WWU53 ENSP000003087084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development TAS1893875
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    TCP11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TCP11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCP11

    1 Novoseek inferred chemical compound relationship for TCP11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 54.7 2 9322250 (1)

    Search CenterWatch for drugs/clinical trials and news about TCP11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCP11 gene (7 alternative transcripts): 
    NM_001093728.2  NM_001261817.1  NM_001261818.1  NM_001261819.1  NM_001261820.1  NM_001261821.1  NM_018679.5  

    Unigene Cluster for TCP11:

    T-complex 11, testis-specific
    Hs.435371  [show with all ESTs]
    Unigene Representative Sequence: NM_001261820
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000412155 ENST00000373979(uc003ojz.1) ENST00000502480 ENST00000504758
    ENST00000505911 ENST00000455706 ENST00000311875(uc003okd.2 uc011dsu.1 uc011dsv.1 uc011dsw.1)
    ENST00000444780 ENST00000373974 ENST00000512012 ENST00000418521 ENST00000427376
    ENST00000486638 ENST00000469514 ENST00000492680 ENST00000507706 ENST00000479418
    ENST00000505400
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCP11
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TCP11
    SwitchGear 3'UTR luciferase reporter plasmidTCP11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TCP11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP11
    Clone
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    OriGene clones in human, mouse for TCP11 (see all 10)
    OriGene ORF clones in mouse, rat for TCP11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TCP11 (NM_001093728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCP11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP11
    Sirion Biotech Customized lentivirus for stable overexpression of TCP11 
                         Customized lentivirus expression plasmids for stable overexpression of TCP11 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TCP11
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP11

    Additional mRNA sequence: 

    AF260330.1 AF269223.1 AF536532.1 AF536533.1 AK057234.1 AK098590.1 AK301778.1 AK301975.1 
    AK302022.1 AK302375.1 AK302456.1 AK315078.1 AK316403.1 AY069943.1 BC033729.1 BC040003.1 
    BC048418.1 BC090050.1 

    16 DOTS entries:

    DT.40256097  DT.91725898  DT.91749044  DT.91725896  DT.121388878  DT.97778236  DT.100786149  DT.121388945 
    DT.95363801  DT.121388922  DT.95363798  DT.121388915  DT.91661294  DT.100786147  DT.121388976  DT.91725895 

    24/116 AceView cDNA sequences (see all 116):

    CD557279 BG721134 AY069943 AF260330 BC040003 AF269223 BI829267 BC048418 
    NM_018679 BG722302 BG700615 BP371219 BI829801 AF536532 BI828236 BC033729 
    BI829842 AF536533 BG716925 BI561278 BX280473 AK057234 BF507838 BX108514 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TCP11 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10 ^
    SP1:                                            -                                               -                                                               
    SP2:                                            -                 -                             -                                                               
    SP3:                                            -                 -     -     -                 -                                                               
    SP4:                                            -     -     -                                   -                                                               
    SP5:                                -     -     -     -     -                 -     -     -     -     -                                                         

    ExUns: 11a · 11b · 11c ^ 12 ^ 13
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for TCP11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCP11 expression in normal human tissues (normalized intensities)      TCP11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAACACCAA
    TCP11 Expression
    About this image


    TCP11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
             sperm   
     
     Eye (Sensory Organs)
             lens   

    See TCP11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCP11

    SOURCE GeneReport for Unigene cluster: Hs.435371

    UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5
    Tissue specificity: Expressed only in fertile adult testis

        SABiosciences Custom PCR Arrays for TCP11
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TCP11 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcp111 , 5 t-complex protein 111, 5 75.83(n)1
    74.42(a)1
      17 (14.62 cM)5
    214631  NM_013687.31  NP_038715.21 
     280667475 
    chicken
    (Gallus gallus)
    Aves TCP111 t-complex 11 homolog (mouse) 59.74(n)
    48.23(a)
      419897  XM_418022.3  XP_418022.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    44(a)
    1 → many
    4(120831421-120853376)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG167216
    --
    25(a)
    1 → many
    X(5773891-5777433)
    worm
    (Caenorhabditis elegans)
    Secernentea M05D6.26
    Protein M05D6.2
    22(a)
    1 → many
    II(8468105-8470160)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SOK16
    Protein whose overexpression suppresses the growth...
    10(a)
    1 → many
    IV(458542-461247)


    ENSEMBL Gene Tree for TCP11 (if available)
    TreeFam Gene Tree for TCP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCP11 gene
    TCP11X12  TCP11L12  TCP11L22  TCP11X22  
    4 SIMAP similar genes for TCP11 using alignment to 13 protein entries:     TCP11_HUMAN (see all proteins):
    LOC100996648    LL0XNC01-19D8.1    TCP11L1    TCP11L2

    TCP11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 SNPs in TCP11 are shown (see all 518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349483241,2
    C--34813541(+) CTTTC-/TTTTTT 5 -- int10--------
    rs1885395061,2
    --35085506(+) CTTGTC/TGCATT 7 -- int10--------
    rs1491303761,2
    --35085567(+) AACCAC/TGTCCT 7 -- int10--------
    rs412700481,2
    F--35085821(+) GGCCTC/TAGCTG 7 -- int11Minor allele frequency- T:0.01NA 120
    rs1812020261,2
    --35085874(+) ATTAAC/TGAATG 7 -- ut310--------
    rs1862020231,2
    --35085932(+) GTACTA/GGCTGC 7 -- ut310--------
    rs42564201,2
    H--35085958(+) AGCTCA/TCTGTC 7 -- ut314Minor allele frequency- T:0.00NS EA 416
    rs788237601,2
    C--35086010(+) TCCTCT/CTGGGT 7 -- ut312Minor allele frequency- C:0.14CSA WA 120
    rs1126055931,2
    C,F--35086073(+) TCCAGT/GGCCTG 14 /A syn13Minor allele frequency- G:0.01CSA NA EU 5873
    rs22340511,2,4
    C,F,H--35086272(-) TCAGCG/AGATCC 14 /Q /R mis1 ese38Minor allele frequency- A:0.01NS EA NA EU 6379

    HapMap Linkage Disequilibrium report for TCP11 (35085848 - 35116387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TCP11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1001098CNV Deletion20482838
    esv2633690CNV Deletion19546169
    esv1533887CNV Deletion17803354
    nsv349272CNV Loss16902084
    nsv511879CNV Loss21212237

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 186982    OMIM disorders: --

    2 diseases for TCP11:    About MalaCards
    pancreatic cancer    pancreatitis


    TCP11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TCP11
    Human Genome Epidemiology (HuGE) Navigator: TCP11 (1 document)

    Export disorders for TCP11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCP11 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with TCP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide. (PubMed id 11756566)1, 2, 3 Ma Y.... Milunsky A. (2002)
    2. A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. (PubMed id 1427894)1, 3, 9 Ragoussis J.... Trowsdale J. (1992)
    3. Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. (PubMed id 21597245)1, 3 Liu Y....Ma Y. (2011)
    4. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene. (PubMed id 12545228)1, 2 Ma Y.X.... Sun Y. (2003)
    8. Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene. (PubMed id 12905703)1, 2 Ma Y.X.... Xu W.M. (2003)
    9. TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction. (PubMed id 9322250)1, 9 Fraser L.R....Dudley R.K. (1997)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6954 HGNC: 11658 AceView: TCP11 Ensembl:ENSG00000124678 euGenes: HUgn6954
    ECgene: TCP11 H-InvDB: TCP11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCP11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCP11 gene:
    Search GeneIP for patents involving TCP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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