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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCP11 Gene

protein-coding GIFtS: 52
GCID: GC06M035133

t-complex 11, testis-specific

(Previous names: t-complex 11 (a murine tcp homolog), t-complex 11 homolog...)
(Previous symbol: D6S230E)

Explore 2 diseases affiliated with
TCP11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T-Complex 11, Testis-Specific¹ ²		T-Complex 11 Homolog (Mouse)¹
D6S230E¹ ² ⁵		Fertilization-Promoting Peptide Receptor²
FPPR¹ ²		T-Complex 11 Homolog²
T-Complex 11 (A Murine Tcp Homolog)¹ ²		T-Complex Protein 11 Homolog²
KIAA0229¹

External Ids:	HGNC: 11658¹	Entrez Gene: 6954²	Ensembl: ENSG00000124678⁷	OMIM: 186982⁵	UniProtKB: Q8WWU5³

Export aliases for TCP11 gene to outside databases

Previous GC identifers: GC06M035087 GC06M035132 GC06M035193 GC06M034807

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5

Function: May play an important role in sperm function and fertility

Gene Wiki entry for TCP11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCP11 gene promoter:
HOXA9 HOXA9B MIF-1 Meis-1b MEF-2A FOXI1 POU2F1 POU2F1a aMEF-2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCP11 promoter sequence

Search SABiosciences Chromatin IP Primers for TCP11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21.31

TCP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP11 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M035133: view genomic region (about GC identifiers)

Start:	35,085,848 bp from pter	End:	35,116,387 bp from pter
Size:	30,540 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5 (See protein sequence)

Recommended Name: T-complex protein 11 homolog

Size: 503 amino acids; 56141 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: B2RCE9 B3KQ27 B7Z7G1 Q8NF85 Q9NQZ9 Q9NR39

Alternative splicing: 4 isoforms: Q8WWU5-1 Q8WWU5-2 Q8WWU5-3 Q8WWU5-4

Explore the universe of human proteins at neXtProt for TCP11: NX_Q8WWU5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WWU5

TCP11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001087197.1 NP_001248746.1 NP_001248747.1 NP_001248748.1 NP_001248749.1 NP_001248750.1 NP_061149.1

ENSEMBL proteins:

ENSP00000363091 ENSP00000402816 ENSP00000422105 ENSP00000399012 ENSP00000308708

ENSP00000423293 ENSP00000421916 ENSP00000404479 ENSP00000363085 ENSP00000415320

ENSP00000425995 ENSP00000415562 ENSP00000421103 ENSP00000422259 ENSP00000422774

ENSP00000423183 ENSP00000425849 ENSP00000421333 ENSP00000421386 ENSP00000424209

ENSP00000422940 ENSP00000421349 ENSP00000424332 ENSP00000244645

Human Recombinant Protein Products:

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	OriGene Purified Protein: TCP11 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for TCP11
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	Novus Biologicals TCP11 Proteins Novus Biologicals TCP11 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TCP11

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TCP11 for ontologies About GeneDecksing

TCP11 Antibody Products:

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	Novus Biologicals TCP11 Antibodies
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	Uscn Antibodies for TCP11
	ThermoFisher Antibodies for TCP11

Assay Products for TCP11:

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	GenScript Custom Assay Services for TCP11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TCP11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCP11 for domains About GeneDecksing

1 InterPro domain/family:

IPR008862 Tcp11

Graphical View of Domain Structure for InterPro Entry Q8WWU5

ProtoNet protein and cluster: Q8WWU5

UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5

Similarity: Belongs to the TCP11 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5

Function: May play an important role in sperm function and fertility

Genatlas biochemistry entry for TCP11:

T-complex 11 (murine tcp homolog)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCP11
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		SwitchGear 3'UTR luciferase reporter plasmid: TCP11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCP11 (see all 7) OriGene shRNA RFP: TCP11 OriGene siRNA: TCP11
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TCP11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCP11 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCP11 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TCP11 (NM_001093728)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TCP11
		Search LifeMap BioReagents cell lines for TCP11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCP11

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TCP11 (Q8WWU5³ ENSP00000308708⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VAV2	P52735³, ENSP00000360916⁴	I2D: score=1 STRING: ENSP00000360916
IKBKG	Q9Y6K9³, ENSP00000358622⁴	I2D: score=1 STRING: ENSP00000358622

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	TAS	1893875
GO:0007283	spermatogenesis	IEA	--
GO:0030154	cell differentiation	IEA	--

TCP11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TCP11 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCP11
1 Novoseek chemical compound relationship for TCP11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
adenylate	54.7	2	9322250 (1)

Search CenterWatch for drugs/clinical trials and news about TCP11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCP11 gene (7 alternative transcripts):

NM_001093728.2 NM_001261817.1 NM_001261818.1 NM_001261819.1 NM_001261820.1 NM_001261821.1 NM_018679.5

Unigene Cluster for TCP11:

T-complex 11, testis-specific

Hs.435371 [show with all ESTs]

Unigene Representative Sequence: NM_001261820

18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000373979(uc003ojz.1) ENST00000412155 ENST00000502480 ENST00000455706

ENST00000311875(uc003okd.2 uc011dsu.1 uc011dsv.1 uc011dsw.1)

ENST00000505911 ENST00000504758 ENST00000444780 ENST00000373974 ENST00000418521

ENST00000512012 ENST00000427376 ENST00000486638 ENST00000469514 ENST00000492680

ENST00000507706 ENST00000479418 ENST00000505400

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCP11
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		SwitchGear 3'UTR luciferase reporter plasmid: TCP11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCP11 (see all 7) OriGene shRNA RFP: TCP11 OriGene siRNA: TCP11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP11

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCP11 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCP11 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP11

Additional cDNA sequence:

AF260330.1 AF269223.1 AF536532.1 AF536533.1 AK057234.1 AK098590.1 AK301778.1 AK301975.1

AK302022.1 AK302375.1 AK302456.1 AK315078.1 AK316403.1 AY069943.1 BC033729.1 BC040003.1

BC048418.1 BC090050.1

16 DOTS entries:

DT.40256097 DT.91725898 DT.91749044 DT.91725896 DT.121388878 DT.97778236 DT.100786149 DT.121388945

DT.95363801 DT.121388922 DT.95363798 DT.121388915 DT.91661294 DT.100786147 DT.121388976 DT.91725895

24/116 AceView cDNA sequences (see all 116):

BG700615 BG721134 AF536532 BI561278 CD557279 AY069943 BI828236 BG716925

BI829842 BC048418 AK057234 BX280473 BC040003 BC033729 AF536533 BI829801

BG722302 AF269223 BI829267 NM_018679 BP371219 AF260330 BF507838 BG721937

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TCP11 (see all 18) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	·	9c	·	9d	^	10	^
SP1:															-																-
SP2:															-						-										-
SP3:															-						-		-		-						-
SP4:															-		-		-												-
SP5:											-		-		-		-		-						-		-		-		-		-

ExUns:	11a	·	11b	·	11c	^	12	^	13
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TCP11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAACACCAA

About this image

TCP11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Mature Sertoli Cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCP11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCP11

SOURCE GeneReport for Unigene cluster: Hs.435371

UniProtKB/Swiss-Prot: TCP11_HUMAN, Q8WWU5

Tissue specificity: Expressed only in fertile adult testis

SABiosciences Custom PCR Arrays for TCP11

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TCP11 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TCP11¹	t-complex 11 homolog (mouse)	59.74(n) 48.23(a)		419897 XM_418022.3 XP_418022.3
lizard (Anolis carolinensis)	Reptilia	--	--	49(a)	1 → many	4(120834287-120853370)
fruit fly (Drosophila melanogaster)	Insecta	CG16721⁶	--	25(a)	1 → many	X(5773891-5777433)
worm (Caenorhabditis elegans)	Secernentea	M05D6.2⁶	--	20(a)	1 → many	II(8468054-8470109)

ENSEMBL Gene Tree for TCP11 (if available)
TreeFam Gene Tree for TCP11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCP11 gene

TCP11L1² TCP11L2² LOC100996648²

4 SIMAP similar genes for TCP11 using alignment to 16 protein entries: TCP11_HUMAN (see all proteins):

LOC100996648 LL0XNC01-19D8.1 TCP11L2 TCP11L1

TCP11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55829099^1,2	C	--	34826399(+)	`GCAGCA/GAAGAA`	1	--	int¹		0	--	--	--	--
rs56222941^1,2	C	--	34826877(+)	`AGACCA/GGCATG`	1	--	int¹		0	--	--	--	--
rs188539506^1,2		--	35085506(+)	`CTTGTC/TGCATT`	7	--	int¹		0	--	--	--	--
rs149130376^1,2		--	35085567(+)	`AACCAC/TGTCCT`	7	--	int¹		0	--	--	--	--
rs41270048^1,2		--	35085821(+)	`GGCCTC/TAGCTG`	7	--	int¹		1		NA	120
rs181202026^1,2		--	35085874(+)	`ATTAAC/TGAATG`	7	--	ut3¹		0	--	--	--	--
rs186202023^1,2		--	35085932(+)	`GTACTA/GGCTGC`	7	--	ut3¹		0	--	--	--	--
rs4256420^1,2	H	--	35085958(+)	`AGCTCA/TCTGTC`	7	--	ut3¹		4		NS EA	416
rs78823760^1,2	C,	--	35086010(+)	`TCCTCT/CTGGGT`	7	--	ut3¹		2		CSA WA	120
rs112605593^1,2	C,F,	--	35086073(+)	`TCCAGT/GGCCTG`	14	/A	syn¹		3		CSA NA EU	5873

HapMap Linkage Disequilibrium report for TCP11 (35085848 - 35116387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TCP11
1 CNV: 99502
2 Indels: 28289 12833

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCP11

DNA2.0 Custom Variant and Variant Library Synthesis for TCP11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TCP11 for disorders           About GeneDecksing

OMIM gene information: 186982    OMIM disorders: --

2 diseases for TCP11:    About MalaCards

pancreatic cancer pancreatitis

Human Genome Epidemiology (HuGE) Navigator: TCP11 (1 document)

Export disorders for TCP11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCP11 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with TCP11)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide. (PubMed id 11756566)^{1, 2, 3} Ma Y.... Milunsky A. (2002)
A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. (PubMed id 1427894)^{1, 3, 9} Ragoussis J.... Trowsdale J. (1992)
Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. (PubMed id 21597245)^{1, 3} Liu Y....Ma Y. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Cloning, expression and alternative splicing of a novel isoform of human TCP11b gene. (PubMed id 12545228)^{1, 2} Ma Y.X.... Sun Y. (2003)
Cloning, expression, and alternative splicing of the novel isoform of hTCP11 gene. (PubMed id 12905703)^{1, 2} Ma Y.X.... Xu W.M. (2003)
TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction. (PubMed id 9322250)^{1, 9} Fraser L.R....Dudley R.K. (1997)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)¹ Zhao J....Grant S.F. (2010)
Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)¹ Fenner B.J....Prehn J.H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6954	HGNC: 11658	AceView: TCP11	Ensembl:ENSG00000124678	euGenes: HUgn6954
ECgene: TCP11	H-InvDB: TCP11

(According to HUGE)
About This Section

HUGE: KIAA0229

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCP11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCP11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCP11 gene:
Search GeneIP for patents involving TCP11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCP11
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Search for Antibodies & Assays

	Regulatory tfbs in TCP11 promoter
	Search Chromatin IP Primers for TCP11
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TCP11 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TCP11

	Gene Synthesis
	Protein Engineering
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	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP11

	SwitchGear 3'UTR luciferase reporter plasmids for TCP11
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ThermoFisher Antibodies for TCP11

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP11

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TCP11 Gene

t-complex 11, testis-specific

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TCP11 Gene

t-complex 11, testis-specific

Aliasesfor TCP11 gene

Summariesfor TCP11 gene

Genomic Viewsfor TCP11 gene

Proteinsfor TCP11 gene

Protein Domains /Familiesfor TCP11 gene

Functionfor TCP11 gene

Pathways & Interactionsfor TCP11 gene

Drugs & Compoundsfor TCP11 gene

Transcriptsfor TCP11 gene

Expression for TCP11 gene

Orthologsfor TCP11 gene

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Genomic Variantsfor TCP11 gene

Disorders / Diseasesfor TCP11 gene

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External Searches for TCP11 gene

Genome Databases showing TCP11 gene

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Specialized Databases showing TCP11 gene

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for TCP11 gene

Genomic Views
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for TCP11 gene

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for TCP11 gene

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for TCP11 gene

Transcripts
for TCP11 gene

Expression
for TCP11 gene

Orthologs
for TCP11 gene

Paralogs
for TCP11 gene

Genomic Variants
for TCP11 gene

Disorders / Diseases
for TCP11 gene

Publications
for TCP11 gene

Intellectual Property
for TCP11 gene

Products
for TCP11 gene