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Aliases for TCP10L2 Gene

Aliases for TCP10L2 Gene

  • T-Complex 10-Like 2 2 3 5
  • T-Complex 10-Like Protein 2 3 4
  • Putative T-Complex Protein 10A Homolog 2 3
  • T-Complex Protein 10A Homolog 2 3
  • T-Complex 10-Like 2 (Mouse) 2
  • BA517H2.3 3

External Ids for TCP10L2 Gene

Previous GeneCards Identifiers for TCP10L2 Gene

  • GC06P167493
  • GC06U900706
  • GC06P165056
  • GC06P167585
  • GC06P167559

Summaries for TCP10L2 Gene

GeneCards Summary for TCP10L2 Gene

TCP10L2 (T-Complex 10-Like 2) is a Protein Coding gene. An important paralog of this gene is TCP10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10L2 Gene

Genomics for TCP10L2 Gene

Regulatory Elements for TCP10L2 Gene

Enhancers for TCP10L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F167140 1.2 Ensembl ENCODE 6.2 -4.6 -4643 2.3 ARID4B ZNF48 ZNF143 SP5 MXD4 MIER2 REST PPARG KAT8 MIER3 CCR6 FGFR1OP LOC105378120 TCP10L2 LOC105378124 LOC105378122
GH06F167146 1.2 Ensembl ENCODE 5.9 +0.6 617 1.2 TBP ELF3 MLX RAD21 ZNF48 YY1 RARA KAT2B GATA4 THAP11 CCR6 FGFR1OP LOC105378120 ENSG00000249141 RNASET2 TCP10L2 LOC105378124 GPR31
GH06F167233 0.4 ENCODE 6.1 +87.0 87007 0.9 CTCF UNC93A LOC102724220 TCP10L2 ENSG00000280707 LOC102725048
GH06F167150 1.6 FANTOM5 Ensembl ENCODE 0.4 +6.1 6126 3.4 ELF3 TBP PKNOX1 TBL1XR1 SIN3A RAD21 EGR1 ELK1 CBX5 ETV6 GPR31 RNASET2 CCR6 FGFR1OP LOC105378120 ENSG00000249141 UNC93A RPS6KA2 RPS6KA2-AS1 AFDN
GH06F167129 1 ENCODE 0.3 -15.9 -15863 2.7 PKNOX1 MLX ARID4B ZNF48 SLC30A9 FOS SP5 MIER2 TBX21 PPARG FGFR1OP LOC105378120 GPR31 RPS6KA2 RPS6KA2-AS1 RNASET2 LOC105378122 TCP10L2 LOC105378124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCP10L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP10L2 Gene

Chromosome:
6
Start:
167,146,414 bp from pter
End:
167,196,913 bp from pter
Size:
50,500 bases
Orientation:
Plus strand

Genomic View for TCP10L2 Gene

Genes around TCP10L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP10L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP10L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10L2 Gene

Proteins for TCP10L2 Gene

  • Protein details for TCP10L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B9ZVM9-TCP2L_HUMAN
    Recommended name:
    T-complex protein 10A homolog 2
    Protein Accession:
    B9ZVM9

    Protein attributes for TCP10L2 Gene

    Size:
    353 amino acids
    Molecular mass:
    38357 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCP10L2 Gene

Post-translational modifications for TCP10L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10L2 Gene

No data available for DME Specific Peptides for TCP10L2 Gene

Domains & Families for TCP10L2 Gene

Protein Domains for TCP10L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP10L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B9ZVM9

UniProtKB/Swiss-Prot:

TCP2L_HUMAN :
  • Belongs to the TCP10 family.
Family:
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10L2: view

No data available for Gene Families for TCP10L2 Gene

Function for TCP10L2 Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10L2 Gene

Localization for TCP10L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP10L2 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCP10L2 Gene

Pathways & Interactions for TCP10L2 Gene

SuperPathways for TCP10L2 Gene

No Data Available

Interacting Proteins for TCP10L2 Gene

Selected Interacting proteins: B9ZVM9-TCP2L_HUMAN for TCP10L2 Gene via IID

Gene Ontology (GO) - Biological Process for TCP10L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP10L2 Gene

Transcripts for TCP10L2 Gene

mRNA/cDNA for TCP10L2 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(12) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCP10L2 Gene

T-complex 10-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10L2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for TCP10L2 Gene

GeneLoc Exon Structure for
TCP10L2
ECgene alternative splicing isoforms for
TCP10L2

Expression for TCP10L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCP10L2 Gene

mRNA differential expression in normal tissues according to GTEx for TCP10L2 Gene

This gene is overexpressed in Testis (x39.9).

Protein differential expression in normal tissues from HIPED for TCP10L2 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCP10L2 Gene



Protein tissue co-expression partners for TCP10L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCP10L2 Gene:

TCP10L2

SOURCE GeneReport for Unigene cluster for TCP10L2 Gene:

Hs.691976
genes like me logo Genes that share expression patterns with TCP10L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TCP10L2 Gene

Orthologs for TCP10L2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TCP10L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 95 (a)
OneToMany
Species where no ortholog for TCP10L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10L2 Gene

ENSEMBL:
Gene Tree for TCP10L2 (if available)
TreeFam:
Gene Tree for TCP10L2 (if available)

Paralogs for TCP10L2 Gene

Paralogs for TCP10L2 Gene

(2) SIMAP similar genes for TCP10L2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TCP10L2: view

Variants for TCP10L2 Gene

Sequence variations from dbSNP and Humsavar for TCP10L2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1010252 -- 167,174,046(-) CCAGC(A/G)ACAAA intron-variant
rs1014653 -- 167,178,786(+) TAAAA(A/C)TCAAT intron-variant
rs10434826 -- 167,192,366(+) TCAGC(C/T)GGTCC intron-variant
rs10455984 -- 167,178,961(+) TTGCC(A/G)GCTGC intron-variant
rs10946219 -- 167,184,784(+) CAGGA(A/G)CTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP10L2 Gene

Variant ID Type Subtype PubMed ID
nsv981207 CNV duplication 23825009
nsv965787 CNV duplication 23825009
nsv949892 CNV deletion 24416366
nsv8000 CNV gain 18304495
nsv7389 OTHER inversion 18451855
nsv605338 CNV gain 21841781
nsv470873 CNV gain 18288195
nsv469673 CNV loss 16826518
nsv464141 CNV gain 19166990
esv3890997 CNV loss 25118596
esv3611649 CNV gain 21293372
esv3571537 CNV loss 25503493
esv3571536 CNV loss 25503493
esv2759492 CNV gain 17122850
dgv6194n100 CNV gain 25217958
dgv1240e214 CNV gain 21293372

Variation tolerance for TCP10L2 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP10L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP10L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10L2 Gene

Disorders for TCP10L2 Gene

Relevant External Links for TCP10L2

Genetic Association Database (GAD)
TCP10L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP10L2

No disorders were found for TCP10L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP10L2 Gene

Publications for TCP10L2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for TCP10L2 Gene

Sources for TCP10L2 Gene

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