TCP10L2 Gene
protein-coding GIFtS: 33
GCID: GC06P167559
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t-complex 10-like 2(Previous name: t-complex 10-like 2 (mouse) )
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Aliases
for TCP10L2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| T-Complex 10-Like 21 2 | | BA517H2.31 | | T-Complex 10-Like Protein 22 3 | | T-Complex 10-Like 2 (Mouse)1 | | Putative T-Complex Protein 10A Homolog 22 |
Export aliases for TCP10L2 gene to outside databasesPrevious GC identifers: GC06P167493 GC06U900706 GC06P165056 GC06P167585 |
Summaries
for TCP10L2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TCP10L2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TCP10L2 gene promoter:
AML1a NRSF form 1 HNF-4alpha2 NRSF form 2 C/EBPalpha HNF-4alpha1 PPAR-gamma1 SEF-1 (1) PPAR-gamma2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TCP10L2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP10L2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27TCP10L2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P167559: view genomic region
(about GC identifiers)
Start:
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167,559,902 bp from pter |
End:
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167,610,401 bp from pter |
Size:
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50,500 bases |
Orientation:
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plus strand |
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Proteins
for TCP10L2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TCP2L_HUMAN, B9ZVM9 (See
protein sequence)Recommended Name: Putative t-complex protein 10A homolog 2 Size: 353 amino acids; 38357 Da
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for TCP10L2: NX_B9ZVM9
TCP10L2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001138593.1
ENSEMBL proteins: ENSP00000440886 ENSP00000355797 ENSP00000283507
Human Recombinant Protein Products for TCP10L2:
TCP10L2 Antibody Products:
Assay Products for TCP10L2: |
Protein
Domains /
Families
for TCP10L2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TCP10L2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry B9ZVM9ProtoNet protein and cluster: B9ZVM9 UniProtKB/Swiss-Prot: TCP2L_HUMAN, B9ZVM9Similarity: Belongs to the TCP10 family |
Function
for TCP10L2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCP10L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCP10L2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TCP10L2 (NM_001145121) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCP10L2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TCP10L2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10L2 |
|
Pathways & Interactions
for TCP10L2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCP10L2
|
Drugs & Compounds
for TCP10L2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TCP10L2
Search CenterWatch for drugs/clinical trials and news about TCP10L2 / TCP2L
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Transcripts
for TCP10L2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TCP10L2 gene (2 alternative transcripts): NM_001145121.1 NM_001013683.1 Unigene Cluster for TCP10L2: T-complex 10-like 2 Hs.691976 [show with all ESTs]Unigene Representative Sequence: NM_0011451217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000539001 ENST00000486697 ENST00000366832(uc010kkp.3) ENST00000283507
ENST00000382669 ENST00000464222 ENST00000473271
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCP10L2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCP10L2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TCP10L2 (NM_001145121) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TCP10L2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TCP10L2 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCP10L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCP10L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP10L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP10L2 |
7 DOTS entries: DT.102658 DT.101979890 DT.121389275 DT.40105878 DT.40124236 DT.100745561 DT.40131440 12 AceView cDNA sequences: AA563930 BX642943 AA723845 BX088871 BV184084 AW086030 BX282521 BV184083 BV205237 AA705836 AW235358 BG723543
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TCP10L2 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
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| SP1: | | | - | | - | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TCP10L2
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Expression
for TCP10L2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TCP10L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TCP10L2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.691976
SABiosciences Custom PCR Arrays for TCP10L2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCP10L2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCP10L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP10L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP10L2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10L2 |
Orthologs
for TCP10L2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for TCP10L2 (if available)
TreeFam Gene Tree for TCP10L2 (if available) |
Paralogs
for TCP10L2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TCP10L2 gene
- TCP101 2 TCP10L2
2 SIMAP similar genes for TCP10L2 using alignment to 4 protein entries: TCP2L_HUMAN (see all proteins):TCP10 TCP10L
TCP10L2 for paralogs About GeneDecksing
|
Genomic Variants
for TCP10L2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TCP10L2 (167559902 - 167610401 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TCP10L2
3 CNVs: 2098 3653 31309 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCP10L2 |
|
Disorders
/ Diseases
for TCP10L2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TCP10L2 for disorders About GeneDecksing
1  disease for TCP10L2: About MalaCardsspina bifida
1 disease from the University of Copenhagen DISEASES database for TCP10L2:Spina bifida Export disorders for TCP10L2 gene to outside databases
|
Publications
for TCP10L2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for TCP10L2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCP10L2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
|
External Searches for TCP10L2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TCP10L2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TCP10L2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TCP10L2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TCP10L2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TCP10L2 gene:
Search GeneIP for patents involving TCP10L2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TCP10L2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TCP10L2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCP10L2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCP10L2 | | | OriGene Protein Over-expression Lysate for TCP10L2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TCP10L2 | | OriGene 3'-UTR Clone for TCP10L2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCP10L2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCP10L2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TCP10L2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TCP10L2 | | OriGene Custom Protein Services for TCP10L2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TCP10L2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCP10L2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP10L2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP10L2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP10L2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP10L2 |
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 |  |  |  | |
| | | | Search Tocris compounds for TCP10L2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10L2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TCP10L2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TCP10L2 |
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