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Aliases for TCP10L2 Gene

Aliases for TCP10L2 Gene

  • T-Complex 10-Like 2 2 3 5
  • T-Complex 10-Like Protein 2 3 4
  • Putative T-Complex Protein 10A Homolog 2 3
  • T-Complex 10-Like 2 (Mouse) 2
  • BA517H2.3 3

External Ids for TCP10L2 Gene

Previous GeneCards Identifiers for TCP10L2 Gene

  • GC06P167493
  • GC06U900706
  • GC06P165056
  • GC06P167585
  • GC06P167559

Summaries for TCP10L2 Gene

GeneCards Summary for TCP10L2 Gene

TCP10L2 (T-Complex 10-Like 2) is a Protein Coding gene. An important paralog of this gene is TCP10L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10L2 Gene

Genomics for TCP10L2 Gene

Regulatory Elements for TCP10L2 Gene

Promoters for TCP10L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TCP10L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP10L2 Gene

Chromosome:
6
Start:
167,146,414 bp from pter
End:
167,196,913 bp from pter
Size:
50,500 bases
Orientation:
Plus strand

Genomic View for TCP10L2 Gene

Genes around TCP10L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP10L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP10L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10L2 Gene

Proteins for TCP10L2 Gene

  • Protein details for TCP10L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B9ZVM9-TCP2L_HUMAN
    Recommended name:
    T-complex protein 10A homolog 2
    Protein Accession:
    B9ZVM9

    Protein attributes for TCP10L2 Gene

    Size:
    353 amino acids
    Molecular mass:
    38357 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCP10L2 Gene

Proteomics data for TCP10L2 Gene at MOPED

Post-translational modifications for TCP10L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCP10L2 Gene

Domains & Families for TCP10L2 Gene

Protein Domains for TCP10L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP10L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B9ZVM9

UniProtKB/Swiss-Prot:

TCP2L_HUMAN :
  • Belongs to the TCP10 family.
Family:
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10L2: view

No data available for Gene Families for TCP10L2 Gene

Function for TCP10L2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10L2 Gene

Localization for TCP10L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCP10L2 Gene COMPARTMENTS Subcellular localization image for TCP10L2 gene
Compartment Confidence
cytosol 5
nucleus 3
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCP10L2 Gene

Pathways & Interactions for TCP10L2 Gene

SuperPathways for TCP10L2 Gene

No Data Available

Interacting Proteins for TCP10L2 Gene

Gene Ontology (GO) - Biological Process for TCP10L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP10L2 Gene

Drugs & Compounds for TCP10L2 Gene

No Compound Related Data Available

Transcripts for TCP10L2 Gene

mRNA/cDNA for TCP10L2 Gene

(13) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCP10L2 Gene

T-complex 10-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10L2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for TCP10L2 Gene

GeneLoc Exon Structure for
TCP10L2
ECgene alternative splicing isoforms for
TCP10L2

Expression for TCP10L2 Gene

mRNA expression in normal human tissues for TCP10L2 Gene

mRNA differential expression in normal tissues according to GTEx for TCP10L2 Gene

This gene is overexpressed in Testis (x39.9).

Protein differential expression in normal tissues from HIPED for TCP10L2 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCP10L2 Gene



SOURCE GeneReport for Unigene cluster for TCP10L2 Gene Hs.691976

genes like me logo Genes that share expression patterns with TCP10L2: view

Protein tissue co-expression partners for TCP10L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TCP10L2 Gene

Orthologs for TCP10L2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TCP10L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
OneToMany
Species with no ortholog for TCP10L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10L2 Gene

ENSEMBL:
Gene Tree for TCP10L2 (if available)
TreeFam:
Gene Tree for TCP10L2 (if available)

Paralogs for TCP10L2 Gene

Paralogs for TCP10L2 Gene

(2) SIMAP similar genes for TCP10L2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TCP10L2: view

Variants for TCP10L2 Gene

Sequence variations from dbSNP and Humsavar for TCP10L2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1811944 -- 167,174,312(-) GTAGA(C/G)AGTAA intron-variant
rs1974181 -- 167,176,594(-) AATTC(C/G/T)CAACT intron-variant
rs2345789 -- 167,177,598(+) GCCAC(A/G)GTGCA intron-variant
rs2345790 -- 167,177,693(+) CATCC(C/T)AGCTT intron-variant
rs2345791 -- 167,177,720(+) TCGGG(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP10L2 Gene

Variant ID Type Subtype PubMed ID
nsv469673 CNV Loss 16826518
essv22845 CNV CNV 17122850
dgv2033e1 CNV Complex 17122850
nsv464141 CNV Gain 19166990
nsv470873 CNV Gain 18288195
nsv7389 OTHER Inversion 18451855
nsv8000 CNV Gain 18304495

Variation tolerance for TCP10L2 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP10L2 Gene

HapMap Linkage Disequilibrium report
TCP10L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10L2 Gene

Disorders for TCP10L2 Gene

Relevant External Links for TCP10L2

Genetic Association Database (GAD)
TCP10L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP10L2

No disorders were found for TCP10L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP10L2 Gene

Publications for TCP10L2 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 67

Products for TCP10L2 Gene

Sources for TCP10L2 Gene

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