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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCP10L Gene

protein-coding   GIFtS: 43
GCID: GC21M033947

T-Complex 10-Like

(Previous names: t-complex 10 (a murine tcp homolog)-like, t-complex 10 (mouse)-like)
  Search for TCP10L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
T-Complex 10-Like1 2     T-Complex 10 (Mouse)-Like1
T-Complex 10 (A Murine Tcp Homolog)-Like1 2     Gene Similar To TCP10, Spliced ESTs AA465232,T1886511
TCP10-like2 3     C21orf772
TCP10A-22 3     T-Complex 10A-22
T-Complex Protein 10A-22 3     T-Complex Protein 10A Homolog 22

External Ids:    HGNC: 116571   Entrez Gene: 1402902   Ensembl: ENSG000002422207   OMIM: 6083655   UniProtKB: Q8TDR43   

Export aliases for TCP10L gene to outside databases

Previous GC identifers: GC21U990032 GC21M030609 GC21M032869 GC21M032870 GC21M019356


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCP10L Gene: 
TCP10L (t-complex 10-like) is a protein-coding gene. An important paralog of this gene is TCP10L2.

Gene Wiki entry for TCP10L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCP10L gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   AML1a   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCP10L promoter sequence

   Search SABiosciences Chromatin IP Primers for TCP10L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP10L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21p22.11
Nature(405: 311-319) cytogenetic band:   21q22.11
TCP10L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP10L gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M033947:   GeneLoc Nature:405,311-319
Start:
33,947,151 bp from pter       19,531,192 bp from centromere
End:
33,957,845 bp from pter 19,552,136 bp from centromere
Size:
10,695 bases 20,945 bases
Orientation:
minus strand minus strand

genomic clones: pT1866


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCP1L_HUMAN, Q8TDR4 (See protein sequence)
Recommended Name: T-complex protein 10A homolog 2  
Size: 215 amino acids; 23863 Da
Subunit: Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper)
Subcellular location: Nucleus
Secondary accessions: Q53EW0 Q96LN5

Explore the universe of human proteins at neXtProt for TCP10L: NX_Q8TDR4

Explore proteomics data for TCP10L at MOPED 

TCP10L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TCP10L Protein Expression

REFSEQ proteins: NP_653260.1  
ENSEMBL proteins: 
 ENSP00000300258  

Human Recombinant Protein Products for TCP10L: 
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Cloud-Clone Corp. Proteins for TCP10L 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

TCP10L for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026581 TCP10_fam

Graphical View of Domain Structure for InterPro Entry Q8TDR4

ProtoNet protein and cluster: Q8TDR4

UniProtKB/Swiss-Prot: TCP1L_HUMAN, Q8TDR4
Similarity: Belongs to the TCP10 family


TCP10L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TCP10L 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TCP10L

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TCP10L 
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miRNA
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Inhib. RNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TCP10L

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for TCP10L (Q8TDR43 ENSP000003002584) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
MXD4Q145823, ENSP000003378894I2D: score=3 STRING: ENSP00000337889
IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
KIAA1279ENSP000003548484STRING: ENSP00000354848
DAPK3ENSP000003012644STRING: ENSP00000301264
PMF1ENSP000003572604STRING: ENSP00000357260
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCP10L (TCP1L)

Search CenterWatch for drugs/clinical trials and news about TCP10L / TCP1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCP10L gene (2 alternative transcripts): 
NM_018277.1  NM_144659.5  

Unigene Cluster for TCP10L:

T-complex 10-like
Hs.728804  [show with all ESTs]
Unigene Representative Sequence: NM_144659
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000300258(uc002ypw.4) ENST00000491828 ENST00000472557
miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TCP10L
SwitchGear 3'UTR luciferase reporter plasmidTCP10L 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene RNAi products in human, mouse, rat for TCP10L
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP10L
Clone
Products:
     
OriGene clones in human, mouse for TCP10L (see all 9)
OriGene ORF clones in mouse, rat for TCP10L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TCP10L (NM_144659)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCP10L
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP10L
Sirion Biotech Customized lentivirus for stable overexpression of TCP10L 
                     Customized lentivirus expression plasmids for stable overexpression of TCP10L 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TCP10L
OriGene qSTAR qPCR primer pairs in human, mouse for TCP10L
SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCP10L
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP10L
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP10L

Additional mRNA sequence: 

AF115967.1 AK058078.1 AK223529.1 BC022024.1 BC027970.1 BC033855.1 

8 DOTS entries:

DT.452217  DT.92044221  DT.95371622  DT.121131067  DT.100795172  DT.91754960  DT.97805460  DT.115351 

24/62 AceView cDNA sequences (see all 62):

AA382487 AW237236 AA621071 AA609366 AA609387 BI826590 AW590610 BE502161 
BC033855 F11677 H94895 H94947 NM_144659 T18865 BE502219 BG717680 
AI026842 AI336920 BI831049 BI829783 BI464927 BC022024 AA758217 BX111775 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCP10L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGCTCCGAG
TCP10L Expression
About this image


See TCP10L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCP10L

SOURCE GeneReport for Unigene cluster: Hs.728804

UniProtKB/Swiss-Prot: TCP1L_HUMAN, Q8TDR4
Tissue specificity: Expressed in the seminiferous tubules (at protein level). Liver and testis

    SABiosciences Custom PCR Arrays for TCP10L
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP10L
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP10L
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10L

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TCP10L gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcp10a5 t-complex protein 10a   --   17 (4.72 cM) 7324646 


ENSEMBL Gene Tree for TCP10L (if available)
TreeFam Gene Tree for TCP10L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TCP10L gene
TCP10L22  TCP102  
2 SIMAP similar genes for TCP10L using alignment to 1 protein entry:     TCP1L_HUMAN:
TCP10L2    TCP10

TCP10L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/314 SNPs in TCP10L are shown (see all 314)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1811626621,2
--33946839(+) CCTCAC/GGGGAA 1 -- int10--------
rs1482388301,2
--33946897(+) CTCTGC/TAATGT 1 -- int10--------
rs1133247081,2
C,F--33947082(+) GCAAAC/TGTGTG 1 -- int12Minor allele frequency- T:0.02NA 122
rs1494902151,2
--33947124(+) TACAC-/ATGTCAG 1 -- int10--------
rs780165561,2
C,F--33947205(+) TCTTTC/TGAGTA 1 -- ut311Minor allele frequency- T:0.07WA 118
rs1856199511,2
C--33947278(+) GTCCCA/GCAGCA 1 -- ut310--------
rs1915628661,2
--33947346(+) AGGGCC/TACGGG 1 -- ut310--------
rs594531341,2
C,F--33947729(+) GGGGGT/CGGGCA 1 -- ut319Minor allele frequency- C:0.42NA WA CSA EA 367
rs1834016821,2
--33947746(+) CCGGGA/GGGCAG 1 -- ut310--------
rs28339071,2
C,F,O,H--33947780(+) ATTCGA/GCCCTG 1 -- ut3123Minor allele frequency- N:0.00NA EA NS WA 2631

HapMap Linkage Disequilibrium report for TCP10L (33947151 - 33957845 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for TCP10L:    About this table     
Variant IDTypeSubtypePubMed ID
esv2671062CNV Deletion23128226
nsv438321CNV Loss16468122
dgv4733n71CNV Gain21882294
dgv4732n71CNV Gain21882294
dgv4731n71CNV Gain21882294
nsv913691CNV Gain21882294
dgv4730n71CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TCP10L for disorders           About MalaCards
OMIM gene information: 608365    OMIM disorders: --


TCP10L for disorders           About GeneDecksing


Export disorders for TCP10L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TCP10L gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TCP10L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M....Yaspo M.L. (2000)
  2. TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. (PubMed id 15910542)1, 2 Yu H....Yu L. (2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. (PubMed id 14586771)1, 9 Chen Z....Zhao S. (2003)
  6. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
  7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  8. Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (2010)
  9. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
  10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 140290 HGNC: 11657 AceView: TCP10L Ensembl:ENSG00000242220 euGenes: HUgn140290
ECgene: TCP10L H-InvDB: TCP10L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TCP10L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TCP10L gene:
Search GeneIP for patents involving TCP10L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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