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Aliases for TCP10L Gene

Aliases for TCP10L Gene

  • T-Complex 10-Like 2 3 5
  • T-Complex 10 (A Murine Tcp Homolog)-Like 2 3
  • T-Complex Protein 10A-2 3 4
  • TCP10-Like 3 4
  • TCP10A-2 3 4
  • T-Complex Protein 10A Homolog 2 3
  • T-Complex 10 (Mouse)-Like 2
  • T-Complex 10A-2 3
  • C21orf77 3
  • PRED77 3

External Ids for TCP10L Gene

Previous GeneCards Identifiers for TCP10L Gene

  • GC21U990032
  • GC21M030609
  • GC21M032869
  • GC21M032870
  • GC21M033947
  • GC21M019356

Summaries for TCP10L Gene

GeneCards Summary for TCP10L Gene

TCP10L (T-Complex 10-Like) is a Protein Coding gene. Diseases associated with TCP10L include Hepatocellular Carcinoma. GO annotations related to this gene include identical protein binding and repressing transcription factor binding. An important paralog of this gene is TCP10L2.

UniProtKB/Swiss-Prot for TCP10L Gene

  • May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.

Gene Wiki entry for TCP10L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10L Gene

Genomics for TCP10L Gene

Regulatory Elements for TCP10L Gene

Enhancers for TCP10L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F033035 0.7 FANTOM5 48.1 -448.0 -447976 0.1 CTBP2 TCP10L DNAJC28 LOC105372785 OLIG2
GH21F032545 0.2 ENCODE 25.3 +41.6 41593 1.1 ATF1 TBL1XR1 NFRKB YY1 GATA2 CREM ZBTB2 NCOA1 ZEB2 SMARCB1 TCP10L EVA1C URB1 URB1-AS1 ENSG00000252045 PIR42781
GH21F032561 1.1 Ensembl ENCODE 19.6 +25.2 25235 2.2 TBP CTCF ATF1 PKNOX1 MAX RAD21 GTF3C2 POLR3A SMC3 NFE2 TCP10L ENSG00000252045 EVA1C URB1 URB1-AS1 SNORA80A PIR42781 RNA5SP490
GH21F032560 0.8 ENCODE 18.9 +26.5 26468 0.2 ATF3 CEBPB ZEB2 CEBPG TCP10L ENSG00000252045 URB1 URB1-AS1 EVA1C PIR42781
GH21F032519 0.9 FANTOM5 Ensembl ENCODE 16.3 +65.0 65042 6.5 ATF1 PKNOX1 SIN3A GLI4 BRCA1 YY1 FOS ZNF263 REST ZNF518A TCP10L EVA1C EXOSC3P1 SNORA80A PAXBP1 PIR52370
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TCP10L on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP10L Gene

Chromosome:
21
Start:
32,574,841 bp from pter
End:
32,587,373 bp from pter
Size:
12,533 bases
Orientation:
Minus strand

Genomic View for TCP10L Gene

Genes around TCP10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10L Gene

Proteins for TCP10L Gene

  • Protein details for TCP10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDR4-TCP1L_HUMAN
    Recommended name:
    T-complex protein 10A homolog 2
    Protein Accession:
    Q8TDR4
    Secondary Accessions:
    • Q53EW0
    • Q96LN5

    Protein attributes for TCP10L Gene

    Size:
    215 amino acids
    Molecular mass:
    23863 Da
    Quaternary structure:
    • Self-associates (via leucine zipper). Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper). Interacts with MAD4.

neXtProt entry for TCP10L Gene

Post-translational modifications for TCP10L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10L Gene

No data available for DME Specific Peptides for TCP10L Gene

Domains & Families for TCP10L Gene

Protein Domains for TCP10L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP10L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDR4

UniProtKB/Swiss-Prot:

TCP1L_HUMAN :
  • Belongs to the TCP10 family.
Family:
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10L: view

No data available for Gene Families for TCP10L Gene

Function for TCP10L Gene

Molecular function for TCP10L Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.

Gene Ontology (GO) - Molecular Function for TCP10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001106 RNA polymerase II transcription corepressor activity IDA 14586771
GO:0005515 protein binding IPI 15469726
GO:0042802 identical protein binding IPI 17377852
GO:0043621 protein self-association IDA 17377852
GO:0070491 repressing transcription factor binding IDA 15469726
genes like me logo Genes that share ontologies with TCP10L: view
genes like me logo Genes that share phenotypes with TCP10L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10L Gene

Localization for TCP10L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCP10L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCP10L Gene COMPARTMENTS Subcellular localization image for TCP10L gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TCP10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 14586771
genes like me logo Genes that share ontologies with TCP10L: view

Pathways & Interactions for TCP10L Gene

SuperPathways for TCP10L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 14586771
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCP10L: view

No data available for Pathways by source and SIGNOR curated interactions for TCP10L Gene

Transcripts for TCP10L Gene

Unigene Clusters for TCP10L Gene

T-complex 10-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10L Gene

No ASD Table

Relevant External Links for TCP10L Gene

GeneLoc Exon Structure for
TCP10L
ECgene alternative splicing isoforms for
TCP10L

Expression for TCP10L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCP10L Gene

mRNA differential expression in normal tissues according to GTEx for TCP10L Gene

This gene is overexpressed in Testis (x36.7).

Protein differential expression in normal tissues from HIPED for TCP10L Gene

This gene is overexpressed in Testis (45.1) and Heart (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCP10L Gene



Protein tissue co-expression partners for TCP10L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCP10L Gene:

TCP10L

SOURCE GeneReport for Unigene cluster for TCP10L Gene:

Hs.728804

mRNA Expression by UniProt/SwissProt for TCP10L Gene:

Q8TDR4-TCP1L_HUMAN
Tissue specificity: Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).
genes like me logo Genes that share expression patterns with TCP10L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TCP10L Gene

Orthologs for TCP10L Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TCP10L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCP10L 34 35
  • 86.76 (n)
Species where no ortholog for TCP10L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10L Gene

ENSEMBL:
Gene Tree for TCP10L (if available)
TreeFam:
Gene Tree for TCP10L (if available)

Paralogs for TCP10L Gene

Paralogs for TCP10L Gene

(2) SIMAP similar genes for TCP10L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TCP10L: view

Variants for TCP10L Gene

Sequence variations from dbSNP and Humsavar for TCP10L Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1015047 -- 32,577,113(-) ATCCC(A/G)AATTT intron-variant
rs1015048 -- 32,576,996(-) CTGGT(A/G)TGATG intron-variant
rs111482362 -- 32,586,488(+) GGGTC(C/T)TAAGG upstream-variant-2KB
rs111628361 -- 32,577,242(+) CAAGG(C/T)GTGGA intron-variant
rs111872228 -- 32,585,632(+) TTCTT(A/T)ATATA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCP10L Gene

Variant ID Type Subtype PubMed ID
esv2671062 CNV deletion 23128226
esv3557645 CNV deletion 23714750
esv3646886 CNV gain 21293372
esv3646888 CNV loss 21293372
esv3646889 CNV loss 21293372
esv3893405 CNV gain 25118596
nsv1063676 CNV gain 25217958
nsv1066657 CNV gain 25217958
nsv438321 CNV loss 16468122

Variation tolerance for TCP10L Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP10L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP10L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10L Gene

Disorders for TCP10L Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCP10L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TCP10L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP10L
genes like me logo Genes that share disorders with TCP10L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCP10L Gene

Publications for TCP10L Gene

  1. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. (PMID: 14586771) Chen Z. … Zhao S. (J. Hum. Genet. 2003) 3 4 22 64
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3 4 64
  3. TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma. (PMID: 24565846) Zuo J. … Yu L. (Biochem. Biophys. Res. Commun. 2014) 3 4 64
  4. Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif. (PMID: 17377852) Zhong Z. … Yu L. (Mol. Biol. Rep. 2008) 3 4 64
  5. TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. (PMID: 15910542) Yu H. … Yu L. (Int. J. Androl. 2005) 3 4 64

Products for TCP10L Gene

Sources for TCP10L Gene

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