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TCP10L Gene

protein-coding   GIFtS: 40
GCID: GC21M033947

T-Complex 10-Like

(Previous names: t-complex 10 (a murine tcp homolog)-like, t-complex 10 (mouse)-like)
  Search for TCP10L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
T-Complex 10-Like1 2     T-Complex 10 (Mouse)-Like1
T-Complex 10 (A Murine Tcp Homolog)-Like1 2     Gene Similar To TCP10, Spliced ESTs AA465232,T1886511
TCP10-like2 3     C21orf772
TCP10A-22 3     T-Complex 10A-22
T-Complex Protein 10A-22 3     T-Complex Protein 10A Homolog 22

External Ids:    HGNC: 116571   Entrez Gene: 1402902   Ensembl: ENSG000002422207   OMIM: 6083655   UniProtKB: Q8TDR43   

Export aliases for TCP10L gene to outside databases

Previous GC identifers: GC21U990032 GC21M030609 GC21M032869 GC21M032870 GC21M019356


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCP10L Gene:
TCP10L (t-complex 10-like) is a protein-coding gene. An important paralog of this gene is TCP10L2.

Gene Wiki entry for TCP10L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TCP10L gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   AML1a   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCP10L promoter sequence

   Search Chromatin IP Primers for TCP10L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCP10L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21p22.11
Nature(405: 311-319) cytogenetic band:   21q22.11
TCP10L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP10L gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M033947:   GeneLoc Nature:405,311-319
Start:
33,947,151 bp from pter       19,531,192 bp from centromere
End:
33,959,683 bp from pter 19,552,136 bp from centromere
Size:
12,533 bases 20,945 bases
Orientation:
minus strand minus strand

genomic clones: pT1866


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TCP1L_HUMAN, Q8TDR4 (See protein sequence)
Recommended Name: T-complex protein 10A homolog 2  
Size: 215 amino acids; 23863 Da
Subunit: Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper)
Secondary accessions: Q53EW0 Q96LN5

Explore the universe of human proteins at neXtProt for TCP10L: NX_Q8TDR4

Explore proteomics data for TCP10L at MOPED


See TCP10L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_653260.1  
ENSEMBL proteins: 
 ENSP00000300258   ENSP00000476697   ENSP00000476481   ENSP00000463050  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR026581 TCP10_fam

Graphical View of Domain Structure for InterPro Entry Q8TDR4

ProtoNet protein and cluster: Q8TDR4

UniProtKB/Swiss-Prot: TCP1L_HUMAN, Q8TDR4
Similarity: Belongs to the TCP10 family


TCP10L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCP10L
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TCP1L_HUMAN, Q8TDR4: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol3
cytoskeleton1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

TCP10L for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCP10L
Interactions:

    GeneGlobe Interaction Network for TCP10L

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for TCP10L (Q8TDR43 ENSP000003002584) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
InteractantInteraction Details
GeneCardExternal ID(s)
MXD4Q145823, ENSP000003378894I2D: score=3 STRING: ENSP00000337889
IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
KIAA1279ENSP000003548484STRING: ENSP00000354848
DAPK3ENSP000003012644STRING: ENSP00000301264
PMF1ENSP000003572604STRING: ENSP00000357260
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TCP10L (TCP1L)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TCP10L gene (2 alternative transcripts): 
NM_018277.1  NM_144659.5  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000300258(uc002ypw.4) ENST00000491828 ENST00000472557 ENST00000582575

miRNA
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Selected AceView cDNA sequences (see all 62):

AW590610 BE502161 AA609366 AA621071 AA382487 AA609387 BI826590 AW237236 
AA417327 AK058078 AA758217 BX111775 BI464927 AI336920 BI831049 AI979285 
AA621014 H94947 BI829783 BI830140 CD300264 BI520190 AI183985 AI024428 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TCP10L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGCTCCGAG
TCP10L Expression
About this image

TCP10L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TCP10L Protein Expression

UniProtKB/Swiss-Prot: TCP1L_HUMAN, Q8TDR4
Tissue specificity: Expressed in the seminiferous tubules (at protein level). Liver and testis

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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TCP10L gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcp10a5 t-complex protein 10a   --   17 (4.72 cM) 7324646 


ENSEMBL Gene Tree for TCP10L (if available)
TreeFam Gene Tree for TCP10L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TCP10L gene
TCP10L22  TCP102  
2 SIMAP similar genes for TCP10L using alignment to 4 protein entries:     TCP1L_HUMAN (see all proteins):
TCP10L2    TCP10

TCP10L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TCP10L (see all 314)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1811626621,2
--33946839(+) CCTCAC/GGGGAA 1 -- int10--------
rs1482388301,2
--33946897(+) CTCTGC/TAATGT 1 -- int10--------
rs1133247081,2
C,F--33947082(+) GCAAAC/TGTGTG 1 -- int12Minor allele frequency- T:0.02NA 122
rs1494902151,2
--33947124(+) TACAC-/ATGTCAG 1 -- int10--------
rs780165561,2
C,F--33947205(+) TCTTTC/TGAGTA 1 -- ut311Minor allele frequency- T:0.07WA 118
rs1856199511,2
C--33947278(+) GTCCCA/GCAGCA 1 -- ut310--------
rs1915628661,2
--33947346(+) AGGGCC/TACGGG 1 -- ut310--------
rs594531341,2
C,F--33947729(+) GGGGGT/CGGGCA 1 -- ut319Minor allele frequency- C:0.42NA WA CSA EA 367
rs1834016821,2
--33947746(+) CCGGGA/GGGCAG 1 -- ut310--------
rs28339071,2
C,F,O,H--33947780(+) ATTCGA/GCCCTG 1 -- ut3123Minor allele frequency- N:0.00NA EA NS WA 2631

HapMap Linkage Disequilibrium report for TCP10L (33947151 - 33959683 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for TCP10L:    About this table    
Variant IDTypeSubtypePubMed ID
esv2671062CNV Deletion23128226
nsv438321CNV Loss16468122
dgv4733n71CNV Gain21882294
dgv4732n71CNV Gain21882294
dgv4731n71CNV Gain21882294
nsv913691CNV Gain21882294
dgv4730n71CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608365    OMIM disorders: --


TCP10L for disorders           About GeneDecksing


Export disorders for TCP10L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TCP10L gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with TCP10L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2, 3 Hattori M.... Yaspo M.-L. (Nature 2000)
  2. TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. (PubMed id 15910542)1, 2 Yu H.... Yu L. (Int. J. Androl. 2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. (PubMed id 14586771)1, 9 Chen Z....Zhao S. (J. Hum. Genet. 2003)
  6. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
  7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. Expanding the substantial interactome of NEMO using protein microarrays. (PubMed id 20098747)1 Fenner B.J....Prehn J.H. (PLoS ONE 2010)
  10. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (Mol. Syst. Biol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 140290 HGNC: 11657 AceView: TCP10L Ensembl:ENSG00000242220 euGenes: HUgn140290
ECgene: TCP10L H-InvDB: TCP10L

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TCP10L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TCP10L gene:
Search GeneIP for patents involving TCP10L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 SwitchGear 3'UTR luciferase reporter plasmids for TCP10L
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP10L
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCP10L
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCP10L
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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