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Aliases for TCP10L Gene

Aliases for TCP10L Gene

  • T-Complex 10-Like 2 3 5
  • T-Complex 10 (A Murine Tcp Homolog)-Like 2 3
  • T-Complex Protein 10A-2 3 4
  • TCP10-Like 3 4
  • TCP10A-2 3 4
  • T-Complex 10 (Mouse)-Like 2
  • T-Complex 10A-2 3
  • C21orf77 3
  • PRED77 3

External Ids for TCP10L Gene

Previous GeneCards Identifiers for TCP10L Gene

  • GC21U990032
  • GC21M030609
  • GC21M032869
  • GC21M032870
  • GC21M033947
  • GC21M019356

Summaries for TCP10L Gene

GeneCards Summary for TCP10L Gene

TCP10L (T-Complex 10-Like) is a Protein Coding gene. Diseases associated with TCP10L include Hepatocellular Carcinoma. GO annotations related to this gene include identical protein binding and repressing transcription factor binding. An important paralog of this gene is TCP10L2.

UniProtKB/Swiss-Prot for TCP10L Gene

  • May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.

Gene Wiki entry for TCP10L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10L Gene

Genomics for TCP10L Gene

Regulatory Elements for TCP10L Gene

Enhancers for TCP10L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCP10L on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP10L Gene

Chromosome:
21
Start:
32,574,841 bp from pter
End:
32,587,373 bp from pter
Size:
12,533 bases
Orientation:
Minus strand

Genomic View for TCP10L Gene

Genes around TCP10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10L Gene

Proteins for TCP10L Gene

  • Protein details for TCP10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDR4-TCP1L_HUMAN
    Recommended name:
    T-complex protein 10A homolog 2
    Protein Accession:
    Q8TDR4
    Secondary Accessions:
    • Q53EW0
    • Q96LN5

    Protein attributes for TCP10L Gene

    Size:
    215 amino acids
    Molecular mass:
    23863 Da
    Quaternary structure:
    • Self-associates (via leucine zipper). Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper). Interacts with MAD4.

neXtProt entry for TCP10L Gene

Proteomics data for TCP10L Gene at MOPED

Post-translational modifications for TCP10L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10L Gene

No data available for DME Specific Peptides for TCP10L Gene

Domains & Families for TCP10L Gene

Protein Domains for TCP10L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP10L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDR4

UniProtKB/Swiss-Prot:

TCP1L_HUMAN :
  • Belongs to the TCP10 family.
Family:
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10L: view

No data available for Gene Families for TCP10L Gene

Function for TCP10L Gene

Molecular function for TCP10L Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.

Gene Ontology (GO) - Molecular Function for TCP10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043621 protein self-association IDA 17377852
GO:0070491 repressing transcription factor binding IDA 15469726
genes like me logo Genes that share ontologies with TCP10L: view

Phenotypes for TCP10L Gene

genes like me logo Genes that share phenotypes with TCP10L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10L Gene

Localization for TCP10L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCP10L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCP10L Gene COMPARTMENTS Subcellular localization image for TCP10L gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for TCP10L Gene

Pathways & Interactions for TCP10L Gene

SuperPathways for TCP10L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP10L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP10L Gene

Drugs & Compounds for TCP10L Gene

No Compound Related Data Available

Transcripts for TCP10L Gene

Unigene Clusters for TCP10L Gene

T-complex 10-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10L Gene

No ASD Table

Relevant External Links for TCP10L Gene

GeneLoc Exon Structure for
TCP10L
ECgene alternative splicing isoforms for
TCP10L

Expression for TCP10L Gene

mRNA expression in normal human tissues for TCP10L Gene

mRNA differential expression in normal tissues according to GTEx for TCP10L Gene

This gene is overexpressed in Testis (x36.7).

Protein differential expression in normal tissues from HIPED for TCP10L Gene

This gene is overexpressed in Testis (45.1) and Heart (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCP10L Gene



SOURCE GeneReport for Unigene cluster for TCP10L Gene Hs.728804

mRNA Expression by UniProt/SwissProt for TCP10L Gene

Q8TDR4-TCP1L_HUMAN
Tissue specificity: Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).
genes like me logo Genes that share expression patterns with TCP10L: view

Protein tissue co-expression partners for TCP10L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TCP10L Gene

Orthologs for TCP10L Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TCP10L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCP10L 35
  • 86.76 (n)
  • 82.78 (a)
TCP10L 36
  • 82 (a)
OneToOne
Species with no ortholog for TCP10L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10L Gene

ENSEMBL:
Gene Tree for TCP10L (if available)
TreeFam:
Gene Tree for TCP10L (if available)

Paralogs for TCP10L Gene

Paralogs for TCP10L Gene

(2) SIMAP similar genes for TCP10L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TCP10L: view

Variants for TCP10L Gene

Sequence variations from dbSNP and Humsavar for TCP10L Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs9622 - 32,578,758(+) TCTTG(C/T)GGCCA reference, missense
rs16989521 - 32,576,841(+) CTTGA(A/C/T)GTCTC reference, missense
rs1523309 -- 32,575,304(-) CACTT(C/T)TCTGT utr-variant-3-prime
rs2833907 -- 32,575,470(+) ATTCG(A/G)CCCTG utr-variant-3-prime
rs2833908 -- 32,576,063(+) CCAAC(C/G)AGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TCP10L Gene

Variant ID Type Subtype PubMed ID
dgv4730n71 CNV Gain 21882294
dgv4731n71 CNV Gain 21882294
nsv913691 CNV Gain 21882294
dgv4732n71 CNV Gain 21882294
dgv4733n71 CNV Gain 21882294
esv2671062 CNV Deletion 23128226
nsv438321 CNV Loss 16468122

Variation tolerance for TCP10L Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TCP10L Gene

Disorders for TCP10L Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCP10L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TCP10L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP10L
genes like me logo Genes that share disorders with TCP10L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCP10L Gene

Publications for TCP10L Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3 4 67
  2. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. (PMID: 14586771) Chen Z. … Zhao S. (J. Hum. Genet. 2003) 3 23
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma. (PMID: 24565846) Zuo J. … Yu L. (Biochem. Biophys. Res. Commun. 2014) 3
  5. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3

Products for TCP10L Gene

Sources for TCP10L Gene

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