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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TCP10 Gene

protein-coding   GIFtS: 49
GCID: GC06M167741

T-Complex 10

(Previous names: t-complex 10 (a murine tcp homolog), t-complex 10 (mouse),...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
T-Complex 101 2     T-Complex 10 Homolog (Mouse)1
T-Complex 10 (A Murine Tcp Homolog)1 2     T-Complex 10 Homolog2
TCP10A2 3     T-Complex Protein 10A Homolog2
T-Complex 10 (Mouse)1     

External Ids:    HGNC: 116561   Entrez Gene: 69532   Ensembl: ENSG000002036907   OMIM: 1870205   UniProtKB: Q127993   

Export aliases for TCP10 gene to outside databases

Previous GC identifers: GC06M167123 GC06M167644 GC06M167679 GC06M165259


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TCP10 Gene: 
TCP10 (t-complex 10) is a protein-coding gene. Diseases associated with TCP10 include spina bifida. An important paralog of this gene is TCP10L.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TCP10 gene promoter:
         AREB6   CUTL1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TCP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

TCP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M167741:  view genomic region     (about GC identifiers)

Start:
167,770,521 bp from pter      End:
167,797,998 bp from pter
Size:
27,478 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TCP10_HUMAN, Q12799 (See protein sequence)
Recommended Name: T-complex protein 10A homolog  
Size: 353 amino acids; 38267 Da
Sequence caution: Sequence=AAA82109.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAI39675.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu; Sequence=CAI42705.1;
Type=Erroneous termination; Positions=10; Note=Translated as Glu;
Secondary accessions: Q5JR60 Q6P4F4
Alternative splicing: 2 isoforms:  Q12799-1   Q12799-2   

Explore the universe of human proteins at neXtProt for TCP10: NX_Q12799

Explore proteomics data for TCP10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12799

  • TCP10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TCP10 Protein Expression
    REFSEQ proteins: NP_004601.3  
    ENSEMBL proteins: 
     ENSP00000355792   ENSP00000380929   ENSP00000426065   ENSP00000427675   ENSP00000423829  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS8111376

    TCP10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026581 TCP10_fam

    Graphical View of Domain Structure for InterPro Entry Q12799

    ProtoNet protein and cluster: Q12799

    UniProtKB/Swiss-Prot: TCP10_HUMAN, Q12799
    Similarity: Belongs to the TCP10 family


    TCP10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for TCP10:
    T-complex 10 (murine tcp homolog)

    Phenotypes:
         1 GenomeRNAi human phenotype for TCP10:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TCP10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for TCP10 (Q127993 ENSP000003809294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD6AQ9NPB63, ENSP000002192554I2D: score=2 STRING: ENSP00000219255
    PARD6BQ9BYG53, ENSP000003606724I2D: score=1 STRING: ENSP00000360672
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TCP10

    Search CenterWatch for drugs/clinical trials and news about TCP10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TCP10 gene: 
    NM_004610.3  

    Unigene Cluster for TCP10:

    T-complex 10
    Hs.351  [show with all ESTs]
    Unigene Representative Sequence: BC063451
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508373(uc003qvu.3) ENST00000366827 ENST00000397829(uc003qvv.1)
    ENST00000514083 ENST00000460930(uc003qvw.3) ENST00000463894 ENST00000491085
    ENST00000476779 ENST00000485157
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of TCP10 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TCP10
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TCP10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP10

    Additional mRNA sequence: 

    BC063451.1 U03399.1 

    6 DOTS entries:

    DT.101979890  DT.102658  DT.65284802  DT.91789901  DT.121389275  DT.121389288 

    24 AceView cDNA sequences:

    AA723845 AA431681 NM_004610 BC068592 BV184084 BV205237 BC034995 BC063451 
    U03399 BC065839 AW086030 AA563930 BC033909 BF057216 BI458674 AA705836 
    BI828613 AI954817 AI209148 AA994391 AW027471 BG717741 BG723543 CD358571 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TCP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAACATTT
    TCP10 Expression
    About this image


    See TCP10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TCP10

    SOURCE GeneReport for Unigene cluster: Hs.351
        SABiosciences Custom PCR Arrays for TCP10
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TCP10 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcp105 t-complex protein 10   --   17 -


    ENSEMBL Gene Tree for TCP10 (if available)
    TreeFam Gene Tree for TCP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TCP10 gene
    TCP10L21 2  TCP10L2  
    2 SIMAP similar genes for TCP10 using alignment to 5 protein entries:     TCP10_HUMAN (see all proteins):
    TCP10L2    TCP10L

    TCP10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/414 SNPs in TCP10 are shown (see all 414)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438594721,2
    C--167786310(+) AGAGGC/TGTGAG 1 -- ds50010--------
    rs2015935611,2
    C--167786574(+) AAACAA/TATCTT 1 -- ds50010--------
    rs1388886621,2
    C,F--167786643(+) GAAACG/ACCTGG 1 -- ut311Minor allele frequency- A:0.01EU 1015
    rs1816712681,2
    C--167786673(+) TGTCCC/TGTCTG 2 Q R mis10--------
    rs1406499851,2
    C,F--167786686(+) GGGAGC/TGGCGT 2 T A mis11Minor allele frequency- T:0.00EU 1269
    rs1463215151,2
    C,F--167786690(+) GCGGCG/ATGCAG 2 /H syn11Minor allele frequency- A:0.01EU 961
    rs1430945881,2
    C,F--167786750(+) TTGCCC/ATTTGG 2 /K /N mis11Minor allele frequency- A:0.19EU 369
    rs785009301,2
    C--167786757(+) TTGGAG/TGTCGT 2 H P mis10--------
    rs2009488501,2
    C--167786761(+) ATGTCA/GTTTTT 2 R * stg10--------
    rs1859086781,2
    --167786926(+) CTTGCA/CCTGGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TCP10 (167770521 - 167797998 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for TCP10 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733230CNV Deletion23290073
    esv2678340CNV Deletion23128226
    nsv886946CNV Loss21882294
    nsv886950CNV Loss21882294
    nsv470873CNV Gain18288195
    nsv8002CNV Gain18304495
    dgv7036n71CNV Gain21882294
    nsv464141CNV Gain19166990
    esv34252CNV Gain17911159
    essv22845CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 187020    OMIM disorders: --

    2 diseases for TCP10:    About MalaCards
    spina bifida    

    1 disease from the University of Copenhagen DISEASES database for TCP10:
    Spina bifida

    TCP10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TCP10

    Export disorders for TCP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TCP10 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TCP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. (PubMed id 8111376)1, 2, 3 Islam S.D.... Silver L.M. (1993)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PubMed id 10934474)1 Joberty G.... Macara I.G. (2000)
    10. miR319a targeting of TCP4 is critical for petal growt h and development in Arabidopsis. (PubMed id 20007771)9 Nag A....Jack T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6953 HGNC: 11656 AceView: TCP10 Ensembl:ENSG00000203690 euGenes: HUgn6953
    ECgene: TCP10 H-InvDB: TCP10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TCP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TCP10 gene:
    Search GeneIP for patents involving TCP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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