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TCP10 Gene

protein-coding   GIFtS: 49
GCID: GC06M167741

T-Complex 10

(Previous names: t-complex 10 (a murine tcp homolog), t-complex 10 (mouse),...)
  Search for TCP10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
T-Complex 101 2     T-Complex 10 Homolog (Mouse)1
T-Complex 10 (A Murine Tcp Homolog)1 2     T-Complex 10 Homolog2
TCP10A2 3     T-Complex Protein 10A Homolog2
T-Complex 10 (Mouse)1     

External Ids:    HGNC: 116561   Entrez Gene: 69532   Ensembl: ENSG000002036907   OMIM: 1870205   UniProtKB: Q127993   
ORGUL members:         

Export aliases for TCP10 gene to outside databases

Previous GC identifers: GC06M167123 GC06M167644 GC06M167679 GC06M165259


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TCP10 Gene:
TCP10 (t-complex 10) is a protein-coding gene. An important paralog of this gene is TCP10L.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCP10 gene promoter:
         AREB6   CUTL1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TCP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

TCP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M167741:  view genomic region     (about GC identifiers)

Start:
167,770,521 bp from pter      End:
167,797,998 bp from pter
Size:
27,478 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TCP10_HUMAN, Q12799 (See protein sequence)
Recommended Name: T-complex protein 10A homolog  
Size: 353 amino acids; 38267 Da
Sequence caution: Sequence=AAA82109.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAI39675.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu; Sequence=CAI42705.1;
Type=Erroneous termination; Positions=10; Note=Translated as Glu;
Secondary accessions: Q5JR60 Q6P4F4
Alternative splicing: 2 isoforms:  Q12799-1   Q12799-2   

Explore the universe of human proteins at neXtProt for TCP10: NX_Q12799

Explore proteomics data for TCP10 at MOPED


See TCP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004601.3  
ENSEMBL proteins: 
 ENSP00000355792   ENSP00000380929   ENSP00000426065   ENSP00000427675   ENSP00000423829  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR026581 TCP10_fam

Graphical View of Domain Structure for InterPro Entry Q12799

ProtoNet protein and cluster: Q12799

UniProtKB/Swiss-Prot: TCP10_HUMAN, Q12799
Similarity: Belongs to the TCP10 family


Find genes that share domains with TCP10           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for TCP10:
T-complex 10 (murine tcp homolog)

Phenotypes:
     1 GenomeRNAi human phenotype for TCP10:
 Increased gamma-H2AX phosphory 

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
nucleus3

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005829cytosol TAS8111376

Find genes that share ontologies with TCP10           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TCP10
Interactions:

    Search GeneGlobe Interaction Network for TCP10

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TCP10 (Q127993 ENSP000003809294) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
PARD6AQ9NPB63, ENSP000002192554I2D: score=2 STRING: ENSP00000219255
PARD6BQ9BYG53, ENSP000003606724I2D: score=1 STRING: ENSP00000360672
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TCP10



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for TCP10 gene: 
NM_004610.3  

Unigene Cluster for TCP10:

T-complex 10
Hs.351  [show with all ESTs]
Unigene Representative Sequence: BC063451
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000508373(uc003qvu.3) ENST00000366827 ENST00000397829(uc003qvv.1)
ENST00000514083 ENST00000460930(uc003qvw.3) ENST00000463894 ENST00000491085
ENST00000476779 ENST00000485157
miRNA
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Additional mRNA sequence: 

BC063451.1 U03399.1 

6 DOTS entries:

DT.101979890  DT.102658  DT.65284802  DT.91789901  DT.121389275  DT.121389288 

24 AceView cDNA sequences:

BC068592 AA563930 BC033909 BC034995 NM_004610 AA431681 U03399 AA723845 
BV184084 BV205237 BC063451 BC065839 AW086030 BF057216 AA994391 BI458674 
AW027471 AI954817 BI828613 AA705836 AI209148 BG717741 BG723543 CD358571 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TCP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGGAACATTT
TCP10 Expression
About this image

TCP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TCP10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.351
    Custom PCR Arrays for TCP10
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TCP10 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tcp105 t-complex protein 10   --   17 -


ENSEMBL Gene Tree for TCP10 (if available)
TreeFam Gene Tree for TCP10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TCP10 gene
TCP10L21 2  TCP10L2  
2 SIMAP similar genes for TCP10 using alignment to 5 protein entries:     TCP10_HUMAN (see all proteins):
TCP10L2    TCP10L

Find genes that share paralogs with TCP10           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TCP10 (see all 414)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1438594721,2
C--167786310(+) AGAGGC/TGTGAG 1 -- ds50010--------
rs2015935611,2
C--167786574(+) AAACAA/TATCTT 1 -- ds50010--------
rs1388886621,2
C,F--167786643(+) GAAACG/ACCTGG 1 -- ut311Minor allele frequency- A:0.01EU 1015
rs1816712681,2
C--167786673(+) TGTCCC/TGTCTG 2 Q R mis10--------
rs1406499851,2
C,F--167786686(+) GGGAGC/TGGCGT 2 T A mis11Minor allele frequency- T:0.00EU 1269
rs1463215151,2
C,F--167786690(+) GCGGCG/ATGCAG 2 /H syn11Minor allele frequency- A:0.01EU 961
rs1430945881,2
C,F--167786750(+) TTGCCC/ATTTGG 2 /K /N mis11Minor allele frequency- A:0.19EU 369
rs785009301,2
C--167786757(+) TTGGAG/TGTCGT 2 H P mis10--------
rs2009488501,2
C--167786761(+) ATGTCA/GTTTTT 2 R * stg10--------
rs1859086781,2
--167786926(+) CTTGCA/CCTGGC 1 -- int10--------

HapMap Linkage Disequilibrium report for TCP10 (167770521 - 167797998 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TCP10 (see all 12):    About this table    
Variant IDTypeSubtypePubMed ID
esv2733230CNV Deletion23290073
esv2678340CNV Deletion23128226
nsv886946CNV Loss21882294
nsv886950CNV Loss21882294
nsv470873CNV Gain18288195
nsv8002CNV Gain18304495
dgv7036n71CNV Gain21882294
nsv464141CNV Gain19166990
esv34252CNV Gain17911159
essv22845CNV CNV17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 187020    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for TCP10:
Spina bifida

Find genes that share disorders with TCP10           About GenesLikeMe

Genetic Association Database (GAD): TCP10

Export disorders for TCP10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TCP10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TCP10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. (PubMed id 8111376)1, 2, 3 Islam S.D.... Silver L.M. (Hum. Mol. Genet. 1993)
  2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
  3. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  5. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PubMed id 10934474)1 Joberty G.... Macara I.G. (Nat. Cell Biol. 2000)
  10. miR319a targeting of TCP4 is critical for petal growth and development in Arabidopsis. (PubMed id 20007771)9 Nag A....Jack T. (Proc. Natl. Acad. Sci. U.S.A. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6953 HGNC: 11656 AceView: TCP10 Ensembl:ENSG00000203690 euGenes: HUgn6953
ECgene: TCP10 H-InvDB: TCP10

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TCP10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TCP10 gene:
Search GeneIP for patents involving TCP10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for TCP10
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 Browse ESI BIO Cell Lines and PureStem Progenitors for TCP10
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10
 Browse SwitchGear 3'UTR luciferase reporter plasmids for TCP10
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 Search ThermoFisher Antibodies for TCP10
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP10
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TCP10
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TCP10
 LSBio Antibodies in human, mouse, rat for TCP10
Customized transgenic rodents for:
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 Browse compounds at ApexBio
 Search Addgene for plasmids for TCP10
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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