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Aliases for TCP10 Gene

Aliases for TCP10 Gene

  • T-Complex 10 2 3
  • T-Complex 10 (A Murine Tcp Homolog) 2 3
  • TCP10A 3 4
  • T-Complex 10 Homolog (Mouse) 2
  • T-Complex 10 (Mouse) 2
  • T-Complex 10 Homolog 3

External Ids for TCP10 Gene

Previous GeneCards Identifiers for TCP10 Gene

  • GC06M167123
  • GC06M167644
  • GC06M167679
  • GC06M167741
  • GC06M165259

Summaries for TCP10 Gene

GeneCards Summary for TCP10 Gene

TCP10 (T-Complex 10) is a Protein Coding gene. An important paralog of this gene is TCP10L2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10 Gene

Genomics for TCP10 Gene

Regulatory Elements for TCP10 Gene

Genomic Location for TCP10 Gene

167,357,031 bp from pter
167,384,552 bp from pter
27,522 bases
Minus strand

Genomic View for TCP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TCP10 Gene

Proteins for TCP10 Gene

  • Protein details for TCP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 10A homolog
    Protein Accession:
    Secondary Accessions:
    • Q5JR60
    • Q6P4F4

    Protein attributes for TCP10 Gene

    353 amino acids
    Molecular mass:
    38267 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA82109.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAI39675.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=CAI42705.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for TCP10 Gene


neXtProt entry for TCP10 Gene

Proteomics data for TCP10 Gene at MOPED

Post-translational modifications for TCP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10 Gene

No data available for DME Specific Peptides for TCP10 Gene

Domains & Families for TCP10 Gene

Protein Domains for TCP10 Gene


Suggested Antigen Peptide Sequences for TCP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP10 family.
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10: view

No data available for Gene Families for TCP10 Gene

Function for TCP10 Gene

Molecular function for TCP10 Gene

GENATLAS Biochemistry:
T-complex 10 (murine tcp homolog)

Phenotypes for TCP10 Gene

genes like me logo Genes that share phenotypes with TCP10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCP10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10 Gene

Localization for TCP10 Gene

Subcellular locations from

Jensen Localization Image for TCP10 Gene COMPARTMENTS Subcellular localization image for TCP10 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for TCP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 8111376
genes like me logo Genes that share ontologies with TCP10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCP10 Gene

Pathways & Interactions for TCP10 Gene

SuperPathways for TCP10 Gene

No Data Available

Interacting Proteins for TCP10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q12799-TCP10_HUMAN ENSP00000380929 for TCP10 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TCP10 Gene


No data available for Pathways by source and SIGNOR curated interactions for TCP10 Gene

Drugs & Compounds for TCP10 Gene

No Compound Related Data Available

Transcripts for TCP10 Gene

Unigene Clusters for TCP10 Gene

T-complex 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TCP10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10 Gene

No ASD Table

Relevant External Links for TCP10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCP10 Gene

mRNA expression in normal human tissues for TCP10 Gene

mRNA differential expression in normal tissues according to GTEx for TCP10 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for TCP10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCP10 Gene

SOURCE GeneReport for Unigene cluster for TCP10 Gene Hs.351

genes like me logo Genes that share expression patterns with TCP10: view

Protein tissue co-expression partners for TCP10 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TCP10 Gene

Orthologs for TCP10 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TCP10 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Tcp10 16
(Pan troglodytes)
Mammalia -- 36
  • 83 (a)
Species with no ortholog for TCP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10 Gene

Gene Tree for TCP10 (if available)
Gene Tree for TCP10 (if available)

Paralogs for TCP10 Gene

Paralogs for TCP10 Gene

(2) SIMAP similar genes for TCP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TCP10: view

Variants for TCP10 Gene

Sequence variations from dbSNP and Humsavar for TCP10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1014654 -- 167,376,291(-) TACTT(G/T)CCCGA intron-variant
rs1570058 -- 167,380,370(-) ctcag(A/T)tagac intron-variant
rs1977189 -- 167,380,735(+) CTCCA(A/T)CATGG intron-variant
rs1977191 -- 167,380,620(-) AATGC(A/G)ATAGA intron-variant
rs1977192 -- 167,378,733(-) AGGGA(C/G)TGAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TCP10 Gene

Variant ID Type Subtype PubMed ID
essv22845 CNV CNV 17122850
dgv2033e1 CNV Complex 17122850
nsv464141 CNV Gain 19166990
nsv470873 CNV Gain 18288195
nsv7389 OTHER Inversion 18451855
esv34252 CNV Gain 17911159
nsv886946 CNV Loss 21882294
esv2733230 CNV Deletion 23290073
dgv7036n71 CNV Gain 21882294
nsv886950 CNV Loss 21882294
nsv8002 CNV Gain 18304495
esv2678340 CNV Deletion 23128226

Variation tolerance for TCP10 Gene

Residual Variation Intolerance Score: 98.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10 Gene

Disorders for TCP10 Gene

Relevant External Links for TCP10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TCP10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP10 Gene

Publications for TCP10 Gene

  1. miR319a targeting of TCP4 is critical for petal growth and development in Arabidopsis. (PMID: 20007771) Nag A. … Jack T. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  2. The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. (PMID: 8111376) Islam S.D. … Silver L.M. (Hum. Mol. Genet. 1993) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for TCP10 Gene

Sources for TCP10 Gene

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