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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCP10 Gene

protein-coding GIFtS: 49
GCID: GC06M167741

t-complex 10

(Previous names: t-complex 10 (a murine tcp homolog), t-complex 10 (mouse),...)

Explore 1 disease affiliated with
TCP10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T-Complex 10¹ ²		T-Complex 10 Homolog (Mouse)¹
T-Complex 10 (A Murine Tcp Homolog)¹ ²		T-Complex 10 Homolog²
TCP10A² ³		T-Complex Protein 10A Homolog²
T-Complex 10 (Mouse)¹

External Ids:	HGNC: 11656¹	Entrez Gene: 6953²	Ensembl: ENSG00000203690⁷	OMIM: 187020⁵	UniProtKB: Q12799³

Export aliases for TCP10 gene to outside databases

Previous GC identifers: GC06M167123 GC06M167644 GC06M167679 GC06M165259

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCP10 gene promoter:
AREB6 CUTL1 C/EBPalpha
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TCP10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

TCP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP10 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M167741: view genomic region (about GC identifiers)

Start:	167,770,521 bp from pter	End:	167,797,998 bp from pter
Size:	27,478 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCP10_HUMAN, Q12799 (See protein sequence)

Recommended Name: T-complex protein 10A homolog

Size: 353 amino acids; 38267 Da

Sequence caution: Sequence=AAA82109.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAI39675.1;

Type=Erroneous termination; Positions=10; Note=Translated as Glu; Sequence=CAI42705.1; Type=Erroneous termination;

Positions=10; Note=Translated as Glu;

Secondary accessions: Q5JR60 Q6P4F4

Alternative splicing: 2 isoforms: Q12799-1 Q12799-2

Explore the universe of human proteins at neXtProt for TCP10: NX_Q12799

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12799

TCP10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004601.3

ENSEMBL proteins:

ENSP00000355792 ENSP00000380929 ENSP00000426065 ENSP00000427675 ENSP00000423829

Human Recombinant Protein Products for TCP10:

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	Uscn Proteins for TCP10

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	8111376

TCP10 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TCP10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCP10 for domains About GeneDecksing

1 InterPro domain/family:

IPR026581 TCP10_fam

Graphical View of Domain Structure for InterPro Entry Q12799

ProtoNet protein and cluster: Q12799

UniProtKB/Swiss-Prot: TCP10_HUMAN, Q12799

Similarity: Belongs to the TCP10 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for TCP10:

T-complex 10 (murine tcp homolog)

Phenotypes:
1 GenomeRNAi human phenotype for TCP10:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TCP10

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCP10

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TCP10 (Q12799³ ENSP00000380929⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARD6A	Q9NPB6³, ENSP00000219255⁴	I2D: score=2 STRING: ENSP00000219255
PARD6B	Q9BYG5³, ENSP00000360672⁴	I2D: score=1 STRING: ENSP00000360672

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCP10
Search CenterWatch for drugs/clinical trials and news about TCP10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCP10 gene:

NM_004610.3

Unigene Cluster for TCP10:

T-complex 10

Hs.351 [show with all ESTs]

Unigene Representative Sequence: BC063451

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000508373(uc003qvu.3) ENST00000366827 ENST00000397829(uc003qvv.1)

ENST00000514083 ENST00000460930(uc003qvw.3) ENST00000463894 ENST00000491085

ENST00000476779 ENST00000485157

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCP10 OriGene shRNA RFP: TCP10 OriGene siRNA: TCP10
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Additional cDNA sequence:

BC063451.1 U03399.1

6 DOTS entries:

DT.101979890 DT.102658 DT.65284802 DT.91789901 DT.121389275 DT.121389288

24 AceView cDNA sequences:

BV184084 NM_004610 AA723845 BC063451 AA563930 BC033909 U03399 BV205237

BC065839 BC068592 AA431681 BC034995 AW086030 AI209148 BF057216 AA994391

BI458674 AW027471 BI828613 AA705836 AI954817 CD358571 BG723543 BG717741

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAACATTT

About this image

TCP10 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCP10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCP10

SOURCE GeneReport for Unigene cluster: Hs.351

SABiosciences Custom PCR Arrays for TCP10

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for TCP10 (if available)
TreeFam Gene Tree for TCP10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCP10 gene

TCP10L2¹ ² TCP10L²

2 SIMAP similar genes for TCP10 using alignment to 5 protein entries: TCP10_HUMAN (see all proteins):

TCP10L2 TCP10L

TCP10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138888662^1,2	C,F	--	167786643(+)	`GAAACG/ACCTGG`	1	--	ut3¹		1		EU	1015
rs181671268^1,2	C	--	167786673(+)	`TGTCCC/TGTCTG`	2	Q R	mis¹		0	--	--	--	--
rs140649985^1,2	C,F	--	167786686(+)	`GGGAGC/TGGCGT`	2	T A	mis¹		1		EU	1269
rs146321515^1,2	C,F	--	167786690(+)	`GCGGCG/ATGCAG`	2	/H	syn¹		1		EU	961
rs143094588^1,2	C,F	--	167786750(+)	`TTGCCC/ATTTGG`	2	/K /N	mis¹		1		EU	369
rs78500930^1,2	C	--	167786757(+)	`TTGGAG/TGTCGT`	2	H P	mis¹		0	--	--	--	--
rs185908678^1,2		--	167786926(+)	`CTTGCA/CCTGGC`	1	--	int¹		0	--	--	--	--
rs144315967^1,2		--	167787360(+)	`TCATAC/TGTAAG`	1	--	int¹		0	--	--	--	--
rs147785606^1,2		--	167787388(+)	`CTGGCA/GTAGAG`	1	--	int¹		0	--	--	--	--
rs188719082^1,2		--	167787398(+)	`GAAAAC/TAATTT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TCP10 (167770521 - 167797998 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TCP10
4 CNVs: 31311 2666 8539 3653
1 Inversion: 37270

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TCP10 for disorders           About GeneDecksing

OMIM gene information: 187020    OMIM disorders: --

1 disease for TCP10:    About MalaCards

spina bifida

1 disease from the University of Copenhagen DISEASES database for TCP10:

Spina bifida

Export disorders for TCP10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCP10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TCP10)

Utopia: connect your pdf to the dynamic
world of online information

The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. (PubMed id 8111376)^{1, 2, 3} Islam S.D.... Silver L.M. (1993)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. (PubMed id 10934474)¹ Joberty G.... Macara I.G. (2000)
miR319a targeting of TCP4 is critical for petal growt h and development in Arabidopsis. (PubMed id 20007771)⁹ Nag A....Jack T. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6953	HGNC: 11656	AceView: TCP10	Ensembl:ENSG00000203690	euGenes: HUgn6953
ECgene: TCP10	H-InvDB: TCP10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCP10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCP10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCP10 gene:
Search GeneIP for patents involving TCP10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP10

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TCP10 gene at Home site.

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TCP10 Gene

t-complex 10

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TCP10 Gene

t-complex 10

Aliasesfor TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene

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for TCP10 gene