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Aliases for TCP10 Gene

Aliases for TCP10 Gene

  • T-Complex 10 2 3 5
  • T-Complex 10 (A Murine Tcp Homolog) 2 3
  • TCP10A 3 4
  • T-Complex Protein 10A Homolog 3
  • T-Complex 10 Homolog (Mouse) 2
  • T-Complex 10 (Mouse) 2
  • T-Complex 10 Homolog 3

External Ids for TCP10 Gene

Previous GeneCards Identifiers for TCP10 Gene

  • GC06M167123
  • GC06M167644
  • GC06M167679
  • GC06M167741
  • GC06M165259

Summaries for TCP10 Gene

GeneCards Summary for TCP10 Gene

TCP10 (T-Complex 10) is a Protein Coding gene. An important paralog of this gene is TCP10L2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10 Gene

Genomics for TCP10 Gene

Regulatory Elements for TCP10 Gene

Enhancers for TCP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G167349 1.2 Ensembl ENCODE 5.8 +33.9 33907 2.7 FOXA2 ARNT ZNF2 YY1 GLIS2 ZHX2 MXD4 REST NFIL3 SSRP1 UNC93A LINC01558 TTLL2 TCP10 LOC100420305 LOC100421518 GC06M167354
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP10 Gene

Chromosome:
6
Start:
167,357,031 bp from pter
End:
167,384,552 bp from pter
Size:
27,522 bases
Orientation:
Minus strand

Genomic View for TCP10 Gene

Genes around TCP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10 Gene

Proteins for TCP10 Gene

  • Protein details for TCP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12799-TCP10_HUMAN
    Recommended name:
    T-complex protein 10A homolog
    Protein Accession:
    Q12799
    Secondary Accessions:
    • Q5JR60
    • Q6P4F4

    Protein attributes for TCP10 Gene

    Size:
    353 amino acids
    Molecular mass:
    38267 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA82109.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAI39675.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=CAI42705.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for TCP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCP10 Gene

Post-translational modifications for TCP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP10 Gene

Domains & Families for TCP10 Gene

Protein Domains for TCP10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12799

UniProtKB/Swiss-Prot:

TCP10_HUMAN :
  • Belongs to the TCP10 family.
Family:
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10: view

No data available for Gene Families for TCP10 Gene

Function for TCP10 Gene

Molecular function for TCP10 Gene

GENATLAS Biochemistry:
T-complex 10 (murine tcp homolog)
genes like me logo Genes that share phenotypes with TCP10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10 Gene

Localization for TCP10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP10 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TCP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 8111376
genes like me logo Genes that share ontologies with TCP10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCP10 Gene

Pathways & Interactions for TCP10 Gene

SuperPathways for TCP10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP10 Gene

Drugs & Compounds for TCP10 Gene

No Compound Related Data Available

Transcripts for TCP10 Gene

Unigene Clusters for TCP10 Gene

T-complex 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10 Gene

No ASD Table

Relevant External Links for TCP10 Gene

GeneLoc Exon Structure for
TCP10
ECgene alternative splicing isoforms for
TCP10

Expression for TCP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP10 Gene

mRNA differential expression in normal tissues according to GTEx for TCP10 Gene

This gene is overexpressed in Testis (x49.3).

Protein differential expression in normal tissues from HIPED for TCP10 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCP10 Gene



Protein tissue co-expression partners for TCP10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCP10 Gene:

TCP10

SOURCE GeneReport for Unigene cluster for TCP10 Gene:

Hs.351

Evidence on tissue expression from TISSUES for TCP10 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TCP10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP10 Gene

Orthologs for TCP10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TCP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 83 (a)
OneToMany
Species where no ortholog for TCP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10 Gene

ENSEMBL:
Gene Tree for TCP10 (if available)
TreeFam:
Gene Tree for TCP10 (if available)

Paralogs for TCP10 Gene

Paralogs for TCP10 Gene

(2) SIMAP similar genes for TCP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TCP10: view

Variants for TCP10 Gene

Sequence variations from dbSNP and Humsavar for TCP10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000397277 -- 167,358,691(+) ACTGC(-/T)TGTGA intron-variant
rs1000532702 -- 167,381,768(+) CCTGC(C/T)TCGGC intron-variant
rs1000704508 -- 167,370,469(+) TAATT(A/G)TCAGC intron-variant
rs1000857634 -- 167,363,455(+) GACAC(G/T)CTCTG intron-variant
rs1000862949 -- 167,370,741(+) TAACT(A/G)AGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP10 Gene

Variant ID Type Subtype PubMed ID
dgv6194n100 CNV gain 25217958
dgv6196n100 CNV gain 25217958
dgv6197n100 CNV loss 25217958
dgv6198n100 CNV gain 25217958
esv2678340 CNV deletion 23128226
esv2733230 CNV deletion 23290073
esv2759492 CNV gain 17122850
esv2761058 CNV gain 21179565
esv3282385 CNV deletion 24192839
esv34252 CNV gain 17911159
esv3576253 CNV gain 25503493
esv3611649 CNV gain 21293372
esv3611661 CNV gain 21293372
nsv1019214 CNV gain 25217958
nsv1024654 CNV loss 25217958
nsv464141 CNV gain 19166990
nsv470873 CNV gain 18288195
nsv605338 CNV gain 21841781
nsv7389 OTHER inversion 18451855
nsv8002 CNV gain 18304495
nsv949894 CNV deletion 24416366
nsv970193 CNV duplication 23825009

Variation tolerance for TCP10 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10 Gene

Disorders for TCP10 Gene

Relevant External Links for TCP10

Genetic Association Database (GAD)
TCP10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP10

No disorders were found for TCP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP10 Gene

Publications for TCP10 Gene

  1. The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. (PMID: 8111376) Islam S.D. … Silver L.M. (Hum. Mol. Genet. 1993) 2 3 4 64
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64

Products for TCP10 Gene

Sources for TCP10 Gene

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