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Aliases for TCP10 Gene

Aliases for TCP10 Gene

  • T-Complex 10 2 3
  • T-Complex 10 (A Murine Tcp Homolog) 2 3
  • TCP10A 3 4
  • T-Complex Protein 10A Homolog 3
  • T-Complex 10 Homolog (Mouse) 2
  • T-Complex 10 (Mouse) 2
  • T-Complex 10 Homolog 3

External Ids for TCP10 Gene

Previous GeneCards Identifiers for TCP10 Gene

  • GC06M167123
  • GC06M167644
  • GC06M167679
  • GC06M167741
  • GC06M165259

Summaries for TCP10 Gene

GeneCards Summary for TCP10 Gene

TCP10 (T-Complex 10) is a Protein Coding gene. An important paralog of this gene is TCP10L2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10 Gene

Genomics for TCP10 Gene

Regulatory Elements for TCP10 Gene

Genomic Location for TCP10 Gene

Start:
167,357,031 bp from pter
End:
167,384,510 bp from pter
Size:
27,480 bases
Orientation:
Minus strand

Genomic View for TCP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TCP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10 Gene

Proteins for TCP10 Gene

  • Protein details for TCP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12799-TCP10_HUMAN
    Recommended name:
    T-complex protein 10A homolog
    Protein Accession:
    Q12799
    Secondary Accessions:
    • Q5JR60
    • Q6P4F4

    Protein attributes for TCP10 Gene

    Size:
    353 amino acids
    Molecular mass:
    38267 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA82109.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAI39675.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=CAI42705.1; Type=Erroneous termination; Positions=10; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for TCP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCP10 Gene

Proteomics data for TCP10 Gene at MOPED

Post-translational modifications for TCP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10 Gene

No data available for DME Specific Peptides for TCP10 Gene

Domains for TCP10 Gene

Protein Domains for TCP10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12799

UniProtKB/Swiss-Prot:

TCP10_HUMAN :
  • Q12799
Family:
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10: view

No data available for Gene Families for TCP10 Gene

Function for TCP10 Gene

Molecular function for TCP10 Gene

GENATLAS Biochemistry: T-complex 10 (murine tcp homolog)

Phenotypes for TCP10 Gene

GenomeRNAi human phenotypes for TCP10:
genes like me logo Genes that share phenotypes with TCP10: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TCP10 Gene

Localization for TCP10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCP10 Gene COMPARTMENTS Subcellular localization image for TCP10 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for TCP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS 8111376
genes like me logo Genes that share ontologies with TCP10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCP10 Gene

Pathways for TCP10 Gene

SuperPathways for TCP10 Gene

No Data Available

Interacting Proteins for TCP10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000380929%0d%0a9606.ENSP00000219255%0d%0a9606.ENSP00000360672%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000380929 Q12799-TCP10_HUMAN for TCP10 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TCP10 Gene

None

No data available for Pathways by source for TCP10 Gene

Transcripts for TCP10 Gene

Unigene Clusters for TCP10 Gene

T-complex 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10 Gene

No ASD Table

Relevant External Links for TCP10 Gene

GeneLoc Exon Structure for
TCP10
ECgene alternative splicing isoforms for
TCP10

Expression for TCP10 Gene

mRNA expression in normal human tissues for TCP10 Gene

mRNA differential expression in normal tissues according to GTEx for TCP10 Gene

This gene is overexpressed in Testis (49.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TCP10 Gene

SOURCE GeneReport for Unigene cluster for TCP10 Gene Hs.351

genes like me logo Genes that share expressions with TCP10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TCP10 Gene

Orthologs for TCP10 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for TCP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tcp10 16
Species with no ortholog for TCP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10 Gene

ENSEMBL:
Gene Tree for TCP10 (if available)
TreeFam:
Gene Tree for TCP10 (if available)

Paralogs for TCP10 Gene

Paralogs for TCP10 Gene

Selected SIMAP similar genes for TCP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TCP10: view

Variants for TCP10 Gene

Sequence variations from dbSNP and Humsavar for TCP10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1977189 -- 167,380,735(+) CTCCA(A/T)CATGG intron-variant
rs1977191 -- 167,380,620(-) AATGC(A/G)ATAGA intron-variant
rs1977192 -- 167,378,733(-) AGGGA(C/G)TGAGC intron-variant
rs2038467 -- 167,374,895(-) AGTGA(C/T)GCCAT intron-variant
rs2038468 -- 167,374,783(-) GGATC(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP10 Gene

Variant ID Type Subtype PubMed ID
essv22845 CNV CNV 17122850
dgv2033e1 CNV Complex 17122850
nsv464141 CNV Gain 19166990
nsv470873 CNV Gain 18288195
nsv7389 OTHER Inversion 18451855
esv34252 CNV Gain 17911159
nsv886946 CNV Loss 21882294
esv2733230 CNV Deletion 23290073
dgv7036n71 CNV Gain 21882294
nsv886950 CNV Loss 21882294
nsv8002 CNV Gain 18304495
esv2678340 CNV Deletion 23128226

Relevant External Links for TCP10 Gene

HapMap Linkage Disequilibrium report
TCP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10 Gene

Disorders for TCP10 Gene

(1) University of Copenhagen DISEASES for TCP10 Gene

Relevant External Links for TCP10

Genetic Association Database (GAD)
TCP10
genes like me logo Genes that share disorders with TCP10: view

No data available for UniProtKB/Swiss-Prot for TCP10 Gene

Publications for TCP10 Gene

  1. The human homolog of a candidate mouse t complex responder gene: conserved motifs and evolution with punctuated equilibria. (PMID: 8111376) Islam S.D. … Silver L.M. (Hum. Mol. Genet. 1993) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for TCP10 Gene

Sources for TCP10 Gene

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