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Aliases for TCP1 Gene

Aliases for TCP1 Gene

  • T-Complex 1 2 3 5
  • TCP-1-Alpha 3 4
  • CCT-Alpha 3 4
  • CCTA 3 4
  • CCT1 3 4
  • T-Complex Protein 1, Alpha Subunit 3
  • Tailless Complex Polypeptide 1 3
  • D6S230E 3

External Ids for TCP1 Gene

Previous GeneCards Identifiers for TCP1 Gene

  • GC06M159639
  • GC06M160073
  • GC06M160109
  • GC06M160170
  • GC06M160120
  • GC06M160122
  • GC06M160199

Summaries for TCP1 Gene

Entrez Gene Summary for TCP1 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

GeneCards Summary for TCP1 Gene

TCP1 (T-Complex 1) is a Protein Coding gene. Diseases associated with TCP1 include epididymo-orchitis. Among its related pathways are HIF1Alpha Pathway and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.

UniProtKB/Swiss-Prot for TCP1 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for TCP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP1 Gene

Genomics for TCP1 Gene

Regulatory Elements for TCP1 Gene

Enhancers for TCP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TCP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TCP1 Gene

Chromosome:
6
Start:
159,778,498 bp from pter
End:
159,789,749 bp from pter
Size:
11,252 bases
Orientation:
Minus strand

Genomic View for TCP1 Gene

Genes around TCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP1 Gene

Proteins for TCP1 Gene

  • Protein details for TCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17987-TCPA_HUMAN
    Recommended name:
    T-complex protein 1 subunit alpha
    Protein Accession:
    P17987
    Secondary Accessions:
    • E1P5B2
    • Q15556
    • Q5TCM3

    Protein attributes for TCP1 Gene

    Size:
    556 amino acids
    Molecular mass:
    60344 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.

neXtProt entry for TCP1 Gene

Proteomics data for TCP1 Gene at MOPED

Post-translational modifications for TCP1 Gene

  • Ubiquitination at Lys 33, Lys 63, Lys 73, Lys 109, Lys 111, Lys 243, Lys 259, Lys 365, Lys 484, Lys 494, Lys 499, Lys 532, and Lys 538
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCP1 Gene

Domains & Families for TCP1 Gene

Gene Families for TCP1 Gene

Graphical View of Domain Structure for InterPro Entry

P17987

UniProtKB/Swiss-Prot:

TCPA_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with TCP1: view

Function for TCP1 Gene

Molecular function for TCP1 Gene

GENATLAS Biochemistry:
T-complex 1,cytosolic,potential chaperonin,TF55/TCP-1,overlapping in opposite sense,the 3 region of ACAT2
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
genes like me logo Genes that share phenotypes with TCP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP1 Gene

Localization for TCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TCP1 Gene COMPARTMENTS Subcellular localization image for TCP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 4
golgi apparatus 3
plasma membrane 2
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 20080638
GO:0005874 microtubule IDA 21525035
GO:0044297 cell body IEA --
genes like me logo Genes that share ontologies with TCP1: view

Pathways & Interactions for TCP1 Gene

genes like me logo Genes that share pathways with TCP1: view

Gene Ontology (GO) - Biological Process for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050821 protein stabilization IMP 25467444
GO:0051973 positive regulation of telomerase activity IMP 25467444
GO:0090666 scaRNA localization to Cajal body IMP 25467444
GO:1904874 positive regulation of telomerase RNA localization to Cajal body IMP 25467444
GO:2000109 regulation of macrophage apoptotic process IEA --
genes like me logo Genes that share ontologies with TCP1: view

No data available for SIGNOR curated interactions for TCP1 Gene

Drugs & Compounds for TCP1 Gene

(1) Drugs for TCP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TCP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCP1: view

Transcripts for TCP1 Gene

Unigene Clusters for TCP1 Gene

T-complex 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TCP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^
SP1: - - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4:
SP5:
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - -
SP14: - - -
SP15: - -
SP16:
SP17: - - - - -
SP18:

ExUns: 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCP1 Gene

GeneLoc Exon Structure for
TCP1
ECgene alternative splicing isoforms for
TCP1

Expression for TCP1 Gene

mRNA expression in normal human tissues for TCP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TCP1 Gene



SOURCE GeneReport for Unigene cluster for TCP1 Gene Hs.363137

genes like me logo Genes that share expression patterns with TCP1: view

Protein tissue co-expression partners for TCP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TCP1 Gene

Orthologs for TCP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TCP1 35
  • 92.67 (n)
  • 97.3 (a)
TCP1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCP1 35
  • 92.69 (n)
  • 97.66 (a)
TCP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tcp1 35
  • 90.65 (n)
  • 96.4 (a)
Tcp1 16
Tcp1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TCP1 35
  • 99.82 (n)
  • 100 (a)
TCP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tcp1 35
  • 90.05 (n)
  • 97.66 (a)
oppossum
(Monodelphis domestica)
Mammalia TCP1 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCP1 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCP1 35
  • 80.84 (n)
  • 91.17 (a)
TCP1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCP1 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp1 35
  • 77.18 (n)
  • 88.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia tcp1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii tcp1 35
  • 73.48 (n)
  • 87.16 (a)
tcp1 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9170 35
fruit fly
(Drosophila melanogaster)
Insecta T-cp1 37
  • 73 (a)
T-cp1 35
  • 64.86 (n)
  • 73.6 (a)
T-cp1 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004238 35
  • 63.02 (n)
  • 74.68 (a)
worm
(Caenorhabditis elegans)
Secernentea cct-1 37
  • 69 (a)
cct-1 35
  • 62.02 (n)
  • 69.33 (a)
cct-1 36
  • 68 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL092W 35
  • 56.4 (n)
  • 62.15 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04191g 35
  • 60.28 (n)
  • 62.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TCP1 35
  • 60.72 (n)
  • 64.31 (a)
TCP1 36
  • 61 (a)
OneToOne
TCP1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TCP-1 35
  • 63.36 (n)
  • 66.85 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2766 35
barley
(Hordeum vulgare)
Liliopsida Hv.1928 35
rice
(Oryza sativa)
Liliopsida Os.22700 35
Os04g0551800 35
  • 65.09 (n)
  • 68.11 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28393 35
corn
(Zea mays)
Liliopsida Zm.6975 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12384 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04448 35
  • 58.95 (n)
  • 64.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct1 35
  • 61.93 (n)
  • 66.61 (a)
Species with no ortholog for TCP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TCP1 Gene

ENSEMBL:
Gene Tree for TCP1 (if available)
TreeFam:
Gene Tree for TCP1 (if available)

Paralogs for TCP1 Gene

Pseudogenes.org Pseudogenes for TCP1 Gene

genes like me logo Genes that share paralogs with TCP1: view

No data available for Paralogs for TCP1 Gene

Variants for TCP1 Gene

Sequence variations from dbSNP and Humsavar for TCP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036258 A breast cancer sample
rs5881340 -- 159,784,308(+) TTTTA(-/T)TTTTT intron-variant
rs1547093 -- 159,784,959(+) TAAAG(A/C)AGCAA intron-variant
rs1547094 -- 159,785,083(+) ATTTC(A/C)ATACA intron-variant
rs10640995 -- 159,783,361(+) AGGTC(-/TGGT/TGGTT)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TCP1 Gene

Variant ID Type Subtype PubMed ID
dgv2023e1 CNV Complex 17122850
nsv5563 CNV Insertion 18451855

Variation tolerance for TCP1 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP1 Gene

HapMap Linkage Disequilibrium report
TCP1
Human Gene Mutation Database (HGMD)
TCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP1 Gene

Disorders for TCP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epididymo-orchitis
- elite association - COSMIC cancer census association via MalaCards
Search TCP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCP1

Genetic Association Database (GAD)
TCP1
Human Genome Epidemiology (HuGE) Navigator
TCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP1
genes like me logo Genes that share disorders with TCP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCP1 Gene

Publications for TCP1 Gene

  1. The human homologue of the mouse T-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. (PMID: 3653076) Willison K. … Trowsdale J. (EMBO J. 1987) 2 3 4 67
  2. Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding. (PMID: 15745879) Humrich J. … Lohse M.J. (J. Biol. Chem. 2005) 3 23
  3. Expression patterns of chaperone proteins in cerebral cortex of the fetus with Down syndrome: dysregulation of T-complex protein 1. (PMID: 11771755) Yoo B.C. … Lubec G. (J. Neural Transm. Suppl. 2001) 3 23
  4. Origin of gene overlap: the case of TCP1 and ACAT2. (PMID: 10353914) Shintani S. … Klein J. (Genetics 1999) 3 23
  5. Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. (PMID: 9250675) Liou A.K. … Willison K.R. (EMBO J. 1997) 3 23

Products for TCP1 Gene

Sources for TCP1 Gene

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