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TCP1 Gene

protein-coding   GIFtS: 68
GCID: GC06M160199

T-Complex 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
T-Complex 11 2     D6S230E2
CCT-alpha2 3     T-Complex Protein 1 Subunit Alpha2
CCT12 3     T-Complex Protein 1, Alpha Subunit2
TCP-1-alpha2 3     Tailless Complex Polypeptide 12
CCTa2     CCTA3

External Ids:    HGNC: 116551   Entrez Gene: 69502   Ensembl: ENSG000001204387   OMIM: 1869805   UniProtKB: P179873   

Export aliases for TCP1 gene to outside databases

Previous GC identifers: GC06M159639 GC06M160073 GC06M160109 GC06M160170 GC06M160120 GC06M160122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TCP1 Gene:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1
complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings,
each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are
folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate
transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition,
three pseudogenes that appear to be derived from this gene have been found. (provided by RefSeq, Jun 2010)

GeneCards Summary for TCP1 Gene:
TCP1 (t-complex 1) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: TCPA_HUMAN, P17987
Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for TCP1 (T-complex 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TCP1 gene promoter:
         AML1a   p53   Lmo2   USF-1:USF-2   IRF-1   Egr-2   SRY   USF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTCP1 promoter sequence
   Search Chromatin IP Primers for TCP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TCP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3-q26   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25-q27

TCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M160199:  view genomic region     (about GC identifiers)

Start:
160,199,530 bp from pter      End:
160,210,781 bp from pter
Size:
11,252 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TCPA_HUMAN, P17987 (See protein sequence)
Recommended Name: T-complex protein 1 subunit alpha  
Size: 556 amino acids; 60344 Da
Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,
CCT4, CCT5 AND CCT8
Secondary accessions: E1P5B2 Q15556 Q5TCM3

Explore the universe of human proteins at neXtProt for TCP1: NX_P17987

Explore proteomics data for TCP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33, Lys63, Lys73, Lys109, Lys111, Lys243, Lys259, Lys365, Lys400, Lys466,
                                 Lys484, Lys494, Lys499, Lys532, Lys538, Lys541
  • Modification sites at PhosphoSitePlus

  • See TCP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001008897.1  NP_110379.2  

    ENSEMBL proteins: 
     ENSP00000317334   ENSP00000439447   ENSP00000390159   ENSP00000376008   ENSP00000441345  
     ENSP00000440617   ENSP00000442185   ENSP00000444423   ENSP00000439671   ENSP00000437840  
     ENSP00000442856  
    Reactome Protein details: P17987

    TCP1 Human Recombinant Protein Products:

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    Novus Biologicals TCP1 Proteins
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    ProSpec Recombinant Protein for TCP1
    Cloud-Clone Corp. Proteins for TCP1

     
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    antibodies-online proteins for TCP1 (13 products) 

     
    antibodies-online peptides for TCP1

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    TCP1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHAP: Heat Shock Proteins / Chaperonins

    Selected InterPro protein domains (see all 7):
     IPR017998 Chaperone_TCP-1
     IPR027410 TCP-1-like_intermed
     IPR027409 GroEL-like_apical_dom
     IPR002194 Chaperonin_TCP-1_CS
     IPR002423 Cpn60/TCP-1

    Graphical View of Domain Structure for InterPro Entry P17987

    ProtoNet protein and cluster: P17987

    2 Blocks protein domains:
    IPB001844 Chaperonin Cpn60
    IPB002194 Chaperonin TCP-1


    UniProtKB/Swiss-Prot: TCPA_HUMAN, P17987
    Similarity: Belongs to the TCP-1 chaperonin family


    Find genes that share domains with TCP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TCPA_HUMAN, P17987
    Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex
    may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to
    the cilia. Known to play a role, in vitro, in the folding of actin and tubulin

         Genatlas biochemistry entry for TCP1:
    T-complex 1,cytosolic,potential chaperonin,TF55/TCP-1,overlapping in opposite sense,the 3' region of ACAT2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with TCP1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for TCP1:
     Cell cycle / mitosis defect  Decreased POU5F1-GFP protein e  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 
     Increased G2M DNA content  Increased number of mitotic ce  Metaphase cells 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TCP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TCP1:
    hsa-mir-378a-3p (MIRT043872), hsa-mir-100-5p (MIRT048447), hsa-mir-23b-3p (MIRT046287), hsa-mir-331-3p (MIRT043392), hsa-mir-320a (MIRT044438), hsa-mir-615-3p (MIRT039658), hsa-mir-342-3p (MIRT043731), hsa-mir-652-3p (MIRT039480), hsa-mir-15b-5p (MIRT046434), hsa-mir-16-5p (MIRT051234), hsa-mir-18a-5p (MIRT050683), hsa-mir-186-5p (MIRT045307), hsa-mir-26a-5p (MIRT050084)

    Block miRNA regulation of human, mouse, rat TCP1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TCP1:
    hsa-miR-3143 hsa-miR-543 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTCP1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TCP1 (NM_001018025)
    Sino Biological Human cDNA Clone for TCP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TCPA_HUMAN, P17987: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material IEA--
    GO:0000792heterochromatin ----
    GO:0001669acrosomal vesicle IEA--
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005634nucleus ----

    Find genes that share ontologies with TCP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TCP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76
    Folding of actin by CCT/TriC0.00
    2Protein folding
    Chaperonin-mediated protein folding0.91
    Association of TriC/CCT with target proteins during biosynthesis0.58
    Protein folding0.91
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4HIF1Alpha Pathway
    HIF1Alpha Pathway
    5Cell cycle Role of APC in cell cycle regulation
    Cell cycle Role of APC in cell cycle regulation


    Find genes that share SuperPaths with TCP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TCP1
        HIF1Alpha Pathway

    1 GeneGo (Thomson Reuters) Pathway for TCP1
        Cell cycle Role of APC in cell cycle regulation


    4 Reactome Pathways for TCP1
        Association of TriC/CCT with target proteins during biosynthesis
    Formation of tubulin folding intermediates by CCT/TriC
    Prefoldin mediated transfer of substrate to CCT/TriC
    Folding of actin by CCT/TriC


        Pathway & Disease-focused RT2 Profiler PCR Arrays including TCP1: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TCP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TCP1 (P179872, 3 ENSP000003173344) via UniProtKB, MINT, STRING, and/or I2D (see all 1224)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS--
    GO:0007021tubulin complex assembly NAS11532003
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0051084'de novo' posttranslational protein folding TAS--

    Find genes that share ontologies with TCP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TCP1 (TCPA)

    3 Novoseek inferred chemical compound relationships for TCP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetyl-coa 29 2 7904580 (2)
    atp 27.8 2 15696173 (2)
    glucose 0 2 11771755 (1)



    Find genes that share compounds with TCP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TCP1 gene (2 alternative transcripts): 
    NM_001008897.1  NM_030752.2  

    Unigene Cluster for TCP1:

    T-complex 1
    Hs.363137  [show with all ESTs]
    Unigene Representative Sequence: NM_030752
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321394(uc003qsr.3 uc003qss.3) ENST00000544255 ENST00000420894
    ENST00000392168 ENST00000546204 ENST00000539756 ENST00000536807 ENST00000538530
    ENST00000543532 ENST00000467544 ENST00000538128 ENST00000543517 ENST00000539948
    ENST00000545764 ENST00000537390 ENST00000536394 ENST00000536607 ENST00000546023(uc010kka.1)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TCP1:
    hsa-miR-3143 hsa-miR-543 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTCP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TCP1
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    Primer
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    OriGene qPCR primer pairs and template standards for TCP1
    OriGene qSTAR qPCR primer pairs in human, mouse for TCP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TCP1
      QuantiTect SYBR Green Assays in human, mouse, rat TCP1
      QuantiFast Probe-based Assays in human, mouse, rat TCP1

    Additional mRNA sequence: 

    AJ609472.1 AK308551.1 AK312604.1 BC000665.1 BT006969.1 NR_002965.1 X52882.1 

    Selected DOTS entries (see all 59):

    DT.91782027  DT.99989299  DT.100884486  DT.100764164  DT.100884460  DT.100803010  DT.100884480  DT.100884491 
    DT.100884463  DT.121326743  DT.86852813  DT.121326983  DT.121327106  DT.100884490  DT.121326990  DT.121326756 
    DT.121326906  DT.100884457  DT.121327008  DT.100031507  DT.100759125  DT.100884454  DT.100884483  DT.121326778 

    Selected AceView cDNA sequences (see all 419):

    CB152137 BM453258 AA406608 BQ073448 AI263498 BP375889 BU160449 BU178175 
    BX403819 BQ691724 CR613792 BQ428169 CR609567 AA129091 BU169343 AA345254 
    BX366747 CR606609 CD518956 BM827784 CB132679 BF970241 BM851527 BX416030 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TCP1 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^
    SP1:                                      -     -     -     -     -           -           -                       -                                             
    SP2:                                                                                                              -                                             
    SP3:                                      -     -     -     -     -     -     -           -                       -                                             
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                                                  -                           
    SP5:                                                                              


    ECgene alternative splicing isoforms for TCP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TCP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTTATGA
    TCP1 Expression
    About this image


    TCP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    TCP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TCP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.363137
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TCP1: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TCP1 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tcp11 , 5 t-complex protein 11, 5 90.65(n)1
    96.4(a)1
      17 (8.72 cM)5
    214541  NM_013686.31  NP_038714.21 
     129157015 
    chicken
    (Gallus gallus)
    Aves TCP11 t-complex 1 80.84(n)
    91.17(a)
      421586  NM_001006405.1  NP_001006405.1 
    lizard
    (Anolis carolinensis)
    Reptilia TCP16
    t-complex 1
    90(a)
    1 ↔ 1
    1(212182649-212199391)
    African clawed frog
    (Xenopus laevis)
    Amphibia tcp1-A-prov2 t-complex polypeptide 1 79.33(n)    AF143494.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tcp12 t-complex polypeptide 1 75.37(n)   30477  AF143493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta T-cp11 , 3 protein folding chaperone3
    Tcp1-like1
    73(a)3
    64.86(n)1
    73.6(a)1
      94B13
    426491  NM_079726.41  NP_524450.21 
    worm
    (Caenorhabditis elegans)
    Secernentea cct-11 , 3 T-complex protein3
    cct-11
    69(a)3
    62.02(n)1
    69.33(a)1
      II(8185368-8187309)3
    1743181  NM_063321.41  NP_495722.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TCP1(YDR212W)4
    TCP11
    Alpha subunit of chaperonin-containing T-complex, which more4
    TCP11
    60.72(n)1
    64.31(a)1
      4(887232-888911)4
    8517981, 4  NP_010498.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TCP-11 TCP-1 63.36(n)
    66.85(a)
      821544  NM_112896.3  NP_188640.1 
    rice
    (Oryza sativa)
    Liliopsida Os.227002 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.85(n)    AK121568.1 


    ENSEMBL Gene Tree for TCP1 (if available)
    TreeFam Gene Tree for TCP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TCP1 gene
    9 SIMAP similar genes for TCP1 using alignment to 11 protein entries:     TCPA_HUMAN (see all proteins):
    LOC401329    CCT3    CCT7    CCT2    CCT5    CCT6A
    CCT4    CCT6B    CCT8

    Find genes that share paralogs with TCP1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for TCP1
    PGOHUM00000239701 PGOHUM00000235201 PGOHUM00000233205


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TCP1 (see all 102)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362584
    A breast cancer sample4--see VAR_0362582 V L mis40--------
    rs2019388251,2
    C--160200674(+) TTTTAC/TGTTCT 4 H R mis11Minor allele frequency- T:0.00EU 1323
    rs2003893921,2
    C--160200781(+) AGAAGT/CGATCT 4 /S syn11Minor allele frequency- C:0.00EU 1313
    rs1914517911,2
    C--160203436(+) ACAGAA/GTATAA 2 -- int10--------
    rs1438486591,2
    --160203470(+) GCTTCC/TCTAAG 2 -- int10--------
    rs1149301751,2
    F--160203578(+) ATTAGG/CAGAAA 2 -- int11Minor allele frequency- C:0.02WA 118
    rs1837662511,2
    --160203595(+) TGGTAA/GAAAGG 2 -- int10--------
    rs2007878501,2
    C--160203796(+) GGCAT-/AGAGAGA 2 -- int10--------
    rs1486179501,2
    --160203803(+) AGAGAG/TAATAC 2 -- int10--------
    rs125259351,2
    C,F,A,H--160203829(+) CAAAGG/AGGCTA 2 -- int15Minor allele frequency- A:0.02NS EA 538

    HapMap Linkage Disequilibrium report for TCP1 (160199530 - 160210781 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TCP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5563CNV Insertion18451855
    dgv2023e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): TCP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TCP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TCP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 186980    OMIM disorders: --


    Find genes that share disorders with TCP1           About GenesLikeMe

    3 Novoseek inferred disease relationships for TCP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 24 1 11441917 (1)
    shock 15.1 3 11048656 (1), 11771755 (1)
    alzheimers disease 8.52 2 11441917 (2)

    Genetic Association Database (GAD): TCP1
    Human Genome Epidemiology (HuGE) Navigator: TCP1 (5 documents)

    Export disorders for TCP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TCP1 gene, integrated from 10 sources (see all 188):
    (articles sorted by number of sources associating them with TCP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human homologue of the mouse T-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. (PubMed id 3653076)1, 2, 3 Willison K.... Trowsdale J. (EMBO J. 1987)
    2. T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. (PubMed id 1630492)1, 2, 9 Lewis V.A.... Willison K.R. (Nature 1992)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PubMed id 19132087)1, 4 Burgner D....Hibberd M.L. (PLoS Genet. 2009)
    5. Family-based association studies of the TCP1 gene and schizophrenia in the Chinese Han population. (PubMed id 16465465)1, 4 Tang W....He L. (J Neural Transm 2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    10. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6950 HGNC: 11655 AceView: TCP1 Ensembl:ENSG00000120438 euGenes: HUgn6950
    ECgene: TCP1 H-InvDB: TCP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TCP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TCP1 gene:
    Search GeneIP for patents involving TCP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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