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Aliases for TCP1 Gene

Aliases for TCP1 Gene

  • T-Complex 1 2 3 5
  • TCP-1-Alpha 3 4
  • CCT-Alpha 3 4
  • CCTA 3 4
  • CCT1 3 4
  • T-Complex Protein 1, Alpha Subunit 3
  • T-Complex Protein 1 Subunit Alpha 3
  • Tailless Complex Polypeptide 1 3
  • T-Complex 1 Protein 3
  • D6S230E 3

External Ids for TCP1 Gene

Previous GeneCards Identifiers for TCP1 Gene

  • GC06M159639
  • GC06M160073
  • GC06M160109
  • GC06M160170
  • GC06M160120
  • GC06M160122
  • GC06M160199

Summaries for TCP1 Gene

Entrez Gene Summary for TCP1 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

GeneCards Summary for TCP1 Gene

TCP1 (T-Complex 1) is a Protein Coding gene. Diseases associated with TCP1 include Epididymo-Orchitis. Among its related pathways are Chaperonin-mediated protein folding and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.

UniProtKB/Swiss-Prot for TCP1 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for TCP1 Gene

Additional gene information for TCP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP1 Gene

Genomics for TCP1 Gene

Regulatory Elements for TCP1 Gene

Enhancers for TCP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H159787 1.1 ENCODE 31.7 -0.3 -269 5.4 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MRPL18 TCP1 WTAP PNLDC1
GH06H158847 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +936.6 936628 11.2 MLX YBX1 FEZF1 SLC30A9 ZNF548 SP3 MCM3 MEF2D GLIS1 RCOR2 WTAP LOC442272 DYNLT1 OSTCP1 ENSG00000238019 SYNJ2-IT1 LOC105378078 EZR SYTL3 RNU6-293P
GH06H159714 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +73.2 73175 3.2 CTCF PKNOX1 ETV1 BACH1 CEBPG RAD21 ZNF507 YY1 FOSL1 FOXK2 IGF2R MRPL18 SOD2 WTAP TCP1 PNLDC1 RNU4ATAC18P HNRNPH1P1
GH06H159725 1.4 ENCODE dbSUPER 11.5 +61.5 61485 5.4 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D MRPL18 WTAP PNLDC1 ACAT2 SOD2-OT1 SOD2 SNORA29 TCP1 SNORA20 IGF2R
GH06H159690 1.4 ENCODE dbSUPER 11.2 +96.4 96350 5.8 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 MRPL18 WTAP PNLDC1 SOD2-OT1 SOD2 ACAT2 SNORA29 TCP1 SNORA20 LOC105378085
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCP1 on UCSC Golden Path with GeneCards custom track

Promoters for TCP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000206288 -151 3001 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Locations for TCP1 Gene

Genomic Locations for TCP1 Gene
chr6:159,778,498-159,789,749
(GRCh38/hg38)
Size:
11,252 bases
Orientation:
Minus strand
chr6:160,199,530-160,210,781
(GRCh37/hg19)

Genomic View for TCP1 Gene

Genes around TCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP1 Gene

Proteins for TCP1 Gene

  • Protein details for TCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17987-TCPA_HUMAN
    Recommended name:
    T-complex protein 1 subunit alpha
    Protein Accession:
    P17987
    Secondary Accessions:
    • E1P5B2
    • Q15556
    • Q5TCM3

    Protein attributes for TCP1 Gene

    Size:
    556 amino acids
    Molecular mass:
    60344 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.

neXtProt entry for TCP1 Gene

Post-translational modifications for TCP1 Gene

  • Ubiquitination at posLast=3333, posLast=6363, Lys73, Lys109, posLast=111111, Lys243, posLast=259259, Lys365, Lys484, posLast=494494, Lys499, posLast=532532, and Lys538
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCP1 Gene

Domains & Families for TCP1 Gene

Gene Families for TCP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P17987

UniProtKB/Swiss-Prot:

TCPA_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with TCP1: view

Function for TCP1 Gene

Molecular function for TCP1 Gene

GENATLAS Biochemistry:
T-complex 1,cytosolic,potential chaperonin,TF55/TCP-1,overlapping in opposite sense,the 3 region of ACAT2
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Phenotypes From GWAS Catalog for TCP1 Gene

Gene Ontology (GO) - Molecular Function for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 21753002
GO:0044183 protein binding involved in protein folding IBA --
genes like me logo Genes that share ontologies with TCP1: view
genes like me logo Genes that share phenotypes with TCP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP1 Gene

Localization for TCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 4
golgi apparatus 3
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000792 heterochromatin IEA --
GO:0001669 acrosomal vesicle IEA --
GO:0002199 zona pellucida receptor complex IEA --
GO:0005720 nuclear heterochromatin IEA --
genes like me logo Genes that share ontologies with TCP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCP1 Gene

Pathways & Interactions for TCP1 Gene

genes like me logo Genes that share pathways with TCP1: view

Gene Ontology (GO) - Biological Process for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding TAS,IEA --
GO:0006458 de novo protein folding IBA --
GO:0007021 tubulin complex assembly NAS 11532003
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
genes like me logo Genes that share ontologies with TCP1: view

No data available for SIGNOR curated interactions for TCP1 Gene

Drugs & Compounds for TCP1 Gene

(2) Drugs for TCP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TCP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCP1: view

Transcripts for TCP1 Gene

Unigene Clusters for TCP1 Gene

T-complex 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^
SP1: - - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4:
SP5:
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - -
SP14: - - -
SP15: - -
SP16:
SP17: - - - - -
SP18:

ExUns: 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCP1 Gene

GeneLoc Exon Structure for
TCP1
ECgene alternative splicing isoforms for
TCP1

Expression for TCP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCP1 Gene



Protein tissue co-expression partners for TCP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCP1 Gene:

TCP1

SOURCE GeneReport for Unigene cluster for TCP1 Gene:

Hs.363137

Evidence on tissue expression from TISSUES for TCP1 Gene

  • Nervous system(5)
  • Intestine(4.8)
  • Blood(4.6)
  • Liver(4.5)
  • Lung(3.6)
  • Kidney(3.1)
  • Skin(2.9)
  • Eye(2.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with TCP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP1 Gene

Orthologs for TCP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCP1 33 34
  • 99.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCP1 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCP1 33 34
  • 92.69 (n)
cow
(Bos Taurus)
Mammalia TCP1 33 34
  • 92.67 (n)
mouse
(Mus musculus)
Mammalia Tcp1 33 16 34
  • 90.65 (n)
rat
(Rattus norvegicus)
Mammalia Tcp1 33
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia TCP1 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCP1 33 34
  • 80.84 (n)
lizard
(Anolis carolinensis)
Reptilia TCP1 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp1 33
  • 77.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia tcp1-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii tcp1 33 34
  • 73.48 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9170 33
fruit fly
(Drosophila melanogaster)
Insecta T-cp1 35 33 34
  • 64.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004238 33
  • 63.02 (n)
worm
(Caenorhabditis elegans)
Secernentea cct-1 35 33 34
  • 62.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TCP1 33 34 36
  • 60.72 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04191g 33
  • 60.28 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL092W 33
  • 56.4 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TCP-1 33
  • 63.36 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2766 33
rice
(Oryza sativa)
Liliopsida Os04g0551800 33
  • 65.09 (n)
Os.22700 33
barley
(Hordeum vulgare)
Liliopsida Hv.1928 33
wheat
(Triticum aestivum)
Liliopsida Ta.28393 33
corn
(Zea mays)
Liliopsida Zm.6975 33
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct1 33
  • 61.93 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04448 33
  • 58.95 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12384 33
Species where no ortholog for TCP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TCP1 Gene

ENSEMBL:
Gene Tree for TCP1 (if available)
TreeFam:
Gene Tree for TCP1 (if available)

Paralogs for TCP1 Gene

Pseudogenes.org Pseudogenes for TCP1 Gene

genes like me logo Genes that share paralogs with TCP1: view

No data available for Paralogs for TCP1 Gene

Variants for TCP1 Gene

Sequence variations from dbSNP and Humsavar for TCP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036258 A breast cancer sample
rs1000196918 -- 159,786,139(+) TGGGC(A/G)TGAAG intron-variant, upstream-variant-2KB
rs1000332075 -- 159,786,281(+) GAAAA(C/G)TTGTT intron-variant, upstream-variant-2KB
rs1000518769 -- 159,789,892(+) GGTTG(-/T)TAAGA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000545945 -- 159,785,160(+) TTGAT(-/ACTG)CTGCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TCP1 Gene

Variant ID Type Subtype PubMed ID
esv2759483 CNV gain 17122850
nsv5563 CNV insertion 18451855

Variation tolerance for TCP1 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP1 Gene

Human Gene Mutation Database (HGMD)
TCP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP1 Gene

Disorders for TCP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCP1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
epididymo-orchitis
- elite association - COSMIC cancer census association via MalaCards
Search TCP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCP1

Genetic Association Database (GAD)
TCP1
Human Genome Epidemiology (HuGE) Navigator
TCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP1
genes like me logo Genes that share disorders with TCP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCP1 Gene

Publications for TCP1 Gene

  1. T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. (PMID: 1630492) Lewis VA … Willison K (Nature 1992) 3 4 22 60
  2. The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. (PMID: 3653076) Willison K … Trowsdale J (The EMBO journal 1987) 2 3 4 60
  3. BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S … Sheffield VC (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D … International Kawasaki Disease Genetics Consortium (PLoS genetics 2009) 3 45 60

Products for TCP1 Gene

Sources for TCP1 Gene

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