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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TCP1 Gene

protein-coding GIFtS: 67
GCID: GC06M160199

t-complex 1

Explore 20 diseases affiliated with
TCP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
T-Complex 1¹ ²		CCTa²
CCT1¹ ² ³		T-Complex Protein 1 Subunit Alpha²
D6S230E¹ ²		T-Complex Protein 1, Alpha Subunit²
CCT-Alpha¹		Tailless Complex Polypeptide 1²
TCP-1-Alpha¹		CCTA³
Ccta¹

External Ids:	HGNC: 11655¹	Entrez Gene: 6950²	Ensembl: ENSG00000120438⁷	OMIM: 186980⁵	UniProtKB: P17987³

Export aliases for TCP1 gene to outside databases

Previous GC identifers: GC06M159639 GC06M160073 GC06M160109 GC06M160170 GC06M160120 GC06M160122

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TCP1:

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex

(CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each

containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in

an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional

splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes

that appear to be derived from this gene have been found. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: TCPA_HUMAN, P17987

Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may

play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.

Known to play a role, in vitro, in the folding of actin and tubulin

Gene Wiki entry for TCP1 (T-complex 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCP1 gene promoter:
AML1a p53 Lmo2 USF-1:USF-2 IRF-1 Egr-2 SRY USF-1 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TCP1 promoter sequence

Search SABiosciences Chromatin IP Primers for TCP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TCP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3-q26 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25-q27

TCP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M160199: view genomic region (about GC identifiers)

Start:	160,199,530 bp from pter	End:	160,210,781 bp from pter
Size:	11,252 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TCPA_HUMAN, P17987 (See protein sequence)

Recommended Name: T-complex protein 1 subunit alpha

Size: 556 amino acids; 60344 Da

Subunit: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3,

CCT4, CCT5 AND CCT8

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome

Secondary accessions: E1P5B2 Q15556 Q5TCM3

Explore the universe of human proteins at neXtProt for TCP1: NX_P17987

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P17987

TCP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001008897.1 NP_110379.2

ENSEMBL proteins:

ENSP00000317334 ENSP00000439447 ENSP00000390159 ENSP00000376008 ENSP00000441345

ENSP00000440617 ENSP00000442185 ENSP00000444423 ENSP00000439671 ENSP00000437840

ENSP00000442856

Reactome Protein details: P17987
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TCP1 OriGene Protein Over-expression Lysate: TCP1 OriGene Custom Protein Services for TCP1
	GenScript Custom Purified and Recombinant Proteins Services for TCP1
	Novus Biologicals TCP1 Proteins Novus Biologicals TCP1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for TCP1
	Uscn Proteins for TCP1

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000242	pericentriolar material	IEA	--
GO:0005634	nucleus	IDA	--
GO:0005720	nuclear heterochromatin	IEA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

TCP1 for ontologies About GeneDecksing

TCP1 Antibody Products:

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	Novus Biologicals TCP1 Antibodies
	Abcam antibodies for TCP1
	Uscn Antibodies for TCP1
	ThermoFisher Antibodies for TCP1

Assay Products for TCP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for TCP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TCP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCP1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017998 Chaperone_TCP-1

IPR002194 Chaperonin_TCP-1_CS

IPR002423 Cpn60/TCP-1

IPR012715 Chap_CCT_alpha

Graphical View of Domain Structure for InterPro Entry P17987

ProtoNet protein and cluster: P17987

2 Blocks protein families:

IPB001844 Chaperonin Cpn60

IPB002194 Chaperonin TCP-1

UniProtKB/Swiss-Prot: TCPA_HUMAN, P17987

Similarity: Belongs to the TCP-1 chaperonin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TCPA_HUMAN, P17987

Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may

play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.

Known to play a role, in vitro, in the folding of actin and tubulin

Genatlas biochemistry entry for TCP1:

T-complex 1,cytosolic,potential chaperonin,TF55/TCP-1,overlapping in opposite sense,the 3' region of ACAT2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TCP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCP1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate TCP1:
		hsa-miR-3143 hsa-miR-543 hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: TCP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCP1 (see all 7) OriGene shRNA RFP: TCP1 OriGene siRNA: TCP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TCP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCP1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TCP1 (NM_001018025)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TCP1
		Search LifeMap BioReagents cell lines for TCP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005524	ATP binding	IEA	--
GO:0051082	unfolded protein binding	IEA	--

TCP1 for ontologies About GeneDecksing

7 GenomeRNAi human phenotypes for TCP1:

Cell cycle / mitosis defect	Decreased POU5F1-GFP protein e	Downregulation of NF-kappaB pa	Downregulation of NF-kappaB pa
Increased G2M DNA content	Increased number of mitotic ce	Metaphase cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of tubulin folding intermediates by CCT/TriC

	Formation of tubulin folding intermediates by CCT/TriC	1.00			Prefoldin mediated transfer of substrate to CCT/TriC	0.70
	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	0.74			Folding of actin by CCT/TriC	0.38

Chaperonin-mediated protein folding

	Chaperonin-mediated protein folding	1.00			Association of TriC/CCT with target proteins during biosynthesis	0.60
	Protein folding	0.91

Cell cycle Role of APC in cell cycle regulation

Cell cycle Role of APC in cell cycle regulation

1.00

Cell cycle_Role of APC in cell cycle regulation

0.98

HIF1Alpha Pathway

HIF1Alpha Pathway

1.00

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for TCP1

Cell cycle Role of APC in cell cycle regulation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TCP1

HIF1Alpha Pathway

1 GeneGo (Thomson Reuters) Pathway for TCP1

Cell cycle Role of APC in cell cycle regulation

5/8 Reactome Pathways for TCP1 (see all 8)

	Formation of tubulin folding intermediates by CCT/TriC
	Association of TriC/CCT with target proteins during biosynthesis
	Chaperonin-mediated protein folding
	Prefoldin mediated transfer of substrate to CCT/TriC
	Metabolism of proteins

TCP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TCP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1060 Interacting proteins for TCP1 (P17987^{2, 3} ENSP00000317334⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1060)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	TAS	--
GO:0007021	tubulin complex assembly	NAS	11532003
GO:0044267	cellular protein metabolic process	TAS	--
GO:0051084	'de novo' posttranslational protein folding	TAS	--

TCP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TCP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCP1
3 Novoseek chemical compound relationships for TCP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acetyl-coa	29	2	7904580 (2)
atp	27.8	2	15696173 (2)
glucose	0	2	11771755 (1)

Search CenterWatch for drugs/clinical trials and news about TCP1 / TCPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TCP1 gene (2 alternative transcripts):

NM_001008897.1 NM_030752.2

Unigene Cluster for TCP1:

T-complex 1

Hs.363137 [show with all ESTs]

Unigene Representative Sequence: NM_030752

18 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000321394(uc003qsr.3 uc003qss.3) ENST00000544255 ENST00000420894

ENST00000392168 ENST00000546204 ENST00000539756 ENST00000536807 ENST00000538530

ENST00000543532 ENST00000467544 ENST00000538128 ENST00000543517 ENST00000539948

ENST00000545764 ENST00000537390 ENST00000536394 ENST00000536607 ENST00000546023(uc010kka.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TCP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TCP1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate TCP1:
		hsa-miR-3143 hsa-miR-543 hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: TCP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TCP1 (see all 7) OriGene shRNA RFP: TCP1 OriGene siRNA: TCP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TCP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TCP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TCP1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TCP1 (NM_001018025)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TCP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TCP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TCP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP1

Additional cDNA sequence:

AK308551.1 AK312604.1 BC000665.1 BT006969.1 X52882.1

24/56 DOTS entries (see all 56):

DT.91782027 DT.99989299 DT.100884486 DT.100884460 DT.100803010 DT.100764164 DT.100884480 DT.100884491

DT.100884463 DT.121326743 DT.121326983 DT.86852813 DT.121327106 DT.100884490 DT.121326990 DT.121326756

DT.121327008 DT.100031507 DT.100884457 DT.100884454 DT.100884483 DT.121326778 DT.121326873 DT.121326906

24/419 AceView cDNA sequences (see all 419):

AW162558 AI271474 BQ773714 BP375550 BG577112 BI870274 BX344297 BQ431866

CB152137 BP374226 AA706069 BP347390 AA320480 CR624087 BQ431077 BX474568

AA381537 BM990555 AU102947 BE254796 BE280212 CR603769 AA406608 BX403819

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TCP1 (see all 18) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	·	8d	^
SP1:													-		-		-		-		-				-				-								-
SP2:																																					-
SP3:													-		-		-		-		-		-		-				-								-
SP4:
SP5:

ExUns:	9a	·	9b	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14a	·	14b
SP1:
SP2:
SP3:
SP4:																	-
SP5:

ECgene alternative splicing isoforms for TCP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TCP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGTTATGA

About this image

TCP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TCP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TCP1

SOURCE GeneReport for Unigene cluster: Hs.363137

SABiosciences Expression via Pathway-Focused PCR Arrays including TCP1:

Cellular Stress Responses in human mouse rat

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Heat Shock Proteins & Chaperones in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TCP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TCP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TCP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TCP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TCP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCP1 gene from 9/40 species (see all 40) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TCP1¹	t-complex 1	80.84(n) 91.17(a)		421586 NM_001006405.1 NP_001006405.1
lizard (Anolis carolinensis)	Reptilia	TCP1⁶	--	90(a)	1 ↔ 1	1(212182772-212197186)
African clawed frog (Xenopus laevis)	Amphibia	tcp1-A-prov²	t-complex polypeptide 1	79.33(n)		AF143494.1
zebrafish (Danio rerio)	Actinopterygii	tcp1²	t-complex polypeptide 1	75.37(n)		30477 AF143493.1
fruit fly (Drosophila melanogaster)	Insecta	T-cp1^{1 , 3}	protein folding chaperone³ Tcp1-like¹	73(a)³ 64.86(n)¹ 73.6(a)¹		94B1³ 42649¹ NM_079726.3¹ NP_524450.2¹
worm (Caenorhabditis elegans)	Secernentea	cct-1^{1 , 3}	T-complex protein³ Protein CCT-1¹	69(a)³ 62.07(n)¹ 69.46(a)¹		II(8185368-8187309)³ 174318¹ NM_063321.3¹ NP_495722.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TCP1(YDR212W)⁴ TCP1¹	Alpha subunit of chaperonin-containing T-complex, which more⁴ Tcp1p¹	60.92(n)¹ 64.61(a)¹		4(887232-888911)⁴ 851798^{1, 4} NP_010498.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	TCP-1¹	T-complex protein 1 subunit alpha	63.36(n) 66.85(a)		821544 NM_112896.3 NP_188640.1
rice (Oryza sativa)	Liliopsida	Os.22700²	Oryza sativa (japonica cultivar-group) cDNA cloneJ more	73.85(n)		AK121568.1

ENSEMBL Gene Tree for TCP1 (if available)
TreeFam Gene Tree for TCP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TCP1 gene

9 SIMAP similar genes for TCP1 using alignment to 11 protein entries: TCPA_HUMAN (see all proteins):

LOC401329 CCT3 CCT2 CCT7 CCT5 CCT6A

CCT4 CCT6B CCT8

TCP1 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TCP1
PGOHUM00000239701 PGOHUM00000235201 PGOHUM00000233205

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147097290^1,2	C,	--	160200861(+)	`AAGGGA/GAAAAA`	3	--	ds500¹ int¹		0	--	--	--	--
rs200419393^1,2		--	160200884(+)	`CACAGA/CTACTG`	3	--	ds500¹ int¹		0	--	--	--	--
rs191839059^1,2	C,	--	160200916(+)	`AAATGA/GCTGTT`	3	--	ds500¹ int¹		0	--	--	--	--
rs199731783^1,2		--	160200996(+)	`ACCACA/GGATTT`	5	S	ds500¹ syn¹		0	--	--	--	--
rs201063084^1,2		--	160201049(+)	`AGAGCA/GCTCCA`	5	R C	ds500¹ mis¹		0	--	--	--	--
rs200792657^1,2		--	160201104(+)	`GCAGAC/TGTACG`	5	T	syn¹ ds500¹		0	--	--	--	--
rs73781663^1,2	C,F,	--	160201160(+)	`TTTTTA/TAAAAT`	3	--	ds500¹ int¹		3		WA	122
rs200143758^1,2		--	160201164(+)	`TAAAAA/TTTTTT`	3	--	ds500¹ int¹		0	--	--	--	--
rs184311122^1,2		--	160201273(+)	`ATACTA/CTACAG`	3	--	ds500¹ int¹		0	--	--	--	--
rs2295901^1,2	C,F,H,	--	160201295(-)	`CTGCAT/GGGACT`	3	--	int¹ nc-transcript-variant		28		EA NA NS WA CSA EU	5192

HapMap Linkage Disequilibrium report for TCP1 (160199530 - 160210781 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TCP1
1 CNV: 3647
Human Gene Mutation Database (HGMD): TCP1

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TCP1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TCP1 for disorders           About GeneDecksing

OMIM gene information: 186980    OMIM disorders: --

20 diseases for TCP1:    About MalaCards

cerebral cavernous malformations cavernous malformation cerebral cavernous malformations 3 temporal lobe epilepsy

spina bifida down syndrome fanconi's anemia gaucher's disease

kawasaki disease alzheimer's disease endocarditis cerebritis

anemia colorectal cancer breast cancer schizophrenia

malaria neuronitis pancreatic cancer pancreatitis

3 Novoseek disease relationships for TCP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
down syndrome	24	1	11441917 (1)
shock	15.1	3	11048656 (1), 11771755 (1)
alzheimers disease	8.52	2	11441917 (2)

Human Genome Epidemiology (HuGE) Navigator: TCP1 (5 documents)

Export disorders for TCP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TCP1 gene, integrated from 9 sources (see all 161):
(articles sorted by number of sources associating them with TCP1)

Utopia: connect your pdf to the dynamic
world of online information

The human homologue of the mouse T-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. (PubMed id 3653076)^{1, 2, 3} Willison K.... Trowsdale J. (1987)
T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. (PubMed id 1630492)^{1, 2, 9} Lewis V.A.... Willison K.R. (1992)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)^{1, 2} Imai Y.... Takahashi R. (2003)
Nucleotide and amino-acid sequence of human testis-derived TCP1. (PubMed id 2377466)^{1, 2} Kirchhoff C. and Willison K.R. (1990)
Assignment of the TCP1 locus to the long arm of human chromosome 6 by in situ hybridization. (PubMed id 3476253)^{1, 3} Fonatsch C....Ziegler A. (1987)
Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes. (PubMed id 7904580)^{1, 9} Ashworth A. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6950	HGNC: 11655	AceView: TCP1	Ensembl:ENSG00000120438	euGenes: HUgn6950
ECgene: TCP1	H-InvDB: TCP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TCP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TCP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TCP1 gene:
Search GeneIP for patents involving TCP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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