Aliases for TCP1 Gene
External Ids for TCP1 Gene
Previous GeneCards Identifiers for TCP1 Gene
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
GeneCards Summary for TCP1 Gene
TCP1 (T-Complex 1) is a Protein Coding gene. Diseases associated with TCP1 include Epididymo-Orchitis and Gaucher's Disease. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and HIF1Alpha Pathway. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.
UniProtKB/Swiss-Prot for TCP1 Gene
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.