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Aliases for TCP1 Gene

Aliases for TCP1 Gene

  • T-Complex 1 2 3 5
  • TCP-1-Alpha 3 4
  • CCT-Alpha 3 4
  • CCTA 3 4
  • CCT1 3 4
  • T-Complex Protein 1, Alpha Subunit 3
  • T-Complex Protein 1 Subunit Alpha 3
  • Tailless Complex Polypeptide 1 3
  • T-Complex 1 Protein 3
  • D6S230E 3

External Ids for TCP1 Gene

Previous GeneCards Identifiers for TCP1 Gene

  • GC06M159639
  • GC06M160073
  • GC06M160109
  • GC06M160170
  • GC06M160120
  • GC06M160122
  • GC06M160199

Summaries for TCP1 Gene

Entrez Gene Summary for TCP1 Gene

  • The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

GeneCards Summary for TCP1 Gene

TCP1 (T-Complex 1) is a Protein Coding gene. Diseases associated with TCP1 include Epididymo-Orchitis and Orchitis. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Chaperonin-mediated protein folding. GO annotations related to this gene include poly(A) RNA binding and unfolded protein binding.

UniProtKB/Swiss-Prot for TCP1 Gene

  • Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Wiki entry for TCP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP1 Gene

Genomics for TCP1 Gene

Regulatory Elements for TCP1 Gene

Enhancers for TCP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G159787 1.2 ENCODE 23.5 -0.3 -269 5.4 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A MRPL18 TCP1 PNLDC1
GH06G160455 1.2 Ensembl ENCODE 21.2 -666.1 -666089 1.7 ZFP64 ARID4B ZNF48 ZNF143 ZNF202 NFYC REST ZNF623 ZNF518A KAT8 SLC22A3 TCP1 SNORA29 PIR50129 LPAL2
GH06G159972 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -184.1 -184147 3.4 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 FOS IGF2R WTAP SOD2 TCP1 SLC22A1 LOC729603 MAS1 AIRN
GH06G159725 1.4 ENCODE dbSUPER 11.5 +61.5 61485 5.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MRPL18 PNLDC1 ACAT2 SOD2-OT1 SOD2 SNORA29 TCP1 SNORA20 WTAP IGF2R
GH06G159699 1.5 Ensembl ENCODE dbSUPER 10.6 +88.8 88765 3.5 FOXA2 YY1 FOS SP3 REST TSHZ1 ZNF623 ZNF518A SMARCA4 MYNN MRPL18 WTAP PNLDC1 SOD2 SOD2-OT1 ACAT2 SNORA29 TCP1 GC06M159698 PIR54448
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TCP1 on UCSC Golden Path with GeneCards custom track

Promoters for TCP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000206288 -151 3001 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A

Genomic Location for TCP1 Gene

Chromosome:
6
Start:
159,778,498 bp from pter
End:
159,789,749 bp from pter
Size:
11,252 bases
Orientation:
Minus strand

Genomic View for TCP1 Gene

Genes around TCP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP1 Gene

Proteins for TCP1 Gene

  • Protein details for TCP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17987-TCPA_HUMAN
    Recommended name:
    T-complex protein 1 subunit alpha
    Protein Accession:
    P17987
    Secondary Accessions:
    • E1P5B2
    • Q15556
    • Q5TCM3

    Protein attributes for TCP1 Gene

    Size:
    556 amino acids
    Molecular mass:
    60344 Da
    Quaternary structure:
    • Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8.

neXtProt entry for TCP1 Gene

Post-translational modifications for TCP1 Gene

  • Ubiquitination at isoforms=33, Lys63, isoforms=73, isoforms=109, posLast=111111, posLast=243243, isoforms=259, isoforms=365, posLast=484484, posLast=494494, posLast=499499, posLast=532532, and posLast=538538
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCP1 Gene

Domains & Families for TCP1 Gene

Gene Families for TCP1 Gene

Graphical View of Domain Structure for InterPro Entry

P17987

UniProtKB/Swiss-Prot:

TCPA_HUMAN :
  • Belongs to the TCP-1 chaperonin family.
Family:
  • Belongs to the TCP-1 chaperonin family.
genes like me logo Genes that share domains with TCP1: view

Function for TCP1 Gene

Molecular function for TCP1 Gene

GENATLAS Biochemistry:
T-complex 1,cytosolic,potential chaperonin,TF55/TCP-1,overlapping in opposite sense,the 3 region of ACAT2
UniProtKB/Swiss-Prot Function:
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.

Gene Ontology (GO) - Molecular Function for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0005515 protein binding IPI 14532270
GO:0005524 ATP binding IEA --
GO:0031625 ubiquitin protein ligase binding IPI 21753002
GO:0044183 protein binding involved in protein folding IBA --
genes like me logo Genes that share ontologies with TCP1: view
genes like me logo Genes that share phenotypes with TCP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP1 Gene

Localization for TCP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 4
golgi apparatus 3
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000792 heterochromatin IEA --
GO:0001669 acrosomal vesicle IEA --
GO:0002199 zona pellucida receptor complex IEA --
GO:0005720 nuclear heterochromatin IEA --
genes like me logo Genes that share ontologies with TCP1: view

Pathways & Interactions for TCP1 Gene

genes like me logo Genes that share pathways with TCP1: view

Gene Ontology (GO) - Biological Process for TCP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA,TAS --
GO:0006458 de novo protein folding IBA --
GO:0007021 tubulin complex assembly NAS 11532003
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 25467444
genes like me logo Genes that share ontologies with TCP1: view

No data available for SIGNOR curated interactions for TCP1 Gene

Drugs & Compounds for TCP1 Gene

(2) Drugs for TCP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TCP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCP1: view

Transcripts for TCP1 Gene

Unigene Clusters for TCP1 Gene

T-complex 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^
SP1: - - - - - - - -
SP2: -
SP3: - - - - - - - - -
SP4:
SP5:
SP6: - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - - - - - -
SP8: - - - - - -
SP9:
SP10: - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - -
SP14: - - -
SP15: - -
SP16:
SP17: - - - - -
SP18:

ExUns: 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCP1 Gene

GeneLoc Exon Structure for
TCP1
ECgene alternative splicing isoforms for
TCP1

Expression for TCP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCP1 Gene



Protein tissue co-expression partners for TCP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCP1 Gene:

TCP1

SOURCE GeneReport for Unigene cluster for TCP1 Gene:

Hs.363137

Evidence on tissue expression from TISSUES for TCP1 Gene

  • Nervous system(5)
  • Intestine(4.8)
  • Blood(4.6)
  • Liver(4.5)
  • Lung(3.6)
  • Kidney(3.1)
  • Skin(2.9)
  • Eye(2.4)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with TCP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP1 Gene

Orthologs for TCP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCP1 34 35
  • 99.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCP1 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCP1 34 35
  • 92.69 (n)
cow
(Bos Taurus)
Mammalia TCP1 34 35
  • 92.67 (n)
mouse
(Mus musculus)
Mammalia Tcp1 34 16 35
  • 90.65 (n)
rat
(Rattus norvegicus)
Mammalia Tcp1 34
  • 90.05 (n)
oppossum
(Monodelphis domestica)
Mammalia TCP1 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCP1 34 35
  • 80.84 (n)
lizard
(Anolis carolinensis)
Reptilia TCP1 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp1 34
  • 77.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia tcp1-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii tcp1 34 35
  • 73.48 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9170 34
fruit fly
(Drosophila melanogaster)
Insecta T-cp1 36 34 35
  • 64.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004238 34
  • 63.02 (n)
worm
(Caenorhabditis elegans)
Secernentea cct-1 36 34 35
  • 62.02 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TCP1 34 35 37
  • 60.72 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A04191g 34
  • 60.28 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL092W 34
  • 56.4 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TCP-1 34
  • 63.36 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2766 34
rice
(Oryza sativa)
Liliopsida Os04g0551800 34
  • 65.09 (n)
Os.22700 34
barley
(Hordeum vulgare)
Liliopsida Hv.1928 34
wheat
(Triticum aestivum)
Liliopsida Ta.28393 34
corn
(Zea mays)
Liliopsida Zm.6975 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cct1 34
  • 61.93 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04448 34
  • 58.95 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12384 34
Species where no ortholog for TCP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TCP1 Gene

ENSEMBL:
Gene Tree for TCP1 (if available)
TreeFam:
Gene Tree for TCP1 (if available)

Paralogs for TCP1 Gene

Pseudogenes.org Pseudogenes for TCP1 Gene

genes like me logo Genes that share paralogs with TCP1: view

No data available for Paralogs for TCP1 Gene

Variants for TCP1 Gene

Sequence variations from dbSNP and Humsavar for TCP1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036258 A breast cancer sample
rs1000196918 -- 159,786,139(+) TGGGC(A/G)TGAAG intron-variant, upstream-variant-2KB
rs1000332075 -- 159,786,281(+) GAAAA(C/G)TTGTT intron-variant, upstream-variant-2KB
rs1000518769 -- 159,789,892(+) GGTTG(-/T)TAAGA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000545945 -- 159,785,160(+) TTGAT(-/ACTG)CTGCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TCP1 Gene

Variant ID Type Subtype PubMed ID
esv2759483 CNV gain 17122850
nsv5563 CNV insertion 18451855

Variation tolerance for TCP1 Gene

Residual Variation Intolerance Score: 14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TCP1 Gene

Human Gene Mutation Database (HGMD)
TCP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP1 Gene

Disorders for TCP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
epididymo-orchitis
orchitis
  • inflammation of testis
- elite association - COSMIC cancer census association via MalaCards
Search TCP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TCP1

Genetic Association Database (GAD)
TCP1
Human Genome Epidemiology (HuGE) Navigator
TCP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TCP1
genes like me logo Genes that share disorders with TCP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCP1 Gene

Publications for TCP1 Gene

  1. T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cytosol. (PMID: 1630492) Lewis V.A. … Willison K.R. (Nature 1992) 3 4 22 64
  2. The human homologue of the mouse T-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. (PMID: 3653076) Willison K. … Trowsdale J. (EMBO J. 1987) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly. (PMID: 20080638) Seo S. … Sheffield V.C. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
  5. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D. … Hibberd M.L. (PLoS Genet. 2009) 3 46 64

Products for TCP1 Gene

Sources for TCP1 Gene

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