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TCOF1 Gene

protein-coding GIFtS: 62

GC05P149717

Treacher Collins-Franceschetti syndrome 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MFD1 ^², ⁵
treacle ^¹, ²

Descriptions
Treacher Collins syndrome protein ^², ³
Treacher Collins-Franceschetti syndrome 1 ^²
nucleolar trafficking phosphoprotein ^²

External Ids
HGNC: 11654¹
Entrez Gene: 6949²
UniProtKB: Q13428³
Ensembl: ENSG00000070814⁷

Search outside databases for aliases for TCOF1 gene

Previous GC identifers: GC05P149806 GC05P150198 GC05P149720 GC05P149765

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TCOF1:

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in

ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF).

Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which

includes abnormal craniofacial development. Multiple transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TCOF_HUMAN, Q13428

Function: May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early

embryonic development, particularly in development of the craniofacial complex (By similarity)

Gene Wiki entry for TCOF1 (Treacle_protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TCOF1 gene

Entrez Gene cytogenetic band: 5q32-q33.1 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q31.3-q33.3

TCOF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P149717: (about GC identifiers)

Start:	149,717,428 bp from pter
End:	149,760,064 bp from pter
Size:	42,637 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TCOF_HUMAN, Q13428 (See protein sequence)

Recommended Name: Treacle protein

Size: 1488 amino acids; 152104 Da

Subcellular location: Nucleus, nucleolus (Potential)

Secondary accessions: Q6SC72 Q7Z5W9 Q96A52 Q99408 Q99860

Alternative splicing: 5 isoforms: Q13428-1 Q13428-2 Q13428-3 Q13428-4 Q13428-5

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_000347.2 NP_001008656.1 NP_001008657.1 NP_001128715.1 NP_001128716.1 NP_001128717.1

ENSEMBL proteins:

ENSP00000377811 ENSP00000367028 ENSP00000314349 ENSP00000325223

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Treacher Collins syndrome protein)
	Human Recombinant Proteins from Abnova (TCOF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	15249688

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Antibodies for TCOF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TCOF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Treacher Collins syndrome protein), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TCOF1)
	Novus Biologicals Antibodies for TCOF1

Assays for TCOF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13428

ProtoNet protein and cluster: Q13428

2 Blocks protein families:

IPB003993 Treacher Collins syndrome protein Treacle signature

IPB006594 Lissencephaly type-1-like homology motif

UniProtKB/Swiss-Prot: TCOF_HUMAN, Q13428

Similarity: Contains 1 LisH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCOF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCOF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_001135243

Applied Biosystems Silencer® siRNAs for TCOF1

Sigma-Aldrich siRNA and siRNA Panels for TCOF1

Sigma-Aldrich shRNA for TCOF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TCOF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_000356
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_000356
untagged cDNA clones in CMV expression vector (see all 6): NM_000356

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001135243

UniProtKB/Swiss-Prot: TCOF_HUMAN, Q13428

Function: May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early

embryonic development, particularly in development of the craniofacial complex (By similarity)

13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tcof1):

cellular	craniofacial	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	lethality-prenatal/perinatal	nervous system	respiratory system
skeleton	taste/olfaction	vision/eye

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	TAS	9096354
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TCOF1

5/16 Interacting proteins for TCOF1 (Q13428¹ ENSP00000314349³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARRB1	P49407¹	EBI-396105, EBI-743313
ARRB2	P32121¹	EBI-396105, EBI-714559
MKLN1	ENSP00000323527³	STRING (score=.933)
UBTF	ENSP00000302640³	STRING (score=.904)
SUCLG2	ENSP00000307432³	STRING (score=.874)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	TAS	9096354
GO:0006810	transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TCOF1
1 Novoseek chemical compound relationship for TCOF1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rrna	27.63	1	12777385 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TCOF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TCOF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_001135243

Sigma-Aldrich siRNA and siRNA Panels for TCOF1

Sigma-Aldrich shRNA for TCOF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000356 NM_001008656 NM_001008657 NM_001135243 NM_001135244 NM_001135245

REFSEQ mRNAs for TCOF1 gene (6 alternative transcripts):

NM_000356.3 NM_001008656.2 NM_001008657.2 NM_001135243.1 NM_001135244.1 NM_001135245.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000356 NM_001008656 NM_001008657 NM_001135243 NM_001135244 NM_001135245

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_000356
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_000356
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_000356

Additional cDNA sequence:

AB209317.1 AK096467.1 AK225284.1 AK296918.1 AK299167.1 AK303611.1 AK307586.1 AL133039.1

AY460334.1 BC008331.1 BC011764.2 BC014559.2 BC016144.1 BC027252.1 BC033093.1 U40847.1

U76366.1

21 DOTS entries:

DT.91754561 DT.99946398 DT.92365041 DT.313465 DT.91754556 DT.313464 DT.91639367 DT.100810088

DT.91754562 DT.99963839 DT.101982234 DT.120836695 DT.92005727 DT.97862262 DT.100772141 DT.100772142

DT.102828287 DT.86856410 DT.95178450 DT.120836709 DT.95178449

24/298 AceView cDNA sequences (see all 298 ):

BE792061 BX424546 BM556446 BU156635 BQ878420 BE728897 BM852328 BG750853

AW001182 CD654855 BQ680644 AI638669 BE793163 BM549968 BC011764 CD643248

BM664489 BP355691 BQ226231 BM834587 BQ052523 BQ637879 BM835081 CA487251

highest scoring ESTs for TCOF1:

U76366 AA343053 AA399645 AA504058 AA580140 AA988028 AI034160 AI086146 AI304411 AI345337

Unigene Cluster for TCOF1:

Treacher Collins-Franceschetti syndrome 1

Hs.519672 [show with all ESTs]

Unigene Representative Sequence: AB209317

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for TCOF1 (see all 15 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	·	13c	^	14a	·	14b	·	14c	^	15a	·	15b	·	15c	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	16	^	17	^	18a	·	18b	^	19a	·	19b	·	19c	^	20	^	21a	·	21b	^	22a	·	22b	·	22c	^	23
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TCOF1

4 Ensembl transcripts including schematic representations:

ENST00000394269 ENST00000377797 ENST00000323753 ENST00000323668

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TCOF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TCOF1

¹ / ² / ³

9 probe-sets matching TCOF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40596_at²^{, 3}	U95-A	1	1.00	1.00	0.59	1.16	U76366	1.00	1.00	1.00	1
40597_g_at²^{, 3}	U95-A	1	1.00	1.00	0.86	0.37	U76366	1.00	1.00	1.00	1
84119_at²^{, 3}	U95-D	2	1.00	0.97	0.18	1.47	AI939467	0.60	1.00	0.82	1
244686_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI939467	0.60	1.00	0.82	1
202385_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000356	0.60	1.00	0.82	1
202384_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW167713	0.60	1.00	0.82	1
244686_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202385_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202384_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.519672
Expression variation in blood from EXPOLDB for TCOF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TCOF1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TCOF1¹	--	Treacher Collins-Franceschetti syndrome 1	67.25(n) 58.47(a)	403592 NM_001003057.1 NP_001003057.1
chimpanzee (Pan troglodytes)	TCOF1¹	--	Treacher Collins-Franceschetti syndrome 1	97.64(n) 97.02(a)	471696 XM_527074.2 XP_527074.2
cow (Bos taurus)	TCOF1¹	--	Treacher Collins-Franceschetti syndrome 1	77.46(n) 67.92(a)	513591 XM_591291.3 XP_591291.3
rat (Rattus norvegicus)	Tcof1¹	--	Treacher Collins Franceschetti syndrome 1, homolog	71.71(n) 61.39(a)	291571 XM_214552.4 XP_214552.4
mouse (Mus musculus)	Tcof1^{1, 5}	18 (32.00 cM)⁵	Treacher Collins Franceschetti syndrome 1, homolog^{1, 5}	70.98(n)¹ 61.34(a)¹	21453¹ NM_011552.2¹ NP_035682.1¹ AA408847⁵ AF001794⁵ (see all 18)

About this table Species with no ortholog for TCOF1

ENSEMBL Gene Tree for TCOF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TCOF1 gene

AKAP12² NOLC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/169 NCBI SNPs in TCOF1 are shown (see all 169 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 82)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2748220^1,2	A,C,F,H,O	149744486(+)	`AGGATT/GCGGGG`	3	--	int¹ ng3¹		7		NA EU EA WA	560
	rs15251^1,2	A,C,F,H,O	149756425(+)	`GAAAGC/TAAAGA`	5	A/V	mis¹		20		EA NA MN EU WA	1710
	rs7713638^1,2	A,C,F,H	149739289(+)	`CCAGGT/CGAAGC`	6	A/V	mis¹		4		EU EA WA	418
	rs7715100^1,2	C,F,H	149743498(+)	`GGACCA/GGGAGT`	3	Q/R	mis¹ int¹		7		NA EU EA WA	560
	rs2071240^1,2	C,F,H	149735937(+)	`CCCAAC/GCCCCC`	6	A/P	mis¹ ese³		9		EU EA WA NA	876
	rs1136103^1,2	C,F	149752473(-)	`TGGAGG/CGGGTG`	5	R/P	mis¹		4		EU EA WA	420
	rs11747800^1,2	C,H	149716564(+)	`TTGTAG/AGCCTT`	3	--	ng5¹		4		EU EA WA	416
	rs15253^1,2	C	149756536(+)	`GGGGAA/CGGTTG`	5	T/K	mis¹		0	--	--	--	--
--	rs11541812^1,2	H	149756094(+)	`AGAAAG/AGGGCT`	5	R/G	mis¹ ese³ trp³		4		EU EA WA	406
	rs28372961^1,2	F	149717171(+)	`GAGAAT/CTAACA`	3	--	ng5¹ tfbs³		2		MN EA	1252

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HapMap Linkage Disequilibrium images for TCOF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606847 disorders: 154500

UniProtKB/Swiss-Prot: TCOF_HUMAN, Q13428

Defects in TCOF1 are the cause of Treacher Collins syndrome (TCS) [MIM:154500]. TCS is an

autosomal dominant disorder of craniofacial development that occurs with an incidence of 1/50,000

live births. The clinical features of TCS are bilaterally symmetrical and include: (1)

abnormalities of the external ears, atresia of the external ear canals, and malformation of the

middle ear ossicles, which may result in conductive hearing loss; (2) lateral downward sloping of

palpebral fissures, frequently with colobomas of the lower eyelids; (3) hypoplasia of the mandible

and zygomatic complex; (4) cleft palate

5 Novoseek disease relationships for TCOF1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
treacher collins syndrome	98.32	41	11013442 (2), 12777385 (2), 15150774 (2), 14598341 (2) (see all 34)
microtia	80.06	2	15770127 (2)
conductive hearing loss	79.72	2	8488840 (1), 8281138 (1)
cleft palate	72.48	6	18688869 (4), 8488840 (1), 8281138 (1)
congenital malformation	16.22	2	15249688 (1), 10888597 (1)

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Genatlas disease: TCOF1

Treacher Collins-Franceschetti syndrome,mandibulofacial dysostosis characterized by antimongoloid

slant of eyes,coloboma of inferior lid,narrowing of the external ears and malformation of the

middle ear ossicles which may lead to deafness,hypoplasia of the mandible (macrognathia) and cleft

palate and macrostomia

GeneTests: TCOF1

Treacher Collins Syndrome

Human Gene Mutation Database: TCOF1
Genetic Association Database: TCOF1
Human Genome Epidemiology Navigator: TCOF1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/72 PubMed articles for TCOF1 gene (see all 72 ):

TCOF1 gene encodes a putative nucleolar phosphoprotein that exhibits mutations in Treacher Collins syndrome throughout its coding region. (PubMed id 9096354)^{1, 3, 4} Wise C.A.... Jabs E.W. (1997)
Identification of the complete coding sequence and genomic organization of the Treacher Collins syndrome gene. (PubMed id 9074926)^{1, 3, 4} Dixon J....Dixon M.J. (1997)
Genotyping in 46 patients with tentative diagnosis of Treacher Collins syndrome revealed unexpected phenotypic variation. (PubMed id 15340364)^{1, 3, 6} Teber O.A....Wieczorek D. (2004)
The mutational spectrum in Treacher Collins syndrome reveals a predominance of mutations that create a premature-termination codon. (PubMed id 9042910)^{1, 3, 4} Edwards S.J.... Dixon M.J. (1997)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons. (PubMed id 15019983)^{3, 4} So R.B.... Valdez B.C. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Positional cloning of a gene involved in the pathogenesis of Treacher Collins syndrome. (PubMed id 8563749)^{3, 4} Dixon J.... Wasmuth J.J. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6949	HGNC: 11654	AceView: TCOF1	Ensembl:ENSG00000070814	euGenes: HUgn6949
ECgene: TCOF1	H-InvDB: TCOF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=TCOF1

Licensable Technologies for TCOF1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TCOF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TCOF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TCOF1		Antibodies for TCOF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TCOF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
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Antibodies for TCOF1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TCOF1 Gene at Home site.
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TCOF1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for TCOF1

Summaries
for TCOF1

Genomic Location
for TCOF1

Proteins
for TCOF1

Protein Domains/
Families
for TCOF1

Gene Function
for TCOF1

Pathways & Interactions
for TCOF1

Drugs & Compounds
for TCOF1

Transcripts
for TCOF1

Expression
for TCOF1

Orthologs
for TCOF1

Paralogs
for TCOF1

SNPs/Variants
for TCOF1

Disorders & Mutations
for TCOF1

Medical News
for TCOF1

Publications
for TCOF1

Search for TCOF1

Genome Databases showing TCOF1

Other Databases showing TCOF1

Specialized Databases showing TCOF1

Licensable Technologies
for TCOF1

Services
for TCOF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TCOF1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor TCOF1

Summariesfor TCOF1

Genomic Locationfor TCOF1

Proteinsfor TCOF1

Protein Domains/Familiesfor TCOF1

Gene Functionfor TCOF1

Pathways & Interactionsfor TCOF1

Drugs & Compoundsfor TCOF1

Transcriptsfor TCOF1

Expression for TCOF1

Orthologsfor TCOF1

Paralogsfor TCOF1

SNPs/Variantsfor TCOF1

Disorders & Mutationsfor TCOF1

Medical Newsfor TCOF1

Publicationsfor TCOF1

Search for TCOF1

Genome Databases showing TCOF1

Other Databases showing TCOF1

Specialized Databases showing TCOF1

Licensable Technologiesfor TCOF1

Servicesfor TCOF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TCOF1

Summaries
for TCOF1

Genomic Location
for TCOF1

Proteins
for TCOF1

Protein Domains/
Families
for TCOF1

Gene Function
for TCOF1

Pathways & Interactions
for TCOF1

Drugs & Compounds
for TCOF1

Transcripts
for TCOF1

Expression
for TCOF1

Orthologs
for TCOF1

Paralogs
for TCOF1

SNPs/Variants
for TCOF1

Disorders & Mutations
for TCOF1

Medical News
for TCOF1

Publications
for TCOF1

Licensable Technologies
for TCOF1

Services
for TCOF1